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DRLIFRRLMPLLIAAYIIAFIDRTNIGLAKHHLEVDLGISAAAYGLGAGLFFLAYSLCEVPSNLIMHRVG ARIWIARIMATWGLLSAAMAFVQGPASFYVLRILLGAAEAGLFPGVMLYLTYWFGRDQLARANGAFLVAV CLANIVGAPVGGALLGMDGVLGWQGWQWMFVIEGIPAVLLAAVVLKVLPNGPLEAKWLDPAAARALVDRL EREKAEGAAASGTHSFAGVFRDKQILLVIAVYFTHQIAVYSLTYFLPGIIGGWGEMSDLTIGLLTALPWV AAAIGTLVLPRHATDGRRSRMLLFGGMAAMVVGFVIGAVAGPALALIGFCIAASTFFVVQSILFTVPASR LTGAALAGGLALVNTLGILGGFVGPFVMGLLESVTDNPGAGLWFVIALLVIGTAVSLTLKVRAAPQPELK GVKA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6375 | - | - | 100% (425) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_5347 | - | 6e-89 | 43.52% (409) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_2537 | - | 6e-67 | 35.11% (413) | transporter protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1699c | - | 5e-62 | 37.44% (414) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_3439 | - | 7e-14 | 25.80% (376) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1672c | - | 5e-62 | 37.44% (414) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0284c | - | 5e-09 | 23.35% (364) | major facilitator transporter |
| M. marinum M | MMAR_0596 | - | 6e-73 | 36.58% (421) | integral membrane transport protein |
| M. avium 104 | MAV_4306 | - | 6e-11 | 24.37% (394) | transporter, major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_0390 | - | 2e-11 | 24.30% (391) | major facilitator superfamily protein permease |
| M. ulcerans Agy99 | MUL_1444 | sugI | 1e-08 | 21.78% (450) | sugar-transport integral membrane protein SugI |
| M. vanbaalenii PYR-1 | Mvan_3193 | - | 9e-12 | 23.34% (377) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6375|M.smegmatis_MC2_155 ------------MDRLIFR----RLMPLLIAAYIIAFIDRTNIGLAKHHL
MMAR_0596|M.marinum_M --MAVLDTGERSLEARTIRKLGIRIVPFLMALYFVNYLDRTNLGIARADI
Mb1699c|M.bovis_AF2122/97 -----MATIAASPTHNALGKAARRLLPLLFVLYVINFVDRANISVAALAM
Rv1672c|M.tuberculosis_H37Rv -----MATIAASPTHNALGKAARRLLPLLFVLYVINFVDRANISVAALAM
MAV_4306|M.avium_104 --------------MARGSRRGLLVGLTAASVGVIYGYDLSIIAGAQLFV
MUL_1444|M.ulcerans_Agy99 ------------------MQRGILVALTAASVGLIYGYDLSIIAGAQLFI
Mflv_3439|M.gilvum_PYR-GCK ---MSAPAAAETTSDTHGPTRAWSAVCVLAVVGTLNYADRFLPAVLAEPI
Mvan_3193|M.vanbaalenii_PYR-1 ---MSAPTAPATTTETHGPRRAWAAVSVLAVVGTLNYADRFLPAVLAEPI
MAB_0284c|M.abscessus_ATCC_199 ----------------------MTRVVLIVLCALQVTMQLYVWIPIHDIV
TH_0390|M.thermoresistible__bu MNPGRRARTAAGDDDERLAVRPWIVWATGLLAYIVAVLDRTTLGVSGLAA
:
MSMEG_6375|M.smegmatis_MC2_155 EVDLGISAAAYGLGAGL-FFLAYSLCEVPSNLIMHRVGARIWIARIMATW
MMAR_0596|M.marinum_M SAHLQLTATMFGLASGI-FFIGYVLVEVPSNLALDRYGARRWLARIAVSW
Mb1699c|M.bovis_AF2122/97 NADLRLSATAYGTAAGV-FFLGYVLFQVPANAALARFGAGRTLTAVVLAW
Rv1672c|M.tuberculosis_H37Rv NADLRLSATAYGTAAGV-FFLGYVLFQVPANAALARFGAGRTLTAVVLAW
MAV_4306|M.avium_104 TEDFGLSTRQQELLTTM-AVIGQIGGALFAGVLANAIGRRRSVLLILSGY
MUL_1444|M.ulcerans_Agy99 TEEFGLSTHQQELLTTM-VVIGQIVGALGAGVLANAIGRKKSVVMLLVAY
Mflv_3439|M.gilvum_PYR-GCK REDLSLSDTAIGVINGFGFLAVYALIGIPIARISDRGAYGLVISGCLSLW
Mvan_3193|M.vanbaalenii_PYR-1 REELALTDTALGVINGFGFLVVYALVGIPIARISDRGAYGLVISGCLSLW
MAB_0284c|M.abscessus_ATCC_199 SASYGGQDMTPALSAAL---FGYAAGFLLFGPVTDRFGRRRVLLAGVAVM
TH_0390|M.thermoresistible__bu ADRFNAAPAALSTFVVL-QVIVYALAQVPAGLLLDRFGSKALIVAGAAVM
. : . :
MSMEG_6375|M.smegmatis_MC2_155 GLLSAAMAFVQGPASFYVLRILLGAAEAGLFPGVMLYLTYWFGRDQLARA
MMAR_0596|M.marinum_M GIVVVATGFAPNATTLLVLRFLLGVAEAGLFPGVIYYLSRWFPRDYRARV
Mb1699c|M.bovis_AF2122/97 GVCSAATALVTSAHTLYLARFALGVAEGGFFPGVIAYLTVWFPCAQRARA
Rv1672c|M.tuberculosis_H37Rv GVCSAATALVTSAHTLYLARFALGVAEGGFFPGVIAYLTVWFPCAQRARA
MAV_4306|M.avium_104 AVFALLAAFSVGLPMLLTARLLLGLTIGVTVVVVPVYVAESAPTAVRGAL
MUL_1444|M.ulcerans_Agy99 TMFAVLGALSVSLPMLLAARFLLGLAVGVSIVVVPVYVAESAPAAVRGSL
Mflv_3439|M.gilvum_PYR-GCK GVMTMLGGAVQSGFQLAMTRVGVAIGEAGSTPAAHAYVARNFAPERRAAP
Mvan_3193|M.vanbaalenii_PYR-1 GVMTMLGGAVQSGFQLALTRVGVAIGEAGSTPAAHAYVARNFAPERRAAP
MAB_0284c|M.abscessus_ATCC_199 AVLTFLVPFAPTPVLSGLFRVIQGFAGGAFSPSALSYLGEALPRRAATTA
TH_0390|M.thermoresistible__bu ATGQLILAFTESLTLAILARAIVGLGDAVTFISVLRLVPHWFRPRQVPLV
* . . . :
MSMEG_6375|M.smegmatis_MC2_155 NGAFLVAVCLANIVGAPVGGALLGMD-GVLGWQGWQWMFVIEGIPAVLLA
MMAR_0596|M.marinum_M VALFMMASPIAAALGTPLAAWLIHLGNGVFGLAGWQFMMIAVGVPAIVLG
Mb1699c|M.bovis_AF2122/97 VATFLLAIPVANTVGLPLSGLIVGHV-HMAGLPGWRAMFVIEALPALLLA
Rv1672c|M.tuberculosis_H37Rv VATFLLAIPVANTVGLPLSGLIVGHV-HMAGLPGWRAMFVIEALPALLLA
MAV_4306|M.avium_104 LTAYQLAIVSGLIVGYLSGYLLAGTH-------SWRWMLGLACVPAVLLL
MUL_1444|M.ulcerans_Agy99 LTVYQLTTVSGLIVGYLTGYLLAGTH-------SWRWMLGLATVPAMLLL
Mflv_3439|M.gilvum_PYR-GCK LAVITLAIPLASAASLIGGGLLAQAL-------GWRTAFVVMGAISVLFV
Mvan_3193|M.vanbaalenii_PYR-1 LAVITLAIPLASAASLIGGGLLAQAL-------GWRTAFLVMGALSVVFV
MAB_0284c|M.abscessus_ATCC_199 IGAVSTAYLMAGVLGQVMASVITQAW-------GWQWLFWLSAAGLAVNV
TH_0390|M.thermoresistible__bu TQLTGICGQLGQVLSAVLFLALLTAR-------GWTPAYLSVVALGVLTI
. . : .* :
MSMEG_6375|M.smegmatis_MC2_155 AVVLKVLPNG----------PLEAKWLDPAAARALVDRLEREKAEGAAAS
MMAR_0596|M.marinum_M FACWYYLVDR----------PGDAAWLEPDERQWLVDTLAEEQRQ-VAGD
Mb1699c|M.bovis_AF2122/97 PLLRRLLPDN----------PQRASWLTPEERAELSARLTEDTPAPTGRS
Rv1672c|M.tuberculosis_H37Rv PLLRRLLPDN----------PQRASWLTPEERAELSARLTEDTPAPTGRS
MAV_4306|M.avium_104 PLVFRMPDTARWYLLKGRVDDARRALLRVEPAARVDDELAEIGRAVSEEA
MUL_1444|M.ulcerans_Agy99 PLLIRMPDTPRWYVMKGRIQEARAALLRVDPAADVEEELAEIGTALSEGS
Mflv_3439|M.gilvum_PYR-GCK PVVLAVVGRR----------------QKPLVESVAVQQVPVKWWDILRKP
Mvan_3193|M.vanbaalenii_PYR-1 PVVLAVVGRR----------------QRPVIESVAAEQVSANWWDILRKP
MAB_0284c|M.abscessus_ATCC_199 ALLALVMHEER----------------AGDPSTRVVSGFAAQARLLARAD
TH_0390|M.thermoresistible__bu ALTLALVQNTP------------DGRAAPATMGTVREIAASLKTVWLRAG
MSMEG_6375|M.smegmatis_MC2_155 G------THSFAGVFRDKQILLVIAVYFTHQIAVYSLTYFLPGIIGGWG-
MMAR_0596|M.marinum_M F------HFPLRRALTSPRIWALALVYFGIAYGLYALTFFLPSIISGFKK
Mb1699c|M.bovis_AF2122/97 S------GAGWD-------LVLFAVVYGGLYFALYALQFFLPQLVASLAH
Rv1672c|M.tuberculosis_H37Rv S------GAGWD-------LVLFAVVYGGLYFALYALQFFLPQLVASLAH
MAV_4306|M.avium_104 ASLPAMLAEMVRSPYRRATVFVVVLGFLIQITGINAIIYYSPRIFEAMGF
MUL_1444|M.ulcerans_Agy99 G----GVSEMLRPPFLRATIFVITLGFLIQITGINAIIYYSPRIFEAMGF
Mflv_3439|M.gilvum_PYR-GCK S------------------YLAIVAGAASISVAGYALTTFAPAFLMRARG
Mvan_3193|M.vanbaalenii_PYR-1 S------------------YLAIVAGAASISVAGYALTTFAPAFLMRARG
MAB_0284c|M.abscessus_ATCC_199 I------------------AVPLVAVFVLMLSFVAMYTSLATELVDALHL
TH_0390|M.thermoresistible__bu TR-----------------LGFFTHMGTQFSVTVFALMWGVPYLTVGQGL
. . :
MSMEG_6375|M.smegmatis_MC2_155 ----EMSDLTIGLLTALPWVAAAIGTLVLPRHATD--GRRSRMLLFGGMA
MMAR_0596|M.marinum_M SFGIDFSIVQVGLIAAIPYTCAAVAMYLWSRHADAT-GEQVWHVAVPMLL
Mb1699c|M.bovis_AF2122/97 G----TATLTAATLAALPYGVAALAMLAWSHRSIDRSGAQAGHITLPTTA
Rv1672c|M.tuberculosis_H37Rv G----TATLTAATLAALPYGVAALAMLAWSHRSIDRSGAQAGHITLPTTA
MAV_4306|M.avium_104 TG--NFALLALPALVQVAGLVAVGTALLLVDRVGRR-PILLCGTAMMIVA
MUL_1444|M.ulcerans_Agy99 TG--DFALLGLPALVQIAGVAAVITSLLLVDRVGRR-PILLSGIAIMIVA
Mflv_3439|M.gilvum_PYR-GCK MT-LGDVGLQYGIASGVTGILGLLVVGKVADRLSARDPRWLLWLVALMTA
Mvan_3193|M.vanbaalenii_PYR-1 MS-LGEVGLQYGIASGVTGILGLIVVGKVADRLSAADPRWLLWLVAAMTA
MAB_0284c|M.abscessus_ATCC_199 P----ESMGTTIRLAGVPGMLVAPFVGSWVGRVGTETGALVGYLLAAAGL
TH_0390|M.thermoresistible__bu ST---QMAGAMLTLSVAVAIVAGVLIGIFTGRHPHRRSRLVLAIIASNAA
:
MSMEG_6375|M.smegmatis_MC2_155 AMVVGF-VIGAVAGPALALIGFCIAAST-FFVVQSIL-FTVPASRLTG-A
MMAR_0596|M.marinum_M GGLAIP-VALHLHTPVLVMVAVAITAMG-VFAAIPSF-WALPSNFLTG-T
Mb1699c|M.bovis_AF2122/97 AGSAALGAALSPMSPIVTLSWLTIAVAG-ILAAMPAF-WSRCTAALAG-P
Rv1672c|M.tuberculosis_H37Rv AGSAALGAALSPMSPIVTLSWLTIAVAG-ILAAMPAF-WSRCTAALAG-P
MAV_4306|M.avium_104 DVVLVAVFGRGPGGVIAGFAGVLLFIFG-YTMGFGSLGWVYASESFPSRL
MUL_1444|M.ulcerans_Agy99 DVALMAVFARGQGAAILGFAGILLFIIG-YTMGFGSLGWVYASESFPTRL
Mflv_3439|M.gilvum_PYR-GCK ALIPFSTLGLLVASPGLAVLFISLSYVV-GTAYMAPS--IAAIQRLVPAE
Mvan_3193|M.vanbaalenii_PYR-1 TLIPFSTLGFLVDSSTLAVCFIALSYVV-GTAYMAPS--IAAIQRLVPAE
MAB_0284c|M.abscessus_ATCC_199 AVEALG-----AGSVPIIIAGSNIFVAG-IAVSSTAMVTMFGDRAAPR--
TH_0390|M.thermoresistible__bu AWTAVLALPDRAPLWLLITLIVVISVGGPGSMVGFDFARTFNPSATLGTA
:
MSMEG_6375|M.smegmatis_MC2_155 ALAGGLALVNTLGILGGFVGPFVMGLLESVTDNPGAGLWFVIALLVIGTA
MMAR_0596|M.marinum_M AAAGAIGLINSVGNLGGFAAPYLTGALEQVTGTDKAGMWAVGAMMLMSAF
Mb1699c|M.bovis_AF2122/97 RVAVAIATVNAVASLASFAGPYATGHLKDATGTYHLALLTVAAVLAAAAA
Rv1672c|M.tuberculosis_H37Rv RVAVAIATVNAVASLASFAGPYATGHLKDATGTYHLALLTVAAVLAAAAA
MAV_4306|M.avium_104 RSIGSSTMLTSNLVANAIVAAVFLTLLHSLGGAGTFAVFAVLAVVAFAFV
MUL_1444|M.ulcerans_Agy99 RSIGSSTMLTANLIANAIVAAVFLTMLHSLGGSGAFAVFGVLALVAFGVV
Mflv_3439|M.gilvum_PYR-GCK QRATASAIFLFFSAILGSAGPFVAGLISDAMK-AELGSGSLGRALLCVVP
Mvan_3193|M.vanbaalenii_PYR-1 QRATASAIFLFFSAILGSVGPLVTGLISDTLK-ADLGTMSLGRALLCVVP
MAB_0284c|M.abscessus_ATCC_199 -RGAGTALYGFTVFLGASSAPYLAHALGFRPLLGILVAALIGGAALVASS
TH_0390|M.thermoresistible__bu QGMVNMGGFLASLLVMQAMGQILDAAGGYSFDSFRLAWTVQYVVWVVAAV
.
MSMEG_6375|M.smegmatis_MC2_155 VSLTLKVRAAPQPELKGVKA-----------------------
MMAR_0596|M.marinum_M VVVLLRAVPGSPTAAERPN------------------------
Mb1699c|M.bovis_AF2122/97 CSLLLRHAGRTVCANDSEIMLHPSPATPFV-------------
Rv1672c|M.tuberculosis_H37Rv CSLLLRHAGRTVCANDSEIMLHPSPATPFV-------------
MAV_4306|M.avium_104 HRYAPETKGRQLEDIRHFWENGGRWD-----------------
MUL_1444|M.ulcerans_Agy99 YRYAPETKGRQLEEIRHFWENGGRWPEKLTEAP----------
Mflv_3439|M.gilvum_PYR-GCK VMHLVAIGCYLLASRRYLRELVN--------------------
Mvan_3193|M.vanbaalenii_PYR-1 LMHLVAIGCYLLASRRYVREIVD--------------------
MAB_0284c|M.abscessus_ATCC_199 RRASGPVKPVVDISTQSSPLP----------------------
TH_0390|M.thermoresistible__bu GILITRKKARRQMALEQERMLLESFEPGPRRHTGPDRTNRPHG