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VTDAPRFGISTSSADGGIAPDELARAVEERRFDWLLFDDHSYFPADTPDAVDPVFRARLPLIRDLFVVLA YAASATSALTIGSGVALLPQRDTLHTAKAVASLATLSGNRVVLGVGVGWNLNDVRNHGADPRRRGAKLDE QLSALRALWSDDEAEFSGTQVRFGPVVARPRPSAPVPILVGGASDAALARTLRFGDGWLPFAELSTPADV ARARKWFAEQGRNDLGVTVSGVPGDASVASAYLDAGAGRVLFNLEPGPEDDVLRALDTVADTVRSI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6703 | - | - | 100% (276) | N5,N10- methylenetetrahydromethanopterin reductase-related protein |
| M. smegmatis MC2 155 | MSMEG_1996 | - | 2e-44 | 40.58% (276) | N5,N10- methylenetetrahydromethanopterin reductase-related |
| M. smegmatis MC2 155 | MSMEG_2811 | - | 4e-29 | 36.57% (216) | hydride transferase 1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3106c | - | 6e-40 | 38.38% (271) | hypothetical protein Mb3106c |
| M. gilvum PYR-GCK | Mflv_1017 | - | 9e-43 | 39.57% (278) | luciferase family protein |
| M. tuberculosis H37Rv | Rv3079c | - | 6e-40 | 38.38% (271) | hypothetical protein Rv3079c |
| M. leprae Br4923 | MLBr_00131 | - | 1e-08 | 27.33% (172) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4908c | - | 1e-105 | 71.16% (267) | putative luciferase-like oxidoreductase |
| M. marinum M | MMAR_3559 | - | 9e-47 | 39.86% (276) | hypothetical protein MMAR_3559 |
| M. avium 104 | MAV_1077 | - | 4e-31 | 32.37% (278) | hypothetical protein MAV_1077 |
| M. thermoresistible (build 8) | TH_2750 | - | 1e-46 | 40.51% (274) | PUTATIVE luciferase family protein |
| M. ulcerans Agy99 | MUL_2792 | - | 1e-43 | 40.61% (261) | hypothetical protein MUL_2792 |
| M. vanbaalenii PYR-1 | Mvan_5819 | - | 2e-44 | 40.00% (275) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6703|M.smegmatis_MC2_155 MTDAPRFGISTSSADGGIAPDELARAVEER----RFDWLLFDDHSYFPAD
MAB_4908c|M.abscessus_ATCC_199 MTG---FGISTTSADGYVSPDVLARAVEER----GFEWLLFDDHSYFPVD
Mflv_1017|M.gilvum_PYR-GCK ----MKFGISTFPNEDTIDPVSLARAVEER----GFAALAVAEHTHIPAS
Mvan_5819|M.vanbaalenii_PYR-1 ----MKFGIATFVNDTTIDPVALARAVEDR----GFGSLAVAEHTHIPAS
TH_2750|M.thermoresistible__bu ----MRFGISTFVNDDTIDPVSLATAIEER----GFDALTVAEHTHIPAS
MMAR_3559|M.marinum_M ----MKFGISTFVNDDSIDPVSLARAIEER----GFSSLVIAEHTHIPAS
MUL_2792|M.ulcerans_Agy99 ----MKFGISTFVNDDSIDPVSLARAIEER----GFSSLVIAEHTHIPAS
Mb3106c|M.bovis_AF2122/97 ----MQFGVLTFVTDEGIGPAELGAALEHR----GFESLFLAEHTHIPVN
Rv3079c|M.tuberculosis_H37Rv ----MQFGVLTFVTDEGIGPAELGAALEHR----GFESLFLAEHTHIPVN
MAV_1077|M.avium_104 ---------MLFTSDRGISPAAAAKLADDH----GFATFYVPEHTHIPIK
MLBr_00131|M.leprae_Br4923 -MAGFRFGFVDALVHTLFPPSLPARASIVSGAVLGADSYWVGDHLNALVP
. . * . . :*
MSMEG_6703|M.smegmatis_MC2_155 --TPDAV---DPVFR-ARLPLIRDLFVVLAYAASAT--SALTIGSGVALL
MAB_4908c|M.abscessus_ATCC_199 --TPDSI---DAEFR-ARLPLIRDLPVVLAYAASAT--ERLIVGSGVALL
Mflv_1017|M.gilvum_PYR-GCK RESAYPL---GGELP-KIYYRTLDPFVTLAAAAAVT--SEIELITGIALL
Mvan_5819|M.vanbaalenii_PYR-1 RESAYPL---GGELP-SIYYRTLDPFVTLAAAAAVT--TSIELVTGIALL
TH_2750|M.thermoresistible__bu RESPYPE---GGELP-SVYYRTLDPFVTLAAAAAVT--SRIQLITGIALL
MMAR_3559|M.marinum_M RETPYPG---GGELP-GVYYRTLDPFVTLAAAAAVT--SKIELFTGIALL
MUL_2792|M.ulcerans_Agy99 RETPYPG---GDELP-GVYYRTLDPFVTLAAAAAVT--SKIELFTGIALL
Mb3106c|M.bovis_AF2122/97 TQSPYPG---GGPIP-EKYYRTLDPFVALAAAAATT--QSLVLGTGIALI
Rv3079c|M.tuberculosis_H37Rv TQSPYPG---GGPIP-EKYYRTLDPFVALAAAAATT--QSLVLGTGIALI
MAV_1077|M.avium_104 REAAHPTTG-DASLPDDRYMRTLDPWVSLGAACAVT--SRVRLSTAVALP
MLBr_00131|M.leprae_Br4923 RSVATPKYLGVAAKVVPKIDANYEPWTMLGNLAAGNRLNGLRLGVCVTDA
. . : . *. .: . : : ::
MSMEG_6703|M.smegmatis_MC2_155 PQRDTLHTAKAVASLATLSGNRVVLGVGVGWNLNDVRNHGADPRRRGAKL
MAB_4908c|M.abscessus_ATCC_199 PQRDVLHTAKAWATVATLSGGRTVLGVGVGWNLGEVRNHGIDPAKRGAVL
Mflv_1017|M.gilvum_PYR-GCK IQRDPIITAKEAASIDVISGGRFVFGVGAGWNIEELRHHGTDPKTRGALL
Mvan_5819|M.vanbaalenii_PYR-1 IQRDPIITAKEAASIDLISNGRFVFGVGAGWNLEELRHHGTDPKTRGALL
TH_2750|M.thermoresistible__bu IQRDPIITAKEAASIDLISDGRFVFGVGAGWNLEEMRHHGTDPRTRGALL
MMAR_3559|M.marinum_M IQRDPITTAKEAASIDLISGGRFVFGVGAGWNIEELRDHGTDPKTRGALL
MUL_2792|M.ulcerans_Agy99 IQRDPITTAKEAASIDLISGGRFVFGVGAGWNIEELRDHGTDPKTRGALL
Mb3106c|M.bovis_AF2122/97 PERDPIVTAKEVASLDLVSQGRFRFGVGVGWLREEVANHGVDPAVRGRVI
Rv3079c|M.tuberculosis_H37Rv PERDPIVTAKEVASLDLVSQGRFRFGVGVGWLREEVANHGVDPAVRGRVI
MAV_1077|M.avium_104 VEHDPITLAKSIATLDHLSGGRVSLGVGFGWNTDELADHGVPAGRRRTML
MLBr_00131|M.leprae_Br4923 GRRNPAVTAQAAATLHLLTRGKAMLGIGVGE-REGNEPYGVEWTKPVARF
.:: *: *:: :: .: :*:* * :* :
MSMEG_6703|M.smegmatis_MC2_155 DEQLSALRALWSD--DEAEFSGTQVRFGPVVARPRPSAP--VPILVGGAS
MAB_4908c|M.abscessus_ATCC_199 DEQLAALHALWTQ--EQAEFHGEHVDFGPVVARPRPARP--LPVHVGGPS
Mflv_1017|M.gilvum_PYR-GCK DERIEAIKVLWTQ--EPAEYHGRFVDFDASYQRPKPVRKPHPPILIGGDS
Mvan_5819|M.vanbaalenii_PYR-1 DERIEAIKALWTA--EPAEYHGKYVDFDASYLRPKPVQKPHPPILIGGDS
TH_2750|M.thermoresistible__bu DERIEAVKALWTD--EPAEYHGRFVDFGPSYLRPKPVQKPHPPIVVGGNS
MMAR_3559|M.marinum_M DERIEAIKALWTD--EPAEYHGKYVDFPPSYSRPKPVRQPHPPIYIGGNS
MUL_2792|M.ulcerans_Agy99 DERIEAIKALWTD--EPAEYHGKYVDFPPSYSRPKPVRQPHPPIYIGGNS
Mb3106c|M.bovis_AF2122/97 DERLRAIIEIWTQ--EQAEFHGTYVDFDPIYCWPKPVTKPYPPLYVGGGP
Rv3079c|M.tuberculosis_H37Rv DERLRAIIEIWTQ--EQAEFHGTYVDFDPIYCWPKPVTKPYPPLYVGGGP
MAV_1077|M.avium_104 REYLEAMRALWTQ--EEAAYDGEFVKFGPSWAWPKPVQPHIPVLVGAAGN
MLBr_00131|M.leprae_Br4923 QEALATIRALWDSNGELVSRESQFFPLHNALFDLPPYRGKWPEIWVAAHG
* : :: :* : . . . : * : ..
MSMEG_6703|M.smegmatis_MC2_155 DAALARTLRFGDGWLPFAELSTPAD--VARARKWFAEQGRND-LGVTVSG
MAB_4908c|M.abscessus_ATCC_199 RAAQARALRVGDGWLPYAGTSTPDD--VRRACGWFAEQGRAD-LPVTVSG
Mflv_1017|M.gilvum_PYR-GCK DATVRRIIRHGAGWIANP--LPIDH--LSRRIEQIREGAGGD-VPLCQFG
Mvan_5819|M.vanbaalenii_PYR-1 DAAVKRIIRHEAGWISNP--LPVDT--LRRRVDQIRAGARHE-VPLSMFG
TH_2750|M.thermoresistible__bu DATVRRIIRHGAGWMSNP--HPPEM--LKRRVQQIRDGAGHD-VLLTTFG
MMAR_3559|M.marinum_M DATVKRVVRHDAGWISNP--LPVRQ--LTQRVDQLRGAAGHD-VPLAMFG
MUL_2792|M.ulcerans_Agy99 DATVKRVVRHDAGWISNP--LPVHQ--LTQRVDQLRSAAGHD-VPLAMFG
Mb3106c|M.bovis_AF2122/97 -ANFPRIARLNAGWIAIS--PSPQR--LSGPLQRLRAMAGGD-VPVTVCQ
Rv3079c|M.tuberculosis_H37Rv -ANFPRIARLNAGWIAIS--PSPQR--LSGPLQRLRAMAGGD-VPVTVCQ
MAV_1077|M.avium_104 EKNFKWIARSADGWITTPRDFDIDE--PVKLLQDTWAAAGRDGAPQIVAL
MLBr_00131|M.leprae_Br4923 PRMLQATGRYADAWIPIVLVRPTDYSCALEVVRTAASDAGRDPMSITPAA
* .*:. . :
MSMEG_6703|M.smegmatis_MC2_155 V------PGDASVASAYLDAGAG---RVLFNLEPG-----------PED-
MAB_4908c|M.abscessus_ATCC_199 V------PGDHQLAGEYLGAGAE---RVLFDVHPL-----------NEA-
Mflv_1017|M.gilvum_PYR-GCK T------PVKPEYWQAAEELGFG---QLNLLLPTK-----------SRD-
Mvan_5819|M.vanbaalenii_PYR-1 T------PVKPEYWQAAEDLGFG---QLNLLLPTK-----------PRD-
TH_2750|M.thermoresistible__bu T------PVDPGYWEVLEELGYQ---QANLLLPTR-----------PRD-
MMAR_3559|M.marinum_M T------PNKPDYWRAAQDLGFG---QLALLLPT-----------CPRD-
MUL_2792|M.ulcerans_Agy99 T------RNKPDYWRAAQDLGFGPAGAAAAHLPAGGVPAAARRIRCPGGS
Mb3106c|M.bovis_AF2122/97 WG-----EAAAKDLEGYRHLGVE---RVLLELPTE-----------PRD-
Rv3079c|M.tuberculosis_H37Rv WG-----EAAAKDLEGYRHLGVE---RVLLELPTE-----------PRD-
MAV_1077|M.avium_104 DF-----KPDAEKLARWAELGVT---EVLFGLPDK-----------SED-
MLBr_00131|M.leprae_Br4923 VRGIITGRTRDDVDEALDSVLVR---MIALGVPGEAWARHGVEHPMGADF
:
MSMEG_6703|M.smegmatis_MC2_155 --------------DVLRALDTVADTVRSI--------------------
MAB_4908c|M.abscessus_ATCC_199 --------------DTLRALDRLTEVVARLT-------------------
Mflv_1017|M.gilvum_PYR-GCK --------------VSLRLLDDYAEQVARYIG------------------
Mvan_5819|M.vanbaalenii_PYR-1 --------------ESLRLLDGYAEQVARY--------------------
TH_2750|M.thermoresistible__bu --------------ESLRMLDQFAERVAGYRG------------------
MMAR_3559|M.marinum_M --------------ESLRLLDEYAALVAQYHR------------------
MUL_2792|M.ulcerans_Agy99 I-------PPVEVPGGPSFLREPLARVSCASRRKIAPRFAAQCDFASARG
Mb3106c|M.bovis_AF2122/97 --------------PTLRYLDKLQAELARLA-------------------
Rv3079c|M.tuberculosis_H37Rv --------------PTLRYLDKLQAELARLA-------------------
MAV_1077|M.avium_104 --------------EVAAYVERLAGKLAALV-------------------
MLBr_00131|M.leprae_Br4923 AGVQDIIPQTIDEETVVSYAAKVPAALMKEVLFSGTPEEVIDQVAEWRDH
:
MSMEG_6703|M.smegmatis_MC2_155 -------------------------------------
MAB_4908c|M.abscessus_ATCC_199 -------------------------------------
Mflv_1017|M.gilvum_PYR-GCK -------------------------------------
Mvan_5819|M.vanbaalenii_PYR-1 -------------------------------------
TH_2750|M.thermoresistible__bu -------------------------------------
MMAR_3559|M.marinum_M -------------------------------------
MUL_2792|M.ulcerans_Agy99 GRLRVGSRPR---------------------------
Mb3106c|M.bovis_AF2122/97 -------------------------------------
Rv3079c|M.tuberculosis_H37Rv -------------------------------------
MAV_1077|M.avium_104 -------------------------------------
MLBr_00131|M.leprae_Br4923 GLKYLVVINGSLVNSSLRKTVSALLPHARVLRGLKKL