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MPRTVQFAEYGDTDVLTVVDTPAPEPGPGQVRLKVRAAGLNPIDWKIVAGFMRELMPVDLPAGVGSDVAG IVDAVGPGVTEWAVGNEVLGRSATGAYAEYALAEAAELIGKPGEITWEVAGSLAGAGGTAHAVLDRLDLK SGETLLVHAAAGGVGTFAVQLAGARGVSVIGTAGEGNHDYLRSIGATPVTYGDGLLERVRAAAPQGVDAV LDASGRGEIPLSIELTGDPQRVLTLVAFDQAGTGIQVHAGGAGDSLSKALSDVVALITDGRLTVPISATY PLDEAAAALDASRTGHATGKIVVVP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6747 | - | - | 100% (305) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_4064 | - | 6e-32 | 32.90% (307) | zinc-binding alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4032 | - | 1e-31 | 32.59% (313) | zinc-binding alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1489c | qor | 5e-31 | 33.64% (330) | quinone reductase |
| M. gilvum PYR-GCK | Mflv_2124 | - | 9e-36 | 32.92% (322) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1454c | qor | 5e-31 | 33.64% (330) | quinone reductase |
| M. leprae Br4923 | MLBr_00118 | - | 5e-24 | 31.19% (311) | putative oxidireductase |
| M. abscessus ATCC 19977 | MAB_0750 | - | 8e-69 | 47.25% (309) | putative oxidoreductase |
| M. marinum M | MMAR_2814 | fadB5 | 1e-29 | 39.47% (228) | oxidoreductase FadB5 |
| M. avium 104 | MAV_5196 | - | 5e-68 | 45.07% (304) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3440 | - | 6e-33 | 31.82% (330) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_2935 | fadB5 | 5e-29 | 39.04% (228) | oxidoreductase FadB5 |
| M. vanbaalenii PYR-1 | Mvan_5758 | - | 3e-34 | 33.75% (317) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2814|M.marinum_M -----------------------------------------------MRA
MUL_2935|M.ulcerans_Agy99 -----------------------------------------------MRA
Mb1489c|M.bovis_AF2122/97 -----------------------------------------------MHA
Rv1454c|M.tuberculosis_H37Rv -----------------------------------------------MHA
TH_3440|M.thermoresistible__bu VQTAAAQRRDEIGVIGVALRAVRTTGQNDPRMEHIRAGELHTGMIGAMKA
MAB_0750|M.abscessus_ATCC_1997 ----------------------------------------------MTKA
MAV_5196|M.avium_104 ------------------------------------------MTAAAARA
MSMEG_6747|M.smegmatis_MC2_155 ----------------------------------------------MPRT
Mflv_2124|M.gilvum_PYR-GCK -------------------------------------------MSDRMKA
Mvan_5758|M.vanbaalenii_PYR-1 -----------------------------------------------MRA
MLBr_00118|M.leprae_Br4923 -----------------------------------------------MHA
::
MMAR_2814|M.marinum_M VVITRHGDPSVLQVQQRPDPPPPGPGQLRISVRAAGVNFADHLARVG--L
MUL_2935|M.ulcerans_Agy99 VVITKHGDPSVLQVQQRPDPPPPGPGQLRIAVRAAGVNFADHLARVG--L
Mb1489c|M.bovis_AF2122/97 IEVTETGGPGVLRHVDQPQPQP-GHGELLIKAEAIGVNFIDTYFRSG--Q
Rv1454c|M.tuberculosis_H37Rv IEVTETGGPGVLRHVDQPQPQP-GHGELLIKAEAIGVNFIDTYFRSG--Q
TH_3440|M.thermoresistible__bu IEVRETGGPEVLTYVDVPEPTP-GPGQVLIKAEAIGVNFIDTYFRSG--L
MAB_0750|M.abscessus_ATCC_1997 VQFDQYGGIDVLQVRDVPRPVP-APDEVLVQVRAAGINPGEAKIRAGMLH
MAV_5196|M.avium_104 VRFDRYGGREVLYVADIEMPAP-GPGEVVVEVRAAGINPGEAAIRVGALH
MSMEG_6747|M.smegmatis_MC2_155 VQFAEYGDTDVLTVVDTPAPEP-GPGQVRLKVRAAGLNPIDWKIVAGFMR
Mflv_2124|M.gilvum_PYR-GCK VVLARFGGADAFELRDVAVPHV-GPRQVRVRVHATAVNPLDYQIRRG-DY
Mvan_5758|M.vanbaalenii_PYR-1 AVLTAYN--SPLLVDELPDPEP-GPGEVLVRVMASGVNPLDIKIRRGEAP
MLBr_00118|M.leprae_Br4923 IVAESAN---QMVWREVPDVTA-GPGEVLIEVAASGVNRADVLQVAG--K
. : : . :: : . * .:* : *
MMAR_2814|M.marinum_M YPDAPKLPAVVGYEVAGTVEAVGAGVDESR----IGERVLAGTRFG----
MUL_2935|M.ulcerans_Agy99 YPDAPKLPAVVGYEVAGTVEAAGAGVDESR----IGERVLAGTRFG----
Mb1489c|M.bovis_AF2122/97 YP--RELPFVIGSEVCGTVEAVGPGVTAADTAISVGDRVVSASANG----
Rv1454c|M.tuberculosis_H37Rv YP--RELPFVIGSEVCGTVEAVGPGVTAADTAISVGDRVVSASANG----
TH_3440|M.thermoresistible__bu YP--REVPFIVGTEVCGTVEAVGDGVAALR----VGDRVLTDKANG----
MAB_0750|M.abscessus_ATCC_1997 DRFPATFPSGQGSDLAGVVVEAGHGVARFA----PGDEVFGYTDNRA---
MAV_5196|M.avium_104 ERFPATFPSGEGSDLAGVVTAVGPGVTEFA----VGDEVLGFSLRRS---
MSMEG_6747|M.smegmatis_MC2_155 ELMPVDLPAGVGSDVAGIVDAVGPGVTEWA----VGNEVLGRSATG----
Mflv_2124|M.gilvum_PYR-GCK TDLVP-LPAIIGHDISGVIEEVGSHVTEFR----AGDAVY-YTPKIFGGP
Mvan_5758|M.vanbaalenii_PYR-1 HAQLP-PPAVLGIDMAGVVEAVGPRVDRFT----VGDEVFGMTGGVGGLQ
MLBr_00118|M.leprae_Br4923 YPHPPGASAIIGMEVAGVVAAVSSGVTEWS----VGQEVCALLAGG----
. * ::.* : .. * *: *
MMAR_2814|M.marinum_M -GYSEIVNVTATDAVVLPEGLSFEQGAAVPVNYATAWAALHGYGSLRAGE
MUL_2935|M.ulcerans_Agy99 -GYSEIVNVTATDSVVLPEGLSFEQGAAVPVNYATAWAALHGYGSLRAGE
Mb1489c|M.bovis_AF2122/97 -AYAEFCTAPASLTAKVPDDVTSEVAASALLKGLTAHYLLKSVYPVKRGD
Rv1454c|M.tuberculosis_H37Rv -AYAEFCTAPASLTAKVPDDVTSEVAASALLKGLTAHYLLKSVYPVKRGD
TH_3440|M.thermoresistible__bu -AYAEYTVAPADYVAYVPDGVAPDTVASALLKGMTAHYLIKSVYEVQRGD
MAB_0750|M.abscessus_ATCC_1997 -SHAEFVVVPASQLVTKPEGLSWEVAGSLFVAGTTAYA-AVGSVHLSPGD
MAV_5196|M.avium_104 -SHATHTAVPVGQLIRKPPELSWEVAGSLYVVGVTAYA-AVRAVAPQPGE
MSMEG_6747|M.smegmatis_MC2_155 -AYAEYALAEAAELIGKPGEITWEVAGSLAGAGGTAHA-VLDRLDLKSGE
Mflv_2124|M.gilvum_PYR-GCK GSYAEQHVADVDLVGRKPDNLDHLEAASLTLVGGTVWESLVTRAQLTVGE
Mvan_5758|M.vanbaalenii_PYR-1 GSLAELAAVDARLIAHKPRTLSMAQAAALPLGFITSWEGLVDRAGVGTGQ
MLBr_00118|M.leprae_Br4923 -GYAEYVAVPASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAHLSAGQ
. : . . * : .. * *:
MMAR_2814|M.marinum_M RVLVHAAAGGVGIAAVQFAKAAGAQVHGTASPGKHQRLAELG-VDRAIDY
MUL_2935|M.ulcerans_Agy99 RVLVHAAAGGVGIAAVQFAKAAGAQVHGTASPGKHQRLAELG-VDRAIDY
Mb1489c|M.bovis_AF2122/97 TVLVHAGAGGVGLILTQWATHLGVRVITTVSTAEKAKLSKDAGADVVLDY
Rv1454c|M.tuberculosis_H37Rv TVLVHAGAGGVGLILTQWATHLGVRVITTVSTAEKAKLSKDAGADVVLDY
TH_3440|M.thermoresistible__bu TILVHAGAGGVGLILTQWATHLGARVITTVSTPQKAELSRKAGAAEVLDY
MAB_0750|M.abscessus_ATCC_1997 TVAVSAAAGGVGTIAVQLARAAGATVIGIAGPD-NDEWLTAHGI-IPVNY
MAV_5196|M.avium_104 TVAVSAAAGGVGSLVTQLLVLRKARVLGIAGPG-NADWLRAHGV-VPIAY
MSMEG_6747|M.smegmatis_MC2_155 TLLVHAAAGGVGTFAVQLAGARGVSVIGTAGEG-NHDYLRSIGA-TPVTY
Mflv_2124|M.gilvum_PYR-GCK TILIHGGAGGVGTIAIQVAKAMGARVITTAKAG-DHAFVNSLGADVAIDH
Mvan_5758|M.vanbaalenii_PYR-1 QVLIHGGAGGVGFLAVQLALARGAQVYATGSTS-SQAVIRAAGA-VPIDY
MLBr_00118|M.leprae_Br4923 LLLLHGGTSGIGSHGIQVARALGAKVAVTAGSEEKLEFCRALGAQITINY
: : ..:.*:* * . * : :
MMAR_2814|M.marinum_M RRDGW--------WKGLDSYDLVLDALGGTSLRRSYELLRPGGRLVGYGV
MUL_2935|M.ulcerans_Agy99 RRDGW--------WKGLDSYDLVLDALGDTYLRRSYELLRPGGRLVGYGV
Mb1489c|M.bovis_AF2122/97 PEDAWQFAGRVRELTGGTGVQAVYDGVGATTFDASLASLAVRGTLALFGA
Rv1454c|M.tuberculosis_H37Rv PEDAWQFAGRVRELTGGTGVQAVYDGVGATTFDASLASLAVRGTLALFGA
TH_3440|M.thermoresistible__bu PTDPEEFGARIRDLTGGEGVPVVYDGVGRSTFDASLASLAVRGTLALFGA
MAB_0750|M.abscessus_ATCC_1997 GDGLAER--ITAAAPQGR-VDAFLDLFGGGYVDLALNELGVDLQRIDTII
MAV_5196|M.avium_104 GDGLTDR--LREAAPDG--IDAFIDLFGPQYVQLAV-DLGVPPERIDTII
MSMEG_6747|M.smegmatis_MC2_155 GDGLLER--VRAAAPQG--VDAVLDASGRGEIPLSI-ELTGDPQRVLTLV
Mflv_2124|M.gilvum_PYR-GCK TSTDYVD--AVAEATRGRGVDVVFDTIGGDTLTRSPLSLAD-SGRVVSIV
Mvan_5758|M.vanbaalenii_PYR-1 TATTVDE--YVAAHTGGEGFDVVADNVGGATLDASFTAVKRYTGHVVSAL
MLBr_00118|M.leprae_Br4923 RDEDFVAR----LQQQNGGADVILDIMGAAYLDRNIDALAIDGQLIVIGL
. * * . :
MMAR_2814|M.marinum_M SNMQEGEKRSLRRVAPHALSMLRGFNLMKQLEESKTVIGLNMLRLWDDRG
MUL_2935|M.ulcerans_Agy99 SNMQEGEKRSLRRVAPHALSMLRGFNLMKQLEESKTVIGLNMLRLWDDRG
Mb1489c|M.bovis_AF2122/97 ASGPVPPVDPQRLNAAGSVYLTR----------------PSLFHFTRTGE
Rv1454c|M.tuberculosis_H37Rv ASGPVPPVDPQRLNAAGSVYLTR----------------PSLFHFTRTGE
TH_3440|M.thermoresistible__bu ASGPVPPFDPQRLNAAGSVYLTR----------------PSLVHFTRTPD
MAB_0750|M.abscessus_ATCC_1997 DFAAIERYGVQSVG-------------------------------NAEGA
MAV_5196|M.avium_104 SFEKAAEVGAKTEG-------------------------------SAEAS
MSMEG_6747|M.smegmatis_MC2_155 AFDQAGTGIQVHAG-------------------------------GAGDS
Mflv_2124|M.gilvum_PYR-GCK DIARPQNLIEAWGRNAAYHFVFTR---------------QNRGKLDALTM
Mvan_5758|M.vanbaalenii_PYR-1 GWG-THSLAPLSFRGAAYSGVFTL---------------MPLLTGRGRDH
MLBr_00118|M.leprae_Br4923 QGGVKGELNLGKVLSKRARIIGSTLR------------ARPVNGPNSKSE
MMAR_2814|M.marinum_M TLEPWIAPLSEALDQGTAAPIVHAAIPFGEAPEAHRILAARENIGKVVLV
MUL_2935|M.ulcerans_Agy99 TLEPWIAPLSEALGQGTAAPIVHAAIPFAEAPEAHRILAARENIGKVVLV
Mb1489c|M.bovis_AF2122/97 EFSWRAAELFDAIGSEAITVAVGGRYPLADALRAHQDLEARKTVGSVVLL
Rv1454c|M.tuberculosis_H37Rv EFSWRAAELFDAIGSEAITVAVGGRYPLADALRAHQDLEARKTVGSVVLL
TH_3440|M.thermoresistible__bu EFGWRAGEFLSAVADGTLTITVGERYPLAEAERAHRDLEGRKTVGSVVLL
MAB_0750|M.abscessus_ATCC_1997 SAQVLSELAALIVDGKLEVT-VAQTFPLDEVRSAYELLERQHTRGKIVLV
MAV_5196|M.avium_104 TPEVLAEMADLIVSGALEFD-IAATYPLDRVADAFAELEQRHTHGKIVLL
MSMEG_6747|M.smegmatis_MC2_155 LSKALSDVVALITDGRLTVP-ISATYPLDEAAAALDASRTGHATGKIVVV
Mflv_2124|M.gilvum_PYR-GCK LVERGLVKPVLGATLPLARMGEAHELLENRRSYALRGKVAIDVAGETVAL
Mvan_5758|M.vanbaalenii_PYR-1 HGEIVAEAAALADSGRLAPRLHPTTFPLDAVNDAHTAVESGSATGKVVVE
MLBr_00118|M.leprae_Br4923 IVAAVTASIWPMIADGSVRPIIGARMAVQQAADAHQLLLSGKVSGKIVLT
* *. *
MMAR_2814|M.marinum_M P-------------
MUL_2935|M.ulcerans_Agy99 P-------------
Mb1489c|M.bovis_AF2122/97 P-------------
Rv1454c|M.tuberculosis_H37Rv P-------------
TH_3440|M.thermoresistible__bu P-------------
MAB_0750|M.abscessus_ATCC_1997 P-------------
MAV_5196|M.avium_104 PTDSQ---------
MSMEG_6747|M.smegmatis_MC2_155 P-------------
Mflv_2124|M.gilvum_PYR-GCK PPRIS---------
Mvan_5758|M.vanbaalenii_PYR-1 PNV-----------
MLBr_00118|M.leprae_Br4923 VAGSGTETLLSRHH