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AGTKLVIGASGFLGSHVTKQLIAAGEDDVRVLIRTTSSTRGIDGLPVQVHYGDIFDTGALRAAMAGCDVV YYCVVDARPWLRDPAPMWRTNVDGLRNVLDVAVGAGLHRFVFTSSIGTIGLAADGLADEDTAHNWLDKGG AYIRSRVEAEQMVLRYSAEKGLPAVAMCVANTYGPGDFLPTPHGGMLAAAVAGRLPFYIDGYDAEVVGIE DAARAMILAAERGRTGERYIVSERFMSTREIHEIGCAAVGVAPPKFGVPIRVMSAAGYLSEGVARLRGKD TMLTPLNIRLMHIMSPMDHSKAVRELDWHPQPTSEAIVAAAHFFRDRRQRAAQGAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4271 | - | - | 100% (337) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_5705 | - | 7e-87 | 50.59% (340) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_0338 | - | 2e-81 | 50.15% (325) | NAD-dependent epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0144 | - | 7e-94 | 53.01% (332) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_2375 | - | 1e-155 | 78.99% (338) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv0139 | - | 2e-94 | 53.31% (332) | oxidoreductase |
| M. leprae Br4923 | MLBr_01964 | rmlB | 2e-08 | 22.69% (238) | dTDP-glucose 4,6-dehydratase |
| M. abscessus ATCC 19977 | MAB_0718c | - | 3e-23 | 27.53% (316) | NAD-dependent epimerase/dehydratase |
| M. marinum M | MMAR_0349 | - | 1e-96 | 54.33% (335) | oxidoreductase |
| M. avium 104 | MAV_1849 | - | 1e-115 | 62.15% (325) | dihydroflavonol-4-reductase family protein |
| M. smegmatis MC2 155 | MSMEG_6563 | - | 1e-126 | 65.77% (336) | dihydrokaempferol 4-reductase |
| M. thermoresistible (build 8) | TH_2143 | - | 1e-108 | 58.48% (330) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_4771 | - | 2e-96 | 54.03% (335) | oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0144|M.bovis_AF2122/97 MNA-PKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSIDDL
Rv0139|M.tuberculosis_H37Rv MNA-PKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSIDDL
MMAR_0349|M.marinum_M MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSIDDL
MUL_4771|M.ulcerans_Agy99 MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSIDDL
Mvan_4271|M.vanbaalenii_PYR-1 -MAGTKLVIGASGFLGSHVTKQLIAAGED---DVRVLIRTTSSTRGIDGL
Mflv_2375|M.gilvum_PYR-GCK -MAGTKLVIGASGFLGSHVTRQLVADGDA---DVRVLIRRTSSTRGIDGL
MSMEG_6563|M.smegmatis_MC2_155 -MTATKLVIGASGFLGSHVTRRLVERGE----DVRILIRSTSSTRGIDDV
MAV_1849|M.avium_104 --MAVKLVIGASGFLGSHVTRQLVERGE----RVRVLLRRTSSTVALDDL
TH_2143|M.thermoresistible__bu -VAKKKLVIGASGFLGSHVTRQLVREGH----DVRVMVRTTSMTRGIDDL
MAB_0718c|M.abscessus_ATCC_199 ---MKTAVTGAAGFIGTNLVNLLVDNGHEVIAIDRVVPASPETREAVTWV
MLBr_01964|M.leprae_Br4923 -MTMRLLVTGGAGFIGANFVHNAVRDHPDDTVTVLDAMTYAGRHESLADV
* *. **:*::... : . .: :
Mb0144|M.bovis_AF2122/97 P--LTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAW--LRDPSPLFRTN
Rv0139|M.tuberculosis_H37Rv P--LTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAW--LRDPSPLFRTN
MMAR_0349|M.marinum_M P--VTRFHGDIFDTAVVREAMQGCDDVYYCVVDARAW--LRDPAPLFHTN
MUL_4771|M.ulcerans_Agy99 P--VTRFHGDIFDTAVVREAMQGCDDVYYCVVDARAW--LRDPAPLFHTN
Mvan_4271|M.vanbaalenii_PYR-1 P--VQVHYGDIFDTGALRAAMAGCDVVYYCVVDARPW--LRDPAPMWRTN
Mflv_2375|M.gilvum_PYR-GCK P--VEVRYGDIFDADALRTAMSGCDVVYYCVVDARPW--LRDPRPMWRTN
MSMEG_6563|M.smegmatis_MC2_155 IDRVDVRHGDIFDAASVRDAADGCDTVYYCVVDARAW--LRDATPLWRTN
MAV_1849|M.avium_104 D--IERRYGDVFDDAVLRDALDGCDDVYYCVVDTRAW--LRDPAPLFRTN
TH_2143|M.thermoresistible__bu D--VERCHGDVFDDAALRAAMTGVDDVYYCVVDARMW--LRDPAPLFRTN
MAB_0718c|M.abscessus_ATCC_199 S-------GDVLDPDSMTKALDGVEVVYHLVAVITLK--HED-ELCWRIN
MLBr_01964|M.leprae_Br4923 DHAVRLVQGNITDTKLVFRLVAESDVVVHFAAETHVDNALDDPEPFLRTN
*:: * : : * : .. * : *
Mb0144|M.bovis_AF2122/97 VAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRGH--VATEEDRVDT
Rv0139|M.tuberculosis_H37Rv VAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRGH--VATEEDRVDT
MMAR_0349|M.marinum_M VEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHGH--VATEEDRIGS
MUL_4771|M.ulcerans_Agy99 VEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHGH--VATEEDRIGS
Mvan_4271|M.vanbaalenii_PYR-1 VDGLRNVLDVAVG----AGLHRFVFTSSIGTIGLAADG-LADEDTAHNWL
Mflv_2375|M.gilvum_PYR-GCK VDGLRTVLDIAAD----AGLTRFVFTSSIGTIGLRAGG-PADERTEHNWL
MSMEG_6563|M.smegmatis_MC2_155 VDGLSGVLDVMTEPEIASGVRRFVFTSSIATIGLPESG-PATEEIENNWL
MAV_1849|M.avium_104 VEGLRQVLDTAVG----ADLRRFVFTSTIGTIALSEDGLPVSEDEPFNWA
TH_2143|M.thermoresistible__bu VEGLRHVLDAAVE----ADLNRFLFTSTTGTMAINPYR-PVTEDDPHNWT
MAB_0718c|M.abscessus_ATCC_199 TEGARTVAQAALT----VGARRMVHCSSIDSYSNSVAT--IDEKSPRSAA
MLBr_01964|M.leprae_Br4923 VIGTFTILEAVRHHS--VRLHHISTDEVYGDLELDEPT----RFTESTPY
. * : : :: .
Mb0144|M.bovis_AF2122/97 RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWGRTPHG-A
Rv0139|M.tuberculosis_H37Rv RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWGRTPHG-A
MMAR_0349|M.marinum_M RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWGRTPHG-A
MUL_4771|M.ulcerans_Agy99 RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWGRTPHG-A
Mvan_4271|M.vanbaalenii_PYR-1 DKGGAYIRSRVEAEQMVLRYSAEKGLPAVAMCVANTYGPGDFLPTPHG-G
Mflv_2375|M.gilvum_PYR-GCK DRGGEYIRSRVVAEEMVLRDSARNRLPGVAMCVANTYGPGDFQPTPHG-A
MSMEG_6563|M.smegmatis_MC2_155 DRGGEYVRSRVRAEQLVLRYHKDRGLPAVAMCVSNTYGPGDWQPTPHG-G
MAV_1849|M.avium_104 DRGGGYIRSRVEAENLVLQYARERGLPAVAMCVSNTYGPGDFQPTPHG-S
TH_2143|M.thermoresistible__bu -EGGAYIEARVAAEQLVLRYARERGLPAVALCISTTYGPGDWQPTPHG-R
MAB_0718c|M.abscessus_ATCC_199 ADLPVYQRSKWGGEVAVRETIAS-GLDAVICNPTGVYGPVDLPNLSRINQ
MLBr_01964|M.leprae_Br4923 NPSSPYSATKAAGDMLVRAWVRSYGVRATISNCSNNYGPYQHVEKFIP-R
* :: .: * : .. : ** :
Mb0144|M.bovis_AF2122/97 FIAGAVFGRLP--FTMRGIRLEAVGVDDAARALILAAERGHNGERYLISE
Rv0139|M.tuberculosis_H37Rv FIAGAVFGRLP--FTMRGIRLEAVGVDDAARALILAAERGRNGERYLISE
MMAR_0349|M.marinum_M FIAGAVFGKLP--FLMNGIKLEVVGVDDAARAMILAAERGRSGQRYLISE
MUL_4771|M.ulcerans_Agy99 FIVGAVFGKLP--FLMNGIKLEVVGVDDAARAMILAAERGRSGQRYLISE
Mvan_4271|M.vanbaalenii_PYR-1 MLAAAVAGRLP--FYIDGYDAEVVGIEDAARAMILAAERGRTGERYIVSE
Mflv_2375|M.gilvum_PYR-GCK MLAAAVRGKLP--FYIRGYEAEAVGIEDAARAMILAGERGRIGERYIVSD
MSMEG_6563|M.smegmatis_MC2_155 LVAAAVRGKMP--FYIDGAEAEAVGVADAAEALVLAGERGTPGERYIVSE
MAV_1849|M.avium_104 LVAAAGKGKMP--VYVKDMSMEVVGIEDAARALILAAEKGRVGERYIVSE
TH_2143|M.thermoresistible__bu LLAMVATGRFP--FYLG-WSAEVVGIEDAARAMLLAAEQGRVGERYIISD
MAB_0718c|M.abscessus_ATCC_199 LLFDSARGRLP--GMVN-SQYDLVDARDVAAGLYLAGEKGRTGENYLLGG
MLBr_01964|M.leprae_Br4923 QITNVLTGRRPKLYGTGVNVRDWIHVDDHNSAVWQILEKGQIGRTYLIGA
: *: * : : * .: *:* *. *::.
Mb0144|M.bovis_AF2122/97 RMMP-LQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGKDTE
Rv0139|M.tuberculosis_H37Rv RMMP-LQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGKDTE
MMAR_0349|M.marinum_M RMIA-LKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGKDAE
MUL_4771|M.ulcerans_Agy99 RMVA-LKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGKDAE
Mvan_4271|M.vanbaalenii_PYR-1 RFMS-TREIHEIGCAAVGVAPPKFGVPIRVMSAAGYLSEGVARLRGKDTM
Mflv_2375|M.gilvum_PYR-GCK RFIS-TREIHEIGCAAVGMRPPRFGVPIRAMAAAAHLGAAVARVRNTDTM
MSMEG_6563|M.smegmatis_MC2_155 RMMS-AREIYEVACDAVGVEPPRRGVPIRVMAAAAGLSSAVARLRRRETR
MAV_1849|M.avium_104 RYIS-ARELYTTAAEAGGARPPRIGIPLKVMYALGLCGDVAAKVLRRDML
TH_2143|M.thermoresistible__bu RYLH-TREVHAIAAEAVGRRAPWFGLPLPVLSVAARGNDLAARLLRRDLM
MAB_0718c|M.abscessus_ATCC_199 HMGS-LLQVCRLAARRAGKRGPRFAVPMGLLNAAIPVIEPIGKLLKN-DA
MLBr_01964|M.leprae_Br4923 ENGHNNLTVLRTLLQMMGRDPNDFDHVTDRVGHDLRYAIDPTPLYNELCW
. : * : :
Mb0144|M.bovis_AF2122/97 LSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMR--TV
Rv0139|M.tuberculosis_H37Rv LSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMR--TV
MMAR_0349|M.marinum_M LSLESVRMMRAEAEVDHAKAVRELGWQPRPVEESIREAARFWASMRKNTQ
MUL_4771|M.ulcerans_Agy99 LSLESVRMMRAEAEVDHAKAVRELGWQPRPVEESIREAARFWASMRKNTQ
Mvan_4271|M.vanbaalenii_PYR-1 LTPLNIRLMHIMSPMDHSKAVRELDWHPQPTSEAIVAAAHFFRDRRQRAA
Mflv_2375|M.gilvum_PYR-GCK LTPLNIRLMHIMTPLDHSKAVRELGWHPRPLADSIVSAAHFFTDRRRSAA
MSMEG_6563|M.smegmatis_MC2_155 LSPLTVRLMHVMSPMDHGKAVRELGWKPAPAPESIAQAARFFASRRRT--
MAV_1849|M.avium_104 LSTLSVRLMHIMSPMDHSKAERELGWRPEPIHDAIRRAVAFYQTR-----
TH_2143|M.thermoresistible__bu FAHVGLKMAELMSPLDHSKAERELGFKPEPVEDSIAKAARFFLEQHR---
MAB_0718c|M.abscessus_ATCC_199 LSRAAFNKLTVSPAVDITKARTELGYEPRSTETTVNEFVDFLLGSGRL--
MLBr_01964|M.leprae_Br4923 APKHANFDEGLRATIDWYRNN-ESWWRP------LKDAVEARYEERGR--
. . :* : * :.* : .
Mb0144|M.bovis_AF2122/97 GKDPAAS-
Rv0139|M.tuberculosis_H37Rv GKDPAAS-
MMAR_0349|M.marinum_M GARTGQSE
MUL_4771|M.ulcerans_Agy99 GARTGQPE
Mvan_4271|M.vanbaalenii_PYR-1 -QGAR---
Mflv_2375|M.gilvum_PYR-GCK PEGTR---
MSMEG_6563|M.smegmatis_MC2_155 --------
MAV_1849|M.avium_104 --------
TH_2143|M.thermoresistible__bu --------
MAB_0718c|M.abscessus_ATCC_199 --------
MLBr_01964|M.leprae_Br4923 --------