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MTKAVQFDQYGGIDVLQVRDVPRPVPAPDEVLVQVRAAGINPGEAKIRAGMLHDRFPATFPSGQGSDLAG VVVEAGHGVARFAPGDEVFGYTDNRASHAEFVVVPASQLVTKPEGLSWEVAGSLFVAGTTAYAAVGSVHL SPGDTVAVSAAAGGVGTIAVQLARAAGATVIGIAGPDNDEWLTAHGIIPVNYGDGLAERITAAAPQGRVD AFLDLFGGGYVDLALNELGVDLQRIDTIIDFAAIERYGVQSVGNAEGASAQVLSELAALIVDGKLEVTVA QTFPLDEVRSAYELLERQHTRGKIVLVP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0750 | - | - | 100% (308) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1874 | - | 3e-53 | 43.09% (311) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1486c | - | 4e-51 | 37.90% (314) | putative oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1947c | fadB5 | 1e-21 | 36.36% (220) | oxidoreductase FADB5 |
| M. gilvum PYR-GCK | Mflv_2124 | - | 4e-29 | 32.31% (325) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1912c | fadB5 | 1e-21 | 36.36% (220) | oxidoreductase FADB5 |
| M. leprae Br4923 | MLBr_00118 | - | 3e-23 | 29.02% (317) | putative oxidireductase |
| M. marinum M | MMAR_1738 | - | 2e-29 | 34.12% (296) | oxidoreductase |
| M. avium 104 | MAV_5196 | - | 9e-99 | 58.82% (306) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_6747 | - | 1e-68 | 47.25% (309) | oxidoreductase |
| M. thermoresistible (build 8) | TH_3440 | - | 2e-27 | 29.48% (329) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_2209 | - | 2e-28 | 32.25% (338) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5758 | - | 3e-30 | 32.81% (317) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1947c|M.bovis_AF2122/97 -----------------------------------------------MRA
Rv1912c|M.tuberculosis_H37Rv -----------------------------------------------MRA
TH_3440|M.thermoresistible__bu VQTAAAQRRDEIGVIGVALRAVRTTGQNDPRMEHIRAGELHTGMIGAMKA
MAB_0750|M.abscessus_ATCC_1997 ----------------------------------------------MTKA
MAV_5196|M.avium_104 ------------------------------------------MTAAAARA
MSMEG_6747|M.smegmatis_MC2_155 ----------------------------------------------MPRT
MMAR_1738|M.marinum_M -----------------------------------------------MRA
MUL_2209|M.ulcerans_Agy99 -----------------------------------------------MKA
Mflv_2124|M.gilvum_PYR-GCK -------------------------------------------MSDRMKA
Mvan_5758|M.vanbaalenii_PYR-1 -----------------------------------------------MRA
MLBr_00118|M.leprae_Br4923 --------------------------------------------------
Mb1947c|M.bovis_AF2122/97 VVITKHGDPSVLQVRQRPDPPPPGPGQLRVAVRAAGVNFADHLARVG---
Rv1912c|M.tuberculosis_H37Rv VVITKHGDPSVLQVRQRPDPPPPGPGQLRVAVRAAGVNFADHLARVG---
TH_3440|M.thermoresistible__bu IEVRETGGPEVLTYVDVPEPTP-GPGQVLIKAEAIGVNFIDTYFRSG---
MAB_0750|M.abscessus_ATCC_1997 VQFDQYGGIDVLQVRDVPRPVP-APDEVLVQVRAAGINPGEAKIRAG-ML
MAV_5196|M.avium_104 VRFDRYGGREVLYVADIEMPAP-GPGEVVVEVRAAGINPGEAAIRVG-AL
MSMEG_6747|M.smegmatis_MC2_155 VQFAEYGDTDVLTVVDTPAPEP-GPGQVRLKVRAAGLNPIDWKIVAG-FM
MMAR_1738|M.marinum_M LRAHRRGGPETLAVERAPVPVP-AAGEVVVAVRAAGITFDELTWDQT-WT
MUL_2209|M.ulcerans_Agy99 MAQRTWNPAEPLEFIELPTPEP-QAGEVRVQVQAIGVNPVDWKMRSS-GP
Mflv_2124|M.gilvum_PYR-GCK VVLARFGGADAFELRDVAVPHV-GPRQVRVRVHATAVNPLDYQIRRG-DY
Mvan_5758|M.vanbaalenii_PYR-1 AVLTAYN--SPLLVDELPDPEP-GPGEVLVRVMASGVNPLDIKIRRGEAP
MLBr_00118|M.leprae_Br4923 MHAIVAESANQMVWREVPDVTA-GPGEVLIEVAASGVNRADVLQVAG---
. : . :: : . * .:. :
Mb1947c|M.bovis_AF2122/97 --LYPD--APKLPAVVGYEVAGTVEAVGDGVDPNRVGERVLAGT-----R
Rv1912c|M.tuberculosis_H37Rv --LYPD--APKLPAVVGYEVAGTVEAVGDGVDPNRVGERVLAGT-----R
TH_3440|M.thermoresistible__bu --LYP----REVPFIVGTEVCGTVEAVGDGVAALRVGDRVLTDK-----A
MAB_0750|M.abscessus_ATCC_1997 HDRFP----ATFPSGQGSDLAGVVVEAGHGVARFAPGDEVFGYT----DN
MAV_5196|M.avium_104 HERFP----ATFPSGEGSDLAGVVTAVGPGVTEFAVGDEVLGFS----LR
MSMEG_6747|M.smegmatis_MC2_155 RELMP----VDLPAGVGSDVAGIVDAVGPGVTEWAVGNEVLGRS----AT
MMAR_1738|M.marinum_M RDGVS-----RTPVIPSHEVSGVIHEIGSGTEDFHCGDEVYGLIGFDRD-
MUL_2209|M.ulcerans_Agy99 LRLAARLIGPKPPVVVGVDFAGVVEAVGPGVTRAAPGDRVVGGTNFSRGQ
Mflv_2124|M.gilvum_PYR-GCK TDLVP------LPAIIGHDISGVIEEVGSHVTEFRAGDAVY-YTPKIFGG
Mvan_5758|M.vanbaalenii_PYR-1 HAQLP------PPAVLGIDMAGVVEAVGPRVDRFTVGDEVFGMTGGVGGL
MLBr_00118|M.leprae_Br4923 --KYPHP--PGASAIIGMEVAGVVAAVSSGVTEWSVGQEVCALLAG----
. . . :..* : . . *: *
Mb1947c|M.bovis_AF2122/97 FGGYCEIVNVAATDSVVLPDALSFEQGAAVPVNYATAWAALHGYGSLRAG
Rv1912c|M.tuberculosis_H37Rv FGGYCEIVNVAATDSVVLPDALSFEQGAAVPVNYATAWAALHGYGSLRAG
TH_3440|M.thermoresistible__bu NGAYAEYTVAPADYVAYVPDGVAPDTVASALLKGMTAHYLIKSVYEVQRG
MAB_0750|M.abscessus_ATCC_1997 RASHAEFVVVPASQLVTKPEGLSWEVAGSLFVAGTTAYAAVGSVHLSPGD
MAV_5196|M.avium_104 RSSHATHTAVPVGQLIRKPPELSWEVAGSLYVVGVTAYAAVRAVAPQPGE
MSMEG_6747|M.smegmatis_MC2_155 G-AYAEYALAEAAELIGKPGEITWEVAGSLAGAGGTAHAVLDRLDLKSGE
MMAR_1738|M.marinum_M -GAAADFVAVPAAHLAAKPATISHTVAAALPLAGLTALQALVDHAAVRPG
MUL_2209|M.ulcerans_Agy99 RGSYADTVLVREDQLCRVPDTVDIAVAAALPVGGVTAWMAVVELGRIRQV
Mflv_2124|M.gilvum_PYR-GCK PGSYAEQHVADVDLVGRKPDNLDHLEAASLTLVGGTVWESLVTRAQLTVG
Mvan_5758|M.vanbaalenii_PYR-1 QGSLAELAAVDARLIAHKPRTLSMAQAAALPLGFITSWEGLVDRAGVGTG
MLBr_00118|M.leprae_Br4923 -GGYAEYVAVPASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAHLSAG
. . . * : .. * :
Mb1947c|M.bovis_AF2122/97 ----ERVLIHAAAGGVGIAAVQFAKAAKAEVHGTAS-PQKHQKLAEFGVD
Rv1912c|M.tuberculosis_H37Rv ----ERVLIHAAAGGVGIAAVQFAKAAKAEVHGTAS-PQKHQKLAEFGVD
TH_3440|M.thermoresistible__bu ----DTILVHAGAGGVGLILTQWATHLGARVITTVSTPQKAELSRKAGAA
MAB_0750|M.abscessus_ATCC_1997 -----TVAVSAAAGGVGTIAVQLARAAGATVIGIAG-PDNDEWLTAHGII
MAV_5196|M.avium_104 -----TVAVSAAAGGVGSLVTQLLVLRKARVLGIAG-PGNADWLRAHGVV
MSMEG_6747|M.smegmatis_MC2_155 -----TLLVHAAAGGVGTFAVQLAGARGVSVIGTAG-EGNHDYLRSIGAT
MMAR_1738|M.marinum_M ----EAVLVHGGAGGVGALVVQLAAILGANVTATVR-SDAGELVSRLGAQ
MUL_2209|M.ulcerans_Agy99 PSADRRVLVLGASGGVGQLAVQIAKLQEAFVVGVCS-TENVEMVKDLGAD
Mflv_2124|M.gilvum_PYR-GCK ----ETILIHGGAGGVGTIAIQVAKAMGARVITTAK-AGDHAFVNSLGAD
Mvan_5758|M.vanbaalenii_PYR-1 ----QQVLIHGGAGGVGFLAVQLALARGAQVYATGS-TSSQAVIRAAGA-
MLBr_00118|M.leprae_Br4923 ----QLLLLHGGTSGIGSHGIQVARALGAKVAVTAGSEEKLEFCRALGAQ
: : ..:.*:* * . * *
Mb1947c|M.bovis_AF2122/97 RAIDYRRD--------GWWQGLGPYDVVLDALGGTSLRRSYTLLRPGGRL
Rv1912c|M.tuberculosis_H37Rv RAIDYRRD--------GWWQGLGPYDVVLDALGGTSLRRSYTLLRPGGRL
TH_3440|M.thermoresistible__bu EVLDYPTDPEEFGARIRDLTGGEGVPVVYDGVGRSTFDASLASLAVRGTL
MAB_0750|M.abscessus_ATCC_1997 PVNYGDGL--AERITAAAPQGR--VDAFLDLFGGGYVDLALNELGVDLQR
MAV_5196|M.avium_104 PIAYGDGL--TDRLREAAPDG---IDAFIDLFGPQYVQLAV-DLGVPPER
MSMEG_6747|M.smegmatis_MC2_155 PVTYGDGL--LERVRAAAPQG---VDAVLDASGRGEIPLSI-ELTGDPQR
MMAR_1738|M.marinum_M RVIDTR-----TEAFERTATD---FDVVIDTVGGDTLDRSFAVLRPGGRL
MUL_2209|M.ulcerans_Agy99 LVLDYNQG--DALAQAKPHAP---FHVVIDCVGSYSGAGCRALLSSRGRH
Mflv_2124|M.gilvum_PYR-GCK VAIDHTST--DYVDAVAEATRGRGVDVVFDTIGGDTLTRSPLSLAD-SGR
Mvan_5758|M.vanbaalenii_PYR-1 VPIDYTAT--TVDEYVAAHTGGEGFDVVADNVGGATLDASFTAVKRYTGH
MLBr_00118|M.leprae_Br4923 ITINYRDE----DFVARLQQQNGGADVILDIMGAAYLDRNIDALAIDGQL
.. * * :
Mb1947c|M.bovis_AF2122/97 VGYGISNMQHGEKRSMRRVAPHALSMLRGFNLMKQLEESKTVIGLNMLRL
Rv1912c|M.tuberculosis_H37Rv VGYGISNMQHGEKRSMRRVAPHALSMLRGFNLMKQLEESKTVIGLNMLRL
TH_3440|M.thermoresistible__bu ALFGAASGPVPPFDPQRLNAAGSVYLTR----------------PSLVHF
MAB_0750|M.abscessus_ATCC_1997 IDTI------IDFAAIERYGVQSVGNAE----------------------
MAV_5196|M.avium_104 IDTI------ISFEKAAEVGAKTEGSAE----------------------
MSMEG_6747|M.smegmatis_MC2_155 VLTL------VAFDQAGTGIQVHAGGAG----------------------
MMAR_1738|M.marinum_M VTLS--AP--PPAGKADEHGVTAMFFIV----------------------
MUL_2209|M.ulcerans_Agy99 IMVAGDEP--SSAVQVVVPPFKSKAILG----------------------
Mflv_2124|M.gilvum_PYR-GCK VVSIVDIARPQNLIEAWGRNAAYHFVFT----------------------
Mvan_5758|M.vanbaalenii_PYR-1 VVSALGWG-THSLAPLSFRGAAYSGVFT----------------------
MLBr_00118|M.leprae_Br4923 IVIGLQGGVKGELNLGKVLSKRARIIGSTLR------------ARPVNGP
Mb1947c|M.bovis_AF2122/97 WDDRRTLEPWIAPLTKALNDGTILPIVHAIVPFAEAPEAHRILA------
Rv1912c|M.tuberculosis_H37Rv WDDRRTLEPWIAPLTKALNDGTILPIVHAIVPFAEAPEAHRILA------
TH_3440|M.thermoresistible__bu TRTPDEFGWRAGEFLSAVADGTLTITVGERYPLAEAERAHRDLE------
MAB_0750|M.abscessus_ATCC_1997 ----GASAQVLSELAALIVDGKLEVTVAQTFPLDEVRSAYELL-------
MAV_5196|M.avium_104 ----ASTPEVLAEMADLIVSGALEFDIAATYPLDRVADAFAEL-------
MSMEG_6747|M.smegmatis_MC2_155 ----DSLSKALSDVVALITDGRLTVPISATYPLDEAAAALDAS-------
MMAR_1738|M.marinum_M ----TPNRDQLNRLGELVGSGRLHVEIAQSFPLANGREAFESGR------
MUL_2209|M.ulcerans_Agy99 ----RPNGARLEPLVDAVAAGKLRVSIAQKLPLTSAEEAHRLS-------
Mflv_2124|M.gilvum_PYR-GCK ----RQNRGKLDALTMLVERGLVKPVLGATLPLARMGEAHELLENRRSYA
Mvan_5758|M.vanbaalenii_PYR-1 ----LMPLLTGRGRDHHGEIVAEAAALADSGRLAPRLHPTTFPLDAVNDA
MLBr_00118|M.leprae_Br4923 NSKSEIVAAVTASIWPMIADGSVRPIIGARMAVQQAADAHQLLL------
: . .
Mb1947c|M.bovis_AF2122/97 -----ARENVGKVVLVP-------------
Rv1912c|M.tuberculosis_H37Rv -----ARENVDKVVLVP-------------
TH_3440|M.thermoresistible__bu -----GRKTVGSVVLLP-------------
MAB_0750|M.abscessus_ATCC_1997 ----ERQHTRGKIVLVP-------------
MAV_5196|M.avium_104 ----EQRHTHGKIVLLPTDSQ---------
MSMEG_6747|M.smegmatis_MC2_155 ----RTGHATGKIVVVP-------------
MMAR_1738|M.marinum_M ----GAARRAGKTVITVGQ-----------
MUL_2209|M.ulcerans_Agy99 ----QTSRMTGKLILEP-------------
Mflv_2124|M.gilvum_PYR-GCK LRGKVAIDVAGETVALPPRIS---------
Mvan_5758|M.vanbaalenii_PYR-1 HTAVESGSATGKVVVEPNV-----------
MLBr_00118|M.leprae_Br4923 -----SGKVSGKIVLTVAGSGTETLLSRHH
.. :