For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MNAPKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSIDDLPLTRFHGDVFDTATVAEAMAG CDDVYYCVVDTRAWLRDPSPLFRTNVAGLRNVLDVATDASLRRFVFTSSYATVGRRRGHVATEEDRVDTR KVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWGRTPHGAFIAGAVFGRLPFTMRGIRLEAV GVDDAARALILAAERGRNGERYLISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLT GKDTELSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMRTVGKDPAAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0139 | - | - | 100% (340) | POSSIBLE OXIDOREDUCTASE |
| M. tuberculosis H37Rv | Rv3725 | - | 1e-10 | 27.54% (276) | oxidoreductase |
| M. tuberculosis H37Rv | Rv1106c | - | 3e-08 | 23.32% (343) | cholesterol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0144 | - | 0.0 | 99.71% (340) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1108 | - | 1e-121 | 63.40% (347) | NAD-dependent epimerase/dehydratase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 2e-09 | 23.37% (338) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0718c | - | 1e-21 | 28.66% (328) | NAD-dependent epimerase/dehydratase |
| M. marinum M | MMAR_0349 | - | 1e-152 | 81.10% (328) | oxidoreductase |
| M. avium 104 | MAV_5157 | - | 1e-150 | 81.16% (329) | 3-beta hydroxysteroid dehydrogenase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_6474 | - | 1e-128 | 70.43% (328) | nucleoside-diphosphate-sugar epimerase |
| M. thermoresistible (build 8) | TH_2143 | - | 6e-89 | 52.94% (323) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_4771 | - | 1e-152 | 80.79% (328) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5705 | - | 1e-125 | 68.48% (330) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1108|M.gilvum_PYR-GCK ---MSAPVLVIGANGYLGSHVTRKLVAA----GNDVRVMVRDGANTVGID
Mvan_5705|M.vanbaalenii_PYR-1 ---MTA--LVIGANGYLGSHVTRRLVAD----GQDVRVMVREGANTIGID
MSMEG_6474|M.smegmatis_MC2_155 ---MSTS-LVIGANGFLGSHVLRQLVADNT-DGSEIRAMVRPGANTVGID
Rv0139|M.tuberculosis_H37Rv --MN-APKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSID
Mb0144|M.bovis_AF2122/97 --MN-APKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSID
MMAR_0349|M.marinum_M --MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSID
MUL_4771|M.ulcerans_Agy99 --MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSID
MAV_5157|M.avium_104 --MSGKPKLVIGANGFLGSHVTRQLVADGA----QVRAMVRAGANTRGID
TH_2143|M.thermoresistible__bu ---VAKKKLVIGASGFLGSHVTRQLVREGH----DVRVMVRTTSMTRGID
MAB_0718c|M.abscessus_ATCC_199 -----MKTAVTGAAGFIGTNLVNLLVDNGH----EVIAIDRVVPASP-ET
MLBr_00204|M.leprae_Br4923 MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLA
* ** *::*: : *: .
Mflv_1108|M.gilvum_PYR-GCK DLAVTRYVGDIWNTDVLREAMTG--CEVVYYCVVDTRGWLRDPAPLFRTN
Mvan_5705|M.vanbaalenii_PYR-1 DLTVTRFVGDIWDDDVLREAMTG--CDVVYYCVVDTRGWLRDPAPLFRTN
MSMEG_6474|M.smegmatis_MC2_155 DLDVTRFTGDIFDTEVLRAAMTG--CDVVYYCVVDTRGWLRHPAPLFRTN
Rv0139|M.tuberculosis_H37Rv DLPLTRFHGDVFDTATVAEAMAG--CDDVYYCVVDTRAWLRDPSPLFRTN
Mb0144|M.bovis_AF2122/97 DLPLTRFHGDVFDTATVAEAMAG--CDDVYYCVVDTRAWLRDPSPLFRTN
MMAR_0349|M.marinum_M DLPVTRFHGDIFDTAVVREAMQG--CDDVYYCVVDARAWLRDPAPLFHTN
MUL_4771|M.ulcerans_Agy99 DLPVTRFHGDIFDTAVVREAMQG--CDDVYYCVVDARAWLRDPAPLFHTN
MAV_5157|M.avium_104 DLSLTRFHGDVFDTAVLSEAMDG--VDDVYYCVVDTRAWVRDTSPLFRTN
TH_2143|M.thermoresistible__bu DLDVERCHGDVFDDAALRAAMTG--VDDVYYCVVDARMWLRDPAPLFRTN
MAB_0718c|M.abscessus_ATCC_199 REAVTWVSGDVLDPDSMTKALDG--VEVVYHLVAVITLKHED-ELCWRIN
MLBr_00204|M.leprae_Br4923 STPALAFVEADIVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFDAS
: : : *:: .. : .
Mflv_1108|M.gilvum_PYR-GCK VEGTRNVLDVAVEPGIAATLRKFVFTSSCVTVGRTRGRVATEADVISDPA
Mvan_5705|M.vanbaalenii_PYR-1 VEGTRNVLNIAVEPAVAAGLRKFVFTSSYVTVGRRRGRVATEADVIAD--
MSMEG_6474|M.smegmatis_MC2_155 VEGTRHVLDVALEPGIG--LRKFVYTSSYVTVGRRRGCVATEDDVIDL--
Rv0139|M.tuberculosis_H37Rv VAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRGHVATEEDRVDT--
Mb0144|M.bovis_AF2122/97 VAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRGHVATEEDRVDT--
MMAR_0349|M.marinum_M VEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHGHVATEEDRIGS--
MUL_4771|M.ulcerans_Agy99 VEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHGHVATEEDRIGS--
MAV_5157|M.avium_104 VEGLRNVLDVAVTQ---PELRKFIFTSTYATVGRRRGHVATEDDVIGT--
TH_2143|M.thermoresistible__bu VEGLRHVLDAAVE----ADLNRFLFTSTTGTMAINPYRPVTEDDPHNW--
MAB_0718c|M.abscessus_ATCC_199 TEGARTVAQAALT----VGARRMVHCSSIDSYSNSVATIDEKSPRSAA--
MLBr_00204|M.leprae_Br4923 VNVIGTVRLAEAAR--HTGVRKIVHTSSGGSIYGTPSQYPTPETVPTD--
. * .:::. *: :
Mflv_1108|M.gilvum_PYR-GCK DLKSLTPYVRSRVQAENLVMEYARERGLPAVAMCVSTTYGAGDWG--RTP
Mvan_5705|M.vanbaalenii_PYR-1 --RGLTPYVRSRVQAENLVLEYARTRGLPAVAMCVSTTYGAGDWG--RTP
MSMEG_6474|M.smegmatis_MC2_155 --RGVTPYVRSRVQAEELVLRYATERGLPAVAMCVSTTYGSGDWG--RTP
Rv0139|M.tuberculosis_H37Rv --RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWG--RTP
Mb0144|M.bovis_AF2122/97 --RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWG--RTP
MMAR_0349|M.marinum_M --RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWG--RTP
MUL_4771|M.ulcerans_Agy99 --RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWG--RTP
MAV_5157|M.avium_104 --RGLSDYVKSRVQAENLVMRYVAEAGLPAVAMCVSTTYGSGDWG--RTP
TH_2143|M.thermoresistible__bu --TEGGAYIEARVAAEQLVLRYARERGLPAVALCISTTYGPGDWQ--PTP
MAB_0718c|M.abscessus_ATCC_199 --ADLPVYQRSKWGGEVAVRETIAS-GLDAVICNPTGVYGPVDLPN-LSR
MLBr_00204|M.leprae_Br4923 ---PTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYGPRQDPYGEAG
* .: .* : ** . : .** : :
Mflv_1108|M.gilvum_PYR-GCK HGAIIAGAAFGKLP---FVMGGIELEAVGIDDAAQAMLLAARKGRAGERY
Mvan_5705|M.vanbaalenii_PYR-1 HGAIIAGAAFGKLP---FVLGGIELEAVGVEDAAHALLLAAEKGRVGERY
MSMEG_6474|M.smegmatis_MC2_155 HGAVIAGAAFGKLP---FVMSGIDLEAVGVDDAARALILAAESGRPGERY
Rv0139|M.tuberculosis_H37Rv HGAFIAGAVFGRLP---FTMRGIRLEAVGVDDAARALILAAERGRNGERY
Mb0144|M.bovis_AF2122/97 HGAFIAGAVFGRLP---FTMRGIRLEAVGVDDAARALILAAERGHNGERY
MMAR_0349|M.marinum_M HGAFIAGAVFGKLP---FLMNGIKLEVVGVDDAARAMILAAERGRSGQRY
MUL_4771|M.ulcerans_Agy99 HGAFIVGAVFGKLP---FLMNGIKLEVVGVDDAARAMILAAERGRSGQRY
MAV_5157|M.avium_104 HGAFIAGAVFGKLP---FTMEGIQLEVVGVTDAAKAMVLAADRGRVGERY
TH_2143|M.thermoresistible__bu HGRLLAMVATGRFP---FYLG-WSAEVVGIEDAARAMLLAAEQGRVGERY
MAB_0718c|M.abscessus_ATCC_199 INQLLFDSARGRLP---GMVN-SQYDLVDARDVAAGLYLAGEKGRTGENY
MLBr_00204|M.leprae_Br4923 VVAIFVQALLSDRPTKVFGDGTHTRDYVFVDDVVDAFIKASGDAGGGQRF
.: . * : * *.. .: *. . *:.:
Mflv_1108|M.gilvum_PYR-GCK LISEKMISNADVVRIAAEAAGVPAPTKKIPLVLSYAMAALGSAKSRLKGT
Mvan_5705|M.vanbaalenii_PYR-1 LISEKMISNADVVRIAAEAAGVPAPSRTMPLPLSYAMAALGSLKGRLKGT
MSMEG_6474|M.smegmatis_MC2_155 LISEKLISNAEVARIAAEAAGVAPPRRSIPLPVSYLLAAIGTVKGKLRGT
Rv0139|M.tuberculosis_H37Rv LISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGK
Mb0144|M.bovis_AF2122/97 LISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGK
MMAR_0349|M.marinum_M LISERMIALKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGK
MUL_4771|M.ulcerans_Agy99 LISERMVALKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGK
MAV_5157|M.avium_104 LISERMIALKEVVRIAADEAGVPPPRRSISVPTLYALGALGDLRARLTGK
TH_2143|M.thermoresistible__bu IISDRYLHTREVHAIAAEAVGRRAPWFGLPLPVLSVAARGNDLAARLLRR
MAB_0718c|M.abscessus_ATCC_199 LLGGHMGSLLQVCRLAARRAGKRGPRFAVPMGLLNAAIPVIEPIGKLL-K
MLBr_00204|M.leprae_Br4923 NIGTGIETSDRQLHTAVSAAVGGPDDPEFHPPRLGDLKR-----------
:. *. . .
Mflv_1108|M.gilvum_PYR-GCK DERMSLGSLRLMRAEAPVDCSKARRELGWQPRP-VEESIREAAKFWVGLK
Mvan_5705|M.vanbaalenii_PYR-1 DERLSLDSLRLMRAEAPVDCGKAKRELGWQPRP-VEESIREAAKFWVGLR
MSMEG_6474|M.smegmatis_MC2_155 DERLSLRSLRLMRAECELDHSKAVRELGWQPRP-VEESIAEAAKFWVGLR
Rv0139|M.tuberculosis_H37Rv DTELSLASVRMMRSEADVDHGKAVRELGWQPRP-VEESIREAARFWAAMR
Mb0144|M.bovis_AF2122/97 DTELSLASVRMMRSEADVDHGKAVRELGWQPRP-VEESIREAARFWAAMR
MMAR_0349|M.marinum_M DAELSLESVRMMRAEAEVDHAKAVRELGWQPRP-VEESIREAARFWASMR
MUL_4771|M.ulcerans_Agy99 DAELSLESVRMMRAEAEVDHAKAVRELGWQPRP-VEESIREAARFWASMR
MAV_5157|M.avium_104 DAELSLASVRMMRAEAPVDHSKAVRELGWQPRP-VEESIREAARFWAAMR
TH_2143|M.thermoresistible__bu DLMFAHVGLKMAELMSPLDHSKAERELGFKPEP-VEDSIAKAARFFLEQH
MAB_0718c|M.abscessus_ATCC_199 NDALSRAAFNKLTVSPAVDITKARTELGYEPRS-TETTVNEFVDFLLGSG
MLBr_00204|M.leprae_Br4923 ---------------SCLDIGLATTVLGWSPQVQLDDGVRRTVEYFRAAQ
:* * **:.*. : : . . :
Mflv_1108|M.gilvum_PYR-GCK AAKRQRTA----
Mvan_5705|M.vanbaalenii_PYR-1 AAKRAGKAAG--
MSMEG_6474|M.smegmatis_MC2_155 AAKQARRGG---
Rv0139|M.tuberculosis_H37Rv TVGKDPAAS---
Mb0144|M.bovis_AF2122/97 TVGKDPAAS---
MMAR_0349|M.marinum_M KNTQGARTGQSE
MUL_4771|M.ulcerans_Agy99 KNTQGARTGQPE
MAV_5157|M.avium_104 NAKGKSATPR--
TH_2143|M.thermoresistible__bu R-----------
MAB_0718c|M.abscessus_ATCC_199 RL----------
MLBr_00204|M.leprae_Br4923 RS----------