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MLLHTARSTRDAASETRSYPAVIALCMVITVIEGFNLIVYGSVVPMLLADASLGVTDEQTGLIGGLVYIG AIIGSVAAPTLADRIGRKRVLVVAISVFAAGAILTGCSVSALMLALARTVTGLGIGASLTTAMTVARNSA AAARASLAMTVTMAGIPLGGVMAALLAVPILPAFGWRPMFFVGAGTGLIILVTVVFMAIPTDTPQELAGR LCSTREKLAILFTGRGLVVTAIVAGCAIANMVSWQGLNVWAAQAMVDLGFTLRTALLMTFVLTASAVAGS FLTAWAADRRGPAVVGIATAGSTFVGLAGLLTLPASLVTVVGCVALMGIGGHSTMNLIHATTADIYPLPA RASALGWSNGTSFVGSFTGPVVGGTAIATGGAHGLFEVFGAAAAVCFLSVSALYVADRRGRRQPTAGTDQ SANSETVAIAFR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3369 | - | - | 100% (432) | putative transport protein |
| M. smegmatis MC2 155 | MSMEG_6711 | - | 6e-36 | 25.98% (435) | 4-hydroxybenzoate transporter |
| M. smegmatis MC2 155 | MSMEG_6718 | - | 1e-24 | 24.05% (395) | transporter, major facilitator family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3364 | sugI | 3e-16 | 23.15% (432) | sugar-transport integral membrane protein SugI |
| M. gilvum PYR-GCK | Mflv_2221 | - | 2e-13 | 25.46% (381) | EmrB/QacA family drug resistance transporter |
| M. tuberculosis H37Rv | Rv3331 | sugI | 6e-16 | 23.15% (432) | sugar-transport integral membrane protein SugI |
| M. leprae Br4923 | MLBr_01562 | - | 2e-10 | 20.12% (492) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_2706c | - | 4e-18 | 26.08% (372) | putative transporter |
| M. marinum M | MMAR_1191 | sugI | 6e-17 | 25.81% (434) | sugar-transport integral membrane protein SugI |
| M. avium 104 | MAV_3053 | - | 8e-15 | 22.11% (407) | sugar transport protein |
| M. thermoresistible (build 8) | TH_0390 | - | 3e-12 | 22.31% (363) | major facilitator superfamily protein permease |
| M. ulcerans Agy99 | MUL_1444 | sugI | 5e-17 | 25.64% (433) | sugar-transport integral membrane protein SugI |
| M. vanbaalenii PYR-1 | Mvan_2691 | - | 1e-13 | 25.44% (338) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3364|M.bovis_AF2122/97 --MTTLWQPHRNDYSPIPGRGVHARRGARRPRPRGGRAERPGTGQLTRSG
Rv3331|M.tuberculosis_H37Rv --MTTLWQPHRNDYSPIPGRGVHARRGARRPRPRGGRAERPGTGQLTRSG
MMAR_1191|M.marinum_M -------------------------------------------------M
MUL_1444|M.ulcerans_Agy99 -------------------------------------------------M
MSMEG_3369|M.smegmatis_MC2_155 ----------------------------------MLLHTARSTRDAASET
MAB_2706c|M.abscessus_ATCC_199 --------------------------MATAASTEGTTTVRNGVDPSPHQT
Mvan_2691|M.vanbaalenii_PYR-1 --------------------------------MHRTPITAKPAPHAGRGA
Mflv_2221|M.gilvum_PYR-GCK --------------------------------------MFDTVTSRAAGT
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
TH_0390|M.thermoresistible__bu -------------------------------MNPGRRARTAAGDDDERLA
MAV_3053|M.avium_104 --------------------------MSAGAQTNTITTHVPARLDRLPWS
Mb3364|M.bovis_AF2122/97 RRALLVGLTAASVGVLYGYDLSAIAG--ALLSLSEEFELTTRE-QELLTT
Rv3331|M.tuberculosis_H37Rv RRALLVGLTAASVGVLYGYDLSAIAG--ALLSLSEEFELTTRE-QELLTT
MMAR_1191|M.marinum_M QRGILVALTAASVGLIYGYDLSIIAG--AQLFITEEFGLSTHQ-QELLTT
MUL_1444|M.ulcerans_Agy99 QRGILVALTAASVGLIYGYDLSIIAG--AQLFITEEFGLSTHQ-QELLTT
MSMEG_3369|M.smegmatis_MC2_155 RSYPAVIALCMVITVIEGFNLIVYGSVVPMLLADASLGVTDEQ-TGLIGG
MAB_2706c|M.abscessus_ATCC_199 GTAGYRRLTGALFAAGLATFAALYGTQAVLPALSADLGVSPAS-AALTVS
Mvan_2691|M.vanbaalenii_PYR-1 INRRIAISAGSLAVVLGALDTYVVVTIMVDIMRDVGIGVNEIQRVTPIIT
Mflv_2221|M.gilvum_PYR-GCK TNPWPALWALLIGFFMILVDATIVAVANPAIMASLNAGYDAVI---WVTS
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAG-RSWGIT
TH_0390|M.thermoresistible__bu VRPWIVWATGLLAYIVAVLDRTTLGVSGLAAADRFNAAPAALS---TFVV
MAV_3053|M.avium_104 RFHWRVVIGLGGVWVLDGLEVTMVGNVSARLMEPGSGIALNPAQIGMAAA
Mb3364|M.bovis_AF2122/97 TAVLGQIAGALGGGILANAIGRKKSVVLIVAGYAVFALLGATSVSVPMLV
Rv3331|M.tuberculosis_H37Rv TAVLGQIAGALGGGILANAIGRKKSVVLIVAGYAVFALLGATSVSVPMLV
MMAR_1191|M.marinum_M MVVIGQIVGALGAGVLANAIGRKKSVVMLLVAYTMFAVLGSLSVSLPMLL
MUL_1444|M.ulcerans_Agy99 MVVIGQIVGALGAGVLANAIGRKKSVVMLLVAYTMFAVLGALSVSLPMLL
MSMEG_3369|M.smegmatis_MC2_155 LVYIGAIIGSVAAPTLADRIGRKRVLVVAISVFAAGAILTGCSVSALMLA
MAB_2706c|M.abscessus_ATCC_199 VTTGMLALSIIPASALSERFGRTRVMLVSAIATTIIGLLLPASPTFAVLL
Mvan_2691|M.vanbaalenii_PYR-1 GYLLGYIAAMPLLGRASDRFGRKILIQVSLAGFAAGSVITAMSTDLVVLV
Mflv_2221|M.gilvum_PYR-GCK AYLLAYAVPLLVSGRLGDRYGPKNVYMVGLTVFTVASLWCGLSDSIGMLI
MLBr_01562|M.leprae_Br4923 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLV
TH_0390|M.thermoresistible__bu LQVIVYALAQVPAGLLLDRFGSKALIVAGAAVMATGQLILAFTESLTLAI
MAV_3053|M.avium_104 IYIAGACSGALFFGHLTDRFGRRNLFILTLALYLIATVATAFAFAPWYFF
: * : :
Mb3364|M.bovis_AF2122/97 VARLLLGVTIGLSVVVVPVYVAESAP-AAVRGSLVTAYQLATLSGIVVGY
Rv3331|M.tuberculosis_H37Rv VARLLLGVTIGLSVVVVPVYVAESAP-AAVRGSLVTAYQLATLSGIVVGY
MMAR_1191|M.marinum_M AARFLLGLAVGVSIVVVPVYVAESAP-AAVRGSLLTVYQLTTVSGLIVGY
MUL_1444|M.ulcerans_Agy99 AARFLLGLAVGVSIVVVPVYVAESAP-AAVRGSLLTVYQLTTVSGLIVGY
MSMEG_3369|M.smegmatis_MC2_155 LARTVTGLGIGASLTTAMTVARNSAA-AARASLAMTVTMAGIPLGGVMAA
MAB_2706c|M.abscessus_ATCC_199 IGRAAEGAALAGIPAVAMAFLAEEVH-PGSLGSAMGRYIAGTTVGGLAGR
Mvan_2691|M.vanbaalenii_PYR-1 VGRVIQGTASGALLPVTLALAADLWA-ARNRAAVLGGVGAAQELGSVLGP
Mflv_2221|M.gilvum_PYR-GCK AARVVQGVGAALLTPQTMTVITRTFP-AHRRGVAMSVWGATAGVATLVGP
MLBr_01562|M.leprae_Br4923 IARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGL
TH_0390|M.thermoresistible__bu LARAIVGLGDAVTFISVLRLVPHWFR-PRQVPLVTQLTGICGQLGQVLSA
MAV_3053|M.avium_104 LTRFFTGAGIGGEYAAINSAIDELIP-ARVRGRVDLVINGTYWLGSAAGA
* * . . .
Mb3364|M.bovis_AF2122/97 LVGYLLAGSH------GWRAMFGLAAAP-ATLLLPLLWRMPDTA------
Rv3331|M.tuberculosis_H37Rv LVGYLLAGSH------GWRAMFGLAAAP-ATLLLPLLWRMPDTA------
MMAR_1191|M.marinum_M LTGYLLAGTH------SWRWMLGLATVP-AMLLLPLLIRMPDTP------
MUL_1444|M.ulcerans_Agy99 LTGYLLAGTH------SWRWMLGLATVP-AMLLLPLLIRMPDTP------
MSMEG_3369|M.smegmatis_MC2_155 LLAVPILPAF------GWRPMFFVGAGTGLIILVTVVFMAIPTD------
MAB_2706c|M.abscessus_ATCC_199 LVASSVLDVS------NWR-IALLGSGAMTLVCTVLFAALLPKS------
Mvan_2691|M.vanbaalenii_PYR-1 VYGISLVWLFG-----HWQSVFWVNVPLAVIAMVMIHFSLPGRSPTEDPQ
Mflv_2221|M.gilvum_PYR-GCK LAGGVLVDSL------GWQWIFIVNVPVGIVGLVMALRLVPALPN-PVRQ
MLBr_01562|M.leprae_Br4923 VVGGALTEVS-------WRLAFLVNVPIGLVMIYLARTALHETHKER--M
TH_0390|M.thermoresistible__bu VLFLALLTAR------GWTPAYLSVVALGVLTIALTLALVQNTPDGR---
MAV_3053|M.avium_104 GGALILLDTSNFAADLGWRLAFGIGAILGIFVLLVRRNVPESPR------
: *
Mb3364|M.bovis_AF2122/97 RWYLLKGRIADARSALRRIQPEAD--------------IDAELADMAAAV
Rv3331|M.tuberculosis_H37Rv RWYLLKGRIADARSALRRIQPEAD--------------IDAELADMAAAV
MMAR_1191|M.marinum_M RWYVMKGRIQEARAALLRVDPAAD--------------VEEELAEIGTAL
MUL_1444|M.ulcerans_Agy99 RWYVMKGRIQEARAALLRVDPAAD--------------VEEELAEIGTAL
MSMEG_3369|M.smegmatis_MC2_155 TPQELAGRLCSTREKLAILFTGRG--------------LVVTAIVAGCAI
MAB_2706c|M.abscessus_ATCC_199 QFFVPKKVRVGTTLRILGVHLRNP--------------VLLIMFGLAFLL
Mvan_2691|M.vanbaalenii_PYR-1 KVDVVGGLLLAVALGLAVIGLYNPKPDGKTVLPSWGLPVLIAAAVAAVAF
Mflv_2221|M.gilvum_PYR-GCK GFDVPGVVLSGVGLFLIVFALQEGQSHG--WALWIWATVLAGVAVMAAFV
MLBr_01562|M.leprae_Br4923 KLDAAGAILATLACTAAVFAFSMGPEKG--WISLTTIGSGLVALVAAIAF
TH_0390|M.thermoresistible__bu AAPATMGTVREIAASLKTVWLRAG--------------TRLGFFTHMGTQ
MAV_3053|M.avium_104 -WLFIHGREEEAEHIVGEIEEAVQQQTG--------RPLPEPQGKALRIR
.
Mb3364|M.bovis_AF2122/97 DERGGGIGEMVRRPYLRATLFVIALGFLVQITGINAIIYYSPRLFAAMGF
Rv3331|M.tuberculosis_H37Rv DERGGGIGEMVRRPYLRATLFVIALGFLVQITGINAIIYYSPRLFAAMGF
MMAR_1191|M.marinum_M SEGSGGVSEMLRPPFLRATIFVITLGFLIQITGINAIIYYSPRIFEAMGF
MUL_1444|M.ulcerans_Agy99 SEGSGGVSEMLRPPFLRATIFVITLGFLIQITGINAIIYYSPRIFEAMGF
MSMEG_3369|M.smegmatis_MC2_155 AN-------------------------MVSWQGLN---VWAAQAMVDLGF
MAB_2706c|M.abscessus_ATCC_199 MG------------------------------GFVTVYNYLGYRLVAPPF
Mvan_2691|M.vanbaalenii_PYR-1 FGWEKFARTRLLEPRGVHFRPFLAALGASLTAGAALMVTLVNVELFGQGV
Mflv_2221|M.gilvum_PYR-GCK YWQSINTAGALIPLVIFRDRNFSMSNLGVATIGFVATGMILPLMFFAQAV
MLBr_01562|M.leprae_Br4923 AVVERTAENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDI
TH_0390|M.thermoresistible__bu FS-------------------------------VTVFALMWGVPYLTVGQ
MAV_3053|M.avium_104 QRTAISFREIAAVAFKLYPRRAVLGLALFIGQAFLYNGVTFNLGTLLSQF
Mb3364|M.bovis_AF2122/97 AG--YFAMLALPAMVQVAGLAAVCASLFLVDRLGRRP-ILLSGIATMITA
Rv3331|M.tuberculosis_H37Rv AG--YFAMLALPAMVQVAGLAAVCASLFLVDRLGRRP-ILLSGIATMITA
MMAR_1191|M.marinum_M TG--DFALLGLPALVQIAGVAAVITSLLLVDRVGRRP-ILLSGIAIMIVA
MUL_1444|M.ulcerans_Agy99 TG--DFALLGLPALVQIAGVAAVITSLLLVDRVGRRP-ILLSGIAIMIVA
MSMEG_3369|M.smegmatis_MC2_155 TL--RTALL-MTFVLTASAVAGSFLTAWAADRRGPAV-VGIATAGSTFVG
MAB_2706c|M.abscessus_ATCC_199 GL--PTAIAGLLFLLYLAGTMSSAVAGRLADRRGRGS-VLIAAIVITAAG
Mvan_2691|M.vanbaalenii_PYR-1 LGQDQNEAAFLLLRFLIALPVGALLGGWLATRVGDRL-VTFAGLLIAAGG
Mflv_2221|M.gilvum_PYR-GCK CGLTPTRAALLTAPMAVATGVLAPFVGKLVDRAHPRS-VVGFGFSLMAIG
MLBr_01562|M.leprae_Br4923 LGYSALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRV-LTIGGGWLLMVA
TH_0390|M.thermoresistible__bu GLSTQMAGAMLTLSVAVAIVAGVLIGIFTGRHPHRRSRLVLAIIASNAAA
MAV_3053|M.avium_104 YAVPSGMVPVFFVLWALSNFAGPLLLGHLFDTVGRKQMITLTYIGSAVVV
: :
Mb3364|M.bovis_AF2122/97 DAVLITVFANDSDGGTGLVLGFAGVLLFIIGFNFGFGSLVWVYAAESFPS
Rv3331|M.tuberculosis_H37Rv DAVLITVFANDSDGGTGLVLGFAGVLLFIIGFNFGFGSLVWVYAAESFPS
MMAR_1191|M.marinum_M DVALMAVFAR---GQGAAILGFAGILLFIIGYTMGFGSLGWVYASESFPT
MUL_1444|M.ulcerans_Agy99 DVALMAVFAR---GQGAAILGFAGILLFIIGYTMGFGSLGWVYASESFPT
MSMEG_3369|M.smegmatis_MC2_155 LAGLLTLPAS-------LVTVVGCVALMGIGGHSTMN-LIHATTADIYPL
MAB_2706c|M.abscessus_ATCC_199 LALTIPNS---------LLTVIVGVGVFTAGFFAAHT--VASGWVGAVAQ
Mvan_2691|M.vanbaalenii_PYR-1 FLLISKWPVDLLAARHDLGFVSLPVLDTDLAIAGLGLGLVIGPLTSATLR
Mflv_2221|M.gilvum_PYR-GCK VTWLSIEMTP---------TTPIWRLLLPLTAMGAAMAFIWSPLAATATR
MLBr_01562|M.leprae_Br4923 MLYGWAFMNR--------GVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIA
TH_0390|M.thermoresistible__bu WTAVLALPDR-------APLWLLITLIVVISVGGPGSMVGFDFARTFNPS
MAV_3053|M.avium_104 VALALVFLTQAG-----GVWAFIGVLIVAFFLASAGASAAYLTVSEIFPM
Mb3364|M.bovis_AF2122/97 RLRSMGSSLMLTSTLTANAIVAAFSLTMLRVLG--GAGVFAVFGTFAVVA
Rv3331|M.tuberculosis_H37Rv RLRSMGSSPMLTSTLTANAIVAAFSLTMLRVLG--GAGVFAVFGTFAVVA
MMAR_1191|M.marinum_M RLRSIGSSTMLTANLIANAIVAGVFLTMLHSLG--GSGAFAVFGVLALVA
MUL_1444|M.ulcerans_Agy99 RLRSIGSSTMLTANLIANAIVAAVFLTMLHSLG--GSGAFAVFGVLALVA
MSMEG_3369|M.smegmatis_MC2_155 PARASALGWSNGTSFVGSFTGPVVGGTAIATGG--AHGLFEVFGAAAAVC
MAB_2706c|M.abscessus_ATCC_199 RDRAEASALYLFSYYLGSSVAGAVGGLAYQAGG--WGLTVLFVGALLAIA
Mvan_2691|M.vanbaalenii_PYR-1 VVPAAQHGIASAAVVVARMIGMLIGIAALSAWG--LYRFNQHLASLPAST
Mflv_2221|M.gilvum_PYR-GCK NLPPHLAGAGSGVYNTTRQVGSVLGSAGMAALM--SSELSTKIPGADAVP
MLBr_01562|M.leprae_Br4923 GVGFDRIGPVSAIALMLQSLGGPLVLAVIQAVI--TSRTLYLGGTTGPVK
TH_0390|M.thermoresistible__bu ATLGTAQGMVNMGGFLASLLVMQAMGQILDAAGGYSFDSFRLAWTVQYVV
MAV_3053|M.avium_104 ETRALAIAFFYAMGTAIGGITGPLLFGQLIDSGQRDHVVWSFLIGAVVMA
.
Mb3364|M.bovis_AF2122/97 FVVVYRFAPETKGRKLEEIRHFWENGGRWPAERSPAADEP----------
Rv3331|M.tuberculosis_H37Rv FVVVYRFAPETKGRKLEEIRHFWENGGRWPAERSPAADEP----------
MMAR_1191|M.marinum_M FGVVYRYAPETKGRQLEEIRHFWENGGRWPEKLTEAP-------------
MUL_1444|M.ulcerans_Agy99 FGVVYRYAPETKGRQLEEIRHFWENGGRWPEKLTEAP-------------
MSMEG_3369|M.smegmatis_MC2_155 FLSVSALYVADRRGRRQPTAGTDQSANSETVAIAFR--------------
MAB_2706c|M.abscessus_ATCC_199 LVLAALMVLRNRFGHINAPE------------------------------
Mvan_2691|M.vanbaalenii_PYR-1 AGGSLAERLAAEANRVREAYVLQYGEIFTITAVVCLVGALLGLLIAAKDD
Mflv_2221|M.gilvum_PYR-GCK QSEGEVAALPQFLREPFALAMSQSMLLPAFVALFGVIAALFLFDLLGDRD
MLBr_01562|M.leprae_Br4923 FMNDAQLRALDHGYTYGLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKE
TH_0390|M.thermoresistible__bu WVVAAVGILITRKKARRQMALEQERMLLESFEPGPRRHTGPDRTNRPHG-
MAV_3053|M.avium_104 AAGLVELWLGIAAEQRPLEDLALPLTVDDAEDTEPQGDSAPVD-------
Mb3364|M.bovis_AF2122/97 --------------------------------------------------
Rv3331|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1191|M.marinum_M --------------------------------------------------
MUL_1444|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3369|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2706c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_2691|M.vanbaalenii_PYR-1 HAEEPSDEAQQRSSPGPIS-------------------------------
Mflv_2221|M.gilvum_PYR-GCK AAAPPAPDVEPLEPFDPDHPLDWADGEDDYVEYEVSREEFDRLATDGTAD
MLBr_01562|M.leprae_Br4923 AVDAGEL-------------------------------------------
TH_0390|M.thermoresistible__bu --------------------------------------------------
MAV_3053|M.avium_104 --------------------------------------------------
Mb3364|M.bovis_AF2122/97 --------------------------------------------------
Rv3331|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1191|M.marinum_M --------------------------------------------------
MUL_1444|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3369|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2706c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_2691|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2221|M.gilvum_PYR-GCK GAAYNITEDFTEDITDVLDTVVEAPPAPADSTPSQQWRDLVDQLLDVSSP
MLBr_01562|M.leprae_Br4923 --------------------------------------------------
TH_0390|M.thermoresistible__bu --------------------------------------------------
MAV_3053|M.avium_104 --------------------------------------------------
Mb3364|M.bovis_AF2122/97 ----------------------
Rv3331|M.tuberculosis_H37Rv ----------------------
MMAR_1191|M.marinum_M ----------------------
MUL_1444|M.ulcerans_Agy99 ----------------------
MSMEG_3369|M.smegmatis_MC2_155 ----------------------
MAB_2706c|M.abscessus_ATCC_199 ----------------------
Mvan_2691|M.vanbaalenii_PYR-1 ----------------------
Mflv_2221|M.gilvum_PYR-GCK PGAPRNGVGSADAEHPGGGPRV
MLBr_01562|M.leprae_Br4923 ----------------------
TH_0390|M.thermoresistible__bu ----------------------
MAV_3053|M.avium_104 ----------------------