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GRCVGLFKGVKAVGVYEFGGPDALEVIDLPEPQAGPGEVRIRVYAAAVSPTDVLLRTGGHAVRMAGRRPP FVPGMDAAGVIDQIGPGCDGRLHVGQRVIAMVMFVGEHGGAYAEQVVVPAASVVPAPANADFAAASTLLM NAMTARLALDTLGLRAGETVAVTGAAGAVGGFAVELAKADGLRVIADAAERDVELLRGFGADHVVERGAE VAARIRGLVPGGVPGLVDGSDQQGEVLGAVADGGMLVELRGWEGPGERGVRVVPVMVPDRITDTEGLTTL SRQAEMGVLTLRVAEVLPAEQAPKAHRMLEAGGLRGRIVLDFS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4032 | - | - | 100% (324) | zinc-binding alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4064 | - | e-178 | 98.12% (320) | zinc-binding alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3409 | - | 9e-39 | 36.17% (329) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0154 | - | 3e-28 | 34.44% (331) | putative quinone oxidoreductase (NADPH:quinone oxidoreductase) |
| M. gilvum PYR-GCK | Mflv_2449 | - | 4e-32 | 33.13% (329) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0149 | - | 3e-28 | 34.44% (331) | quinone oxidoreductase |
| M. leprae Br4923 | MLBr_00118 | - | 1e-18 | 27.86% (323) | putative oxidireductase |
| M. abscessus ATCC 19977 | MAB_1874 | - | 5e-33 | 33.13% (323) | putative oxidoreductase |
| M. marinum M | MMAR_2950 | - | 1e-30 | 30.03% (323) | oxidoreductase |
| M. avium 104 | MAV_0308 | - | 5e-29 | 32.63% (331) | alcohol dehydrogenase, zinc-binding |
| M. thermoresistible (build 8) | TH_3440 | - | 3e-28 | 30.92% (346) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_2209 | - | 2e-30 | 30.03% (323) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4202 | - | 1e-32 | 34.37% (323) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0154|M.bovis_AF2122/97 -----------------------------------------------MKA
Rv0149|M.tuberculosis_H37Rv -----------------------------------------------MKA
TH_3440|M.thermoresistible__bu VQTAAAQRRDEIGVIGVALRAVRTTGQNDPRMEHIRAGELHTGMIGAMKA
Mflv_2449|M.gilvum_PYR-GCK -----------------------------------------------MRA
Mvan_4202|M.vanbaalenii_PYR-1 -----------------------------------------------MRA
MAV_0308|M.avium_104 -----------------------------------------------MRA
MMAR_2950|M.marinum_M -----------------------------------------------MKA
MUL_2209|M.ulcerans_Agy99 -----------------------------------------------MKA
MAB_1874|M.abscessus_ATCC_1997 -----------------------------------------------MRA
MSMEG_4032|M.smegmatis_MC2_155 -------------------------------------MGRCVGLFKGVKA
MLBr_00118|M.leprae_Br4923 -----------------------------------------------MHA
::*
Mb0154|M.bovis_AF2122/97 CVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDLLLTKGEYQ-
Rv0149|M.tuberculosis_H37Rv CVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDLLLTKGEYQ-
TH_3440|M.thermoresistible__bu IEVRETGGPEVLTYVDVPEPTPGPGQVLIKAEAIGVNFIDTYFRSGLYP-
Mflv_2449|M.gilvum_PYR-GCK AMCREYGPPEVVRVEDVAEPVAGPGQIGVRVDAAAVNFPDVLLVAGTYQ-
Mvan_4202|M.vanbaalenii_PYR-1 AVCPQYGPPEVVRVEERPEPSAGPGQVVVRVEAAAVNFPDVLLVADSYQ-
MAV_0308|M.avium_104 VVCRSYGTPEDLVLDEVPDPVPGPGQLLVRVRAAAVNFPDVLFIAGKYQ-
MMAR_2950|M.marinum_M MAQRTWNPAEPLELIELPTPEPKAGEVRVQVQAIGVNPVDWKMRSSGPLR
MUL_2209|M.ulcerans_Agy99 MAQRTWNPAEPLEFIELPTPEPQAGEVRVQVQAIGVNPVDWKMRSSGPLR
MAB_1874|M.abscessus_ATCC_1997 VQLDFFGGPELLAVREIPAPQAGPGQIRVRVTAAGLNPMDWIITADADT-
MSMEG_4032|M.smegmatis_MC2_155 VGVYEFGGPDALEVIDLPEPQAGPGEVRIRVYAAAVSPTDVLLRTGGHA-
MLBr_00118|M.leprae_Br4923 IVAESAN---QMVWREVPDVTAGPGEVLIEVAASGVNRADVLQVAGKYP-
. : : *:: : . * .: * .
Mb0154|M.bovis_AF2122/97 -----LKLTPPFVPGMETAGVVRSAPS-DAGFHVGE------RVSAFGVL
Rv0149|M.tuberculosis_H37Rv -----LKLTPPFVPGMETAGVVRSAPS-DAGFHVGE------RVSAFGVL
TH_3440|M.thermoresistible__bu -----REVP--FIVGTEVCGTVEAVGDGVAALRVGD------RVLTDKAN
Mflv_2449|M.gilvum_PYR-GCK -----ISVPPPFVPGSEFAGVVDEIGPGTEGFTIGD------RVSGTAMF
Mvan_4202|M.vanbaalenii_PYR-1 -----VSVAPPFVPGSEFTGVVDEIGPHTTGFTVGE------RVAGTGMF
MAV_0308|M.avium_104 -----VKIPPPFIPGNEIAGEVIAAGEGAR-FLPGQ------RVAGT-TF
MMAR_2950|M.marinum_M LAARLIGPKPPVVVGVDFAGVVEAVGPGVTRAAPGDRVVGGTN-FSRGQR
MUL_2209|M.ulcerans_Agy99 LAARLIGPKPPVVVGVDFAGVVEAVGPGVTRAAPGDRVVGGTN-FSRGQR
MAB_1874|M.abscessus_ATCC_1997 --AARFGLSLPVGFGTDYAGVIDQVGDGVSGFAVGDRVFGGALSRAVADF
MSMEG_4032|M.smegmatis_MC2_155 --VRMAGRRPPFVPGMDAAGVIDQIGPGCDGRLHVGQRVIAMVMFVGEHG
MLBr_00118|M.leprae_Br4923 -----HPPGASAIIGMEVAGVVAAVSSGVTEWSVGQ------EVCALLAG
* : * :
Mb0154|M.bovis_AF2122/97 GGYAEQIAVPVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAA----L
Rv0149|M.tuberculosis_H37Rv GGYAEQIAVPVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAA----L
TH_3440|M.thermoresistible__bu GAYAEYTVAPADYVAYVPDGVAPDTVASALLKGMTAHYLIKSVYE----V
Mflv_2449|M.gilvum_PYR-GCK GAFAERTVVDAAALAPIPDGVDARTAAAFGVAYRTAYHTLRSVAR----V
Mvan_4202|M.vanbaalenii_PYR-1 GAFAERVVADAAGLTPVPDGVDARTAAAFGVAHRTAYHALRSTAR----L
MAV_0308|M.avium_104 GAFAEQALLDADQAEPIPDDADFASAAAFGVTYRTAYHALRSTAG----V
MMAR_2950|M.marinum_M GSYADTVLVREDQLCRVPDTVDIAVAAALPVGGVTAWMAVVELGRIRQVP
MUL_2209|M.ulcerans_Agy99 GSYADTVLVREDQLCRVPDTVDIAVAAALPVGGVTAWMAVVELGRIRQVP
MAB_1874|M.abscessus_ATCC_1997 VLINVTGGIAAEEAHHIPDGIDDRTAATLAIAGRTASAALAVVN-----P
MSMEG_4032|M.smegmatis_MC2_155 GAYAEQVVVPAASVVPAPANADFAAASTLLMNAMTARLALDTLG-----L
MLBr_00118|M.leprae_Br4923 GGYAEYVAVPASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAH----L
* * :
Mb0154|M.bovis_AF2122/97 RPGDTVLVLGAAGGVGTAAVQIAKAMQAGKVIAMVHREGAIDYVASLGAD
Rv0149|M.tuberculosis_H37Rv RPGDTVLVLGAAGGVGTAAVQIAKAMQAGKVIAMVHREGAIDYVASLGAD
TH_3440|M.thermoresistible__bu QRGDTILVHAGAGGVGLILTQWATHLGA-RVITTVSTPQKAELSRKAGAA
Mflv_2449|M.gilvum_PYR-GCK SEGDELVVLGAGGGVGLAAVQLGVALGA-NVTAVASSAEKLAAAAEYGAA
Mvan_4202|M.vanbaalenii_PYR-1 SAGDELVVLGAGGGVGLATVQLGVALGA-RVTAVASSNEKLAVAGGYGAA
MAV_0308|M.avium_104 TAGDWVVVLGAAGGVGLAAVDLAVAMQA-RVLAAASSPEKLELCRRRGAE
MMAR_2950|M.marinum_M PADRRVLVLGASGGVGQLAVQIAKLQEA--FVVGVCSTKNVEMVKDLGAD
MUL_2209|M.ulcerans_Agy99 SADRRVLVLGASGGVGQLAVQIAKLQEA--FVVGVCSTENVEMVKDLGAD
MAB_1874|M.abscessus_ATCC_1997 GPGDTVLIGGAGGGVGVFAVQLARIAGA--RVIGTGSATSADFLRGLGAE
MSMEG_4032|M.smegmatis_MC2_155 RAGETVAVTGAAGAVGGFAVELAKADGL--RVIADAAERDVELLRGFGAD
MLBr_00118|M.leprae_Br4923 SAGQLLLLHGGTSGIGSHGIQVARALGA-KVAVTAGSEEKLEFCRALGAQ
. : : .. ..:* : . **
Mb0154|M.bovis_AF2122/97 VVLPLTEG---WAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDGKL
Rv0149|M.tuberculosis_H37Rv VVLPLTEG---WAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDGKL
TH_3440|M.thermoresistible__bu EVLDYPTDPEEFGARIRDLTGGEGVPVVYDGVGRSTFDASLASLAVRGTL
Mflv_2449|M.gilvum_PYR-GCK HLVDHREQ--DLRAALRTAVP-DGADVVIDPVGGRLSEPALRSLGRGGRF
Mvan_4202|M.vanbaalenii_PYR-1 TLINHRDG--ELRQALRQAIP-DGADVVVDPVGGDVSEPALRSLGRGGRF
MAV_0308|M.avium_104 ATVDYDRE--DLKTRIRDLTG-DRARVVLDPVGGPYSEPALRGLARGGTF
MMAR_2950|M.marinum_M LVLDY-NQ----GDALAQAKPHAPFHVVIDCVGSYSGAGCRALLSSRGRH
MUL_2209|M.ulcerans_Agy99 LVLDY-NQ----GDALAQAKPHAPFHVVIDCVGSYSGAGCRALLSSRGRH
MAB_1874|M.abscessus_ATCC_1997 PVAYG-DG----LANRVRILAPGGITAAIDLHGTETVYAARELGVPESRI
MSMEG_4032|M.smegmatis_MC2_155 HVVERGAE----VAARIRGLVPGGVPGLVD--GSDQQGEVLGAVADGGML
MLBr_00118|M.leprae_Br4923 ITINYRDE----DFVARLQQQNGGADVILDIMGAAYLDRNIDALAIDGQL
* * .
Mb0154|M.bovis_AF2122/97 LLIGFAAGAVPTLKVNRLLVRNISVVGVGWGEYLNAVP----GSAALFAW
Rv0149|M.tuberculosis_H37Rv LLIGFAAGAVPTLKVNRLLVRNISVVGVGWGEYLNAVP----GSAALFAW
TH_3440|M.thermoresistible__bu ALFGAASGPVPPFDPQRLNAAGSVYLTRPSLVHFTRTP----DEFGWRAG
Mflv_2449|M.gilvum_PYR-GCK VTVGFASGEIPRIPLNLVLLKGVQVLGFQFQDVPGD-------EFVRNDH
Mvan_4202|M.vanbaalenii_PYR-1 VSVGFASGVIPRIPLNLVLIKGVHVLGFQFQDVPAD-------EFTRNEV
MAV_0308|M.avium_104 VTLGYASGTIPAIPLNLVLLKDICVRGMEIRTFMTDRP----DDAVRDLT
MMAR_2950|M.marinum_M IMVAGDEPSSALQVVVPPFKSKAILG----------------RPNGARLE
MUL_2209|M.ulcerans_Agy99 IMVAGDEPSSAVQVVVPPFKSKAILG----------------RPNGARLE
MAB_1874|M.abscessus_ATCC_1997 CTIATQVEG----------ISAANGA----------------NAAEGALE
MSMEG_4032|M.smegmatis_MC2_155 VELRGWEGPGERGVRVVPVMVPDRIT----------------DTEG--LT
MLBr_00118|M.leprae_Br4923 IVIGLQGGVKGELNLGKVLSKRARIIGSTLRARPVNGPNSKSEIVAAVTA
.
Mb0154|M.bovis_AF2122/97 GLNQLVFLG-LRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP------
Rv0149|M.tuberculosis_H37Rv GLNQLVFLG-LRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP------
TH_3440|M.thermoresistible__bu EFLSAVADGTLTITVGERYPLAEAERAHRDLEGRKTVGSVVLLP------
Mflv_2449|M.gilvum_PYR-GCK ELRALLSARRVTPHVGAVYPLEEVAAALRHVGEGRAIGKVLIDVPA----
Mvan_4202|M.vanbaalenii_PYR-1 ELRELLVSGRVKPHVGAVYSLDDTVAALRHVSDGRAIGKVVIDLS-----
MAV_0308|M.avium_104 ELSQMFAAGTVRPYIGARFPLARTAAALRHVADRKVLGKVVIDVA-----
MMAR_2950|M.marinum_M PLVDAVAAGKLRVSIAQKLPLTSAEEAHRLSQTSRMTGKLILEP------
MUL_2209|M.ulcerans_Agy99 PLVDAVAAGKLRVSIAQKLPLTSAEEAHRLSQTSRMTGKLILEP------
MAB_1874|M.abscessus_ATCC_1997 ELARLIAAGQLRVPIAASFPLAQIRRAVELQAGRHVHGKIVIDL------
MSMEG_4032|M.smegmatis_MC2_155 TLSRQAEMGVLTLRVAEVLPAEQAPKAHRMLEAGGLRGRIVLDFS-----
MLBr_00118|M.leprae_Br4923 SIWPMIADGSVRPIIGARMAVQQAADAHQLLLSGKVSGKIVLTVAGSGTE
: : . * . * :::
Mb0154|M.bovis_AF2122/97 -------
Rv0149|M.tuberculosis_H37Rv -------
TH_3440|M.thermoresistible__bu -------
Mflv_2449|M.gilvum_PYR-GCK -------
Mvan_4202|M.vanbaalenii_PYR-1 -------
MAV_0308|M.avium_104 -------
MMAR_2950|M.marinum_M -------
MUL_2209|M.ulcerans_Agy99 -------
MAB_1874|M.abscessus_ATCC_1997 -------
MSMEG_4032|M.smegmatis_MC2_155 -------
MLBr_00118|M.leprae_Br4923 TLLSRHH