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TATKLVIGASGFLGSHVTRRLVERGEDVRILIRSTSSTRGIDDVIDRVDVRHGDIFDAASVRDAADGCDT VYYCVVDARAWLRDATPLWRTNVDGLSGVLDVMTEPEIASGVRRFVFTSSIATIGLPESGPATEEIENNW LDRGGEYVRSRVRAEQLVLRYHKDRGLPAVAMCVSNTYGPGDWQPTPHGGLVAAAVRGKMPFYIDGAEAE AVGVADAAEALVLAGERGTPGERYIVSERMMSAREIYEVACDAVGVEPPRRGVPIRVMAAAAGLSSAVAR LRRRETRLSPLTVRLMHVMSPMDHGKAVRELGWKPAPAPESIAQAARFFASRRRT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6563 | - | - | 100% (336) | dihydrokaempferol 4-reductase |
| M. smegmatis MC2 155 | MSMEG_6474 | - | 2e-91 | 52.51% (339) | nucleoside-diphosphate-sugar epimerase |
| M. smegmatis MC2 155 | MSMEG_2247 | - | 2e-84 | 51.52% (330) | dihydrokaempferol 4-reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0144 | - | 1e-95 | 55.46% (339) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_2375 | - | 1e-127 | 66.77% (337) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv0139 | - | 9e-96 | 55.46% (339) | oxidoreductase |
| M. leprae Br4923 | MLBr_01942 | - | 4e-09 | 24.78% (339) | putative cholesterol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0718c | - | 5e-22 | 26.41% (337) | NAD-dependent epimerase/dehydratase |
| M. marinum M | MMAR_0349 | - | 2e-96 | 54.68% (331) | oxidoreductase |
| M. avium 104 | MAV_1849 | - | 1e-113 | 61.14% (332) | dihydroflavonol-4-reductase family protein |
| M. thermoresistible (build 8) | TH_2143 | - | 2e-99 | 54.08% (331) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_4771 | - | 4e-96 | 54.38% (331) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4271 | - | 1e-126 | 65.77% (336) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0144|M.bovis_AF2122/97 -----------MNA-PKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVR
Rv0139|M.tuberculosis_H37Rv -----------MNA-PKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVR
MMAR_0349|M.marinum_M -----------MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVR
MUL_4771|M.ulcerans_Agy99 -----------MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVR
Mflv_2375|M.gilvum_PYR-GCK ------------MAGTKLVIGASGFLGSHVTRQLVADGDA---DVRVLIR
Mvan_4271|M.vanbaalenii_PYR-1 ------------MAGTKLVIGASGFLGSHVTKQLIAAGED---DVRVLIR
MSMEG_6563|M.smegmatis_MC2_155 ------------MTATKLVIGASGFLGSHVTRRLVERGE----DVRILIR
MAV_1849|M.avium_104 -------------MAVKLVIGASGFLGSHVTRQLVERGE----RVRVLLR
TH_2143|M.thermoresistible__bu ------------VAKKKLVIGASGFLGSHVTRQLVREGH----DVRVMVR
MAB_0718c|M.abscessus_ATCC_199 --------------MKTAVTGAAGFIGTNLVNLLVDNGHEVIAIDRVVPA
MLBr_01942|M.leprae_Br4923 MLRGVGNASLTTELGRVLVTGGSGFVGANLVTALLERGY----QVRSFDR
* *. **:*:::. *: * .
Mb0144|M.bovis_AF2122/97 PAANTRSIDDLP--LTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAW--
Rv0139|M.tuberculosis_H37Rv PAANTRSIDDLP--LTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAW--
MMAR_0349|M.marinum_M PTANTRSIDDLP--VTRFHGDIFDTAVVREAMQGCDDVYYCVVDARAW--
MUL_4771|M.ulcerans_Agy99 PTANTRSIDDLP--VTRFHGDIFDTAVVREAMQGCDDVYYCVVDARAW--
Mflv_2375|M.gilvum_PYR-GCK RTSSTRGIDGLP--VEVRYGDIFDADALRTAMSGCDVVYYCVVDARPW--
Mvan_4271|M.vanbaalenii_PYR-1 TTSSTRGIDGLP--VQVHYGDIFDTGALRAAMAGCDVVYYCVVDARPW--
MSMEG_6563|M.smegmatis_MC2_155 STSSTRGIDDVIDRVDVRHGDIFDAASVRDAADGCDTVYYCVVDARAW--
MAV_1849|M.avium_104 RTSSTVALDDLD--IERRYGDVFDDAVLRDALDGCDDVYYCVVDTRAW--
TH_2143|M.thermoresistible__bu TTSMTRGIDDLD--VERCHGDVFDDAALRAAMTGVDDVYYCVVDARMW--
MAB_0718c|M.abscessus_ATCC_199 SPETREAVTWVS-------GDVLDPDSMTKALDGVEVVYHLVAVITLK--
MLBr_01942|M.leprae_Br4923 APMPLPQHPQLE----VLQGDITDATVCTTAMDSIDTVFHTAAIIELMGG
. : **: * * . : *:: ..
Mb0144|M.bovis_AF2122/97 ----LRDPSPLFRTNVAGLRNVLDVATD----ASLRRFVFTSSYATVGRR
Rv0139|M.tuberculosis_H37Rv ----LRDPSPLFRTNVAGLRNVLDVATD----ASLRRFVFTSSYATVGRR
MMAR_0349|M.marinum_M ----LRDPAPLFHTNVEGLRNVLDVAKN----AGLRRFVFTSSYATVDRR
MUL_4771|M.ulcerans_Agy99 ----LRDPAPLFHTNVEGLRNVLDVAKN----AGLRRFVFTSSYATVDRR
Mflv_2375|M.gilvum_PYR-GCK ----LRDPRPMWRTNVDGLRTVLDIAAD----AGLTRFVFTSSIGTIGLR
Mvan_4271|M.vanbaalenii_PYR-1 ----LRDPAPMWRTNVDGLRNVLDVAVG----AGLHRFVFTSSIGTIGLA
MSMEG_6563|M.smegmatis_MC2_155 ----LRDATPLWRTNVDGLSGVLDVMTEPEIASGVRRFVFTSSIATIGLP
MAV_1849|M.avium_104 ----LRDPAPLFRTNVEGLRQVLDTAVG----ADLRRFVFTSTIGTIALS
TH_2143|M.thermoresistible__bu ----LRDPAPLFRTNVEGLRHVLDAAVE----ADLNRFLFTSTTGTMAIN
MAB_0718c|M.abscessus_ATCC_199 ----HED-ELCWRINTEGARTVAQAALT----VGARRMVHCSSIDSYSNS
MLBr_01942|M.leprae_Br4923 ASVTDEYRQRSYTVNVGGTENLLRAGQK----SGVKRFVYTASNSVVMGG
. : *. * : . *::. ::
Mb0144|M.bovis_AF2122/97 --RGHVATEEDRVDTRKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVST
Rv0139|M.tuberculosis_H37Rv --RGHVATEEDRVDTRKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVST
MMAR_0349|M.marinum_M --HGHVATEEDRIGSRRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVST
MUL_4771|M.ulcerans_Agy99 --HGHVATEEDRIGSRRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVST
Mflv_2375|M.gilvum_PYR-GCK -AGGPADERTEHNWLDRGGEYIRSRVVAEEMVLRDSARNRLPGVAMCVAN
Mvan_4271|M.vanbaalenii_PYR-1 -ADGLADEDTAHNWLDKGGAYIRSRVEAEQMVLRYSAEKGLPAVAMCVAN
MSMEG_6563|M.smegmatis_MC2_155 -ESGPATEEIENNWLDRGGEYVRSRVRAEQLVLRYHKDRGLPAVAMCVSN
MAV_1849|M.avium_104 EDGLPVSEDEPFNWADRGGGYIRSRVEAENLVLQYARERGLPAVAMCVSN
TH_2143|M.thermoresistible__bu -PYRPVTEDDPHNWT-EGGAYIEARVAAEQLVLRYARERGLPAVALCIST
MAB_0718c|M.abscessus_ATCC_199 --VATIDEKSPRSAAADLPVYQRSKWGGEVAVRETIAS-GLDAVICNPTG
MLBr_01942|M.leprae_Br4923 -TPITGGDETMPYTKRFNDLYTETKVVAEKFVLSQNGVPDGETMLTCSIR
* .:: .* * :
Mb0144|M.bovis_AF2122/97 TYGGGDWGRTPHG-AFIAGAVFGRLPFTMRGIRLEAVG--VDDAARALIL
Rv0139|M.tuberculosis_H37Rv TYGGGDWGRTPHG-AFIAGAVFGRLPFTMRGIRLEAVG--VDDAARALIL
MMAR_0349|M.marinum_M TYGSGDWGRTPHG-AFIAGAVFGKLPFLMNGIKLEVVG--VDDAARAMIL
MUL_4771|M.ulcerans_Agy99 TYGSGDWGRTPHG-AFIVGAVFGKLPFLMNGIKLEVVG--VDDAARAMIL
Mflv_2375|M.gilvum_PYR-GCK TYGPGDFQPTPHG-AMLAAAVRGKLPFYIRGYEAEAVG--IEDAARAMIL
Mvan_4271|M.vanbaalenii_PYR-1 TYGPGDFLPTPHG-GMLAAAVAGRLPFYIDGYDAEVVG--IEDAARAMIL
MSMEG_6563|M.smegmatis_MC2_155 TYGPGDWQPTPHG-GLVAAAVRGKMPFYIDGAEAEAVG--VADAAEALVL
MAV_1849|M.avium_104 TYGPGDFQPTPHG-SLVAAAGKGKMPVYVKDMSMEVVG--IEDAARALIL
TH_2143|M.thermoresistible__bu TYGPGDWQPTPHG-RLLAMVATGRFPFYLG-WSAEVVG--IEDAARAMLL
MAB_0718c|M.abscessus_ATCC_199 VYGPVDLPNLSRINQLLFDSARGRLPGMVN-SQYDLVD--ARDVAAGLYL
MLBr_01942|M.leprae_Br4923 PSGIWGRGDQTMFRKAFESVVSGHVKVLIGSKNAKLDNSYVHNLVHGLIL
* . . . *:. : . . : . .: *
Mb0144|M.bovis_AF2122/97 AAERGHNG------ERYLISERMMPLQEVVRIAADEAGVPPPRWSISVPV
Rv0139|M.tuberculosis_H37Rv AAERGRNG------ERYLISERMMPLQEVVRIAADEAGVPPPRWSISVPV
MMAR_0349|M.marinum_M AAERGRSG------QRYLISERMIALKEVVRIAADEAGVAPPQRTISVPT
MUL_4771|M.ulcerans_Agy99 AAERGRSG------QRYLISERMVALKEVVRIAADEAGVAPPQRTISVPT
Mflv_2375|M.gilvum_PYR-GCK AGERGRIG------ERYIVSDRFISTREIHEIGCAAVGMRPPRFGVPIRA
Mvan_4271|M.vanbaalenii_PYR-1 AAERGRTG------ERYIVSERFMSTREIHEIGCAAVGVAPPKFGVPIRV
MSMEG_6563|M.smegmatis_MC2_155 AGERGTPG------ERYIVSERMMSAREIYEVACDAVGVEPPRRGVPIRV
MAV_1849|M.avium_104 AAEKGRVG------ERYIVSERYISARELYTTAAEAGGARPPRIGIPLKV
TH_2143|M.thermoresistible__bu AAEQGRVG------ERYIISDRYLHTREVHAIAAEAVGRRAPWFGLPLPV
MAB_0718c|M.abscessus_ATCC_199 AGEKGRTG------ENYLLGGHMGSLLQVCRLAARRAGKRGPRFAVPMGL
MLBr_01942|M.leprae_Br4923 AAEHLVPGGTAPGQAYFINDGEPINFFDFMGPIIKACGENWPRVRISGRL
*.*: * :: . . :. * * :.
Mb0144|M.bovis_AF2122/97 LYALGALGS-LRARLTGKDTELSLASVRMMRSEADVDHGKAVRELGWQPR
Rv0139|M.tuberculosis_H37Rv LYALGALGS-LRARLTGKDTELSLASVRMMRSEADVDHGKAVRELGWQPR
MMAR_0349|M.marinum_M LYALGALGS-LRARLTGKDAELSLESVRMMRAEAEVDHAKAVRELGWQPR
MUL_4771|M.ulcerans_Agy99 LYALGALGS-LRARLTGKDAELSLESVRMMRAEAEVDHAKAVRELGWQPR
Mflv_2375|M.gilvum_PYR-GCK MAAAAHLGA-AVARVRNTDTMLTPLNIRLMHIMTPLDHSKAVRELGWHPR
Mvan_4271|M.vanbaalenii_PYR-1 MSAAGYLSE-GVARLRGKDTMLTPLNIRLMHIMSPMDHSKAVRELDWHPQ
MSMEG_6563|M.smegmatis_MC2_155 MAAAAGLSS-AVARLRRRETRLSPLTVRLMHVMSPMDHGKAVRELGWKPA
MAV_1849|M.avium_104 MYALGLCGD-VAAKVLRRDMLLSTLSVRLMHIMSPMDHSKAERELGWRPE
TH_2143|M.thermoresistible__bu LSVAARGND-LAARLLRRDLMFAHVGLKMAELMSPLDHSKAERELGFKPE
MAB_0718c|M.abscessus_ATCC_199 LNAAIPVIE-PIGKLLKN-DALSRAAFNKLTVSPAVDITKARTELGYEPR
MLBr_01942|M.leprae_Br4923 VRNVMAVWQRLHFGFGLPKPPMEPLAVERVYLDNYFSIEKAHKELGYRPL
: . : .. .. ** **.:.*
Mb0144|M.bovis_AF2122/97 -PVEESIREAARFWAAMR--TVGKDPAAS----------
Rv0139|M.tuberculosis_H37Rv -PVEESIREAARFWAAMR--TVGKDPAAS----------
MMAR_0349|M.marinum_M -PVEESIREAARFWASMRKNTQGARTGQSE---------
MUL_4771|M.ulcerans_Agy99 -PVEESIREAARFWASMRKNTQGARTGQPE---------
Mflv_2375|M.gilvum_PYR-GCK -PLADSIVSAAHFFTDRRRSAAPEGTR------------
Mvan_4271|M.vanbaalenii_PYR-1 -PTSEAIVAAAHFFRDRRQRAA-QGAR------------
MSMEG_6563|M.smegmatis_MC2_155 -PAPESIAQAARFFASRRRT-------------------
MAV_1849|M.avium_104 -PIHDAIRRAVAFYQTR----------------------
TH_2143|M.thermoresistible__bu -PVEDSIAKAARFFLEQHR--------------------
MAB_0718c|M.abscessus_ATCC_199 -STETTVNEFVDFLLGSGRL-------------------
MLBr_01942|M.leprae_Br4923 FTTEQAMAECLPYYTELFEQIKVAAKPHLASIAATPRPE
. :: :