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MSAPAAAETTSDTHGPTRAWSAVCVLAVVGTLNYADRFLPAVLAEPIREDLSLSDTAIGVINGFGFLAVY ALIGIPIARISDRGAYGLVISGCLSLWGVMTMLGGAVQSGFQLAMTRVGVAIGEAGSTPAAHAYVARNFA PERRAAPLAVITLAIPLASAASLIGGGLLAQALGWRTAFVVMGAISVLFVPVVLAVVGRRQKPLVESVAV QQVPVKWWDILRKPSYLAIVAGAASISVAGYALTTFAPAFLMRARGMTLGDVGLQYGIASGVTGILGLLV VGKVADRLSARDPRWLLWLVALMTAALIPFSTLGLLVASPGLAVLFISLSYVVGTAYMAPSIAAIQRLVP AEQRATASAIFLFFSAILGSAGPFVAGLISDAMKAELGSGSLGRALLCVVPVMHLVAIGCYLLASRRYLR ELVN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3439 | - | - | 100% (424) | major facilitator transporter |
| M. gilvum PYR-GCK | Mflv_2221 | - | 4e-12 | 23.42% (427) | EmrB/QacA family drug resistance transporter |
| M. gilvum PYR-GCK | Mflv_0017 | - | 4e-11 | 23.83% (407) | major facilitator transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1699c | - | 8e-18 | 24.94% (445) | integral membrane transport protein |
| M. tuberculosis H37Rv | Rv1672c | - | 8e-18 | 24.94% (445) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4839c | - | 4e-11 | 29.82% (285) | MFS family transporter |
| M. marinum M | MMAR_0596 | - | 3e-10 | 22.90% (393) | integral membrane transport protein |
| M. avium 104 | MAV_1387 | - | 3e-12 | 25.54% (415) | drug transporter |
| M. smegmatis MC2 155 | MSMEG_3705 | - | 1e-166 | 67.29% (425) | major facilitator superfamily protein MFS_1 |
| M. thermoresistible (build 8) | TH_3965 | - | 3e-08 | 23.56% (348) | PUTATIVE drug transporter |
| M. ulcerans Agy99 | MUL_0949 | - | 8e-08 | 23.45% (354) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_3193 | - | 0.0 | 88.21% (424) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3439|M.gilvum_PYR-GCK ------MSAPAAAETT--SDTHGPTRAWSAVCVLAVVGTLNYADRFLPAV
Mvan_3193|M.vanbaalenii_PYR-1 ------MSAPTAPATT--TETHGPRRAWAAVSVLAVVGTLNYADRFLPAV
MSMEG_3705|M.smegmatis_MC2_155 ------MSAPQAAIDTDHADRHGPRRAWAAVGVLALVGTLNYVDRFLPSV
MAV_1387|M.avium_104 ---------------------------------MMIGFFMIMVDSTIVAI
TH_3965|M.thermoresistible__bu VTSVDAGRSTMSEVFTAYAPRSAAANPWHALWAMLIGFFMILVDATIVPV
Mb1699c|M.bovis_AF2122/97 -------MATIAA---SPTHNALGKAARRLLPLLFVLYVINFVDRANISV
Rv1672c|M.tuberculosis_H37Rv -------MATIAA---SPTHNALGKAARRLLPLLFVLYVINFVDRANISV
MMAR_0596|M.marinum_M -------MAVLDTGERSLEARTIRKLGIRIVPFLMALYFVNYLDRTNLGI
MAB_4839c|M.abscessus_ATCC_199 ----------MSTAAVHAQPHSITGLRGVLITLCLTEITSWGVLYYAFPV
MUL_0949|M.ulcerans_Agy99 -----------------MSRVALACVVGSTVEYYDFCIYGTAAALVFPAV
:
Mflv_3439|M.gilvum_PYR-GCK LAEPIREDLSLSDTAIGVINGFGFLAVYALIGIPIARISDRGAYGLVISG
Mvan_3193|M.vanbaalenii_PYR-1 LAEPIREELALTDTALGVINGFGFLVVYALVGIPIARISDRGAYGLVISG
MSMEG_3705|M.smegmatis_MC2_155 LAEPIKHDLELSDTAIGVINGFGFLIVYAVMGIAVARVADRGAFGAVVAG
MAV_1387|M.avium_104 ANPTIMADLHIGYDTVVWVTSA-YLLGYAVVLLVAGRLGDRFGTKNLYLI
TH_3965|M.thermoresistible__bu ANLEIMADLGADYTAVIWVTSA-YLLAYAVPLLIAGRLGDRFGPRTMYLI
Mb1699c|M.bovis_AF2122/97 AALAMNADLRLSATAYGTAAGV-FFLGYVLFQVPANAALARFGAGRTLTA
Rv1672c|M.tuberculosis_H37Rv AALAMNADLRLSATAYGTAAGV-FFLGYVLFQVPANAALARFGAGRTLTA
MMAR_0596|M.marinum_M ARADISAHLQLTATMFGLASGI-FFIGYVLVEVPSNLALDRYGARRWLAR
MAB_4839c|M.abscessus_ATCC_199 LAPRITADTGWSAPAVTAAFSA-ALVVAAAAGIGVGRWLDRHGPRWLMTA
MUL_0949|M.ulcerans_Agy99 FYPGLSPALATIASMGTFATAF---LSRPLGAAVFGHFGDRLGRKKTLVA
: . * .
Mflv_3439|M.gilvum_PYR-GCK CLSLWGVMTMLGGAVQS--------GFQLAMTRVGVAIGEAGST-PAAHA
Mvan_3193|M.vanbaalenii_PYR-1 CLSLWGVMTMLGGAVQS--------GFQLALTRVGVAIGEAGST-PAAHA
MSMEG_3705|M.smegmatis_MC2_155 CLTLWGTMTMLGGAVQS--------GFQLALTRVGVAIGEAGST-PAAHA
MAV_1387|M.avium_104 GLAVFTVASVWCGLAGS--------AAMLIAARVVQGVGAGVMT-PQTLS
TH_3965|M.thermoresistible__bu GLAIFTAASLWCGLAGT--------IGMLIAARVLQGLGAALLT-PQTLS
Mb1699c|M.bovis_AF2122/97 VVLAWGVCSAATALVTS--------AHTLYLARFALGVAEGGFF-PGVIA
Rv1672c|M.tuberculosis_H37Rv VVLAWGVCSAATALVTS--------AHTLYLARFALGVAEGGFF-PGVIA
MMAR_0596|M.marinum_M IAVSWGIVVVATGFAPN--------ATTLLVLRFLLGVAEAGLF-PGVIY
MAB_4839c|M.abscessus_ATCC_199 GSLWGPAALIGVAMAPN--------YGWFLAAWLMAGIAMAAVFYPPAFA
MUL_0949|M.ulcerans_Agy99 TLLIMALSTVTVGVVPSTATIGVSAPLILVALRLLQGFAVGGEWAGSALL
. . . : . ... . .
Mflv_3439|M.gilvum_PYR-GCK YVARNFAPERRAAPLAVIT--LAIPLASAASLIGGGLLAQALG-------
Mvan_3193|M.vanbaalenii_PYR-1 YVARNFAPERRAAPLAVIT--LAIPLASAASLIGGGLLAQALG-------
MSMEG_3705|M.smegmatis_MC2_155 YVARNFVPQRRSAPLAVIT--IAIPLASTASLLGGGLLAQSLG-------
MAV_1387|M.avium_104 TITRIFPAERRGVAVSVWS--ATAGAASLAGPLAGGVLVDGLG----WQW
TH_3965|M.thermoresistible__bu MITRIFPADRRGVPMGVWG--ATAGVATLIGPLAGGVLVDGLG----WQW
Mb1699c|M.bovis_AF2122/97 YLTVWFPCAQRARAVATFL--LAIPVANTVGLPLSGLIVGHVH-MAGLPG
Rv1672c|M.tuberculosis_H37Rv YLTVWFPCAQRARAVATFL--LAIPVANTVGLPLSGLIVGHVH-MAGLPG
MMAR_0596|M.marinum_M YLSRWFPRDYRARVVALFM--MASPIAAALGTPLAAWLIHLGNGVFGLAG
MAB_4839c|M.abscessus_ATCC_199 ALTRWYGPG-AVRALMVLT--LVAGLASTVFVPLTAVLASHMD-------
MUL_0949|M.ulcerans_Agy99 SIESAPAHKRGYYGMFTVLGGGVALVVSGLTFLGVNYTIGESSSALLQWG
: : . .
Mflv_3439|M.gilvum_PYR-GCK WRTAFVVMGAISVLFVPVVLAVVGRRQK------PLVESVAVQQVPVKWW
Mvan_3193|M.vanbaalenii_PYR-1 WRTAFLVMGALSVVFVPVVLAVVGRRQR------PVIESVAAEQVSANWW
MSMEG_3705|M.smegmatis_MC2_155 WRTAFVIMGAVSVVLAPLVLLVVGVRQS------LPAAPAVVDKTAGGWW
MAV_1387|M.avium_104 IFFVNVPIGVLGLVLAYWLVPVLPTQSHRFDLVGVGLSGVGMLLIVFGLQ
TH_3965|M.thermoresistible__bu IFIVNVPIGIAGLVLGARLMPRLPRQDQGFDVLGMVLSAVGLFLIVFALQ
Mb1699c|M.bovis_AF2122/97 WRAMFVIEALPALLLAPLLRRLLPDNPQ----RASWLTPEERAELSARLT
Rv1672c|M.tuberculosis_H37Rv WRAMFVIEALPALLLAPLLRRLLPDNPQ----RASWLTPEERAELSARLT
MMAR_0596|M.marinum_M WQFMMIAVGVPAIVLGFACWYYLVDRPG----DAAWLEPDERQWLVDTLA
MAB_4839c|M.abscessus_ATCC_199 WRTTYLALAVLLTIITVPAHIIGLRRPWP------SLPATHLAESPTRIA
MUL_0949|M.ulcerans_Agy99 WRVPFLLSALLIAFALYVRLEINETPVFAR----AMAQADDQESTAAARA
: . .
Mflv_3439|M.gilvum_PYR-GCK DILR---------------KPSYLAIVAGAASISVAGYALTTFAP-----
Mvan_3193|M.vanbaalenii_PYR-1 DILR---------------KPSYLAIVAGAASISVAGYALTTFAP-----
MSMEG_3705|M.smegmatis_MC2_155 NLLR---------------KPSFLIVVAGTAFISAAGYSLTTFSP-----
MAV_1387|M.avium_104 QGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREPLIPLVIFSDRDFSL
TH_3965|M.thermoresistible__bu EAQTHRWAPWIWGTLAGGAGVMAMFVIWQSANRRHPLVPLQIFADRNFML
Mb1699c|M.bovis_AF2122/97 EDTPAPTG------RSSGAGWDLVLFAVVYGGLYFALYALQFFLP-----
Rv1672c|M.tuberculosis_H37Rv EDTPAPTG------RSSGAGWDLVLFAVVYGGLYFALYALQFFLP-----
MMAR_0596|M.marinum_M EEQRQVAGDFHFPLRRALTSPRIWALALVYFGIAYGLYALTFFLP-----
MAB_4839c|M.abscessus_ATCC_199 RSRP------------------FISLIIAFALASCASYAVIVNLV-----
MUL_0949|M.ulcerans_Agy99 PLAAVLCR----------QRREIVLAAGAMLAAFGCLYLASTFLP-----
Mflv_3439|M.gilvum_PYR-GCK ---------------AFLMRARGMTLGDVGLQYGIASGVTGILGLLVVGK
Mvan_3193|M.vanbaalenii_PYR-1 ---------------AFLMRARGMSLGEVGLQYGIASGVTGILGLIVVGK
MSMEG_3705|M.smegmatis_MC2_155 ---------------AFLMRTRGMSLGEVGVEYGLATGAIGVLGLLIVGR
MAV_1387|M.avium_104 CNIGVAIISFAATAMMLPLTFYAQAVCGLSPTRSALLIAPMAIANGVFAP
TH_3965|M.thermoresistible__bu ANVGVATIGFVVTAMVLPAMFFAQAVCGLSPTGSALLIAPMAVASGVLAP
Mb1699c|M.bovis_AF2122/97 --------------QLVA----SLAHGTATLTAATLAALPYGVAALAMLA
Rv1672c|M.tuberculosis_H37Rv --------------QLVA----SLAHGTATLTAATLAALPYGVAALAMLA
MMAR_0596|M.marinum_M --------------SIISGFKKSFGIDFSIVQVGLIAAIPYTCAAVAMYL
MAB_4839c|M.abscessus_ATCC_199 -----------------PLMNQRGLDGTVAATALALGGVGQVIGRFGYPA
MUL_0949|M.ulcerans_Agy99 --------------------SYAQLHLGYSRNLVLLIGVLGGLVCIGFVA
Mflv_3439|M.gilvum_PYR-GCK VADRLSARDP-RWLLWLVALMTAALIPFSTLGLLVASPGLAVLFISLSYV
Mvan_3193|M.vanbaalenii_PYR-1 VADRLSAADP-RWLLWLVAAMTATLIPFSTLGFLVDSSTLAVCFIALSYV
MSMEG_3705|M.smegmatis_MC2_155 LADRLAERDP-RWLLWIVVTLTLVLLPASVLAFVVEDRMLCVLFLALSYA
MAV_1387|M.avium_104 FVGKIVDRYHPRPVLGFGFSLLAIALTWLTFEMSPATPIWRLVLPFFAMG
TH_3965|M.thermoresistible__bu MAGRIVDRSHPTPVVGFGFSVVAVGLTWLAVEMAPTTPIWRLVLPFVAVG
Mb1699c|M.bovis_AF2122/97 WSHRSIDRSG-AQAGHITLPTTAAGSAALGAALSPMSPIVTLSWLTIAV-
Rv1672c|M.tuberculosis_H37Rv WSHRSIDRSG-AQAGHITLPTTAAGSAALGAALSPMSPIVTLSWLTIAV-
MMAR_0596|M.marinum_M WS-RHADATG-EQVWHVAVPMLLGG-LAIPVALHLHTPVLVMVAVAITA-
MAB_4839c|M.abscessus_ATCC_199 LAQCISVVPR--------TLLIMGVVAATTALLGVFASAVSLIAVAVAAG
MUL_0949|M.ulcerans_Agy99 LSAILCDRFGRRRVMLVGWAVGLFWSPLVMPLIGSGDTVGFTVALLGLYA
:
Mflv_3439|M.gilvum_PYR-GCK VGTAYMAPSIAAIQR-LVPAEQRATASAIFLFFSAILGSAGPFVAGLISD
Mvan_3193|M.vanbaalenii_PYR-1 VGTAYMAPSIAAIQR-LVPAEQRATASAIFLFFSAILGSVGPLVTGLISD
MSMEG_3705|M.smegmatis_MC2_155 IGTSYLAPSIAAIQR-LVLPEQRATASAMFLFFNAVFGSVGPFVVGMLSD
MAV_1387|M.avium_104 VGMAFVWSPLTATATRNLSAQLAGAGSAVYNSVRQLGAVLG--SAGMAAF
TH_3965|M.thermoresistible__bu VGMAFIWSPLATTATRQLPLHLSGAGSGVYNTTRQIGSVLG--SAGMAAF
Mb1699c|M.bovis_AF2122/97 AGILAAMPAFWSRCTAALAGPRVAVAIATVNAVASLASFAGPYATGHLKD
Rv1672c|M.tuberculosis_H37Rv AGILAAMPAFWSRCTAALAGPRVAVAIATVNAVASLASFAGPYATGHLKD
MMAR_0596|M.marinum_M MGVFAAIPSFWALPSNFLTGTAAAGAIGLINSVGNLGGFAAPYLTGALEQ
MAB_4839c|M.abscessus_ATCC_199 MARGIMTLLQATAITERWGSTHYGHLSGLLTAPIMLTTALAPFTGAALAQ
MUL_0949|M.ulcerans_Agy99 VAASGFGPAASLIPELFATRYRYTGTALALNVAGIVGGAAPPLIAGTLLA
. : .
Mflv_3439|M.gilvum_PYR-GCK AMKAELGSGSLGRALLCVVPVMHLVAIGCYLLASRRYLRELVN-------
Mvan_3193|M.vanbaalenii_PYR-1 TLKADLGTMSLGRALLCVVPLMHLVAIGCYLLASRRYVREIVD-------
MSMEG_3705|M.smegmatis_MC2_155 SLTDDLGAQALGRALLLLVAAMQLVGAICYWLASARYRRDIIEEAR----
MAV_1387|M.avium_104 MTWRIGAEMPGQPGGGGEDSAGPVLPEFLRGPFAAAMSQSVLLPAFIALF
TH_3965|M.thermoresistible__bu LTGRLSAELPFGATAVPAGEQTRVLPEFLHAPYAAAMAQSMLLPAFVALF
Mb1699c|M.bovis_AF2122/97 ATGTYHLALLTVAAVLAAAAACSLLLRHAGRTVCANDSEIMLHPSPATPF
Rv1672c|M.tuberculosis_H37Rv ATGTYHLALLTVAAVLAAAAACSLLLRHAGRTVCANDSEIMLHPSPATPF
MMAR_0596|M.marinum_M VTGTDKAGMWAVGAMMLMSAFVVVLLRAVPGSPTAAE-----RPN-----
MAB_4839c|M.abscessus_ATCC_199 LLHGYPAMFVALGVAGIIGAAAATATNPSQ--------------------
MUL_0949|M.ulcerans_Agy99 SYGSSAVGLMMTALVAASLLCTYLLPETAGAPLTAA--------------
Mflv_3439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3193|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3705|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1387|M.avium_104 GIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYHDDYDDDDAYVELILVR
TH_3965|M.thermoresistible__bu GVLAAIFLAGIVLSTPQP---------DADAQYLDEHDD---YLVIELAR
Mb1699c|M.bovis_AF2122/97 V-------------------------------------------------
Rv1672c|M.tuberculosis_H37Rv V-------------------------------------------------
MMAR_0596|M.marinum_M --------------------------------------------------
MAB_4839c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_0949|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3193|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3705|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1387|M.avium_104 EPEPEAQQRAGQPRRPQPTPAPPADVRRRDPVESRRSVLDERPAQVQPIG
TH_3965|M.thermoresistible__bu -----------------PDPNPRTDIAVTAVIPALRPTLRP---------
Mb1699c|M.bovis_AF2122/97 --------------------------------------------------
Rv1672c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0596|M.marinum_M --------------------------------------------------
MAB_4839c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_0949|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3193|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3705|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1387|M.avium_104 FAHNGSHVDGGKRLRQVAVRRAPKPGPPADRFTRPPRRHHPGPAGHHLGE
TH_3965|M.thermoresistible__bu -----------------TLR--PSLGPPGGPVVQP-------------NN
Mb1699c|M.bovis_AF2122/97 --------------------------------------------------
Rv1672c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0596|M.marinum_M --------------------------------------------------
MAB_4839c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_0949|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3439|M.gilvum_PYR-GCK ---------------------------
Mvan_3193|M.vanbaalenii_PYR-1 ---------------------------
MSMEG_3705|M.smegmatis_MC2_155 ---------------------------
MAV_1387|M.avium_104 GESLRGQHHRPDPDDDPTGYGRHSSGN
TH_3965|M.thermoresistible__bu TAALR----------------------
Mb1699c|M.bovis_AF2122/97 ---------------------------
Rv1672c|M.tuberculosis_H37Rv ---------------------------
MMAR_0596|M.marinum_M ---------------------------
MAB_4839c|M.abscessus_ATCC_199 ---------------------------
MUL_0949|M.ulcerans_Agy99 ---------------------------