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M. thermoresistible (build 8) TH_2143 ()

annotation: POSSIBLE OXIDOREDUCTASE
coordinates: 4218738 - 4219721
length: 328

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2143-100% (328)POSSIBLE OXIDOREDUCTASE
M. thermoresistible (build 8)TH_0078-3e-5460.67% (178) POSSIBLE OXIDOREDUCTASE
M. thermoresistible (build 8)TH_0077-3e-3748.73% (158) POSSIBLE OXIDOREDUCTASE

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0144-2e-8852.63% (323) putative oxidoreductase
M. gilvum PYR-GCKMflv_2375-1e-10556.97% (330) NAD-dependent epimerase/dehydratase
M. tuberculosis H37RvRv0139-6e-8952.94% (323) oxidoreductase
M. leprae Br4923MLBr_01964rmlB3e-1226.16% (237) dTDP-glucose 4,6-dehydratase
M. abscessus ATCC 19977MAB_0718c-7e-2627.08% (325) NAD-dependent epimerase/dehydratase
M. marinum MMMAR_0349-3e-9152.78% (324) oxidoreductase
M. avium 104MAV_1849-1e-11563.24% (321) dihydroflavonol-4-reductase family protein
M. smegmatis MC2 155MSMEG_6563-3e-9954.08% (331) dihydrokaempferol 4-reductase
M. ulcerans Agy99MUL_4771-9e-9152.47% (324) oxidoreductase
M. vanbaalenii PYR-1Mvan_4271-1e-10858.48% (330) NAD-dependent epimerase/dehydratase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0144|M.bovis_AF2122/97            MNA-PKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSIDDL
Rv0139|M.tuberculosis_H37Rv         MNA-PKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSIDDL
MMAR_0349|M.marinum_M               MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSIDDL
MUL_4771|M.ulcerans_Agy99           MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSIDDL
Mflv_2375|M.gilvum_PYR-GCK          -MAGTKLVIGASGFLGSHVTRQLVADGDA---DVRVLIRRTSSTRGIDGL
Mvan_4271|M.vanbaalenii_PYR-1       -MAGTKLVIGASGFLGSHVTKQLIAAGED---DVRVLIRTTSSTRGIDGL
MSMEG_6563|M.smegmatis_MC2_155      -MTATKLVIGASGFLGSHVTRRLVERGE----DVRILIRSTSSTRGIDDV
MAV_1849|M.avium_104                --MAVKLVIGASGFLGSHVTRQLVERGE----RVRVLLRRTSSTVALDDL
TH_2143|M.thermoresistible__bu      -VAKKKLVIGASGFLGSHVTRQLVREGH----DVRVMVRTTSMTRGIDDL
MAB_0718c|M.abscessus_ATCC_199      ---MKTAVTGAAGFIGTNLVNLLVDNGHEVIAIDRVVPASPETREAVTWV
MLBr_01964|M.leprae_Br4923          -MTMRLLVTGGAGFIGANFVHNAVRDHPDDTVTVLDAMTYAGRHESLADV
                                           * *. **:*::...  :                .    .:  :

Mb0144|M.bovis_AF2122/97            P--LTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAW--LRDPSPLFRTN
Rv0139|M.tuberculosis_H37Rv         P--LTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAW--LRDPSPLFRTN
MMAR_0349|M.marinum_M               P--VTRFHGDIFDTAVVREAMQGCDDVYYCVVDARAW--LRDPAPLFHTN
MUL_4771|M.ulcerans_Agy99           P--VTRFHGDIFDTAVVREAMQGCDDVYYCVVDARAW--LRDPAPLFHTN
Mflv_2375|M.gilvum_PYR-GCK          P--VEVRYGDIFDADALRTAMSGCDVVYYCVVDARPW--LRDPRPMWRTN
Mvan_4271|M.vanbaalenii_PYR-1       P--VQVHYGDIFDTGALRAAMAGCDVVYYCVVDARPW--LRDPAPMWRTN
MSMEG_6563|M.smegmatis_MC2_155      IDRVDVRHGDIFDAASVRDAADGCDTVYYCVVDARAW--LRDATPLWRTN
MAV_1849|M.avium_104                D--IERRYGDVFDDAVLRDALDGCDDVYYCVVDTRAW--LRDPAPLFRTN
TH_2143|M.thermoresistible__bu      D--VERCHGDVFDDAALRAAMTGVDDVYYCVVDARMW--LRDPAPLFRTN
MAB_0718c|M.abscessus_ATCC_199      S-------GDVLDPDSMTKALDGVEVVYHLVAVITLK--HED-ELCWRIN
MLBr_01964|M.leprae_Br4923          DHAVRLVQGNITDTKLVFRLVAESDVVVHFAAETHVDNALDDPEPFLRTN
                                            *:: *   :       : * : ..         *     : *

Mb0144|M.bovis_AF2122/97            VAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRGH--VATEEDRVDT
Rv0139|M.tuberculosis_H37Rv         VAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRGH--VATEEDRVDT
MMAR_0349|M.marinum_M               VEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHGH--VATEEDRIGS
MUL_4771|M.ulcerans_Agy99           VEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHGH--VATEEDRIGS
Mflv_2375|M.gilvum_PYR-GCK          VDGLRTVLDIAAD----AGLTRFVFTSSIGTIGLRAGG-PADERTEHNWL
Mvan_4271|M.vanbaalenii_PYR-1       VDGLRNVLDVAVG----AGLHRFVFTSSIGTIGLAADG-LADEDTAHNWL
MSMEG_6563|M.smegmatis_MC2_155      VDGLSGVLDVMTEPEIASGVRRFVFTSSIATIGLPESG-PATEEIENNWL
MAV_1849|M.avium_104                VEGLRQVLDTAVG----ADLRRFVFTSTIGTIALSEDGLPVSEDEPFNWA
TH_2143|M.thermoresistible__bu      VEGLRHVLDAAVE----ADLNRFLFTSTTGTMAINPYR-PVTEDDPHNWT
MAB_0718c|M.abscessus_ATCC_199      TEGARTVAQAALT----VGARRMVHCSSIDSYSNSVAT--IDEKSPRSAA
MLBr_01964|M.leprae_Br4923          VIGTFTILEAVRHHS--VRLHHISTDEVYGDLELDEPT----RFTESTPY
                                    . *   : :            ::   .                       

Mb0144|M.bovis_AF2122/97            RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWGRTPHG-A
Rv0139|M.tuberculosis_H37Rv         RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWGRTPHG-A
MMAR_0349|M.marinum_M               RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWGRTPHG-A
MUL_4771|M.ulcerans_Agy99           RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWGRTPHG-A
Mflv_2375|M.gilvum_PYR-GCK          DRGGEYIRSRVVAEEMVLRDSARNRLPGVAMCVANTYGPGDFQPTPHG-A
Mvan_4271|M.vanbaalenii_PYR-1       DKGGAYIRSRVEAEQMVLRYSAEKGLPAVAMCVANTYGPGDFLPTPHG-G
MSMEG_6563|M.smegmatis_MC2_155      DRGGEYVRSRVRAEQLVLRYHKDRGLPAVAMCVSNTYGPGDWQPTPHG-G
MAV_1849|M.avium_104                DRGGGYIRSRVEAENLVLQYARERGLPAVAMCVSNTYGPGDFQPTPHG-S
TH_2143|M.thermoresistible__bu      -EGGAYIEARVAAEQLVLRYARERGLPAVALCISTTYGPGDWQPTPHG-R
MAB_0718c|M.abscessus_ATCC_199      ADLPVYQRSKWGGEVAVRETIAS-GLDAVICNPTGVYGPVDLPNLSRINQ
MLBr_01964|M.leprae_Br4923          NPSSPYSATKAAGDMLVRAWVRSYGVRATISNCSNNYGPYQHVEKFIP-R
                                         *  ::  .:  *        : ..    :  **  :         

Mb0144|M.bovis_AF2122/97            FIAGAVFGRLP--FTMRGIRLEAVGVDDAARALILAAERGHNGERYLISE
Rv0139|M.tuberculosis_H37Rv         FIAGAVFGRLP--FTMRGIRLEAVGVDDAARALILAAERGRNGERYLISE
MMAR_0349|M.marinum_M               FIAGAVFGKLP--FLMNGIKLEVVGVDDAARAMILAAERGRSGQRYLISE
MUL_4771|M.ulcerans_Agy99           FIVGAVFGKLP--FLMNGIKLEVVGVDDAARAMILAAERGRSGQRYLISE
Mflv_2375|M.gilvum_PYR-GCK          MLAAAVRGKLP--FYIRGYEAEAVGIEDAARAMILAGERGRIGERYIVSD
Mvan_4271|M.vanbaalenii_PYR-1       MLAAAVAGRLP--FYIDGYDAEVVGIEDAARAMILAAERGRTGERYIVSE
MSMEG_6563|M.smegmatis_MC2_155      LVAAAVRGKMP--FYIDGAEAEAVGVADAAEALVLAGERGTPGERYIVSE
MAV_1849|M.avium_104                LVAAAGKGKMP--VYVKDMSMEVVGIEDAARALILAAEKGRVGERYIVSE
TH_2143|M.thermoresistible__bu      LLAMVATGRFP--FYLG-WSAEVVGIEDAARAMLLAAEQGRVGERYIISD
MAB_0718c|M.abscessus_ATCC_199      LLFDSARGRLP--GMVN-SQYDLVDARDVAAGLYLAGEKGRTGENYLLGG
MLBr_01964|M.leprae_Br4923          QITNVLTGRRPKLYGTGVNVRDWIHVDDHNSAVWQILEKGQIGRTYLIGA
                                     :     *: *          : :   *   .:    *:*  *. *::. 

Mb0144|M.bovis_AF2122/97            RMMP-LQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGKDTE
Rv0139|M.tuberculosis_H37Rv         RMMP-LQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGKDTE
MMAR_0349|M.marinum_M               RMIA-LKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGKDAE
MUL_4771|M.ulcerans_Agy99           RMVA-LKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGKDAE
Mflv_2375|M.gilvum_PYR-GCK          RFIS-TREIHEIGCAAVGMRPPRFGVPIRAMAAAAHLGAAVARVRNTDTM
Mvan_4271|M.vanbaalenii_PYR-1       RFMS-TREIHEIGCAAVGVAPPKFGVPIRVMSAAGYLSEGVARLRGKDTM
MSMEG_6563|M.smegmatis_MC2_155      RMMS-AREIYEVACDAVGVEPPRRGVPIRVMAAAAGLSSAVARLRRRETR
MAV_1849|M.avium_104                RYIS-ARELYTTAAEAGGARPPRIGIPLKVMYALGLCGDVAAKVLRRDML
TH_2143|M.thermoresistible__bu      RYLH-TREVHAIAAEAVGRRAPWFGLPLPVLSVAARGNDLAARLLRRDLM
MAB_0718c|M.abscessus_ATCC_199      HMGS-LLQVCRLAARRAGKRGPRFAVPMGLLNAAIPVIEPIGKLLKN-DA
MLBr_01964|M.leprae_Br4923          ENGHNNLTVLRTLLQMMGRDPNDFDHVTDRVGHDLRYAIDPTPLYNELCW
                                    .       :        *            :            :      

Mb0144|M.bovis_AF2122/97            LSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMR--TV
Rv0139|M.tuberculosis_H37Rv         LSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMR--TV
MMAR_0349|M.marinum_M               LSLESVRMMRAEAEVDHAKAVRELGWQPRPVEESIREAARFWASMRKNTQ
MUL_4771|M.ulcerans_Agy99           LSLESVRMMRAEAEVDHAKAVRELGWQPRPVEESIREAARFWASMRKNTQ
Mflv_2375|M.gilvum_PYR-GCK          LTPLNIRLMHIMTPLDHSKAVRELGWHPRPLADSIVSAAHFFTDRRRSAA
Mvan_4271|M.vanbaalenii_PYR-1       LTPLNIRLMHIMSPMDHSKAVRELDWHPQPTSEAIVAAAHFFRDRRQRAA
MSMEG_6563|M.smegmatis_MC2_155      LSPLTVRLMHVMSPMDHGKAVRELGWKPAPAPESIAQAARFFASRRRT--
MAV_1849|M.avium_104                LSTLSVRLMHIMSPMDHSKAERELGWRPEPIHDAIRRAVAFYQTR-----
TH_2143|M.thermoresistible__bu      FAHVGLKMAELMSPLDHSKAERELGFKPEPVEDSIAKAARFFLEQHR---
MAB_0718c|M.abscessus_ATCC_199      LSRAAFNKLTVSPAVDITKARTELGYEPRSTETTVNEFVDFLLGSGRL--
MLBr_01964|M.leprae_Br4923          APKHANFDEGLRATIDWYRNN-ESWWRP------LKDAVEARYEERGR--
                                     .          . :*  :   *  :.*      :   .           

Mb0144|M.bovis_AF2122/97            GKDPAAS-
Rv0139|M.tuberculosis_H37Rv         GKDPAAS-
MMAR_0349|M.marinum_M               GARTGQSE
MUL_4771|M.ulcerans_Agy99           GARTGQPE
Mflv_2375|M.gilvum_PYR-GCK          PEGTR---
Mvan_4271|M.vanbaalenii_PYR-1       -QGAR---
MSMEG_6563|M.smegmatis_MC2_155      --------
MAV_1849|M.avium_104                --------
TH_2143|M.thermoresistible__bu      --------
MAB_0718c|M.abscessus_ATCC_199      --------
MLBr_01964|M.leprae_Br4923          --------