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VAVPGGQVWFQRTGGGAGLPLLVIHGGPGLPHDYLRSLRRLATDREVIFWDQLGCGNSKCPPNPGLWTME RSVAEVDAVVRALRLDRFHLFGNSWGGMLAQQYVLDAAPAGAASLTISNSIASIPQFGKMVARLKSELDP ATQAAIDRHEAAGTTHDPEYQAAIRTWNETYLCRVRPWPRDLEDAFRKMSAEVFETMFGASDFHIVGTVR DWDVFDRLGEIAVPTLVLAGRYDECVPEHMWEMHRRIPGSRFELFESSAHMPFIEEPEKFDAVMRDFLRL HD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0868 | - | - | 100% (283) | proline imino-peptidase |
| M. avium 104 | MAV_3609 | - | 1e-09 | 27.21% (283) | hydrolase |
| M. avium 104 | MAV_4120 | - | 4e-08 | 32.97% (91) | hydrolase, alpha/beta fold family protein, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0863c | pip | 1e-121 | 72.34% (282) | proline iminopeptidase |
| M. gilvum PYR-GCK | Mflv_0627 | - | 7e-09 | 25.99% (277) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0840c | pip | 1e-121 | 72.34% (282) | proline iminopeptidase |
| M. leprae Br4923 | MLBr_01899 | lipG | 2e-05 | 25.59% (211) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0349c | - | 1e-12 | 24.47% (237) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_4789 | pip | 1e-123 | 73.40% (282) | proline iminopeptidase Pip |
| M. smegmatis MC2 155 | MSMEG_2681 | - | 3e-58 | 42.59% (270) | proline imino-peptidase |
| M. thermoresistible (build 8) | TH_4528 | - | 2e-07 | 24.54% (269) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_0358 | pip | 1e-107 | 71.98% (257) | proline iminopeptidase PIP |
| M. vanbaalenii PYR-1 | Mvan_1084 | - | 1e-09 | 23.97% (292) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0863c|M.bovis_AF2122/97 --------------------------MEGTIAVPGGRVWFQRIGGG----
Rv0840c|M.tuberculosis_H37Rv --------------------------MEGTIAVPGGRVWFQRIGGG----
MMAR_4789|M.marinum_M -----------------------MTKPEATIAVPGGKVWSKRVGGG----
MUL_0358|M.ulcerans_Agy99 -----------------------MEQARRRRLRPSPARGAWRPGPA----
MAV_0868|M.avium_104 -----------------------------MVAVPGGQVWFQRTGGG----
MSMEG_2681|M.smegmatis_MC2_155 -------------------MLSRMPVSSRTVPFGDHETWVQVTTPENAQP
Mflv_0627|M.gilvum_PYR-GCK ------------MLKDASICVSLLGAETRFVDVDGVRTRTIQAGEG----
TH_4528|M.thermoresistible__bu ------------VWSDLQGVAFTQG----YLDAGGVRTRYLHAGEAD---
MAB_0349c|M.abscessus_ATCC_199 --------------------MGSAALQDRYLQSCLGGLHVRIGGEG----
Mvan_1084|M.vanbaalenii_PYR-1 MSPMRGPGGTRPFRTAAGDVVPESVAEVGYCRLGGVDQWVLIRGRN---L
MLBr_01899|M.leprae_Br4923 -----------------------MEVRSGYATSGDLKLYYEDMGNVD---
Mb0863c|M.bovis_AF2122/97 PGRPLLVVHGGPGLPHNYLAPLRRLSDE--REVIFWDQLGCGNSACPSDV
Rv0840c|M.tuberculosis_H37Rv PGRPLLVVHGGPGLPHNYLAPLRRLSDE--REVIFWDQLGCGNSACPSDV
MMAR_4789|M.marinum_M SGLPLLVVHGGPGLPHYYLSALQRLAGE--REVIFWDQLGCGNSERPSDV
MUL_0358|M.ulcerans_Agy99 ALLP------------DYLSALQRLAGE--REVIFWDQLGCGNSERPSDV
MAV_0868|M.avium_104 AGLPLLVIHGGPGLPHDYLRSLRRLATD--REVIFWDQLGCGNSKCPPNP
MSMEG_2681|M.smegmatis_MC2_155 HALPLIVLHGGPGMAHNYVANIAALADETGRTVIHYDQVGCGNSTHLPDA
Mflv_0627|M.gilvum_PYR-GCK --PDLILMHGGGGHAEAFARNVTALSRH--FRVHALDLLGHGLTSGCEVA
TH_4528|M.thermoresistible__bu -KPVLIFLHGSGGHAEAYVRNLEAHAEH--FSTWSIDMLGHGYTDKPGHP
MAB_0349c|M.abscessus_ATCC_199 --PVILFWPSLLMTGSMWAAQAEYFADR--YTVILVDPPGHGDSQSLTRM
Mvan_1084|M.vanbaalenii_PYR-1 ANPPLIHLHGGPGFSETRLLRHFNADLEDRFTVVYWDQRGAGKSFRRGMP
MLBr_01899|M.leprae_Br4923 -DPPVLLIMGLGAQLVLWRTAFCEKLVAQGLRVVRYDNRDVGLSSRTDST
. * . * :
Mb0863c|M.bovis_AF2122/97 -----------------------DLWTMNRSVAEMATVAEAL----ALTR
Rv0840c|M.tuberculosis_H37Rv -----------------------DLWTMNRSVAEMATVAEAL----ALTR
MMAR_4789|M.marinum_M -----------------------DLWTMGRSVAEMDAVVRAL----GLEA
MUL_0358|M.ulcerans_Agy99 -----------------------DLWTMGRSVAEIDAVVRAL----GLEA
MAV_0868|M.avium_104 -----------------------GLWTMERSVAEVDAVVRAL----RLDR
MSMEG_2681|M.smegmatis_MC2_155 PA---------------------DFWTPQLFVDEFHAVCTAL----GIER
Mflv_0627|M.gilvum_PYR-GCK P-------------------------KRKDYVSHLLGYMDQE----GIDR
TH_4528|M.thermoresistible__bu L-------------------------EVRHYVEHLAAVLDAI----GADR
MAB_0349c|M.abscessus_ATCC_199 F-------------------------RFEDCAHAITQILDSL----GIER
Mvan_1084|M.vanbaalenii_PYR-1 R----------------------SSMTVEQFLTDLDDLVDMVCARVGREQ
MLBr_01899|M.leprae_Br4923 EQPCPSQPLTARLIRFWLGQRNACAYTLEDMTDDAVALLDHL----SIER
Mb0863c|M.bovis_AF2122/97 FHIFSHSWGGMLAQQYVLDKAPD-AVSLTIANSTASIPEFSASLVSLKSC
Rv0840c|M.tuberculosis_H37Rv FHIFSHSWGGMLAQQYVLDKAPD-AVSLTIANSTASIPEFSASLVSLKSC
MMAR_4789|M.marinum_M FHIFGNSWGGMLAQQYVLDVPSG-AVSLTISNSTASIPRFADNVIRLKAE
MUL_0358|M.ulcerans_Agy99 FHIFGNSWGGMLAQQYVLDVPSG-AVSLTISNSTASIPRFADSVIRLKAE
MAV_0868|M.avium_104 FHLFGNSWGGMLAQQYVLDAAPAGAASLTISNSIASIPQFGKMVARLKSE
MSMEG_2681|M.smegmatis_MC2_155 YHVLGQSWGGMLGAEIAVRQPSG-LVSLAICNSPASMRLWSEAAGDLRAQ
Mflv_0627|M.gilvum_PYR-GCK AHLVGESLGGWIAAWTALEHPDR--VDRLIYVCGARLTLEVGADAEARTA
TH_4528|M.thermoresistible__bu AHISGESLGGWVASRFAIDRPDR--LDRLVLNTAG------GSQADPEVM
MAB_0349c|M.abscessus_ATCC_199 AHVVGNSWGGMIGGTFTAMYPHRAGASVLMN----------ATASRASMR
Mvan_1084|M.vanbaalenii_PYR-1 VVLHGHSWGSLLGVLYADRHPERVAAYLGTAQIGDAAAAESASYACALAA
MLBr_01899|M.leprae_Br4923 AHIVGASMGGMIAQIFAARFPTR-TRSLAVFFSSNNRPFLPPPAPRALLA
: . * *. :. . .
Mb0863c|M.bovis_AF2122/97 LDVA--TRSAIDRHEAAGTTHSAEYQAAIRTWNETYLCRTRPWPRELTE-
Rv0840c|M.tuberculosis_H37Rv LDVA--TRSAIDRHEAAGTTHSAEYQAAIRTWNETYLCRTRPWPRELTE-
MMAR_4789|M.marinum_M LDPG--TQATIDRHEAAGTTHSAEYQSAITTWNETHLCRTLPWPAYLTE-
MUL_0358|M.ulcerans_Agy99 LDPG--TQATIDRHEAAGTTHSAEYQSAITTWNETYLCRTLPWPAYLTE-
MAV_0868|M.avium_104 LDPA--TQAAIDRHEAAGTTHDPEYQAAIRTWNETYLCRVRPWPRDLED-
MSMEG_2681|M.smegmatis_MC2_155 LPAE--TRAALDRHEAAGTITHPDYLQAAAEFYRRHVCRVVPTPQDFAD-
Mflv_0627|M.gilvum_PYR-GCK AGRA--ELARVTRQFLADPSPANVRERMAWLFHHPDRDLTDELVALRWA-
TH_4528|M.thermoresistible__bu KRII--TLSMAAAE---NPSWDTVQARITWLMADKSKGY-DDIVASRQK-
MAB_0349c|M.abscessus_ATCC_199 QRVE--FRLLTEIVRILGRFREPLTTRAVKAFVGPTIMRERPHVEQSIR-
Mvan_1084|M.vanbaalenii_PYR-1 AEHSGNRRALKALRAIGPPPYPASSVFSERTWLQRLDGQLSPSALWKLRG
MLBr_01899|M.leprae_Br4923 LLTG---PPTGSRRDVVVDNVVRVTKITGSPLYRMPEEQVRTNAAEIYDR
Mb0863c|M.bovis_AF2122/97 AFANMGTE--IFETMFGPSDF-----RIVGNVRDWDVVDRLADIAVPTLL
Rv0840c|M.tuberculosis_H37Rv AFANMGTE--IFETMFGPSDF-----RIVGNVRDWDVVDRLADIAVPTLL
MMAR_4789|M.marinum_M AFQNLGPE--IFETMFGPSDF-----RIVGTIRDWDVVDRLAEIALPTLL
MUL_0358|M.ulcerans_Agy99 AFQNLGPE--IFETMFGPSDF-----RIVGTIRDWDVVDRLAEIALPTLL
MAV_0868|M.avium_104 AFRKMSAE--VFETMFGASDF-----HIVGTVRDWDVFDRLGEIAVPTLV
MSMEG_2681|M.smegmatis_MC2_155 SVAQMEAEPTVYHTMNGPNEF-----HVVGTLGDWSVIDRLPDVTAPVLV
Mflv_0627|M.gilvum_PYR-GCK LYQSEESR-SALTNATAPPSA-----ATA--EDNLT-AERLTSLTRPTLV
TH_4528|M.thermoresistible__bu IYRQPGFV-DAMRNIMALQDP-----EIR--ARNLLGPEEYGAITAPTLV
MAB_0349c|M.abscessus_ATCC_199 AELRDLRVDSVYWAVNSVVP------------ARPDQRELLGRITTPILV
Mvan_1084|M.vanbaalenii_PYR-1 AVFGGRPESSPLDLINQIRGFRFTMDAMSREASALNLLSAVPALRMPVVF
MLBr_01899|M.leprae_Br4923 SFYPLGVS-RQFSAILGSGSL----------------LHYNQRIIAPTVV
: * :.
Mb0863c|M.bovis_AF2122/97 VVGRFDECSPEH-MREMQGRIAGS--RLEFFESSSH-MPFIEEPARFDRV
Rv0840c|M.tuberculosis_H37Rv VVGRFDECSPEH-MREMQGRIAGS--RLEFFESSSH-MPFIEEPARFDRV
MMAR_4789|M.marinum_M LAGKYDECSPED-MREMHQRIAGS--RFEFFECSAH-MPFIEEPDRFDRV
MUL_0358|M.ulcerans_Agy99 LAGKYDECSPED-MREMHQRIAGS--RFEFFECSAH-MPFIEEPDRFDRV
MAV_0868|M.avium_104 LAGRYDECVPEH-MWEMHRRIPGS--RFELFESSAH-MPFIEEPEKFDAV
MSMEG_2681|M.smegmatis_MC2_155 IAGEHDEATPKT-WQPFVDHIPDV--RSHVFPGTSH-CTHLEKPEEFRAV
Mflv_0627|M.gilvum_PYR-GCK LWTSHNPSATVEFGRRAAELIPGA--EFALMEDCGH-WPQWERPEEFNQI
TH_4528|M.thermoresistible__bu VWTSDDPTADVDEGKRIASMIPGA--RFEVMPGCGH-WPQYEDPATFNRL
MAB_0349c|M.abscessus_ATCC_199 IAGREDPTFPVAETELMAEAIPGA--ELVIMENTGH-LAALERPEEVNAL
Mvan_1084|M.vanbaalenii_PYR-1 FVGCRDHWVPPATTVAYYDALTAPSKQLLWFDDSGH-EPFVDEPATFNRA
MLBr_01899|M.leprae_Br4923 IHGRADKLVRPSSGRAVARAITGA--RLVLFDGMGHDLPQQLWDQAVGVL
. : :. . : .* . .
Mb0863c|M.bovis_AF2122/97 MREFLRLHDI------
Rv0840c|M.tuberculosis_H37Rv MREFLRLHDI------
MMAR_4789|M.marinum_M MRDFLRSND-------
MUL_0358|M.ulcerans_Agy99 MRDLLRSND-------
MAV_0868|M.avium_104 MRDFLRLHD-------
MSMEG_2681|M.smegmatis_MC2_155 VAQFLHQHDLAADARV
Mflv_0627|M.gilvum_PYR-GCK LTNYLQGDRESRGQR-
TH_4528|M.thermoresistible__bu HIDFLLG-RS------
MAB_0349c|M.abscessus_ATCC_199 IDDFLKRHPIED----
Mvan_1084|M.vanbaalenii_PYR-1 VVDTVGALITP-----
MLBr_01899|M.leprae_Br4923 MSNFAKAS--------
: