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LSRMPVSSRTVPFGDHETWVQVTTPENAQPHALPLIVLHGGPGMAHNYVANIAALADETGRTVIHYDQVG CGNSTHLPDAPADFWTPQLFVDEFHAVCTALGIERYHVLGQSWGGMLGAEIAVRQPSGLVSLAICNSPAS MRLWSEAAGDLRAQLPAETRAALDRHEAAGTITHPDYLQAAAEFYRRHVCRVVPTPQDFADSVAQMEAEP TVYHTMNGPNEFHVVGTLGDWSVIDRLPDVTAPVLVIAGEHDEATPKTWQPFVDHIPDVRSHVFPGTSHC THLEKPEEFRAVVAQFLHQHDLAADARV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2681 | - | - | 100% (309) | proline imino-peptidase |
| M. smegmatis MC2 155 | MSMEG_4867 | - | 3e-11 | 26.10% (295) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. smegmatis MC2 155 | MSMEG_4707 | - | 1e-09 | 28.11% (281) | non-heme bromoperoxidase BPO-A2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0863c | pip | 2e-54 | 39.41% (269) | proline iminopeptidase |
| M. gilvum PYR-GCK | Mflv_1348 | - | 4e-13 | 25.96% (285) | 3-oxoadipate enol-lactonase |
| M. tuberculosis H37Rv | Rv0840c | pip | 2e-54 | 39.41% (269) | proline iminopeptidase |
| M. leprae Br4923 | MLBr_00685 | - | 2e-05 | 35.14% (74) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0349c | - | 8e-13 | 26.98% (252) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_4789 | pip | 1e-55 | 40.15% (269) | proline iminopeptidase Pip |
| M. avium 104 | MAV_0868 | - | 3e-58 | 42.59% (270) | proline imino-peptidase |
| M. thermoresistible (build 8) | TH_4528 | - | 7e-10 | 23.62% (271) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_0358 | pip | 5e-48 | 37.02% (262) | proline iminopeptidase PIP |
| M. vanbaalenii PYR-1 | Mvan_0538 | - | 3e-09 | 25.27% (273) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
TH_4528|M.thermoresistible__bu VWSDLQGVAFTQG----YLDAGGVRTRYLHAGEAD----KPVLIFLHGSG
Mvan_0538|M.vanbaalenii_PYR-1 MLKDASICVSLLGTETRFVDVDGVRTRTIQAGEG------PDLILMHGGG
Mb0863c|M.bovis_AF2122/97 --------------MEGTIAVPGGRVWFQRIGGG----PGRPLLVVHGGP
Rv0840c|M.tuberculosis_H37Rv --------------MEGTIAVPGGRVWFQRIGGG----PGRPLLVVHGGP
MMAR_4789|M.marinum_M -----------MTKPEATIAVPGGKVWSKRVGGG----SGLPLLVVHGGP
MUL_0358|M.ulcerans_Agy99 -----------MEQARRRRLRPSPARGAWRPGPA----ALLP--------
MAV_0868|M.avium_104 -----------------MVAVPGGQVWFQRTGGG----AGLPLLVIHGGP
MSMEG_2681|M.smegmatis_MC2_155 -------MLSRMPVSSRTVPFGDHETWVQVTTPENAQPHALPLIVLHGGP
Mflv_1348|M.gilvum_PYR-GCK --------------------MSAVDVHVIESGLPD----GPAVVLSNSLG
MAB_0349c|M.abscessus_ATCC_199 --------MGSAALQDRYLQSCLGGLHVRIGGEG------PVILFWPSLL
MLBr_00685|M.leprae_Br4923 ----MPACQHQRHRPVVACGTRGTTFRVGSMRQPIHLGSGEPVLLLHPFM
TH_4528|M.thermoresistible__bu GHAEAYVRNLEAHAEH--FSTWSIDMLGHGYTDKPGHPL----EVRHYVE
Mvan_0538|M.vanbaalenii_PYR-1 GHAEAFARNVTALSRH--FRVHALDLLGHGLTSGCEVAP----KRKDYVS
Mb0863c|M.bovis_AF2122/97 GLPHNYLAPLRRLSDE--REVIFWDQLGCGNSACPSDV--DLWTMNRSVA
Rv0840c|M.tuberculosis_H37Rv GLPHNYLAPLRRLSDE--REVIFWDQLGCGNSACPSDV--DLWTMNRSVA
MMAR_4789|M.marinum_M GLPHYYLSALQRLAGE--REVIFWDQLGCGNSERPSDV--DLWTMGRSVA
MUL_0358|M.ulcerans_Agy99 ----DYLSALQRLAGE--REVIFWDQLGCGNSERPSDV--DLWTMGRSVA
MAV_0868|M.avium_104 GLPHDYLRSLRRLATD--REVIFWDQLGCGNSKCPPNP--GLWTMERSVA
MSMEG_2681|M.smegmatis_MC2_155 GMAHNYVANIAALADETGRTVIHYDQVGCGNSTHLPDAPADFWTPQLFVD
Mflv_1348|M.gilvum_PYR-GCK ATHRMWDAQLDALERR--FRVLRYDTRGHGASPVPDGP----YSIDDLAD
MAB_0349c|M.abscessus_ATCC_199 MTGSMWAAQAEYFADR--YTVILVDPPGHGDSQSLTRM----FRFEDCAH
MLBr_00685|M.leprae_Br4923 MSQTVWEIVAPQLANTERYEVFAPTMAAHHGGPSASSWM---MSVSTLAD
: . . .
TH_4528|M.thermoresistible__bu HLAAVLDAIGADRAHISGESLGGWVASRFAIDRPDR--LDRLVLNTAG--
Mvan_0538|M.vanbaalenii_PYR-1 HLLGYMDQEGIDRAHLAGESLGGWIAAWTALEHPDR--VDRLIYVCGARL
Mb0863c|M.bovis_AF2122/97 EMATVAEALALTRFHIFSHSWGGMLAQQYVLDKAPD-AVSLTIANSTASI
Rv0840c|M.tuberculosis_H37Rv EMATVAEALALTRFHIFSHSWGGMLAQQYVLDKAPD-AVSLTIANSTASI
MMAR_4789|M.marinum_M EMDAVVRALGLEAFHIFGNSWGGMLAQQYVLDVPSG-AVSLTISNSTASI
MUL_0358|M.ulcerans_Agy99 EIDAVVRALGLEAFHIFGNSWGGMLAQQYVLDVPSG-AVSLTISNSTASI
MAV_0868|M.avium_104 EVDAVVRALRLDRFHLFGNSWGGMLAQQYVLDAAPAGAASLTISNSIASI
MSMEG_2681|M.smegmatis_MC2_155 EFHAVCTALGIERYHVLGQSWGGMLGAEIAVRQPSG-LVSLAICNSPASM
Mflv_1348|M.gilvum_PYR-GCK DVVGILDRRGIDTAHLVGLSLGGMTAMRVAARNPDR--VNRMVLLCTA--
MAB_0349c|M.abscessus_ATCC_199 AITQILDSLGIERAHVVGNSWGGMIGGTFTAMYPHRAGASVLMNATAS--
MLBr_00685|M.leprae_Br4923 HVEQQLDELGWDTAHLVGNSLGGWVVFELERRGRAR--SVTGIAPAGG--
. *: . * ** : .
TH_4528|M.thermoresistible__bu ----GSQADPEVMKRIITLSMAAAE---NPSWDTVQARITWLMADKSKGY
Mvan_0538|M.vanbaalenii_PYR-1 TLEVGADAEARTAAGRAELARVTRQFLADPSPANVRERMAWLFHHPDRDL
Mb0863c|M.bovis_AF2122/97 PEFSASLVSLKSCLDVATRSAIDRHEAAGTTHSAEYQAAIRTWNETYLCR
Rv0840c|M.tuberculosis_H37Rv PEFSASLVSLKSCLDVATRSAIDRHEAAGTTHSAEYQAAIRTWNETYLCR
MMAR_4789|M.marinum_M PRFADNVIRLKAELDPGTQATIDRHEAAGTTHSAEYQSAITTWNETHLCR
MUL_0358|M.ulcerans_Agy99 PRFADSVIRLKAELDPGTQATIDRHEAAGTTHSAEYQSAITTWNETYLCR
MAV_0868|M.avium_104 PQFGKMVARLKSELDPATQAAIDRHEAAGTTHDPEYQAAIRTWNETYLCR
MSMEG_2681|M.smegmatis_MC2_155 RLWSEAAGDLRAQLPAETRAALDRHEAAGTITHPDYLQAAAEFYRRHVCR
Mflv_1348|M.gilvum_PYR-GCK -------AELAPAQAWTDRAAAVRAGGAESVAPAVIARWFTLSH------
MAB_0349c|M.abscessus_ATCC_199 --------RASMRQRVEFRLLTEIVRILGRFREPLTTRAVKAFVGPTIMR
MLBr_00685|M.leprae_Br4923 ----------WTRWSLAKFEVIAKFVAGMPLVAVARGLGSRALSLPFSHR
TH_4528|M.thermoresistible__bu -DDIVAS-RQKIYRQPGFV-DAMRNIMALQDPEIR--ARNLLGPEEYGAI
Mvan_0538|M.vanbaalenii_PYR-1 TDELVAL-RWALYQSEESR-SALTNATAPPSAATA--EDNLT-AERLTSL
Mb0863c|M.bovis_AF2122/97 TRPWPRE-LTEAFANMGTE--IFETMFGPSDFRIVGNVRDWDVVDRLADI
Rv0840c|M.tuberculosis_H37Rv TRPWPRE-LTEAFANMGTE--IFETMFGPSDFRIVGNVRDWDVVDRLADI
MMAR_4789|M.marinum_M TLPWPAY-LTEAFQNLGPE--IFETMFGPSDFRIVGTIRDWDVVDRLAEI
MUL_0358|M.ulcerans_Agy99 TLPWPAY-LTEAFQNLGPE--IFETMFGPSDFRIVGTIRDWDVVDRLAEI
MAV_0868|M.avium_104 VRPWPRD-LEDAFRKMSAE--VFETMFGASDFHIVGTVRDWDVFDRLGEI
MSMEG_2681|M.smegmatis_MC2_155 VVPTPQD-FADSVAQMEAEPTVYHTMNGPNEFHVVGTLGDWSVIDRLPDV
Mflv_1348|M.gilvum_PYR-GCK LETHPAE-RAEWVDMIAAT-------PAEGYASCCEAIAELDLREQLPTI
MAB_0349c|M.abscessus_ATCC_199 ERPHVEQSIRAELRDLRVD--------SVYWAVNSVVPARPDQRELLGRI
MLBr_00685|M.leprae_Br4923 LASLPLTGSPAGLSEHQLRNIVEDAGHCPAYFLLLIKTLLQPGLRELADI
:
TH_4528|M.thermoresistible__bu TAPTLVVWTSDDPTA-DVDEGKRIASMIPG-ARFEVMPGCGHWPQYEDPA
Mvan_0538|M.vanbaalenii_PYR-1 TRPTLVLWTSHNPSA-TVEFGRRAAELIPG-AEFALMEDCGHWPQWERPE
Mb0863c|M.bovis_AF2122/97 AVPTLLVVGRFDECS-PEH-MREMQGRIAG-SRLEFFESSSHMPFIEEPA
Rv0840c|M.tuberculosis_H37Rv AVPTLLVVGRFDECS-PEH-MREMQGRIAG-SRLEFFESSSHMPFIEEPA
MMAR_4789|M.marinum_M ALPTLLLAGKYDECS-PED-MREMHQRIAG-SRFEFFECSAHMPFIEEPD
MUL_0358|M.ulcerans_Agy99 ALPTLLLAGKYDECS-PED-MREMHQRIAG-SRFEFFECSAHMPFIEEPD
MAV_0868|M.avium_104 AVPTLVLAGRYDECV-PEH-MWEMHRRIPG-SRFELFESSAHMPFIEEPE
MSMEG_2681|M.smegmatis_MC2_155 TAPVLVIAGEHDEAT-PKT-WQPFVDHIPD-VRSHVFPGTSHCTHLEKPE
Mflv_1348|M.gilvum_PYR-GCK TAPTLAIAGADDPAT-PPAKLEQIVSAIPG-ARLLVVDGAAHLANAEQPE
MAB_0349c|M.abscessus_ATCC_199 TTPILVIAGREDPTF-PVAETELMAEAIPG-AELVIMENTGHLAALERPE
MLBr_00685|M.leprae_Br4923 TVPVLLVLCEKDRVLPPPKYSRHFTDHLPERTQVTKFDGMGHVPMFEAPE
: * * : : :. . . .* . * *
TH_4528|M.thermoresistible__bu TFNRLHIDFLLG-RS---------
Mvan_0538|M.vanbaalenii_PYR-1 EFNQILTNYLQGDRESRGQR----
Mb0863c|M.bovis_AF2122/97 RFDRVMREFLRLHDI---------
Rv0840c|M.tuberculosis_H37Rv RFDRVMREFLRLHDI---------
MMAR_4789|M.marinum_M RFDRVMRDFLRSND----------
MUL_0358|M.ulcerans_Agy99 RFDRVMRDLLRSND----------
MAV_0868|M.avium_104 KFDAVMRDFLRLHD----------
MSMEG_2681|M.smegmatis_MC2_155 EFRAVVAQFLHQHDLAADARV---
Mflv_1348|M.gilvum_PYR-GCK QITPAIIEHLEQR-----------
MAB_0349c|M.abscessus_ATCC_199 EVNALIDDFLKRHPIED-------
MLBr_00685|M.leprae_Br4923 VITKLITNFINQCSKPAEAASPAS
. : :