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MAGTKLVIGASGFLGSHVTRQLVADGDADVRVLIRRTSSTRGIDGLPVEVRYGDIFDADALRTAMSGCDV VYYCVVDARPWLRDPRPMWRTNVDGLRTVLDIAADAGLTRFVFTSSIGTIGLRAGGPADERTEHNWLDRG GEYIRSRVVAEEMVLRDSARNRLPGVAMCVANTYGPGDFQPTPHGAMLAAAVRGKLPFYIRGYEAEAVGI EDAARAMILAGERGRIGERYIVSDRFISTREIHEIGCAAVGMRPPRFGVPIRAMAAAAHLGAAVARVRNT DTMLTPLNIRLMHIMTPLDHSKAVRELGWHPRPLADSIVSAAHFFTDRRRSAAPEGTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2375 | - | - | 100% (338) | NAD-dependent epimerase/dehydratase |
| M. gilvum PYR-GCK | Mflv_1108 | - | 2e-84 | 50.76% (327) | NAD-dependent epimerase/dehydratase |
| M. gilvum PYR-GCK | Mflv_0367 | - | 8e-63 | 46.39% (263) | NAD-dependent epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0144 | - | 5e-91 | 51.80% (334) | putative oxidoreductase |
| M. tuberculosis H37Rv | Rv0139 | - | 1e-91 | 52.10% (334) | oxidoreductase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 2e-08 | 27.08% (277) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0718c | - | 1e-24 | 27.83% (309) | NAD-dependent epimerase/dehydratase |
| M. marinum M | MMAR_0349 | - | 5e-93 | 52.58% (329) | oxidoreductase |
| M. avium 104 | MAV_1849 | - | 1e-111 | 60.92% (325) | dihydroflavonol-4-reductase family protein |
| M. smegmatis MC2 155 | MSMEG_6563 | - | 1e-127 | 66.77% (337) | dihydrokaempferol 4-reductase |
| M. thermoresistible (build 8) | TH_2143 | - | 1e-105 | 56.97% (330) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_4771 | - | 1e-92 | 51.98% (329) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4271 | - | 1e-154 | 78.99% (338) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0144|M.bovis_AF2122/97 --MNA-PKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSID
Rv0139|M.tuberculosis_H37Rv --MNA-PKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSID
MMAR_0349|M.marinum_M --MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSID
MUL_4771|M.ulcerans_Agy99 --MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSID
Mflv_2375|M.gilvum_PYR-GCK ---MAGTKLVIGASGFLGSHVTRQLVADGDA---DVRVLIRRTSSTRGID
Mvan_4271|M.vanbaalenii_PYR-1 ---MAGTKLVIGASGFLGSHVTKQLIAAGED---DVRVLIRTTSSTRGID
MSMEG_6563|M.smegmatis_MC2_155 ---MTATKLVIGASGFLGSHVTRRLVERGE----DVRILIRSTSSTRGID
MAV_1849|M.avium_104 ----MAVKLVIGASGFLGSHVTRQLVERGE----RVRVLLRRTSSTVALD
TH_2143|M.thermoresistible__bu ---VAKKKLVIGASGFLGSHVTRQLVREGH----DVRVMVRTTSMTRGID
MAB_0718c|M.abscessus_ATCC_199 -----MKTAVTGAAGFIGTNLVNLLVDNGHEVIAIDRVVPASPETREAVT
MLBr_00204|M.leprae_Br4923 MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLA
* ** **:*: :. *: . . :
Mb0144|M.bovis_AF2122/97 DLP--LTRFHGDVFDTATVAEAMAG-CDDVYYCVVDTRAWLRDPSPLFRT
Rv0139|M.tuberculosis_H37Rv DLP--LTRFHGDVFDTATVAEAMAG-CDDVYYCVVDTRAWLRDPSPLFRT
MMAR_0349|M.marinum_M DLP--VTRFHGDIFDTAVVREAMQG-CDDVYYCVVDARAWLRDPAPLFHT
MUL_4771|M.ulcerans_Agy99 DLP--VTRFHGDIFDTAVVREAMQG-CDDVYYCVVDARAWLRDPAPLFHT
Mflv_2375|M.gilvum_PYR-GCK GLP--VEVRYGDIFDADALRTAMSG-CDVVYYCVVDARPWLRDPRPMWRT
Mvan_4271|M.vanbaalenii_PYR-1 GLP--VQVHYGDIFDTGALRAAMAG-CDVVYYCVVDARPWLRDPAPMWRT
MSMEG_6563|M.smegmatis_MC2_155 DVIDRVDVRHGDIFDAASVRDAADG-CDTVYYCVVDARAWLRDATPLWRT
MAV_1849|M.avium_104 DLD--IERRYGDVFDDAVLRDALDG-CDDVYYCVVDTRAWLRDPAPLFRT
TH_2143|M.thermoresistible__bu DLD--VERCHGDVFDDAALRAAMTG-VDDVYYCVVDARMWLRDPAPLFRT
MAB_0718c|M.abscessus_ATCC_199 WVS-------GDVLDPDSMTKALDG-VEVVYHLVAVITLKHED-ELCWRI
MLBr_00204|M.leprae_Br4923 STP-ALAFVEADIVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFDA
.*:. : *:: .. :
Mb0144|M.bovis_AF2122/97 NVAGLRNVLDVATD----ASLRRFVFTSSYATVGRR--RGHVATEEDRVD
Rv0139|M.tuberculosis_H37Rv NVAGLRNVLDVATD----ASLRRFVFTSSYATVGRR--RGHVATEEDRVD
MMAR_0349|M.marinum_M NVEGLRNVLDVAKN----AGLRRFVFTSSYATVDRR--HGHVATEEDRIG
MUL_4771|M.ulcerans_Agy99 NVEGLRNVLDVAKN----AGLRRFVFTSSYATVDRR--HGHVATEEDRIG
Mflv_2375|M.gilvum_PYR-GCK NVDGLRTVLDIAAD----AGLTRFVFTSSIGTIGLR-AGGPADERTEHNW
Mvan_4271|M.vanbaalenii_PYR-1 NVDGLRNVLDVAVG----AGLHRFVFTSSIGTIGLA-ADGLADEDTAHNW
MSMEG_6563|M.smegmatis_MC2_155 NVDGLSGVLDVMTEPEIASGVRRFVFTSSIATIGLP-ESGPATEEIENNW
MAV_1849|M.avium_104 NVEGLRQVLDTAVG----ADLRRFVFTSTIGTIALSEDGLPVSEDEPFNW
TH_2143|M.thermoresistible__bu NVEGLRHVLDAAVE----ADLNRFLFTSTTGTMAIN-PYRPVTEDDPHNW
MAB_0718c|M.abscessus_ATCC_199 NTEGARTVAQAALT----VGARRMVHCSSIDSYSNS--VATIDEKSPRSA
MLBr_00204|M.leprae_Br4923 SVNVIGTVRLAEAAR--HTGVRKIVHTSSGGSIYGTPSQYPTPETVP---
.. * . :::. *: :
Mb0144|M.bovis_AF2122/97 TRKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWGRTPHG-
Rv0139|M.tuberculosis_H37Rv TRKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWGRTPHG-
MMAR_0349|M.marinum_M SRRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWGRTPHG-
MUL_4771|M.ulcerans_Agy99 SRRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWGRTPHG-
Mflv_2375|M.gilvum_PYR-GCK LDRGGEYIRSRVVAEEMVLRDSARNRLPGVAMCVANTYGPGDFQPTPHG-
Mvan_4271|M.vanbaalenii_PYR-1 LDKGGAYIRSRVEAEQMVLRYSAEKGLPAVAMCVANTYGPGDFLPTPHG-
MSMEG_6563|M.smegmatis_MC2_155 LDRGGEYVRSRVRAEQLVLRYHKDRGLPAVAMCVSNTYGPGDWQPTPHG-
MAV_1849|M.avium_104 ADRGGGYIRSRVEAENLVLQYARERGLPAVAMCVSNTYGPGDFQPTPHG-
TH_2143|M.thermoresistible__bu T-EGGAYIEARVAAEQLVLRYARERGLPAVALCISTTYGPGDWQPTPHG-
MAB_0718c|M.abscessus_ATCC_199 AADLPVYQRSKWGGEVAVRETIAS-GLDAVICNPTGVYGPVDLPNLSRIN
MLBr_00204|M.leprae_Br4923 TDPTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYGP---RQDPYG-
* .: .* : * : .** .
Mb0144|M.bovis_AF2122/97 AFIAGAVFGRLPFTMRGIRLEAVGVDDAARALILAAERGHNGERYLISER
Rv0139|M.tuberculosis_H37Rv AFIAGAVFGRLPFTMRGIRLEAVGVDDAARALILAAERGRNGERYLISER
MMAR_0349|M.marinum_M AFIAGAVFGKLPFLMNGIKLEVVGVDDAARAMILAAERGRSGQRYLISER
MUL_4771|M.ulcerans_Agy99 AFIVGAVFGKLPFLMNGIKLEVVGVDDAARAMILAAERGRSGQRYLISER
Mflv_2375|M.gilvum_PYR-GCK AMLAAAVRGKLPFYIRGYEAEAVGIEDAARAMILAGERGRIGERYIVSDR
Mvan_4271|M.vanbaalenii_PYR-1 GMLAAAVAGRLPFYIDGYDAEVVGIEDAARAMILAAERGRTGERYIVSER
MSMEG_6563|M.smegmatis_MC2_155 GLVAAAVRGKMPFYIDGAEAEAVGVADAAEALVLAGERGTPGERYIVSER
MAV_1849|M.avium_104 SLVAAAGKGKMPVYVKDMSMEVVGIEDAARALILAAEKGRVGERYIVSER
TH_2143|M.thermoresistible__bu RLLAMVATGRFPFYLG-WSAEVVGIEDAARAMLLAAEQGRVGERYIISDR
MAB_0718c|M.abscessus_ATCC_199 QLLFDSARGRLPGMVN-SQYDLVDARDVAAGLYLAGEKGRTGENYLLGGH
MLBr_00204|M.leprae_Br4923 --EAGVVAIFVQALLSDRPTKVFGDGTHTRDYVFVDD-------------
. : . .. : :. :
Mb0144|M.bovis_AF2122/97 MMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGKDTELS
Rv0139|M.tuberculosis_H37Rv MMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGKDTELS
MMAR_0349|M.marinum_M MIALKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGKDAELS
MUL_4771|M.ulcerans_Agy99 MVALKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGKDAELS
Mflv_2375|M.gilvum_PYR-GCK FISTREIHEIGCAAVGMRPPRFGVPIRAMAAAAHLGAAVARVRNTDTMLT
Mvan_4271|M.vanbaalenii_PYR-1 FMSTREIHEIGCAAVGVAPPKFGVPIRVMSAAGYLSEGVARLRGKDTMLT
MSMEG_6563|M.smegmatis_MC2_155 MMSAREIYEVACDAVGVEPPRRGVPIRVMAAAAGLSSAVARLRRRETRLS
MAV_1849|M.avium_104 YISARELYTTAAEAGGARPPRIGIPLKVMYALGLCGDVAAKVLRRDMLLS
TH_2143|M.thermoresistible__bu YLHTREVHAIAAEAVGRRAPWFGLPLPVLSVAARGNDLAARLLRRDLMFA
MAB_0718c|M.abscessus_ATCC_199 MGSLLQVCRLAARRAGKRGPRFAVPMGLLNAAIPVIEPIGKLLKN-DALS
MLBr_00204|M.leprae_Br4923 --VVDAFIKASGDAGGGQRFNIGTGIETSDRQLHTAVSAAVGGPDDPEFH
. . * : . :
Mb0144|M.bovis_AF2122/97 LASVRMMRSEADVDHGKAVRELGWQPRP-VEESIREAARFWAAMR--TVG
Rv0139|M.tuberculosis_H37Rv LASVRMMRSEADVDHGKAVRELGWQPRP-VEESIREAARFWAAMR--TVG
MMAR_0349|M.marinum_M LESVRMMRAEAEVDHAKAVRELGWQPRP-VEESIREAARFWASMRKNTQG
MUL_4771|M.ulcerans_Agy99 LESVRMMRAEAEVDHAKAVRELGWQPRP-VEESIREAARFWASMRKNTQG
Mflv_2375|M.gilvum_PYR-GCK PLNIRLMHIMTPLDHSKAVRELGWHPRP-LADSIVSAAHFFTDRRRSAAP
Mvan_4271|M.vanbaalenii_PYR-1 PLNIRLMHIMSPMDHSKAVRELDWHPQP-TSEAIVAAAHFFRDRRQRAA-
MSMEG_6563|M.smegmatis_MC2_155 PLTVRLMHVMSPMDHGKAVRELGWKPAP-APESIAQAARFFASRRRT---
MAV_1849|M.avium_104 TLSVRLMHIMSPMDHSKAERELGWRPEP-IHDAIRRAVAFYQTR------
TH_2143|M.thermoresistible__bu HVGLKMAELMSPLDHSKAERELGFKPEP-VEDSIAKAARFFLEQHR----
MAB_0718c|M.abscessus_ATCC_199 RAAFNKLTVSPAVDITKARTELGYEPRS-TETTVNEFVDFLLGSGRL---
MLBr_00204|M.leprae_Br4923 PPRLGDLKRS-CLDIGLATTVLGWSPQVQLDDGVRRTVEYFRAAQRS---
. :* * *.: * : . :
Mb0144|M.bovis_AF2122/97 KDPAAS-
Rv0139|M.tuberculosis_H37Rv KDPAAS-
MMAR_0349|M.marinum_M ARTGQSE
MUL_4771|M.ulcerans_Agy99 ARTGQPE
Mflv_2375|M.gilvum_PYR-GCK EGTR---
Mvan_4271|M.vanbaalenii_PYR-1 QGAR---
MSMEG_6563|M.smegmatis_MC2_155 -------
MAV_1849|M.avium_104 -------
TH_2143|M.thermoresistible__bu -------
MAB_0718c|M.abscessus_ATCC_199 -------
MLBr_00204|M.leprae_Br4923 -------