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MSAPTAPATTTETHGPRRAWAAVSVLAVVGTLNYADRFLPAVLAEPIREELALTDTALGVINGFGFLVVY ALVGIPIARISDRGAYGLVISGCLSLWGVMTMLGGAVQSGFQLALTRVGVAIGEAGSTPAAHAYVARNFA PERRAAPLAVITLAIPLASAASLIGGGLLAQALGWRTAFLVMGALSVVFVPVVLAVVGRRQRPVIESVAA EQVSANWWDILRKPSYLAIVAGAASISVAGYALTTFAPAFLMRARGMSLGEVGLQYGIASGVTGILGLIV VGKVADRLSAADPRWLLWLVAAMTATLIPFSTLGFLVDSSTLAVCFIALSYVVGTAYMAPSIAAIQRLVP AEQRATASAIFLFFSAILGSVGPLVTGLISDTLKADLGTMSLGRALLCVVPLMHLVAIGCYLLASRRYVR EIVD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3193 | - | - | 100% (424) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_3219 | - | 2e-12 | 27.42% (361) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_4014 | - | 2e-07 | 23.38% (278) | EmrB/QacA family drug resistance transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1699c | - | 1e-15 | 24.15% (443) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_3439 | - | 0.0 | 88.21% (424) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1672c | - | 1e-15 | 24.15% (443) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4839c | - | 4e-12 | 31.05% (277) | MFS family transporter |
| M. marinum M | MMAR_0596 | - | 1e-10 | 25.20% (254) | integral membrane transport protein |
| M. avium 104 | MAV_1387 | - | 9e-10 | 25.27% (376) | drug transporter |
| M. smegmatis MC2 155 | MSMEG_3705 | - | 1e-168 | 67.37% (426) | major facilitator superfamily protein MFS_1 |
| M. thermoresistible (build 8) | TH_3965 | - | 1e-08 | 23.96% (359) | PUTATIVE drug transporter |
| M. ulcerans Agy99 | MUL_1084 | - | 6e-07 | 21.81% (408) | integral membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3193|M.vanbaalenii_PYR-1 ------MSAPTAPATT--TETHGPRRAWAAVSVLAVVGTLNYADRFLPAV
Mflv_3439|M.gilvum_PYR-GCK ------MSAPAAAETT--SDTHGPTRAWSAVCVLAVVGTLNYADRFLPAV
MSMEG_3705|M.smegmatis_MC2_155 ------MSAPQAAIDTDHADRHGPRRAWAAVGVLALVGTLNYVDRFLPSV
MAV_1387|M.avium_104 ---------------------------------MMIGFFMIMVDSTIVAI
TH_3965|M.thermoresistible__bu VTSVDAGRSTMSEVFTAYAPRSAAANPWHALWAMLIGFFMILVDATIVPV
Mb1699c|M.bovis_AF2122/97 -------MATIAA---SPTHNALGKAARRLLPLLFVLYVINFVDRANISV
Rv1672c|M.tuberculosis_H37Rv -------MATIAA---SPTHNALGKAARRLLPLLFVLYVINFVDRANISV
MMAR_0596|M.marinum_M -------MAVLDTGERSLEARTIRKLGIRIVPFLMALYFVNYLDRTNLGI
MUL_1084|M.ulcerans_Agy99 --------MTSEARTATTAARPWTPRVAAQLSVLAAAAFIYVTAEILPVG
MAB_4839c|M.abscessus_ATCC_199 ----------MSTAAVHAQPHSITGLRGVLITLCLTEITSWGVLYYAFPV
Mvan_3193|M.vanbaalenii_PYR-1 LAEPIREELALTDTALGVINGFGFLVVYALVGIPIARISDRGAYGLVISG
Mflv_3439|M.gilvum_PYR-GCK LAEPIREDLSLSDTAIGVINGFGFLAVYALIGIPIARISDRGAYGLVISG
MSMEG_3705|M.smegmatis_MC2_155 LAEPIKHDLELSDTAIGVINGFGFLIVYAVMGIAVARVADRGAFGAVVAG
MAV_1387|M.avium_104 ANPTIMADLHIGYDTVVWVTSA-YLLGYAVVLLVAGRLGDRFGTKNLYLI
TH_3965|M.thermoresistible__bu ANLEIMADLGADYTAVIWVTSA-YLLAYAVPLLIAGRLGDRFGPRTMYLI
Mb1699c|M.bovis_AF2122/97 AALAMNADLRLSATAYGTAAGV-FFLGYVLFQVPANAALARFGAGRTLTA
Rv1672c|M.tuberculosis_H37Rv AALAMNADLRLSATAYGTAAGV-FFLGYVLFQVPANAALARFGAGRTLTA
MMAR_0596|M.marinum_M ARADISAHLQLTATMFGLASGI-FFIGYVLVEVPSNLALDRYGARRWLAR
MUL_1084|M.ulcerans_Agy99 ALSAIARNLHISVVLVGTLLSW-YALVAALTTVPLVRWTAHWPRRHALMV
MAB_4839c|M.abscessus_ATCC_199 LAPRITADTGWSAPAVTAAFSA-ALVVAAAAGIGVGRWLDRHGPRWLMTA
: . . . : :
Mvan_3193|M.vanbaalenii_PYR-1 CLSLWGVMTMLGGAVQSGFQLALTRVGVAIG-EAGSTPAAHAYVARNFAP
Mflv_3439|M.gilvum_PYR-GCK CLSLWGVMTMLGGAVQSGFQLAMTRVGVAIG-EAGSTPAAHAYVARNFAP
MSMEG_3705|M.smegmatis_MC2_155 CLTLWGTMTMLGGAVQSGFQLALTRVGVAIG-EAGSTPAAHAYVARNFVP
MAV_1387|M.avium_104 GLAVFTVASVWCGLAGSAAMLIAARVVQGVG-AGVMTPQTLSTITRIFPA
TH_3965|M.thermoresistible__bu GLAIFTAASLWCGLAGTIGMLIAARVLQGLG-AALLTPQTLSMITRIFPA
Mb1699c|M.bovis_AF2122/97 VVLAWGVCSAATALVTSAHTLYLARFALGVA-EGGFFPGVIAYLTVWFPC
Rv1672c|M.tuberculosis_H37Rv VVLAWGVCSAATALVTSAHTLYLARFALGVA-EGGFFPGVIAYLTVWFPC
MMAR_0596|M.marinum_M IAVSWGIVVVATGFAPNATTLLVLRFLLGVA-EAGLFPGVIYYLSRWFPR
MUL_1084|M.ulcerans_Agy99 SLVCLTISQLISALAPNFAVLAAGRALCAIT-HGLLWSVIAPIATRLVPP
MAB_4839c|M.abscessus_ATCC_199 GSLWGPAALIGVAMAPNYGWFLAAWLMAGIAMAAVFYPPAFAALTRWYGP
. . . : .: . . :
Mvan_3193|M.vanbaalenii_PYR-1 ERRAAPLAVITLAIPLASAASLIGGGLLAQALG-------WRTAFLVMGA
Mflv_3439|M.gilvum_PYR-GCK ERRAAPLAVITLAIPLASAASLIGGGLLAQALG-------WRTAFVVMGA
MSMEG_3705|M.smegmatis_MC2_155 QRRSAPLAVITIAIPLASTASLLGGGLLAQSLG-------WRTAFVIMGA
MAV_1387|M.avium_104 ERRGVAVSVWSATAGAASLAGPLAGGVLVDGLG----WQWIFFVNVPIGV
TH_3965|M.thermoresistible__bu DRRGVPMGVWGATAGVATLIGPLAGGVLVDGLG----WQWIFIVNVPIGI
Mb1699c|M.bovis_AF2122/97 AQRARAVATFLLAIPVANTVGLPLSGLIVGHVH-MAGLPGWRAMFVIEAL
Rv1672c|M.tuberculosis_H37Rv AQRARAVATFLLAIPVANTVGLPLSGLIVGHVH-MAGLPGWRAMFVIEAL
MMAR_0596|M.marinum_M DYRARVVALFMMASPIAAALGTPLAAWLIHLGNGVFGLAGWQFMMIAVGV
MUL_1084|M.ulcerans_Agy99 SHAGRATTSIYIGTSLALVIGSPLTAALSLMWG-------WRLAAVCVTV
MAB_4839c|M.abscessus_ATCC_199 G-AVRALMVLTLVAGLASTVFVPLTAVLASHMD-------WRTTYLALAV
* . : :
Mvan_3193|M.vanbaalenii_PYR-1 LSVVFVPVVLAVVGRRQR------PVIESVAAEQVSANWWDILR------
Mflv_3439|M.gilvum_PYR-GCK ISVLFVPVVLAVVGRRQK------PLVESVAVQQVPVKWWDILR------
MSMEG_3705|M.smegmatis_MC2_155 VSVVLAPLVLLVVGVRQS------LPAAPAVVDKTAGGWWNLLR------
MAV_1387|M.avium_104 LGLVLAYWLVPVLPTQSHRFDLVGVGLSGVGMLLIVFGLQQGQAAHWQPW
TH_3965|M.thermoresistible__bu AGLVLGARLMPRLPRQDQGFDVLGMVLSAVGLFLIVFALQEAQTHRWAPW
Mb1699c|M.bovis_AF2122/97 PALLLAPLLRRLLPDNPQ----RASWLTPEERAELSARLTEDTPAPTG--
Rv1672c|M.tuberculosis_H37Rv PALLLAPLLRRLLPDNPQ----RASWLTPEERAELSARLTEDTPAPTG--
MMAR_0596|M.marinum_M PAIVLGFACWYYLVDRPG----DAAWLEPDERQWLVDTLAEEQRQVAGDF
MUL_1084|M.ulcerans_Agy99 AAAVVTVAARLLLP---------EMVLSADQLQHVGPRSRHHRN------
MAB_4839c|M.abscessus_ATCC_199 LLTIITVPAHIIGLRRPWP------SLPATHLAESPTRIARSRP------
:.
Mvan_3193|M.vanbaalenii_PYR-1 ---------KPSYLAIVAGAASISVAGYALTTFAP---------------
Mflv_3439|M.gilvum_PYR-GCK ---------KPSYLAIVAGAASISVAGYALTTFAP---------------
MSMEG_3705|M.smegmatis_MC2_155 ---------KPSFLIVVAGTAFISAAGYSLTTFSP---------------
MAV_1387|M.avium_104 IWALIVAGVGFVTVFVFWQSVNVREPLIPLVIFSDRDFSLCNIGVAIISF
TH_3965|M.thermoresistible__bu IWGTLAGGAGVMAMFVIWQSANRRHPLVPLQIFADRNFMLANVGVATIGF
Mb1699c|M.bovis_AF2122/97 ----RSSGAGWDLVLFAVVYGGLYFALYALQFFLP---------------
Rv1672c|M.tuberculosis_H37Rv ----RSSGAGWDLVLFAVVYGGLYFALYALQFFLP---------------
MMAR_0596|M.marinum_M HFPLRRALTSPRIWALALVYFGIAYGLYALTFFLP---------------
MUL_1084|M.ulcerans_Agy99 ---------RALIIVSLITMVGVTGHFVSYTYIVV---------------
MAB_4839c|M.abscessus_ATCC_199 --------FISLIIAFALASCASYAVIVNLVPLMN---------------
:
Mvan_3193|M.vanbaalenii_PYR-1 -----AFLMRARGMSLGEVGLQYGIASGVTGILGLIVVGKVADRLSAADP
Mflv_3439|M.gilvum_PYR-GCK -----AFLMRARGMTLGDVGLQYGIASGVTGILGLLVVGKVADRLSARDP
MSMEG_3705|M.smegmatis_MC2_155 -----AFLMRTRGMSLGEVGVEYGLATGAIGVLGLLIVGRLADRLAERDP
MAV_1387|M.avium_104 AATAMMLPLTFYAQAVCGLSPTRSALLIAPMAIANGVFAPFVGKIVDRYH
TH_3965|M.thermoresistible__bu VVTAMVLPAMFFAQAVCGLSPTGSALLIAPMAVASGVLAPMAGRIVDRSH
Mb1699c|M.bovis_AF2122/97 ----QLVA----SLAHGTATLTAATLAALPYGVAALAMLAWSHRSIDRSG
Rv1672c|M.tuberculosis_H37Rv ----QLVA----SLAHGTATLTAATLAALPYGVAALAMLAWSHRSIDRSG
MMAR_0596|M.marinum_M ----SIISGFKKSFGIDFSIVQVGLIAAIPYTCAAVAMYLWS-RHADATG
MUL_1084|M.ulcerans_Agy99 -------IIRQVVGVRGPSLAWLLAAYGVAGVVAVALVARPLDRRPKGTI
MAB_4839c|M.abscessus_ATCC_199 -----------QRGLDGTVAATALALGGVGQVIGRFGYPALAQCISVVPR
.
Mvan_3193|M.vanbaalenii_PYR-1 -RWLLWLVAAMTATLIPFSTLGFLVDSSTLAVCFIALSYVVGTAYMAPSI
Mflv_3439|M.gilvum_PYR-GCK -RWLLWLVALMTAALIPFSTLGLLVASPGLAVLFISLSYVVGTAYMAPSI
MSMEG_3705|M.smegmatis_MC2_155 -RWLLWIVVTLTLVLLPASVLAFVVEDRMLCVLFLALSYAIGTSYLAPSI
MAV_1387|M.avium_104 PRPVLGFGFSLLAIALTWLTFEMSPATPIWRLVLPFFAMGVGMAFVWSPL
TH_3965|M.thermoresistible__bu PTPVVGFGFSVVAVGLTWLAVEMAPTTPIWRLVLPFVAVGVGMAFIWSPL
Mb1699c|M.bovis_AF2122/97 -AQAGHITLPTTAAGSAALGAALSPMSPIVTLSWLTIAV-AGILAAMPAF
Rv1672c|M.tuberculosis_H37Rv -AQAGHITLPTTAAGSAALGAALSPMSPIVTLSWLTIAV-AGILAAMPAF
MMAR_0596|M.marinum_M -EQVWHVAVPMLLGG-LAIPVALHLHTPVLVMVAVAITA-MGVFAAIPSF
MUL_1084|M.ulcerans_Agy99 IFCVAGLTFAFVLLTALAFGGHLAPMTALVVGTGAIVLWGAAVTAVSPML
MAB_4839c|M.abscessus_ATCC_199 ----TLLIMGVVAATTALLGVFASAVSLIAVAVAAGMARGIMTLLQATAI
. . . :
Mvan_3193|M.vanbaalenii_PYR-1 AAIQR-LVPAEQRATASAIFLFFSAILGSVGPLVTGLISDTLKADLGTMS
Mflv_3439|M.gilvum_PYR-GCK AAIQR-LVPAEQRATASAIFLFFSAILGSAGPFVAGLISDAMKAELGSGS
MSMEG_3705|M.smegmatis_MC2_155 AAIQR-LVLPEQRATASAMFLFFNAVFGSVGPFVVGMLSDSLTDDLGAQA
MAV_1387|M.avium_104 TATATRNLSAQLAGAGSAVYNSVRQLGAVLG--SAGMAAFMTWRIGAEMP
TH_3965|M.thermoresistible__bu ATTATRQLPLHLSGAGSGVYNTTRQIGSVLG--SAGMAAFLTGRLSAELP
Mb1699c|M.bovis_AF2122/97 WSRCTAALAGPRVAVAIATVNAVASLASFAGPYATGHLKDATGTYHLALL
Rv1672c|M.tuberculosis_H37Rv WSRCTAALAGPRVAVAIATVNAVASLASFAGPYATGHLKDATGTYHLALL
MMAR_0596|M.marinum_M WALPSNFLTGTAAAGAIGLINSVGNLGGFAAPYLTGALEQVTGTDKAGMW
MUL_1084|M.ulcerans_Agy99 QSAAMRSGADD-PDGASGLYVTAFQVGIMAGSLIGGLLYERSVAMMLTAS
MAB_4839c|M.abscessus_ATCC_199 TERWGSTHYGHLSGLLTAPIMLTTALAPFTGAALAQLLHGYPAMFVALGV
. : .
Mvan_3193|M.vanbaalenii_PYR-1 LGRALLCVVPLMHLVAIGCYLLASRRYVREIVD-----------------
Mflv_3439|M.gilvum_PYR-GCK LGRALLCVVPVMHLVAIGCYLLASRRYLRELVN-----------------
MSMEG_3705|M.smegmatis_MC2_155 LGRALLLLVAAMQLVGAICYWLASARYRRDIIEEAR--------------
MAV_1387|M.avium_104 GQPGGGGEDSAGPVLPEFLRGPFAAAMSQSVLLPAFIALFGIVAALFLVG
TH_3965|M.thermoresistible__bu FGATAVPAGEQTRVLPEFLHAPYAAAMAQSMLLPAFVALFGVLAAIFLAG
Mb1699c|M.bovis_AF2122/97 TVAAVLAAAAACSLLLRHAGRTVCANDSEIMLHPSPATPFV---------
Rv1672c|M.tuberculosis_H37Rv TVAAVLAAAAACSLLLRHAGRTVCANDSEIMLHPSPATPFV---------
MMAR_0596|M.marinum_M AVGAMMLMSAFVVVLLRAVPGSPTAAE-----RPN---------------
MUL_1084|M.ulcerans_Agy99 AGLMGVALVGMTSARRVFEAPVAVAGATSHNQ------------------
MAB_4839c|M.abscessus_ATCC_199 AGIIGAAAATATNPSQ----------------------------------
Mvan_3193|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3439|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3705|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1387|M.avium_104 FRPWAHRDGGTDAFGPDDYGGDYHDDYDDDDAYVELILVREPEPEAQQRA
TH_3965|M.thermoresistible__bu IVLSTPQP---------DADAQYLDEHDD---YLVIELAR----------
Mb1699c|M.bovis_AF2122/97 --------------------------------------------------
Rv1672c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0596|M.marinum_M --------------------------------------------------
MUL_1084|M.ulcerans_Agy99 --------------------------------------------------
MAB_4839c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_3193|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3439|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3705|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1387|M.avium_104 GQPRRPQPTPAPPADVRRRDPVESRRSVLDERPAQVQPIGFAHNGSHVDG
TH_3965|M.thermoresistible__bu -------PDPNPRTDIAVTAVIPALRPTLRP-------------------
Mb1699c|M.bovis_AF2122/97 --------------------------------------------------
Rv1672c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0596|M.marinum_M --------------------------------------------------
MUL_1084|M.ulcerans_Agy99 --------------------------------------------------
MAB_4839c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_3193|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3439|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3705|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1387|M.avium_104 GKRLRQVAVRRAPKPGPPADRFTRPPRRHHPGPAGHHLGEGESLRGQHHR
TH_3965|M.thermoresistible__bu -------TLR--PSLGPPGGPVVQP-------------NNTAALR-----
Mb1699c|M.bovis_AF2122/97 --------------------------------------------------
Rv1672c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0596|M.marinum_M --------------------------------------------------
MUL_1084|M.ulcerans_Agy99 --------------------------------------------------
MAB_4839c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_3193|M.vanbaalenii_PYR-1 -----------------
Mflv_3439|M.gilvum_PYR-GCK -----------------
MSMEG_3705|M.smegmatis_MC2_155 -----------------
MAV_1387|M.avium_104 PDPDDDPTGYGRHSSGN
TH_3965|M.thermoresistible__bu -----------------
Mb1699c|M.bovis_AF2122/97 -----------------
Rv1672c|M.tuberculosis_H37Rv -----------------
MMAR_0596|M.marinum_M -----------------
MUL_1084|M.ulcerans_Agy99 -----------------
MAB_4839c|M.abscessus_ATCC_199 -----------------