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MDRRRKVLVMGASGNVGACVTRQLVERGDDVRVLLRRNSSTKGIDGLDVERHYGDIFDTGAVAAAVADRD VVFYCVVDTRAHLAAPAPLFRTNVEGLRNVLEVADHVDLHRFVFLSTIGTIAVGRNGEAVDEDTPFNWAG IGGPYIESRRKAEELVLSYAAERGFPAVVMNVSNPYGPPDWQPRQGALVAMAAFGKLPVYIRGVGAEVVG IDDAARALILAAEHGRIGERYIVSERYMSQQEMLTVAAEAVGARPPRIGIPMAAVYAFGSLAGLSNRLFR TDFPINLTAARLMWWTSPADHSKATRELGWKPAPTADAIARAAQFYVERKNNNEKVISL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2247 | - | - | 100% (339) | dihydrokaempferol 4-reductase |
| M. smegmatis MC2 155 | MSMEG_6563 | - | 2e-84 | 51.52% (330) | dihydrokaempferol 4-reductase |
| M. smegmatis MC2 155 | MSMEG_6474 | - | 1e-79 | 50.31% (326) | nucleoside-diphosphate-sugar epimerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0144 | - | 7e-78 | 48.77% (324) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0367 | - | 2e-97 | 66.92% (260) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv0139 | - | 2e-78 | 49.07% (324) | oxidoreductase |
| M. leprae Br4923 | MLBr_01964 | rmlB | 9e-14 | 28.36% (268) | dTDP-glucose 4,6-dehydratase |
| M. abscessus ATCC 19977 | MAB_0718c | - | 3e-20 | 26.91% (327) | NAD-dependent epimerase/dehydratase |
| M. marinum M | MMAR_0349 | - | 1e-79 | 46.95% (328) | oxidoreductase |
| M. avium 104 | MAV_1849 | - | 1e-106 | 61.92% (323) | dihydroflavonol-4-reductase family protein |
| M. thermoresistible (build 8) | TH_2143 | - | 2e-90 | 53.99% (326) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_4771 | - | 3e-79 | 46.65% (328) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0338 | - | 1e-117 | 66.88% (314) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0144|M.bovis_AF2122/97 -MNA-PKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSIDD
Rv0139|M.tuberculosis_H37Rv -MNA-PKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSIDD
MMAR_0349|M.marinum_M -MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSIDD
MUL_4771|M.ulcerans_Agy99 -MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSIDD
Mflv_0367|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0338|M.vanbaalenii_PYR-1 ---------------MGACVARQLAAGGA----DVRVLLRKSSSTKGVDR
MSMEG_2247|M.smegmatis_MC2_155 MDRRRKVLVMGASGNVGACVTRQLVERGD----DVRVLLRRNSSTKGIDG
MAV_1849|M.avium_104 ---MAVKLVIGASGFLGSHVTRQLVERGE----RVRVLLRRTSSTVALDD
TH_2143|M.thermoresistible__bu --VAKKKLVIGASGFLGSHVTRQLVREGH----DVRVMVRTTSMTRGIDD
MAB_0718c|M.abscessus_ATCC_199 ----MKTAVTGAAGFIGTNLVNLLVDNGH-----EVIAIDRVVPASPETR
MLBr_01964|M.leprae_Br4923 --MTMRLLVTGGAGFIGANFVHNAVRDHPDDTVTVLDAMTYAGRHESLAD
Mb0144|M.bovis_AF2122/97 LP--LTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAW--LRDPSPLFRT
Rv0139|M.tuberculosis_H37Rv LP--LTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAW--LRDPSPLFRT
MMAR_0349|M.marinum_M LP--VTRFHGDIFDTAVVREAMQGCDDVYYCVVDARAW--LRDPAPLFHT
MUL_4771|M.ulcerans_Agy99 LP--VTRFHGDIFDTAVVREAMQGCDDVYYCVVDARAW--LRDPAPLFHT
Mflv_0367|M.gilvum_PYR-GCK --------------------------MVYYCIVDTRAE--LKDPAPLFAT
Mvan_0338|M.vanbaalenii_PYR-1 ID--VERAVGDPFDPATAAAAMADRDVVYYCIVDTRAE--LKDPAPLFAT
MSMEG_2247|M.smegmatis_MC2_155 LD--VERHYGDIFDTGAVAAAVADRDVVFYCVVDTRAH--LAAPAPLFRT
MAV_1849|M.avium_104 LD--IERRYGDVFDDAVLRDALDGCDDVYYCVVDTRAW--LRDPAPLFRT
TH_2143|M.thermoresistible__bu LD--VERCHGDVFDDAALRAAMTGVDDVYYCVVDARMW--LRDPAPLFRT
MAB_0718c|M.abscessus_ATCC_199 EA--VTWVSGDVLDPDSMTKALDGVEVVYHLVAVITLK--HED-ELCWRI
MLBr_01964|M.leprae_Br4923 VDHAVRLVQGNITDTKLVFRLVAESDVVVHFAAETHVDNALDDPEPFLRT
* : .
Mb0144|M.bovis_AF2122/97 NVAGLRNVLDVATDASLRRFVFTSSYATVGRRRGHVATEEDR--VDTRKV
Rv0139|M.tuberculosis_H37Rv NVAGLRNVLDVATDASLRRFVFTSSYATVGRRRGHVATEEDR--VDTRKV
MMAR_0349|M.marinum_M NVEGLRNVLDVAKNAGLRRFVFTSSYATVDRRHGHVATEEDR--IGSRRV
MUL_4771|M.ulcerans_Agy99 NVEGLRNVLDVAKNAGLRRFVFTSSYATVDRRHGHVATEEDR--IGSRRV
Mflv_0367|M.gilvum_PYR-GCK NVEGLRKVLDVAADANLDKFVFLSTIGTIAVGADGEQVDEDTPFNWAERA
Mvan_0338|M.vanbaalenii_PYR-1 NVEGLRKVLDVAAAANLKRFVFLSTIGTIAVGENGETVDEDTPFNWADRA
MSMEG_2247|M.smegmatis_MC2_155 NVEGLRNVLEVADHVDLHRFVFLSTIGTIAVGRNGEAVDEDTPFNWAGIG
MAV_1849|M.avium_104 NVEGLRQVLDTAVGADLRRFVFTSTIGTIALSEDGLPVSEDEPFNWADRG
TH_2143|M.thermoresistible__bu NVEGLRHVLDAAVEADLNRFLFTSTTGTMAINPYR-PVTEDDPHNWT-EG
MAB_0718c|M.abscessus_ATCC_199 NTEGARTVAQAALTVGARRMVHCSSIDSYS--NSVATIDEKSPRSAAADL
MLBr_01964|M.leprae_Br4923 NVIGTFTILEAVRHHSVR--LHHISTDEVYGDLELDEPTRFTESTPYNPS
*. * : :.. . :. : .
Mb0144|M.bovis_AF2122/97 TPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWGRTP-HGAFIA
Rv0139|M.tuberculosis_H37Rv TPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWGRTP-HGAFIA
MMAR_0349|M.marinum_M SSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWGRTP-HGAFIA
MUL_4771|M.ulcerans_Agy99 SSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWGRTP-HGAFIV
Mflv_0367|M.gilvum_PYR-GCK GSYIESRRAAEQLVLSYAAERGVPAVVVNVSNPYGPPDWQPR--QGMFVQ
Mvan_0338|M.vanbaalenii_PYR-1 GGYIESRRAAEQLVLSYATERGLPAVVVNVSNPYGPPDFQPR--QGMFVQ
MSMEG_2247|M.smegmatis_MC2_155 GPYIESRRKAEELVLSYAAERGFPAVVMNVSNPYGPPDWQPR--QGALVA
MAV_1849|M.avium_104 GGYIRSRVEAENLVLQYARERGLPAVAMCVSNTYGPGDFQPTP-HGSLVA
TH_2143|M.thermoresistible__bu GAYIEARVAAEQLVLRYARERGLPAVALCISTTYGPGDWQPTP-HGRLLA
MAB_0718c|M.abscessus_ATCC_199 PVYQRSKWGGEVAVRETIAS-GLDAVICNPTGVYGPVDLPNLSRINQLLF
MLBr_01964|M.leprae_Br4923 SPYSATKAAGDMLVRAWVRSYGVRATISNCSNNYGPYQHVEKF-IPRQIT
* :: .: * . *. *. : ** : :
Mb0144|M.bovis_AF2122/97 GAVFGRLP--FTMRGIRLEAVGVDDAARALILAAERGHNGERYLISERMM
Rv0139|M.tuberculosis_H37Rv GAVFGRLP--FTMRGIRLEAVGVDDAARALILAAERGRNGERYLISERMM
MMAR_0349|M.marinum_M GAVFGKLP--FLMNGIKLEVVGVDDAARAMILAAERGRSGQRYLISERMI
MUL_4771|M.ulcerans_Agy99 GAVFGKLP--FLMNGIKLEVVGVDDAARAMILAAERGRSGQRYLISERMV
Mflv_0367|M.gilvum_PYR-GCK MAALGKMP--FYVRGVGSEVVGIDDAADAMLRASVRGRVGERYIASERFM
Mvan_0338|M.vanbaalenii_PYR-1 LAALGKLP--FYVKGVGAEVVGIDDAADAMLRASLRGRVGERYIASERFM
MSMEG_2247|M.smegmatis_MC2_155 MAAFGKLP--VYIRGVGAEVVGIDDAARALILAAEHGRIGERYIVSERYM
MAV_1849|M.avium_104 AAGKGKMP--VYVKDMSMEVVGIEDAARALILAAEKGRVGERYIVSERYI
TH_2143|M.thermoresistible__bu MVATGRFP--FYLG-WSAEVVGIEDAARAMLLAAEQGRVGERYIISDRYL
MAB_0718c|M.abscessus_ATCC_199 DSARGRLP--GMVN-SQYDLVDARDVAAGLYLAGEKGRTGENYLLGGHMG
MLBr_01964|M.leprae_Br4923 NVLTGRRPKLYGTGVNVRDWIHVDDHNSAVWQILEKGQIGRTYLIGAENG
*: * : : * .: :*: *. *: . .
Mb0144|M.bovis_AF2122/97 PL-QEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGKDTELSL
Rv0139|M.tuberculosis_H37Rv PL-QEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGKDTELSL
MMAR_0349|M.marinum_M AL-KEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGKDAELSL
MUL_4771|M.ulcerans_Agy99 AL-KEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGKDAELSL
Mflv_0367|M.gilvum_PYR-GCK TH-RELVTTAADAVGARRPRIGIPMAVVYGFAYLADAIGSVLPVQVPMSR
Mvan_0338|M.vanbaalenii_PYR-1 TH-RELLTTAADAVGARRPRFGVPMAVVYGFAWLADAVGSILPVQVPMSR
MSMEG_2247|M.smegmatis_MC2_155 SQ-QEMLTVAAEAVGARPPRIGIPMAAVYAFGSLAGLSNRLFRTDFPINL
MAV_1849|M.avium_104 SA-RELYTTAAEAGGARPPRIGIPLKVMYALGLCGDVAAKVLRRDMLLST
TH_2143|M.thermoresistible__bu HT-REVHAIAAEAVGRRAPWFGLPLPVLSVAARGNDLAARLLRRDLMFAH
MAB_0718c|M.abscessus_ATCC_199 SL-LQVCRLAARRAGKRGPRFAVPMGLLNAAIPVIEPIGKLLKND-ALSR
MLBr_01964|M.leprae_Br4923 HNNLTVLRTLLQMMGRDPNDFDHVTDRVGHDLRYAIDPTPLYNELCWAPK
: * : :
Mb0144|M.bovis_AF2122/97 ASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMR--TVGKD
Rv0139|M.tuberculosis_H37Rv ASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMR--TVGKD
MMAR_0349|M.marinum_M ESVRMMRAEAEVDHAKAVRELGWQPRPVEESIREAARFWASMRKNTQGAR
MUL_4771|M.ulcerans_Agy99 ESVRMMRAEAEVDHAKAVRELGWQPRPVEESIREAARFWASMRKNTQGAR
Mflv_0367|M.gilvum_PYR-GCK QSAFLLAHTSPASHAKATRELGWTPKPTEGFIARAAEHYVQRQ-QAGV--
Mvan_0338|M.vanbaalenii_PYR-1 QSAFLLAHTSPASHAKATRELGWHPKPTENFIARAAENYVQRAGAEGAKT
MSMEG_2247|M.smegmatis_MC2_155 TAARLMWWTSPADHSKATRELGWKPAPTADAIARAAQFYVERKNNNEKVI
MAV_1849|M.avium_104 LSVRLMHIMSPMDHSKAERELGWRPEPIHDAIRRAVAFYQTR--------
TH_2143|M.thermoresistible__bu VGLKMAELMSPLDHSKAERELGFKPEPVEDSIAKAARFFLEQHR------
MAB_0718c|M.abscessus_ATCC_199 AAFNKLTVSPAVDITKARTELGYEPRSTETTVNEFVDFLLGSGRL-----
MLBr_01964|M.leprae_Br4923 HANFDEGLRATIDWYRNN-ESWWRP------LKDAVEARYEERGR-----
. . . : * : * : .
Mb0144|M.bovis_AF2122/97 PAAS-
Rv0139|M.tuberculosis_H37Rv PAAS-
MMAR_0349|M.marinum_M TGQSE
MUL_4771|M.ulcerans_Agy99 TGQPE
Mflv_0367|M.gilvum_PYR-GCK -----
Mvan_0338|M.vanbaalenii_PYR-1 SQA--
MSMEG_2247|M.smegmatis_MC2_155 SL---
MAV_1849|M.avium_104 -----
TH_2143|M.thermoresistible__bu -----
MAB_0718c|M.abscessus_ATCC_199 -----
MLBr_01964|M.leprae_Br4923 -----