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VATAVHIAIRDLIDRNPIGGHQRRTLVLCFFCIVVDGLEVTVVGFLSAALKDDWAIGTAQLAPAVTAGLI GLGVGALLGGPLGDRFGRRYVIVWAIGSFAATTLLTAAADGVLTFSLLRLLTGFGLGASMPNVAALVSET VPTPRRRSIVAVVWSGFPSGAAIGAVVVPFVVETFGWRVAILGCGAAAAVIFVCVGTLLSESPVYLANSG HDPARLRRYCNAIEPGSADAGSVFVRDEKVRPRAYPIGALLTPELRIGTLTLWVGFMAVMFSIYLTNTWL PYLFKVAGFATGSISILSTALQIGGAVGCAAIGFIQDRFGPHITLVWTSVLGGGTAAAIAVSPNTTVVLG TLIFVLGMCTNAISTGYTAVSTTFYPTDIRSTGTSWAAGMSRVGAVLGAGIGTSLASLGVSLQQVFLLLL IPITIGALCMAIKAVTSQRAGITPAPDNTMNGARK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6718 | - | - | 100% (455) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_6711 | - | e-104 | 44.37% (435) | 4-hydroxybenzoate transporter |
| M. smegmatis MC2 155 | MSMEG_3369 | - | 1e-24 | 24.05% (395) | putative transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3364 | sugI | 3e-19 | 26.10% (364) | sugar-transport integral membrane protein SugI |
| M. gilvum PYR-GCK | Mflv_1730 | - | 1e-14 | 23.80% (458) | EmrB/QacA family drug resistance transporter |
| M. tuberculosis H37Rv | Rv3331 | sugI | 4e-19 | 26.10% (364) | sugar-transport integral membrane protein SugI |
| M. leprae Br4923 | MLBr_01562 | - | 6e-11 | 25.57% (176) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_2481 | - | 1e-14 | 25.55% (411) | putative integral membrane transporter |
| M. marinum M | MMAR_2574 | - | 9e-22 | 27.10% (476) | sugar transporter |
| M. avium 104 | MAV_4306 | - | 1e-20 | 25.58% (391) | transporter, major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_4243 | - | 8e-13 | 27.25% (356) | PUTATIVE General substrate transporter |
| M. ulcerans Agy99 | MUL_3187 | - | 8e-21 | 27.35% (446) | sugar transporter |
| M. vanbaalenii PYR-1 | Mvan_4014 | - | 1e-14 | 23.78% (429) | EmrB/QacA family drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2574|M.marinum_M ----------------------------MSARAQTGTISTHVPARLDRLP
MUL_3187|M.ulcerans_Agy99 --------------------------------------------------
Mb3364|M.bovis_AF2122/97 ----MTTLWQPHRNDYSPIPGRGVHARRGARRPRPRGGRAERPGTGQLTR
Rv3331|M.tuberculosis_H37Rv ----MTTLWQPHRNDYSPIPGRGVHARRGARRPRPRGGRAERPGTGQLTR
MAV_4306|M.avium_104 -----------------------------------------------MAR
MAB_2481|M.abscessus_ATCC_1997 --------------------------------MTTTSAVPAVHAGGPADG
TH_4243|M.thermoresistible__bu -------------------------------------------VSAPASG
MSMEG_6718|M.smegmatis_MC2_155 ---------------------------------MATAVHIAIRDLIDRNP
Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_4014|M.vanbaalenii_PYR-1 ------------------------------------MSQHRPHDAIAAEP
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
MMAR_2574|M.marinum_M WGRFHWRVVIGLGGVWVLDGLEVTMVGNVSARLTEHGSGINLTPAQIGVA
MUL_3187|M.ulcerans_Agy99 --------MIGLGGVWVLDGLEVTMVGNVSARLTEHGSGINLTPAQIGVA
Mb3364|M.bovis_AF2122/97 SGRRALLVGLTAASVGVLYGYDLSAIAGALLSLSEE---FELTTREQELL
Rv3331|M.tuberculosis_H37Rv SGRRALLVGLTAASVGVLYGYDLSAIAGALLSLSEE---FELTTREQELL
MAV_4306|M.avium_104 GSRRGLLVGLTAASVGVIYGYDLSIIAGAQLFVTED---FGLSTRQQELL
MAB_2481|M.abscessus_ATCC_1997 DAPAARTVALSCMVGTTIEWYDFYLYATAAALVLKPLFFP-SVSPTAGTL
TH_4243|M.thermoresistible__bu ----LKRVVAASMAGTVVEWYEFFLYGTAATLVFNKVFFAQGDNELDAIL
MSMEG_6718|M.smegmatis_MC2_155 IGGHQRRTLVLCFFCIVVDGLEVTVVGFLSAALKDD---WAIGTAQLAPA
Mflv_1730|M.gilvum_PYR-GCK TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRAD---LSASPAQMQWV
Mvan_4014|M.vanbaalenii_PYR-1 TDDHPFRALWVMMVGFFLIVVDSTVIAVANPVLKND---FDVEYHSVIWV
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNE---LSLSDAGRSWG
: : :
MMAR_2574|M.marinum_M ASFYIAGA-----CLGALFFGHLTDRFGRRNLFLLTLAVYLTATVAT---
MUL_3187|M.ulcerans_Agy99 ASFYIAGA-----CLGALFFGHLTDRFGRRNLFLLTLAVYLTATVAT---
Mb3364|M.bovis_AF2122/97 TTTAVLGQ-----IAGALGGGILANAIGRKKSVVLIVAGYAVFALLG---
Rv3331|M.tuberculosis_H37Rv TTTAVLGQ-----IAGALGGGILANAIGRKKSVVLIVAGYAVFALLG---
MAV_4306|M.avium_104 TTMAVIGQ-----IGGALFAGVLANAIGRRRSVLLILSGYAVFALLA---
MAB_2481|M.abscessus_ATCC_1997 ASFATYAAGFGARPVGAVIAGHLGDRVGRKAVLVGALLLMGVATAVIGAL
TH_4243|M.thermoresistible__bu AAFVTYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCL
MSMEG_6718|M.smegmatis_MC2_155 VTAGLIGLG-----VGALLGGPLGDRFGRRYVIVWAIGSFAATTLLT---
Mflv_1730|M.gilvum_PYR-GCK VDIYTLVLAS-----LLMLSGATGDRFGRRRLFQIGLTVFALGSLAC---
Mvan_4014|M.vanbaalenii_PYR-1 TSGYLLAFA-----AFLLIGGRLGDRFGSKPVYLVGLTLFAAASVWCG--
MLBr_01562|M.leprae_Br4923 ITAYVLTFG-----GLMLLGGRLGDTIGRKRTFIVGVALFTISSVLC---
: * : * : : :
MMAR_2574|M.marinum_M -----AFAFAPWYFFIARFFTGSGIGGEYAAINSAIDELIPARVRGRVDL
MUL_3187|M.ulcerans_Agy99 -----AFAFAPWYFFIARFFTGSGIGGEYAAINSAIDELIPARVRGRVDL
Mb3364|M.bovis_AF2122/97 -----ATSVSVPMLVVARLLLGVTIGLSVVVVPVYVAESAPAAVRGSLVT
Rv3331|M.tuberculosis_H37Rv -----ATSVSVPMLVVARLLLGVTIGLSVVVVPVYVAESAPAAVRGSLVT
MAV_4306|M.avium_104 -----AFSVGLPMLLTARLLLGLTIGVTVVVVPVYVAESAPTAVRGALLT
MAB_2481|M.abscessus_ATCC_1997 PTYSEAGVLAPAALATLRVLQGLAAGAEWGGAALLAVEHAPVGRRGLFGS
TH_4243|M.thermoresistible__bu PTFGQIGYWAPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSS
MSMEG_6718|M.smegmatis_MC2_155 -----AAADGVLTFSLLRLLTGFGLGASMPNVAALVSETVPTPRRRSIVA
Mflv_1730|M.gilvum_PYR-GCK -----SLAPTIDTLIGARFLQGVGGSMLNPVALSIISQIFTKPVERARAL
Mvan_4014|M.vanbaalenii_PYR-1 ------LSTSVGMLIAARVAQGVGAALLTPQIMSTITRTFPPQRHG-MAM
MLBr_01562|M.leprae_Br4923 -----AVAWDEVTLVIARLLQGIGSAIASPTGLALVATTFSKGSARNTAT
: *. * . .
MMAR_2574|M.marinum_M IINGTYW-LGSAAGAAGALVLLDTSNFAPNM--GWRLAFG-----LGAIF
MUL_3187|M.ulcerans_Agy99 IINGTYW-LGSAAGAAGALVLLDTSNFAPNM--GWRLAFG-----LGAIF
Mb3364|M.bovis_AF2122/97 AYQLATL-SGIVVGYLVGYLLAGSH--------GWRAMFG-----LAAAP
Rv3331|M.tuberculosis_H37Rv AYQLATL-SGIVVGYLVGYLLAGSH--------GWRAMFG-----LAAAP
MAV_4306|M.avium_104 AYQLAIV-SGLIVGYLSGYLLAGTH--------SWRWMLG-----LACVP
MAB_2481|M.abscessus_ATCC_1997 FTQLGSP-AGMLLATGVFGLTRALTGPEAFLAFGWRIPFL-----SSIVL
TH_4243|M.thermoresistible__bu WPQAAVP-VGNMLATVVLLVLTTTLPESAFLSWGWRVAFW-----LSAVV
MSMEG_6718|M.smegmatis_MC2_155 VVWSGFP-SGAAIGAVVVPFVVETF--------GWRVAILG----CGAAA
Mflv_1730|M.gilvum_PYR-GCK GIWGGVTGISMAAGPIVGGLLIETV--------GWRSVFWINLPICAAAI
Mvan_4014|M.vanbaalenii_PYR-1 SVWGATAGVGMLAGPLIGGVLLAGL--------GWQWIFFVN-APIGAIG
MLBr_01562|M.leprae_Br4923 AVFAAMTAIGSVMGLVVGGALTEVS---------WRLAFLVN-VPIGLVM
. . *: : .
MMAR_2574|M.marinum_M GIFVLLVRRNVPESPRWLFIHGREQEAEQIVREIEEEVE------RDTGQ
MUL_3187|M.ulcerans_Agy99 GIFVLLVRRNVPESPRWLFIHGREQEAEQIVREIEEEVE------RDTGQ
Mb3364|M.bovis_AF2122/97 ATLLLPLLWRMPDTARWYLLKGRIADARSALRRIQPEAD------IDA--
Rv3331|M.tuberculosis_H37Rv ATLLLPLLWRMPDTARWYLLKGRIADARSALRRIQPEAD------IDA--
MAV_4306|M.avium_104 AVLLLPLVFRMPDTARWYLLKGRVDDARRALLRVEPAAR------VDD--
MAB_2481|M.abscessus_ATCC_1997 VVVGLAIRLRLRDSVVFRKVLERGEAARLP---VVEVLR------TQS--
TH_4243|M.thermoresistible__bu VLIGYYIRTKVSDAPIFLAVQQEVEQARSTSYGVVEVLR------RYP--
MSMEG_6718|M.smegmatis_MC2_155 AVIFVCVGTLLSESPVYLANSGHDPARLRRYCNAIEPGS------ADAG-
Mflv_1730|M.gilvum_PYR-GCK ILTAVFVPESKSQTMRNVDPIGQGLGILFLFGTVFTLIEGPVLGWTNPRV
Mvan_4014|M.vanbaalenii_PYR-1 IALAVRLVPNLPGRPVRIDVVGALLSGAGICLIVLGLQEGQHERWSWWIW
MLBr_01562|M.leprae_Br4923 IYLARTALHETHKERMKLDAAGAILATLACTAAVFAFSMGPEKGWISLTT
MMAR_2574|M.marinum_M RLPDPPGRPLKIRQRQRISLWEIARVAFTRYPRRAFLGLAL-FIGQAFLY
MUL_3187|M.ulcerans_Agy99 RLPDPPGRPLKIRQRQRISLWEIARVAFTRYPRRAFLGLAL-FIGQAFLY
Mb3364|M.bovis_AF2122/97 ---ELADMAAAVDERGG----GIGEMVRRPYLRATLFVIALGFLVQITGI
Rv3331|M.tuberculosis_H37Rv ---ELADMAAAVDERGG----GIGEMVRRPYLRATLFVIALGFLVQITGI
MAV_4306|M.avium_104 ---ELAEIGRAVSEEAASLPAMLAEMVRSPYRRATVFVVVLGFLIQITGI
MAB_2481|M.abscessus_ATCC_1997 --------------------------------RNVLLTTGLRLSQIALFV
TH_4243|M.thermoresistible__bu --------------------------------RGVLTAMGLRFAENIMYY
MSMEG_6718|M.smegmatis_MC2_155 --------SVFVRDEKVRPRAYPIGALLTPELRIGTLTLWVGFMAVMFSI
Mflv_1730|M.gilvum_PYR-GCK LAIAAVAVVALIAFLRFESRRHDPFLDLRFFRSIPFTTATINAISAFAAW
Mvan_4014|M.vanbaalenii_PYR-1 VAIAGGLVSITAFLRWQTVHADEPLIPMSLMSHRNFVLSTAGIALVSFVF
MLBr_01562|M.leprae_Br4923 IGSGLVALVAAIAFAVVERTAENPVVPFDLFRDRNRLVTFIAIFLAGGVI
MMAR_2574|M.marinum_M NGVTFNLGTLLSGFYGVESGHVPLFFIVWALSNFVGPLVLGRLFDTVGRK
MUL_3187|M.ulcerans_Agy99 NGVTFNLGTLLSGFYGVESGHVPLFFIVWALSNFVGPLVLGRLFDTVGRK
Mb3364|M.bovis_AF2122/97 NAIIYYSPRLFAAMGFAGYFAMLALPAMVQVAGLAAVCASLFLVDRLGRR
Rv3331|M.tuberculosis_H37Rv NAIIYYSPRLFAAMGFAGYFAMLALPAMVQVAGLAAVCASLFLVDRLGRR
MAV_4306|M.avium_104 NAIIYYSPRIFEAMGFTGNFALLALPALVQVAGLVAVGTALLLVDRVGRR
MAB_2481|M.abscessus_ATCC_1997 LLTTFSLTYLQGSFGGDSQIGLTAVLISSALG-ILSTPVWSALSDRVGRR
TH_4243|M.thermoresistible__bu LVVTFSITYLKVHVGADTSDILWYLMAAHAVH-FVAIPTVGRLADEFGRR
MSMEG_6718|M.smegmatis_MC2_155 YLTNTWLPYLFKVAG-FATGSISILSTALQIGGAVGCAAIGFIQDRFGPH
Mflv_1730|M.gilvum_PYR-GCK GAFLFMMSLYLQGERGFSAMQTGLIYLPIALGALFCSPLSGRLVGRYGAR
Mvan_4014|M.vanbaalenii_PYR-1 VSFGVPLMIYLQEVCGLSPVHAALLTAPMAVATAVLAPVVGRIVDRAHPR
MLBr_01562|M.leprae_Br4923 FSLTVSIGLYIQDILGYSALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPR
: : . :
MMAR_2574|M.marinum_M PMITMSYIGSAVIAVVLAVIFVN----QTGGVWTFIIVLAAAFFLASAGA
MUL_3187|M.ulcerans_Agy99 PMITMSYIGSAVIAVVLAVIFVN----QTGGVWTFIIVLAAAFFLASAGA
Mb3364|M.bovis_AF2122/97 PILLSGIATMITADAVLITVFANDSDGGTGLVLGFAGVLLFIIGFNFGFG
Rv3331|M.tuberculosis_H37Rv PILLSGIATMITADAVLITVFANDSDGGTGLVLGFAGVLLFIIGFNFGFG
MAV_4306|M.avium_104 PILLCGTAMMIVADVVLVAVFGR---GPGGVIAGFAGVLLFIFGYTMGFG
MAB_2481|M.abscessus_ATCC_1997 PLYLFGSAAGPLALGLFFLAAGS-----GSKVLVVLSIVFGINVVHDAMY
TH_4243|M.thermoresistible__bu PVYLVGTLAAGAWGFIAFPMMNS-----ANYVIITGAVVLGL-IAHAFMY
MSMEG_6718|M.smegmatis_MC2_155 ITLVWTSVLGGGTAAAIAVSPNT--------TVVLGTLIFVLGMCTNAIS
Mflv_1730|M.gilvum_PYR-GCK PSLVAAGILITTAATLLTLLTAT------TPVWHLLIVFAVFGVGFSMVN
Mvan_4014|M.vanbaalenii_PYR-1 PVVGFGFGLLTAGLIWLAVEMTP-----DTPAWRLALPLTMVGAAGAFTW
MLBr_01562|M.leprae_Br4923 VLTIGGGWLLMVAMLYGWAFMNRG----VPYFPNLLAPIVVGGIGIGMAV
.
MMAR_2574|M.marinum_M SAAYLTVSEIFPMETRALAIAFFYAVGTAIGGISGPLLFGQLIE---SGQ
MUL_3187|M.ulcerans_Agy99 SAAYLTVSEIFPMETRALAIAFFYAVGTAIGGISGPLLFGQLIE---SGQ
Mb3364|M.bovis_AF2122/97 SLVWVYAAESFPSRLRSMGSSLMLTSTLTANAIVAAFSLTMLRV---LGG
Rv3331|M.tuberculosis_H37Rv SLVWVYAAESFPSRLRSMGSSPMLTSTLTANAIVAAFSLTMLRV---LGG
MAV_4306|M.avium_104 SLGWVYASESFPSRLRSIGSSTMLTSNLVANAIVAAVFLTLLHS---LGG
MAB_2481|M.abscessus_ATCC_1997 GPQAAWFAELFDTRVRYSGASLGYQIGAVLSGGFAPLIAAALLA---ANH
TH_4243|M.thermoresistible__bu APQPALMAEMFPTRMRYSGVSVGYQVTAIVAGSMAPIIAVRLLD---VYS
MSMEG_6718|M.smegmatis_MC2_155 TGYTAVSTTFYPTDIRSTGTSWAAGMSRVG-AVLGAGIGTSLAS---LGV
Mflv_1730|M.gilvum_PYR-GCK APITNAAVSGMPLDRAGAASAVTSTSRQVGVSIGVALCGSVAGA---AMA
Mvan_4014|M.vanbaalenii_PYR-1 EPLSAIATRGLTSELAGAGSAVCNTARHVGAALSSAGIAALMAV---LLG
MLBr_01562|M.leprae_Br4923 VPLTLSAIAGVGFDRIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLG
: .
MMAR_2574|M.marinum_M RSQVFWSFIIGAAVMAVAGLVELWLGIAAEQRPLEELALPLTVADAED--
MUL_3187|M.ulcerans_Agy99 RSQVFWSFIIGAAVMAVAGLVELWLGIAAEQRPLEELALPLTVVDAED--
Mb3364|M.bovis_AF2122/97 AG----VFAVFGTFAVVAFVVVYRFAPETKGRKLEEIRHFWENGGRWP--
Rv3331|M.tuberculosis_H37Rv AG----VFAVFGTFAVVAFVVVYRFAPETKGRKLEEIRHFWENGGRWP--
MAV_4306|M.avium_104 AG----TFAVFAVLAVVAFAFVHRYAPETKGRQLEDIRHFWENGGRWD--
MAB_2481|M.abscessus_ATCC_1997 GDPR--LIVCYYLALSVLTFGAACVARETY--------RDQIGDSL----
TH_4243|M.thermoresistible__bu -SAV--PIALYLAGAAVVTLIALAFTRETNGIDLAGVDRADAEESARXXP
MSMEG_6718|M.smegmatis_MC2_155 SLQQ--VFLLLLIPITIGALCMAIKAVTSQRAGITPAPDNTMNGARK---
Mflv_1730|M.gilvum_PYR-GCK GSGTDFATAARPLWFVCIALGLVILAVGFFSTSQRAVRSAERLAPLVAG-
Mvan_4014|M.vanbaalenii_PYR-1 DEHAEEAGARHETLAPLVDSLKDPFAGAMAQSMLLPAAAAAMGVLTALFL
MLBr_01562|M.leprae_Br4923 GTTGPVKFMNDAQLRALDHGYTYGLLWVAGAVVIVGVAALFIGYTPEQVA
MMAR_2574|M.marinum_M --DDEPADGAGARGAQHPGS------------------------------
MUL_3187|M.ulcerans_Agy99 --DDEPADGAGARGAQHPGS------------------------------
Mb3364|M.bovis_AF2122/97 --AERSPAADEP--------------------------------------
Rv3331|M.tuberculosis_H37Rv --AERSPAADEP--------------------------------------
MAV_4306|M.avium_104 --------------------------------------------------
MAB_2481|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4243|M.thermoresistible__bu TTTDRPAQCPGVPVCRRLRSSGPRARRRTERCWRTPGIQPAVRPTRSPTP
MSMEG_6718|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1730|M.gilvum_PYR-GCK --APDPVNGAHVR-------------------------------------
Mvan_4014|M.vanbaalenii_PYR-1 VGGDATARAAPLSLRPWGDASVSS--------------------------
MLBr_01562|M.leprae_Br4923 YAQEVKEAVDAGEL------------------------------------
MMAR_2574|M.marinum_M ---------------------------
MUL_3187|M.ulcerans_Agy99 ---------------------------
Mb3364|M.bovis_AF2122/97 ---------------------------
Rv3331|M.tuberculosis_H37Rv ---------------------------
MAV_4306|M.avium_104 ---------------------------
MAB_2481|M.abscessus_ATCC_1997 ---------------------------
TH_4243|M.thermoresistible__bu GPSAARTRRAAPVTRSAGSAATIRRSR
MSMEG_6718|M.smegmatis_MC2_155 ---------------------------
Mflv_1730|M.gilvum_PYR-GCK ---------------------------
Mvan_4014|M.vanbaalenii_PYR-1 ---------------------------
MLBr_01562|M.leprae_Br4923 ---------------------------