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VTKPEATIAVPGGKVWSKRVGGGSGLPLLVVHGGPGLPHYYLSALQRLAGEREVIFWDQLGCGNSERPSD VDLWTMGRSVAEMDAVVRALGLEAFHIFGNSWGGMLAQQYVLDVPSGAVSLTISNSTASIPRFADNVIRL KAELDPGTQATIDRHEAAGTTHSAEYQSAITTWNETHLCRTLPWPAYLTEAFQNLGPEIFETMFGPSDFR IVGTIRDWDVVDRLAEIALPTLLLAGKYDECSPEDMREMHQRIAGSRFEFFECSAHMPFIEEPDRFDRVM RDFLRSND
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4789 | pip | - | 100% (288) | proline iminopeptidase Pip |
| M. marinum M | MMAR_4778 | bphD_1 | 5e-08 | 23.97% (267) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD_1 |
| M. marinum M | MMAR_4428 | - | 8e-07 | 30.77% (117) | haloalkane dehalogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0863c | pip | 1e-126 | 75.00% (284) | proline iminopeptidase |
| M. gilvum PYR-GCK | Mflv_3952 | - | 6e-11 | 26.18% (275) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0840c | pip | 1e-126 | 75.00% (284) | proline iminopeptidase |
| M. leprae Br4923 | MLBr_00862 | ephD | 5e-05 | 26.79% (112) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0139c | - | 1e-05 | 30.59% (85) | alpha/beta fold family hydrolase |
| M. avium 104 | MAV_0868 | - | 1e-123 | 73.40% (282) | proline imino-peptidase |
| M. smegmatis MC2 155 | MSMEG_2681 | - | 9e-56 | 40.15% (269) | proline imino-peptidase |
| M. thermoresistible (build 8) | TH_4528 | - | 9e-09 | 23.97% (267) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_0358 | pip | 1e-143 | 98.39% (248) | proline iminopeptidase PIP |
| M. vanbaalenii PYR-1 | Mvan_2445 | - | 6e-11 | 25.82% (275) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4789|M.marinum_M -------MTKPEATIAVPGGKVWSKRVGGG-------SGLPLLVVHGGPG
MUL_0358|M.ulcerans_Agy99 -------MEQARRRRLRPSPARGAWRPGPA-------ALLP---------
Mb0863c|M.bovis_AF2122/97 ----------MEGTIAVPGGRVWFQRIGGG-------PGRPLLVVHGGPG
Rv0840c|M.tuberculosis_H37Rv ----------MEGTIAVPGGRVWFQRIGGG-------PGRPLLVVHGGPG
MAV_0868|M.avium_104 -------------MVAVPGGQVWFQRTGGG-------AGLPLLVIHGGPG
MSMEG_2681|M.smegmatis_MC2_155 ---MLSRMPVSSRTVPFGDHETWVQVTTPENAQ---PHALPLIVLHGGPG
Mflv_3952|M.gilvum_PYR-GCK ---MTARTPNLRPVRELTPTLRYCTIHGYRRAYRIAGSGPAILLIHGIGD
Mvan_2445|M.vanbaalenii_PYR-1 ---MTERKPNLRPVRELTPTLKFCTIHGYRRAFRVAGSGPAILLIHGIGD
TH_4528|M.thermoresistible__bu VWSDLQGVAFTQGYLDAGGVRTRYLHAGEA-------DKPVLIFLHGSGG
MAB_0139c|M.abscessus_ATCC_199 ---------MTSARFTFRGDTLAYSRTGTG---------PPILFLHNGGS
MLBr_00862|M.leprae_Br4923 -MPATQSIHKVPHQFVESPDGVRLAIYQSGQ-----PEGPAIVLVHGFPD
MMAR_4789|M.marinum_M LPHYYLSALQRLAGE--REVIFWDQLGCGNSERPSDV--DLWTMGRSVAE
MUL_0358|M.ulcerans_Agy99 ---DYLSALQRLAGE--REVIFWDQLGCGNSERPSDV--DLWTMGRSVAE
Mb0863c|M.bovis_AF2122/97 LPHNYLAPLRRLSDE--REVIFWDQLGCGNSACPSDV--DLWTMNRSVAE
Rv0840c|M.tuberculosis_H37Rv LPHNYLAPLRRLSDE--REVIFWDQLGCGNSACPSDV--DLWTMNRSVAE
MAV_0868|M.avium_104 LPHDYLRSLRRLATD--REVIFWDQLGCGNSKCPPNP--GLWTMERSVAE
MSMEG_2681|M.smegmatis_MC2_155 MAHNYVANIAALADETGRTVIHYDQVGCGNSTHLPDAPADFWTPQLFVDE
Mflv_3952|M.gilvum_PYR-GCK NSTTWAGVQTQLAQR--FTVIAPDLLGHGKSDKPRAD----YSVAAYANG
Mvan_2445|M.vanbaalenii_PYR-1 NSTTWSTVQTQLAQR--FTVIAPDLLGHGRSDKPRAD----YSVAAYANG
TH_4528|M.thermoresistible__bu HAEAYVRNLEAHAEH--FSTWSIDMLGHGYTDKPGHP----LEVRHYVEH
MAB_0139c|M.abscessus_ATCC_199 AKEIWTRQVEVLRQR--YEVICLDHLGYGESDMPERG----YTIDQHVER
MLBr_00862|M.leprae_Br4923 SHVLWDGVVPLLAKR--FRIVRYDNRGVGQSSVPKPVS--AYTMTRFADD
: * * * : .
MMAR_4789|M.marinum_M MDAVVRALGLEA-FHIFGNSWGGMLAQQYVLDVPSG-AVSLTISNSTASI
MUL_0358|M.ulcerans_Agy99 IDAVVRALGLEA-FHIFGNSWGGMLAQQYVLDVPSG-AVSLTISNSTASI
Mb0863c|M.bovis_AF2122/97 MATVAEALALTR-FHIFSHSWGGMLAQQYVLDKAPD-AVSLTIANSTASI
Rv0840c|M.tuberculosis_H37Rv MATVAEALALTR-FHIFSHSWGGMLAQQYVLDKAPD-AVSLTIANSTASI
MAV_0868|M.avium_104 VDAVVRALRLDR-FHLFGNSWGGMLAQQYVLDAAPAGAASLTISNSIASI
MSMEG_2681|M.smegmatis_MC2_155 FHAVCTALGIER-YHVLGQSWGGMLGAEIAVRQPSG-LVSLAICNSPASM
Mflv_3952|M.gilvum_PYR-GCK MRDLLSVLNIDS-ATVVGHSLGGGVAMQFAYQFPQL--VDRLILVGAGGV
Mvan_2445|M.vanbaalenii_PYR-1 MRDLLSVLDIDD-VTVIGHSLGGGVAMQFAYQFPQL--VNRLILVGAGGV
TH_4528|M.thermoresistible__bu LAAVLDAIGADR-AHISGESLGGWVASRFAIDRPDR--LDRLVLNTAGGS
MAB_0139c|M.abscessus_ATCC_199 LSAFIEHLGHER-ISVVGNCMGSAMALLLADRRPEL-FDSLVLINPLSKN
MLBr_00862|M.leprae_Br4923 FAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQ
. . : : .. *.
MMAR_4789|M.marinum_M PRFADNVIRLKAELDPGTQATIDRHEAAGTTHSAEY----QSAITTWNET
MUL_0358|M.ulcerans_Agy99 PRFADSVIRLKAELDPGTQATIDRHEAAGTTHSAEY----QSAITTWNET
Mb0863c|M.bovis_AF2122/97 PEFSASLVSLKSCLDVATRSAIDRHEAAGTTHSAEY----QAAIRTWNET
Rv0840c|M.tuberculosis_H37Rv PEFSASLVSLKSCLDVATRSAIDRHEAAGTTHSAEY----QAAIRTWNET
MAV_0868|M.avium_104 PQFGKMVARLKSELDPATQAAIDRHEAAGTTHDPEY----QAAIRTWNET
MSMEG_2681|M.smegmatis_MC2_155 RLWSEAAGDLRAQLPAETRAALDRHEAAGTITHPDY----LQAAAEFYRR
Mflv_3952|M.gilvum_PYR-GCK TKDVNIALRAASLPMGTEALALLRLPLLLPTLRLLG----RVGGPLLGNT
Mvan_2445|M.vanbaalenii_PYR-1 TKDVNIALRLASLPMGSEALALLRLPLVLPALQVLG----RVSGTVFGST
TH_4528|M.thermoresistible__bu QADPEVMKRIITLSMAAAENPSWDTVQARITWLMAD----KSKG------
MAB_0139c|M.abscessus_ATCC_199 TARRGVLGWLLPLVSRFPTLSMAISRRVRIPQALTN----IVITVQFGPR
MLBr_00862|M.leprae_Br4923 DQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIAL
.
MMAR_4789|M.marinum_M HLCRTLPWPAYLTEAFQNLGPE--IFETMFGPSDFR--IVGTIRDWDVVD
MUL_0358|M.ulcerans_Agy99 YLCRTLPWPAYLTEAFQNLGPE--IFETMFGPSDFR--IVGTIRDWDVVD
Mb0863c|M.bovis_AF2122/97 YLCRTRPWPRELTEAFANMGTE--IFETMFGPSDFR--IVGNVRDWDVVD
Rv0840c|M.tuberculosis_H37Rv YLCRTRPWPRELTEAFANMGTE--IFETMFGPSDFR--IVGNVRDWDVVD
MAV_0868|M.avium_104 YLCRVRPWPRDLEDAFRKMSAE--VFETMFGASDFH--IVGTVRDWDVFD
MSMEG_2681|M.smegmatis_MC2_155 HVCRVVPTPQDFADSVAQMEAEPTVYHTMNGPNEFH--VVGTLGDWSVID
Mflv_3952|M.gilvum_PYR-GCK RIGRDIPNMLRILADLPEPTASSAFARTLRSVVDWRG-QVVTMLDRCYLT
Mvan_2445|M.vanbaalenii_PYR-1 GVGRDIPDMLRILADLPEPTASSAFARTLRAVVDWRG-QVVTMLDRCYLT
TH_4528|M.thermoresistible__bu --------YDDIVASRQKIYRQPGFVDAMRNIMALQD-PEIRARNLLGPE
MAB_0139c|M.abscessus_ATCC_199 NWLRGIRAPRPGTAQAGKGWSVRGRLAALAEMFCDQT-SLGAVDEIRPGP
MLBr_00862|M.leprae_Br4923 SSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGK
:
MMAR_4789|M.marinum_M RLAEIALPTLLLAGKYDECSPEDMREMHQ-RIAGSRFEFFECSAHMPFIE
MUL_0358|M.ulcerans_Agy99 RLAEIALPTLLLAGKYDECSPEDMREMHQ-RIAGSRFEFFECSAHMPFIE
Mb0863c|M.bovis_AF2122/97 RLADIAVPTLLVVGRFDECSPEHMREMQG-RIAGSRLEFFESSSHMPFIE
Rv0840c|M.tuberculosis_H37Rv RLADIAVPTLLVVGRFDECSPEHMREMQG-RIAGSRLEFFESSSHMPFIE
MAV_0868|M.avium_104 RLGEIAVPTLVLAGRYDECVPEHMWEMHR-RIPGSRFELFESSAHMPFIE
MSMEG_2681|M.smegmatis_MC2_155 RLPDVTAPVLVIAGEHDEATPKTWQPFVD-HIPDVRSHVFPGTSHCTHLE
Mflv_3952|M.gilvum_PYR-GCK ----QSVPVQLIWGSQDSVIPVSHAEMAHTAMPGSRLEIFEGAGHFPFHD
Mvan_2445|M.vanbaalenii_PYR-1 ----QSVPVQLIWGDCDAVIPVSHGEMAHAAMPGSRLEVFEGSGHFPFHD
TH_4528|M.thermoresistible__bu EYGAITAPTLVVWTSDDPTADVDEGKRIASMIPGARFEVMPGCGHWPQYE
MAB_0139c|M.abscessus_ATCC_199 DFP----PFAVIWGDSNLGLSPRAGRALNRTLQPDREEFLTRCGHLPMME
MLBr_00862|M.leprae_Br4923 GVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIK-AGHFSPMS
* :: : : . : .* . .
MMAR_4789|M.marinum_M EPDRFDRVMRDFLRSND---------------------------------
MUL_0358|M.ulcerans_Agy99 EPDRFDRVMRDLLRSND---------------------------------
Mb0863c|M.bovis_AF2122/97 EPARFDRVMREFLRLHDI--------------------------------
Rv0840c|M.tuberculosis_H37Rv EPARFDRVMREFLRLHDI--------------------------------
MAV_0868|M.avium_104 EPEKFDAVMRDFLRLHD---------------------------------
MSMEG_2681|M.smegmatis_MC2_155 KPEEFRAVVAQFLHQHDLAADARV--------------------------
Mflv_3952|M.gilvum_PYR-GCK EPDRFVELVEKFIDSTEPAVYDQEYLRTLLRTGTSEN----TLSGDVDTQ
Mvan_2445|M.vanbaalenii_PYR-1 DPDRFVEVVEKFIDTSEPAVYDHEYLRGLLRAGISEG----TISGPADTR
TH_4528|M.thermoresistible__bu DPATFNRLHIDFLLGRS---------------------------------
MAB_0139c|M.abscessus_ATCC_199 SPEEVTAIITEFIARPPARRLGDLATSPGSA-------------------
MLBr_00862|M.leprae_Br4923 HPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSG
* . .:
MMAR_4789|M.marinum_M --------------------------------------------------
MUL_0358|M.ulcerans_Agy99 --------------------------------------------------
Mb0863c|M.bovis_AF2122/97 --------------------------------------------------
Rv0840c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0868|M.avium_104 --------------------------------------------------
MSMEG_2681|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3952|M.gilvum_PYR-GCK VAVLDAIGADERSAT-----------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 VAVLDAMGADERSAT-----------------------------------
TH_4528|M.thermoresistible__bu --------------------------------------------------
MAB_0139c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 IGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDA
MMAR_4789|M.marinum_M --------------------------------------------------
MUL_0358|M.ulcerans_Agy99 --------------------------------------------------
Mb0863c|M.bovis_AF2122/97 --------------------------------------------------
Rv0840c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0868|M.avium_104 --------------------------------------------------
MSMEG_2681|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3952|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4528|M.thermoresistible__bu --------------------------------------------------
MAB_0139c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGG
MMAR_4789|M.marinum_M --------------------------------------------------
MUL_0358|M.ulcerans_Agy99 --------------------------------------------------
Mb0863c|M.bovis_AF2122/97 --------------------------------------------------
Rv0840c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0868|M.avium_104 --------------------------------------------------
MSMEG_2681|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3952|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4528|M.thermoresistible__bu --------------------------------------------------
MAB_0139c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFS
MMAR_4789|M.marinum_M --------------------------------------------------
MUL_0358|M.ulcerans_Agy99 --------------------------------------------------
Mb0863c|M.bovis_AF2122/97 --------------------------------------------------
Rv0840c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0868|M.avium_104 --------------------------------------------------
MSMEG_2681|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3952|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4528|M.thermoresistible__bu --------------------------------------------------
MAB_0139c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLD
MMAR_4789|M.marinum_M --------------------------------------------------
MUL_0358|M.ulcerans_Agy99 --------------------------------------------------
Mb0863c|M.bovis_AF2122/97 --------------------------------------------------
Rv0840c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0868|M.avium_104 --------------------------------------------------
MSMEG_2681|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3952|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4528|M.thermoresistible__bu --------------------------------------------------
MAB_0139c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRS
MMAR_4789|M.marinum_M -------
MUL_0358|M.ulcerans_Agy99 -------
Mb0863c|M.bovis_AF2122/97 -------
Rv0840c|M.tuberculosis_H37Rv -------
MAV_0868|M.avium_104 -------
MSMEG_2681|M.smegmatis_MC2_155 -------
Mflv_3952|M.gilvum_PYR-GCK -------
Mvan_2445|M.vanbaalenii_PYR-1 -------
TH_4528|M.thermoresistible__bu -------
MAB_0139c|M.abscessus_ATCC_199 -------
MLBr_00862|M.leprae_Br4923 TARIRVI