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AVQDAATRAGGRPPLITVADIVSAGRELGMNRLSINAVATRLGVSATALYRHIGGRWQLERLVGESLLAD LELTDAGDTIEEHLLAFGTTLHGFALQNPGLARYMQLLFPRGEAGARLLSDEVAILGRRGYTAEAAALLS SSVALIAIGMAAQHEMKAEASHSDEGYDRERDAAAQRLAADAELGPVHSAGMQLTAEKYLELLLNAVIRG LLTAAQAGRSIGDIVAELTNTGEDR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6555 | - | - | 100% (236) | transcriptional regulator, TetR family protein, putative |
| M. smegmatis MC2 155 | MSMEG_0561 | - | 3e-07 | 26.91% (223) | putative TetR family protein receptor protein |
| M. smegmatis MC2 155 | MSMEG_2583 | - | 1e-05 | 24.39% (123) | putative transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0700 | - | 8e-05 | 29.91% (117) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0013 | - | 8e-07 | 26.54% (211) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0681 | - | 8e-05 | 29.91% (117) | TetR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4320c | - | 2e-05 | 37.50% (80) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3679 | - | 5e-08 | 26.74% (187) | putative regulatory protein |
| M. avium 104 | MAV_5055 | - | 9e-06 | 29.50% (139) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1893 | - | 2e-05 | 28.38% (148) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY |
| M. ulcerans Agy99 | MUL_3622 | - | 1e-07 | 26.46% (189) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_5480 | - | 4e-07 | 28.69% (122) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3679|M.marinum_M ----------------MFTLRTMYLSTVWEGDVRARFTVSDIASAALAIV
MUL_3622|M.ulcerans_Agy99 --------MISIRTSYVFTLRTMYLSTVWEGDVRARFTVSDIASAALAIV
Mb0700|M.bovis_AF2122/97 ------------------------------MARPAKLSRESIVEGALTFL
Rv0681|M.tuberculosis_H37Rv ------------------------------MARPAKLSRESIVEGALTFL
TH_1893|M.thermoresistible__bu -----------VNTQMSAGPGGAPGARTKSPARAGRLSRDTIVNAALTFL
Mvan_5480|M.vanbaalenii_PYR-1 ---------------------MARTRRAGAALPYGALDRDHLVKHLLELA
MAB_4320c|M.abscessus_ATCC_199 --------------MQRDRESDDTARRGRGRPSVGVLNRDRIVDAALAEL
MAV_5055|M.avium_104 -------------------------------MRRAGLKREAVVRAAVKIA
MSMEG_6555|M.smegmatis_MC2_155 ------------------------MAVQDAATRAGGRPPLITVADIVSAG
Mflv_0013|M.gilvum_PYR-GCK MAVRKKPTRARGAGRSVRVCRMAASVGVRDARRRPKDRKQQIARASAEAF
.
MMAR_3679|M.marinum_M DQDGLSGLSMRSLAAALGTGPMTLYNYVR----DRRELEALVADAVVADV
MUL_3622|M.ulcerans_Agy99 DQDGLSGLSMRSLAAALGTGPMTLYNYVR----DRRELEALVADAVVADV
Mb0700|M.bovis_AF2122/97 DREGWDSLTINALATQLGTKGPSLYNHVDSLEDLRRAVRIRVIDDIITML
Rv0681|M.tuberculosis_H37Rv DREGWDSLTINALATQLGTKGPSLYNHVDSLEDLRRAVRIRVIDDIITML
TH_1893|M.thermoresistible__bu DREGWDALTINALATQLGTKGPSLYNHVQSLDDLRRSVRMRVVDDIIGML
Mvan_5480|M.vanbaalenii_PYR-1 RRVGVENVTMRALATEAGTSASSVYYHVK----DKAALLDLLAESVIESI
MAB_4320c|M.abscessus_ATCC_199 RASGLRKLTMRAVAVRLGVTVAALYNHVP----SRAGLLVAVQERFTAGL
MAV_5055|M.avium_104 DAEGIEAISMRRVSQALGVTPMALYRYLP----DKDALIDVVVDESLAVV
MSMEG_6555|M.smegmatis_MC2_155 RELGMNRLSINAVATRLGVSATALYRHIG----GRWQLERLVGESLLADL
Mflv_0013|M.gilvum_PYR-GCK SELGYHAVSMEDIASRVGVTAASLYRHYSGKYDLFRAAVLNLGEQLVSAT
* :::. :: *. ::* : : :
MMAR_3679|M.marinum_M KVPAPTD--DWRADVHAIATAMWETMRQHP------NAIPLVLTR-----
MUL_3622|M.ulcerans_Agy99 KVPAPID--DWRADVHAIATAMWETMRQHP------NAIPLVLTR-----
Mb0700|M.bovis_AF2122/97 NRVGAGR--ARDDAVLVMAGAYRSYAHHHPGRYSAFTRMPLGGDD-----
Rv0681|M.tuberculosis_H37Rv NRVGAGR--ARDDAVLVMAGAYRSYAHHHPGRYSAFTRMPLGGDD-----
TH_1893|M.thermoresistible__bu NAAGQGR--TRDDAVLAMASAYRSYAHHHPGRYSAFTRMPLGGDD-----
Mvan_5480|M.vanbaalenii_PYR-1 EVPTEG---DWEQRTRALYTNAWKVMIAIP-------GIAAMLQQ-----
MAB_4320c|M.abscessus_ATCC_199 DVSGFGVV-PLREALSRWAWSYLDQLRRRP------ELVPLIVEV-----
MAV_5055|M.avium_104 PVPDPSG--SVTAELLRCFGGLYDLLLDHP-------GLARAAGE-----
MSMEG_6555|M.smegmatis_MC2_155 ELTDAGD--TIEEHLLAFGTTLHGFALQNP-------GLARYMQL-----
Mflv_0013|M.gilvum_PYR-GCK AFADDESGDSPEELWERIVAALADAAIKTRASGGLYRWEARFLQESDQAI
.
MMAR_3679|M.marinum_M --------------------RTVSASSY-MVADRLIAALG-----RSGVG
MUL_3622|M.ulcerans_Agy99 --------------------RTVWASSY-MVADRLIAALG-----RSGVG
Mb0700|M.bovis_AF2122/97 --------------------PEYTAATR-GAAAPVIAVLS-----SYGLD
Rv0681|M.tuberculosis_H37Rv --------------------PEYTAATR-GAAAPVIAVLS-----SYGLD
TH_1893|M.thermoresistible__bu --------------------PEFSAAAR-AAAGPVIAVLG-----SYGLE
Mvan_5480|M.vanbaalenii_PYR-1 --------------------RPLTGAAD-AVDRTVKAIMA-----ESGWT
MAB_4320c|M.abscessus_ATCC_199 --------------------PLAQAPLTSGMYQRVTAGFA-----AAGWP
MAV_5055|M.avium_104 --------------------RPLEGPFATRLGNNVLTLLQ-----HNKID
MSMEG_6555|M.smegmatis_MC2_155 --------------------LFPRGEAGARLLSDEVAILG-----RRGYT
Mflv_0013|M.gilvum_PYR-GCK SNEQIRLVNRRLQRPLSALRPELDSRQRWTVTASVLSAIGSICDHRAKLP
. : :
MMAR_3679|M.marinum_M DADLLASFRGVLGLVMGSAQA-----ELAGPLAGTGREKEQ-VAVAARIG
MUL_3622|M.ulcerans_Agy99 DADLLASFRGVLGLVMGSAQA-----ELAGPLAGTGREKEQ-VAVAARIG
Mb0700|M.bovis_AF2122/97 GEQAFYAALEFWSALHGFVLL-----EMTGVMDDIDTDAVF-TDMVLRLA
Rv0681|M.tuberculosis_H37Rv GEQAFYAALEFWSALHGFVLL-----EMTGVMDDIDTDAVF-TDMVLRLA
TH_1893|M.thermoresistible__bu GEEAFYAALEFWSALHGFVLL-----EMTGVMDDVDSDKVF-TDMVLRLA
Mvan_5480|M.vanbaalenii_PYR-1 ADEVAAAHVVLYIHLLGSVQL-----EHHLRHSGIEIKSDDGAESVFQHG
MAB_4320c|M.abscessus_ATCC_199 EESIIASMSILETFIFGAAVD-----SPGPTDVYAPYDPANAPQMGRVYE
MAV_5055|M.avium_104 EADAANLLVSAFSLTLGCALY-----RTSRSGRTASSRLSQVGDEAPAVR
MSMEG_6555|M.smegmatis_MC2_155 AEAAALLSSSVALIAIGMAAQHEMKAEASHSDEGYDRERDAAAQRLAADA
Mflv_0013|M.gilvum_PYR-GCK VNDMRRLLVSLARRLRDADLPPVSAREKPGRRAAPSVGPAGEYEAILAAA
.
MMAR_3679|M.marinum_M G---LAGAEHPHIAALAQASQRSTPAADFERALDILLAGIESFERRRDRR
MUL_3622|M.ulcerans_Agy99 G---LAGAEHPHIAALAQASQRSTPAADFERALDILLAGIESFERRRDRR
Mb0700|M.bovis_AF2122/97 -----AGMERRTTHGGTAST------------------------------
Rv0681|M.tuberculosis_H37Rv -----AGMERRTTHGGTAST------------------------------
TH_1893|M.thermoresistible__bu -----AGMEKRS--------------------------------------
Mvan_5480|M.vanbaalenii_PYR-1 LRVILAGLRSCHTETSTPTT------------------------------
MAB_4320c|M.abscessus_ATCC_199 AFARSVRERQTRAHDLVFTMGLDAALIGLHHIWGTGRGWAGVRLPVQRQ-
MAV_5055|M.avium_104 ------RLRGRLTVASADDTVFRDALTRLIAGYVTTAAKTGGRRR-----
MSMEG_6555|M.smegmatis_MC2_155 ELGPVHSAGMQLTAEKYLELLLNAVIRGLLTAAQAGRSIGDIVAELTNTG
Mflv_0013|M.gilvum_PYR-GCK LR-LFHEHGFRETGMDDIASAIGLPASTIYRYFSGKSAVLSTIYRRAADR
MMAR_3679|M.marinum_M --------------------------------------------------
MUL_3622|M.ulcerans_Agy99 --------------------------------------------------
Mb0700|M.bovis_AF2122/97 --------------------------------------------------
Rv0681|M.tuberculosis_H37Rv --------------------------------------------------
TH_1893|M.thermoresistible__bu --------------------------------------------------
Mvan_5480|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4320c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_5055|M.avium_104 --------------------------------------------------
MSMEG_6555|M.smegmatis_MC2_155 EDR-----------------------------------------------
Mflv_0013|M.gilvum_PYR-GCK VSGDMGAILAMAPDERTAVGQLIDAYVWRTFAEPELAYVYYAEQLNVPAE
MMAR_3679|M.marinum_M --------------------------------------------------
MUL_3622|M.ulcerans_Agy99 --------------------------------------------------
Mb0700|M.bovis_AF2122/97 --------------------------------------------------
Rv0681|M.tuberculosis_H37Rv --------------------------------------------------
TH_1893|M.thermoresistible__bu --------------------------------------------------
Mvan_5480|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4320c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_5055|M.avium_104 --------------------------------------------------
MSMEG_6555|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0013|M.gilvum_PYR-GCK DRAALHNIQRSIVEGWARQVVAARPDLSVREARFAVHAGLGLVVDIGRLE
MMAR_3679|M.marinum_M -------------------------
MUL_3622|M.ulcerans_Agy99 -------------------------
Mb0700|M.bovis_AF2122/97 -------------------------
Rv0681|M.tuberculosis_H37Rv -------------------------
TH_1893|M.thermoresistible__bu -------------------------
Mvan_5480|M.vanbaalenii_PYR-1 -------------------------
MAB_4320c|M.abscessus_ATCC_199 -------------------------
MAV_5055|M.avium_104 -------------------------
MSMEG_6555|M.smegmatis_MC2_155 -------------------------
Mflv_0013|M.gilvum_PYR-GCK RFADTESSRRLIGRLLRVLLLPEHA