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MNAPKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSIDDLPLTRFHGDVFDTATVAEAMAG CDDVYYCVVDTRAWLRDPSPLFRTNVAGLRNVLDVATDASLRRFVFTSSYATVGRRRGHVATEEDRVDTR KVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWGRTPHGAFIAGAVFGRLPFTMRGIRLEAV GVDDAARALILAAERGHNGERYLISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLT GKDTELSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMRTVGKDPAAS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0144 | - | - | 100% (340) | putative oxidoreductase |
M. bovis AF2122 / 97 | Mb3752 | - | 7e-11 | 24.13% (344) | putative oxidoreductase |
M. bovis AF2122 / 97 | Mb3497c | rmlB2 | 4e-08 | 29.35% (184) | dTDP-glucose 4,6-dehydratase RmlB2 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_1108 | - | 1e-120 | 63.11% (347) | NAD-dependent epimerase/dehydratase |
M. tuberculosis H37Rv | Rv0139 | - | 0.0 | 99.71% (340) | oxidoreductase |
M. leprae Br4923 | MLBr_00204 | rmlB2 | 2e-09 | 23.37% (338) | putative sugar-nucleotide dehydratase |
M. abscessus ATCC 19977 | MAB_0718c | - | 5e-21 | 28.35% (328) | NAD-dependent epimerase/dehydratase |
M. marinum M | MMAR_0349 | - | 1e-152 | 80.79% (328) | oxidoreductase |
M. avium 104 | MAV_5157 | - | 1e-149 | 80.85% (329) | 3-beta hydroxysteroid dehydrogenase/isomerase family protein |
M. smegmatis MC2 155 | MSMEG_6474 | - | 1e-128 | 70.12% (328) | nucleoside-diphosphate-sugar epimerase |
M. thermoresistible (build 8) | TH_2143 | - | 2e-88 | 52.63% (323) | POSSIBLE OXIDOREDUCTASE |
M. ulcerans Agy99 | MUL_4771 | - | 1e-151 | 80.49% (328) | oxidoreductase |
M. vanbaalenii PYR-1 | Mvan_5705 | - | 1e-124 | 68.18% (330) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_1108|M.gilvum_PYR-GCK ---MSAPVLVIGANGYLGSHVTRKLVAA----GNDVRVMVRDGANTVGID Mvan_5705|M.vanbaalenii_PYR-1 ---MTA--LVIGANGYLGSHVTRRLVAD----GQDVRVMVREGANTIGID MSMEG_6474|M.smegmatis_MC2_155 ---MSTS-LVIGANGFLGSHVLRQLVADNT-DGSEIRAMVRPGANTVGID Mb0144|M.bovis_AF2122/97 --MN-APKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSID Rv0139|M.tuberculosis_H37Rv --MN-APKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSID MMAR_0349|M.marinum_M --MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSID MUL_4771|M.ulcerans_Agy99 --MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSID MAV_5157|M.avium_104 --MSGKPKLVIGANGFLGSHVTRQLVADGA----QVRAMVRAGANTRGID TH_2143|M.thermoresistible__bu ---VAKKKLVIGASGFLGSHVTRQLVREGH----DVRVMVRTTSMTRGID MAB_0718c|M.abscessus_ATCC_199 -----MKTAVTGAAGFIGTNLVNLLVDNGH----EVIAIDRVVPASP-ET MLBr_00204|M.leprae_Br4923 MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLA * ** *::*: : *: . Mflv_1108|M.gilvum_PYR-GCK DLAVTRYVGDIWNTDVLREAMTG--CEVVYYCVVDTRGWLRDPAPLFRTN Mvan_5705|M.vanbaalenii_PYR-1 DLTVTRFVGDIWDDDVLREAMTG--CDVVYYCVVDTRGWLRDPAPLFRTN MSMEG_6474|M.smegmatis_MC2_155 DLDVTRFTGDIFDTEVLRAAMTG--CDVVYYCVVDTRGWLRHPAPLFRTN Mb0144|M.bovis_AF2122/97 DLPLTRFHGDVFDTATVAEAMAG--CDDVYYCVVDTRAWLRDPSPLFRTN Rv0139|M.tuberculosis_H37Rv DLPLTRFHGDVFDTATVAEAMAG--CDDVYYCVVDTRAWLRDPSPLFRTN MMAR_0349|M.marinum_M DLPVTRFHGDIFDTAVVREAMQG--CDDVYYCVVDARAWLRDPAPLFHTN MUL_4771|M.ulcerans_Agy99 DLPVTRFHGDIFDTAVVREAMQG--CDDVYYCVVDARAWLRDPAPLFHTN MAV_5157|M.avium_104 DLSLTRFHGDVFDTAVLSEAMDG--VDDVYYCVVDTRAWVRDTSPLFRTN TH_2143|M.thermoresistible__bu DLDVERCHGDVFDDAALRAAMTG--VDDVYYCVVDARMWLRDPAPLFRTN MAB_0718c|M.abscessus_ATCC_199 REAVTWVSGDVLDPDSMTKALDG--VEVVYHLVAVITLKHED-ELCWRIN MLBr_00204|M.leprae_Br4923 STPALAFVEADIVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFDAS : : : *:: .. : . Mflv_1108|M.gilvum_PYR-GCK VEGTRNVLDVAVEPGIAATLRKFVFTSSCVTVGRTRGRVATEADVISDPA Mvan_5705|M.vanbaalenii_PYR-1 VEGTRNVLNIAVEPAVAAGLRKFVFTSSYVTVGRRRGRVATEADVIAD-- MSMEG_6474|M.smegmatis_MC2_155 VEGTRHVLDVALEPGIG--LRKFVYTSSYVTVGRRRGCVATEDDVIDL-- Mb0144|M.bovis_AF2122/97 VAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRGHVATEEDRVDT-- Rv0139|M.tuberculosis_H37Rv VAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRGHVATEEDRVDT-- MMAR_0349|M.marinum_M VEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHGHVATEEDRIGS-- MUL_4771|M.ulcerans_Agy99 VEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHGHVATEEDRIGS-- MAV_5157|M.avium_104 VEGLRNVLDVAVTQ---PELRKFIFTSTYATVGRRRGHVATEDDVIGT-- TH_2143|M.thermoresistible__bu VEGLRHVLDAAVE----ADLNRFLFTSTTGTMAINPYRPVTEDDPHNW-- MAB_0718c|M.abscessus_ATCC_199 TEGARTVAQAALT----VGARRMVHCSSIDSYSNSVATIDEKSPRSAA-- MLBr_00204|M.leprae_Br4923 VNVIGTVRLAEAAR--HTGVRKIVHTSSGGSIYGTPSQYPTPETVPTD-- . * .:::. *: : Mflv_1108|M.gilvum_PYR-GCK DLKSLTPYVRSRVQAENLVMEYARERGLPAVAMCVSTTYGAGDWG--RTP Mvan_5705|M.vanbaalenii_PYR-1 --RGLTPYVRSRVQAENLVLEYARTRGLPAVAMCVSTTYGAGDWG--RTP MSMEG_6474|M.smegmatis_MC2_155 --RGVTPYVRSRVQAEELVLRYATERGLPAVAMCVSTTYGSGDWG--RTP Mb0144|M.bovis_AF2122/97 --RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWG--RTP Rv0139|M.tuberculosis_H37Rv --RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWG--RTP MMAR_0349|M.marinum_M --RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWG--RTP MUL_4771|M.ulcerans_Agy99 --RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWG--RTP MAV_5157|M.avium_104 --RGLSDYVKSRVQAENLVMRYVAEAGLPAVAMCVSTTYGSGDWG--RTP TH_2143|M.thermoresistible__bu --TEGGAYIEARVAAEQLVLRYARERGLPAVALCISTTYGPGDWQ--PTP MAB_0718c|M.abscessus_ATCC_199 --ADLPVYQRSKWGGEVAVRETIAS-GLDAVICNPTGVYGPVDLPN-LSR MLBr_00204|M.leprae_Br4923 ---PTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYGPRQDPYGEAG * .: .* : ** . : .** : : Mflv_1108|M.gilvum_PYR-GCK HGAIIAGAAFGKLP---FVMGGIELEAVGIDDAAQAMLLAARKGRAGERY Mvan_5705|M.vanbaalenii_PYR-1 HGAIIAGAAFGKLP---FVLGGIELEAVGVEDAAHALLLAAEKGRVGERY MSMEG_6474|M.smegmatis_MC2_155 HGAVIAGAAFGKLP---FVMSGIDLEAVGVDDAARALILAAESGRPGERY Mb0144|M.bovis_AF2122/97 HGAFIAGAVFGRLP---FTMRGIRLEAVGVDDAARALILAAERGHNGERY Rv0139|M.tuberculosis_H37Rv HGAFIAGAVFGRLP---FTMRGIRLEAVGVDDAARALILAAERGRNGERY MMAR_0349|M.marinum_M HGAFIAGAVFGKLP---FLMNGIKLEVVGVDDAARAMILAAERGRSGQRY MUL_4771|M.ulcerans_Agy99 HGAFIVGAVFGKLP---FLMNGIKLEVVGVDDAARAMILAAERGRSGQRY MAV_5157|M.avium_104 HGAFIAGAVFGKLP---FTMEGIQLEVVGVTDAAKAMVLAADRGRVGERY TH_2143|M.thermoresistible__bu HGRLLAMVATGRFP---FYLG-WSAEVVGIEDAARAMLLAAEQGRVGERY MAB_0718c|M.abscessus_ATCC_199 INQLLFDSARGRLP---GMVN-SQYDLVDARDVAAGLYLAGEKGRTGENY MLBr_00204|M.leprae_Br4923 VVAIFVQALLSDRPTKVFGDGTHTRDYVFVDDVVDAFIKASGDAGGGQRF .: . * : * *.. .: *. . *:.: Mflv_1108|M.gilvum_PYR-GCK LISEKMISNADVVRIAAEAAGVPAPTKKIPLVLSYAMAALGSAKSRLKGT Mvan_5705|M.vanbaalenii_PYR-1 LISEKMISNADVVRIAAEAAGVPAPSRTMPLPLSYAMAALGSLKGRLKGT MSMEG_6474|M.smegmatis_MC2_155 LISEKLISNAEVARIAAEAAGVAPPRRSIPLPVSYLLAAIGTVKGKLRGT Mb0144|M.bovis_AF2122/97 LISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGK Rv0139|M.tuberculosis_H37Rv LISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGK MMAR_0349|M.marinum_M LISERMIALKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGK MUL_4771|M.ulcerans_Agy99 LISERMVALKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGK MAV_5157|M.avium_104 LISERMIALKEVVRIAADEAGVPPPRRSISVPTLYALGALGDLRARLTGK TH_2143|M.thermoresistible__bu IISDRYLHTREVHAIAAEAVGRRAPWFGLPLPVLSVAARGNDLAARLLRR MAB_0718c|M.abscessus_ATCC_199 LLGGHMGSLLQVCRLAARRAGKRGPRFAVPMGLLNAAIPVIEPIGKLL-K MLBr_00204|M.leprae_Br4923 NIGTGIETSDRQLHTAVSAAVGGPDDPEFHPPRLGDLKR----------- :. *. . . Mflv_1108|M.gilvum_PYR-GCK DERMSLGSLRLMRAEAPVDCSKARRELGWQPRP-VEESIREAAKFWVGLK Mvan_5705|M.vanbaalenii_PYR-1 DERLSLDSLRLMRAEAPVDCGKAKRELGWQPRP-VEESIREAAKFWVGLR MSMEG_6474|M.smegmatis_MC2_155 DERLSLRSLRLMRAECELDHSKAVRELGWQPRP-VEESIAEAAKFWVGLR Mb0144|M.bovis_AF2122/97 DTELSLASVRMMRSEADVDHGKAVRELGWQPRP-VEESIREAARFWAAMR Rv0139|M.tuberculosis_H37Rv DTELSLASVRMMRSEADVDHGKAVRELGWQPRP-VEESIREAARFWAAMR MMAR_0349|M.marinum_M DAELSLESVRMMRAEAEVDHAKAVRELGWQPRP-VEESIREAARFWASMR MUL_4771|M.ulcerans_Agy99 DAELSLESVRMMRAEAEVDHAKAVRELGWQPRP-VEESIREAARFWASMR MAV_5157|M.avium_104 DAELSLASVRMMRAEAPVDHSKAVRELGWQPRP-VEESIREAARFWAAMR TH_2143|M.thermoresistible__bu DLMFAHVGLKMAELMSPLDHSKAERELGFKPEP-VEDSIAKAARFFLEQH MAB_0718c|M.abscessus_ATCC_199 NDALSRAAFNKLTVSPAVDITKARTELGYEPRS-TETTVNEFVDFLLGSG MLBr_00204|M.leprae_Br4923 ---------------SCLDIGLATTVLGWSPQVQLDDGVRRTVEYFRAAQ :* * **:.*. : : . . : Mflv_1108|M.gilvum_PYR-GCK AAKRQRTA---- Mvan_5705|M.vanbaalenii_PYR-1 AAKRAGKAAG-- MSMEG_6474|M.smegmatis_MC2_155 AAKQARRGG--- Mb0144|M.bovis_AF2122/97 TVGKDPAAS--- Rv0139|M.tuberculosis_H37Rv TVGKDPAAS--- MMAR_0349|M.marinum_M KNTQGARTGQSE MUL_4771|M.ulcerans_Agy99 KNTQGARTGQPE MAV_5157|M.avium_104 NAKGKSATPR-- TH_2143|M.thermoresistible__bu R----------- MAB_0718c|M.abscessus_ATCC_199 RL---------- MLBr_00204|M.leprae_Br4923 RS----------