For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. bovis AF2122 / 97 Mb0144 (-)

annotation: putative oxidoreductase
coordinates: 166017 - 167039
length: 340

MNAPKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSIDDLPLTRFHGDVFDTATVAEAMAG
CDDVYYCVVDTRAWLRDPSPLFRTNVAGLRNVLDVATDASLRRFVFTSSYATVGRRRGHVATEEDRVDTR
KVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWGRTPHGAFIAGAVFGRLPFTMRGIRLEAV
GVDDAARALILAAERGHNGERYLISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLT
GKDTELSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMRTVGKDPAAS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0144--100% (340)putative oxidoreductase
M. bovis AF2122 / 97Mb3752-7e-1124.13% (344) putative oxidoreductase
M. bovis AF2122 / 97Mb3497crmlB24e-0829.35% (184) dTDP-glucose 4,6-dehydratase RmlB2

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_1108-1e-12063.11% (347) NAD-dependent epimerase/dehydratase
M. tuberculosis H37RvRv0139-0.099.71% (340) oxidoreductase
M. leprae Br4923MLBr_00204rmlB22e-0923.37% (338) putative sugar-nucleotide dehydratase
M. abscessus ATCC 19977MAB_0718c-5e-2128.35% (328) NAD-dependent epimerase/dehydratase
M. marinum MMMAR_0349-1e-15280.79% (328) oxidoreductase
M. avium 104MAV_5157-1e-14980.85% (329) 3-beta hydroxysteroid dehydrogenase/isomerase family protein
M. smegmatis MC2 155MSMEG_6474-1e-12870.12% (328) nucleoside-diphosphate-sugar epimerase
M. thermoresistible (build 8)TH_2143-2e-8852.63% (323) POSSIBLE OXIDOREDUCTASE
M. ulcerans Agy99MUL_4771-1e-15180.49% (328) oxidoreductase
M. vanbaalenii PYR-1Mvan_5705-1e-12468.18% (330) NAD-dependent epimerase/dehydratase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1108|M.gilvum_PYR-GCK          ---MSAPVLVIGANGYLGSHVTRKLVAA----GNDVRVMVRDGANTVGID
Mvan_5705|M.vanbaalenii_PYR-1       ---MTA--LVIGANGYLGSHVTRRLVAD----GQDVRVMVREGANTIGID
MSMEG_6474|M.smegmatis_MC2_155      ---MSTS-LVIGANGFLGSHVLRQLVADNT-DGSEIRAMVRPGANTVGID
Mb0144|M.bovis_AF2122/97            --MN-APKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSID
Rv0139|M.tuberculosis_H37Rv         --MN-APKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSID
MMAR_0349|M.marinum_M               --MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSID
MUL_4771|M.ulcerans_Agy99           --MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSID
MAV_5157|M.avium_104                --MSGKPKLVIGANGFLGSHVTRQLVADGA----QVRAMVRAGANTRGID
TH_2143|M.thermoresistible__bu      ---VAKKKLVIGASGFLGSHVTRQLVREGH----DVRVMVRTTSMTRGID
MAB_0718c|M.abscessus_ATCC_199      -----MKTAVTGAAGFIGTNLVNLLVDNGH----EVIAIDRVVPASP-ET
MLBr_00204|M.leprae_Br4923          MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLA
                                             * ** *::*: :   *:                 .      

Mflv_1108|M.gilvum_PYR-GCK          DLAVTRYVGDIWNTDVLREAMTG--CEVVYYCVVDTRGWLRDPAPLFRTN
Mvan_5705|M.vanbaalenii_PYR-1       DLTVTRFVGDIWDDDVLREAMTG--CDVVYYCVVDTRGWLRDPAPLFRTN
MSMEG_6474|M.smegmatis_MC2_155      DLDVTRFTGDIFDTEVLRAAMTG--CDVVYYCVVDTRGWLRHPAPLFRTN
Mb0144|M.bovis_AF2122/97            DLPLTRFHGDVFDTATVAEAMAG--CDDVYYCVVDTRAWLRDPSPLFRTN
Rv0139|M.tuberculosis_H37Rv         DLPLTRFHGDVFDTATVAEAMAG--CDDVYYCVVDTRAWLRDPSPLFRTN
MMAR_0349|M.marinum_M               DLPVTRFHGDIFDTAVVREAMQG--CDDVYYCVVDARAWLRDPAPLFHTN
MUL_4771|M.ulcerans_Agy99           DLPVTRFHGDIFDTAVVREAMQG--CDDVYYCVVDARAWLRDPAPLFHTN
MAV_5157|M.avium_104                DLSLTRFHGDVFDTAVLSEAMDG--VDDVYYCVVDTRAWVRDTSPLFRTN
TH_2143|M.thermoresistible__bu      DLDVERCHGDVFDDAALRAAMTG--VDDVYYCVVDARMWLRDPAPLFRTN
MAB_0718c|M.abscessus_ATCC_199      REAVTWVSGDVLDPDSMTKALDG--VEVVYHLVAVITLKHED-ELCWRIN
MLBr_00204|M.leprae_Br4923          STPALAFVEADIVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFDAS
                                                    :   :     : *:: ..            :  .

Mflv_1108|M.gilvum_PYR-GCK          VEGTRNVLDVAVEPGIAATLRKFVFTSSCVTVGRTRGRVATEADVISDPA
Mvan_5705|M.vanbaalenii_PYR-1       VEGTRNVLNIAVEPAVAAGLRKFVFTSSYVTVGRRRGRVATEADVIAD--
MSMEG_6474|M.smegmatis_MC2_155      VEGTRHVLDVALEPGIG--LRKFVYTSSYVTVGRRRGCVATEDDVIDL--
Mb0144|M.bovis_AF2122/97            VAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRGHVATEEDRVDT--
Rv0139|M.tuberculosis_H37Rv         VAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRGHVATEEDRVDT--
MMAR_0349|M.marinum_M               VEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHGHVATEEDRIGS--
MUL_4771|M.ulcerans_Agy99           VEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHGHVATEEDRIGS--
MAV_5157|M.avium_104                VEGLRNVLDVAVTQ---PELRKFIFTSTYATVGRRRGHVATEDDVIGT--
TH_2143|M.thermoresistible__bu      VEGLRHVLDAAVE----ADLNRFLFTSTTGTMAINPYRPVTEDDPHNW--
MAB_0718c|M.abscessus_ATCC_199      TEGARTVAQAALT----VGARRMVHCSSIDSYSNSVATIDEKSPRSAA--
MLBr_00204|M.leprae_Br4923          VNVIGTVRLAEAAR--HTGVRKIVHTSSGGSIYGTPSQYPTPETVPTD--
                                    .     *             .:::. *:  :                   

Mflv_1108|M.gilvum_PYR-GCK          DLKSLTPYVRSRVQAENLVMEYARERGLPAVAMCVSTTYGAGDWG--RTP
Mvan_5705|M.vanbaalenii_PYR-1       --RGLTPYVRSRVQAENLVLEYARTRGLPAVAMCVSTTYGAGDWG--RTP
MSMEG_6474|M.smegmatis_MC2_155      --RGVTPYVRSRVQAEELVLRYATERGLPAVAMCVSTTYGSGDWG--RTP
Mb0144|M.bovis_AF2122/97            --RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWG--RTP
Rv0139|M.tuberculosis_H37Rv         --RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWG--RTP
MMAR_0349|M.marinum_M               --RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWG--RTP
MUL_4771|M.ulcerans_Agy99           --RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWG--RTP
MAV_5157|M.avium_104                --RGLSDYVKSRVQAENLVMRYVAEAGLPAVAMCVSTTYGSGDWG--RTP
TH_2143|M.thermoresistible__bu      --TEGGAYIEARVAAEQLVLRYARERGLPAVALCISTTYGPGDWQ--PTP
MAB_0718c|M.abscessus_ATCC_199      --ADLPVYQRSKWGGEVAVRETIAS-GLDAVICNPTGVYGPVDLPN-LSR
MLBr_00204|M.leprae_Br4923          ---PTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYGPRQDPYGEAG
                                           *  .:  .*  :       ** .     : .**  :     : 

Mflv_1108|M.gilvum_PYR-GCK          HGAIIAGAAFGKLP---FVMGGIELEAVGIDDAAQAMLLAARKGRAGERY
Mvan_5705|M.vanbaalenii_PYR-1       HGAIIAGAAFGKLP---FVLGGIELEAVGVEDAAHALLLAAEKGRVGERY
MSMEG_6474|M.smegmatis_MC2_155      HGAVIAGAAFGKLP---FVMSGIDLEAVGVDDAARALILAAESGRPGERY
Mb0144|M.bovis_AF2122/97            HGAFIAGAVFGRLP---FTMRGIRLEAVGVDDAARALILAAERGHNGERY
Rv0139|M.tuberculosis_H37Rv         HGAFIAGAVFGRLP---FTMRGIRLEAVGVDDAARALILAAERGRNGERY
MMAR_0349|M.marinum_M               HGAFIAGAVFGKLP---FLMNGIKLEVVGVDDAARAMILAAERGRSGQRY
MUL_4771|M.ulcerans_Agy99           HGAFIVGAVFGKLP---FLMNGIKLEVVGVDDAARAMILAAERGRSGQRY
MAV_5157|M.avium_104                HGAFIAGAVFGKLP---FTMEGIQLEVVGVTDAAKAMVLAADRGRVGERY
TH_2143|M.thermoresistible__bu      HGRLLAMVATGRFP---FYLG-WSAEVVGIEDAARAMLLAAEQGRVGERY
MAB_0718c|M.abscessus_ATCC_199      INQLLFDSARGRLP---GMVN-SQYDLVDARDVAAGLYLAGEKGRTGENY
MLBr_00204|M.leprae_Br4923          VVAIFVQALLSDRPTKVFGDGTHTRDYVFVDDVVDAFIKASGDAGGGQRF
                                       .:     .  *           : *   *.. .:  *.  .  *:.:

Mflv_1108|M.gilvum_PYR-GCK          LISEKMISNADVVRIAAEAAGVPAPTKKIPLVLSYAMAALGSAKSRLKGT
Mvan_5705|M.vanbaalenii_PYR-1       LISEKMISNADVVRIAAEAAGVPAPSRTMPLPLSYAMAALGSLKGRLKGT
MSMEG_6474|M.smegmatis_MC2_155      LISEKLISNAEVARIAAEAAGVAPPRRSIPLPVSYLLAAIGTVKGKLRGT
Mb0144|M.bovis_AF2122/97            LISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGK
Rv0139|M.tuberculosis_H37Rv         LISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGK
MMAR_0349|M.marinum_M               LISERMIALKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGK
MUL_4771|M.ulcerans_Agy99           LISERMVALKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGK
MAV_5157|M.avium_104                LISERMIALKEVVRIAADEAGVPPPRRSISVPTLYALGALGDLRARLTGK
TH_2143|M.thermoresistible__bu      IISDRYLHTREVHAIAAEAVGRRAPWFGLPLPVLSVAARGNDLAARLLRR
MAB_0718c|M.abscessus_ATCC_199      LLGGHMGSLLQVCRLAARRAGKRGPRFAVPMGLLNAAIPVIEPIGKLL-K
MLBr_00204|M.leprae_Br4923          NIGTGIETSDRQLHTAVSAAVGGPDDPEFHPPRLGDLKR-----------
                                     :.            *.  .        .                     

Mflv_1108|M.gilvum_PYR-GCK          DERMSLGSLRLMRAEAPVDCSKARRELGWQPRP-VEESIREAAKFWVGLK
Mvan_5705|M.vanbaalenii_PYR-1       DERLSLDSLRLMRAEAPVDCGKAKRELGWQPRP-VEESIREAAKFWVGLR
MSMEG_6474|M.smegmatis_MC2_155      DERLSLRSLRLMRAECELDHSKAVRELGWQPRP-VEESIAEAAKFWVGLR
Mb0144|M.bovis_AF2122/97            DTELSLASVRMMRSEADVDHGKAVRELGWQPRP-VEESIREAARFWAAMR
Rv0139|M.tuberculosis_H37Rv         DTELSLASVRMMRSEADVDHGKAVRELGWQPRP-VEESIREAARFWAAMR
MMAR_0349|M.marinum_M               DAELSLESVRMMRAEAEVDHAKAVRELGWQPRP-VEESIREAARFWASMR
MUL_4771|M.ulcerans_Agy99           DAELSLESVRMMRAEAEVDHAKAVRELGWQPRP-VEESIREAARFWASMR
MAV_5157|M.avium_104                DAELSLASVRMMRAEAPVDHSKAVRELGWQPRP-VEESIREAARFWAAMR
TH_2143|M.thermoresistible__bu      DLMFAHVGLKMAELMSPLDHSKAERELGFKPEP-VEDSIAKAARFFLEQH
MAB_0718c|M.abscessus_ATCC_199      NDALSRAAFNKLTVSPAVDITKARTELGYEPRS-TETTVNEFVDFLLGSG
MLBr_00204|M.leprae_Br4923          ---------------SCLDIGLATTVLGWSPQVQLDDGVRRTVEYFRAAQ
                                                     :*   *   **:.*.   :  : . . :     

Mflv_1108|M.gilvum_PYR-GCK          AAKRQRTA----
Mvan_5705|M.vanbaalenii_PYR-1       AAKRAGKAAG--
MSMEG_6474|M.smegmatis_MC2_155      AAKQARRGG---
Mb0144|M.bovis_AF2122/97            TVGKDPAAS---
Rv0139|M.tuberculosis_H37Rv         TVGKDPAAS---
MMAR_0349|M.marinum_M               KNTQGARTGQSE
MUL_4771|M.ulcerans_Agy99           KNTQGARTGQPE
MAV_5157|M.avium_104                NAKGKSATPR--
TH_2143|M.thermoresistible__bu      R-----------
MAB_0718c|M.abscessus_ATCC_199      RL----------
MLBr_00204|M.leprae_Br4923          RS----------