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ATIAASPTHNALGKAARRLLPLLFVLYVINFVDRANISVAALAMNADLRLSATAYGTAAGVFFLGYVLFQ VPANAALARFGAGRTLTAVVLAWGVCSAATALVTSAHTLYLARFALGVAEGGFFPGVIAYLTVWFPCAQR ARAVATFLLAIPVANTVGLPLSGLIVGHVHMAGLPGWRAMFVIEALPALLLAPLLRRLLPDNPQRASWLT PEERAELSARLTEDTPAPTGRSSGAGWDLVLFAVVYGGLYFALYALQFFLPQLVASLAHGTATLTAATLA ALPYGVAALAMLAWSHRSIDRSGAQAGHITLPTTAAGSAALGAALSPMSPIVTLSWLTIAVAGILAAMPA FWSRCTAALAGPRVAVAIATVNAVASLASFAGPYATGHLKDATGTYHLALLTVAAVLAAAAACSLLLRHA GRTVCANDSEIMLHPSPATPFV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1672c | - | - | 100% (443) | PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN |
| M. tuberculosis H37Rv | Rv3331 | sugI | 5e-13 | 26.53% (294) | sugar-transport integral membrane protein SugI |
| M. tuberculosis H37Rv | Rv1250 | - | 2e-09 | 21.63% (416) | drug-transport integral membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1699c | - | 0.0 | 100.00% (443) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_3439 | - | 1e-17 | 24.94% (445) | major facilitator transporter |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1429 | - | 2e-10 | 24.93% (365) | major facilitator superfamily permease |
| M. marinum M | MMAR_0596 | - | 9e-77 | 38.57% (420) | integral membrane transport protein |
| M. avium 104 | MAV_4306 | - | 4e-08 | 26.53% (196) | transporter, major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2537 | - | 4e-66 | 34.17% (439) | transporter protein |
| M. thermoresistible (build 8) | TH_0390 | - | 2e-11 | 24.16% (418) | major facilitator superfamily protein permease |
| M. ulcerans Agy99 | MUL_0838 | - | 2e-12 | 24.88% (418) | transmembrane carbohydrate transport protein |
| M. vanbaalenii PYR-1 | Mvan_3193 | - | 1e-15 | 24.15% (443) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1672c|M.tuberculosis_H37Rv ---------MATIAASPTHNALGKAARRLLPLLFVLYVINFVDRANISVA
Mb1699c|M.bovis_AF2122/97 ---------MATIAASPTHNALGKAARRLLPLLFVLYVINFVDRANISVA
MMAR_0596|M.marinum_M MA------VLDTGERSLEARTIRKLGIRIVPFLMALYFVNYLDRTNLGIA
MSMEG_2537|M.smegmatis_MC2_155 MANAPGNNLTPKSDDSARRSALRKVNLRLMPFIFLLYLVNYVDRTALGIA
Mflv_3439|M.gilvum_PYR-GCK -------MSAPAAAETTSDTHGPTRAWSAVCVLAVVGTLNYADRFLPAVL
Mvan_3193|M.vanbaalenii_PYR-1 -------MSAPTAPATTTETHGPRRAWAAVSVLAVVGTLNYADRFLPAVL
MUL_0838|M.ulcerans_Agy99 ------MTASPQVNETEGRPVVGRPGAVLFTVCAALFLV-VVDVTVLHVA
MAB_1429|M.abscessus_ATCC_1997 -------MTAVVDSRVQPAAPVSPRVRRGAILALALGGFGIGTTEFVAMG
MAV_4306|M.avium_104 -------------------MARGSRRGLLVGLTAASVGVIYGYDLSIIAG
TH_0390|M.thermoresistible__bu ----MNPGRRARTAAGDDDERLAVRPWIVWATGLLAYIVAVLDRTTLGVS
.
Rv1672c|M.tuberculosis_H37Rv ALA-MNADLRLSATAYGTAAGV-FFLGYVLFQVPANAALARFGAGRTLTA
Mb1699c|M.bovis_AF2122/97 ALA-MNADLRLSATAYGTAAGV-FFLGYVLFQVPANAALARFGAGRTLTA
MMAR_0596|M.marinum_M RAD-ISAHLQLTATMFGLASGI-FFIGYVLVEVPSNLALDRYGARRWLAR
MSMEG_2537|M.smegmatis_MC2_155 APNGMSDELQMTATLFGLASGI-FFVGYILLEVPSAMAAQRTGARVWIAR
Mflv_3439|M.gilvum_PYR-GCK AEP-IREDLSLSDTAIGVINGFGFLAVYALIGIPIARISDRGAYGLVISG
Mvan_3193|M.vanbaalenii_PYR-1 AEP-IREELALTDTALGVINGFGFLVVYALVGIPIARISDRGAYGLVISG
MUL_0838|M.ulcerans_Agy99 APR-IAEELSPSPTEFLWIVDI-YPLIMASLMLMAGAASDRFGRKRLLMT
MAB_1429|M.abscessus_ATCC_1997 LLPNIAHGLHVTEPQAGHVISA-YALGVVVGAPVIAALTARASRRTLLVA
MAV_4306|M.avium_104 AQLFVTEDFGLSTRQQELLTTM-AVIGQIGGALFAGVLANAIGRRRSVLL
TH_0390|M.thermoresistible__bu GLA-AADRFNAAPAALSTFVVL-QVIVYALAQVPAGLLLDRFGSKALIVA
: : . :
Rv1672c|M.tuberculosis_H37Rv VVLAWGVCSAATALVTSAHTLYLARFALGVAEGGFFPGVIAYLTVWFPC-
Mb1699c|M.bovis_AF2122/97 VVLAWGVCSAATALVTSAHTLYLARFALGVAEGGFFPGVIAYLTVWFPC-
MMAR_0596|M.marinum_M IAVSWGIVVVATGFAPNATTLLVLRFLLGVAEAGLFPGVIYYLSRWFPR-
MSMEG_2537|M.smegmatis_MC2_155 IAITWGAVASLTAFVPNYQWLIVARFLLGVAEAGFAPTVLLYLTIWFSN-
Mflv_3439|M.gilvum_PYR-GCK CLSLWGVMTMLGGAVQSGFQLAMTRVGVAIGEAGSTPAAHAYVARNFAP-
Mvan_3193|M.vanbaalenii_PYR-1 CLSLWGVMTMLGGAVQSGFQLALTRVGVAIGEAGSTPAAHAYVARNFAP-
MUL_0838|M.ulcerans_Agy99 GLVIFGLVSIPAAFAATPLMLILARSVMAVGAAMILPATVSLLRVAFPDR
MAB_1429|M.abscessus_ATCC_1997 LMVAFTIGNAATVFAPGYAALIASRFVAGLPHGAYFG-VAALVAAHLAGP
MAV_4306|M.avium_104 ILSGYAVFALLAAFSVGLPMLLTARLLLGLTIGVTVVVVPVYVAESAPT-
TH_0390|M.thermoresistible__bu GAAVMATGQLILAFTESLTLAILARAIVGLGDAVTFISVLRLVPHWFRP-
* .: . . :
Rv1672c|M.tuberculosis_H37Rv AQRARAVATFLLAIPVANTVGLPLSGLIVGHVH-MAGLPGWRAMFVIEAL
Mb1699c|M.bovis_AF2122/97 AQRARAVATFLLAIPVANTVGLPLSGLIVGHVH-MAGLPGWRAMFVIEAL
MMAR_0596|M.marinum_M DYRARVVALFMMASPIAAALGTPLAAWLIHLGNGVFGLAGWQFMMIAVGV
MSMEG_2537|M.smegmatis_MC2_155 RERPKAFSVYLLGIPISSVVAGPVASWLINAGDGVFGLSGWRFMTLMTGV
Mflv_3439|M.gilvum_PYR-GCK ERRAAPLAVITLAIPLASAASLIGGGLLAQALG-------WRTAFVVMGA
Mvan_3193|M.vanbaalenii_PYR-1 ERRAAPLAVITLAIPLASAASLIGGGLLAQALG-------WRTAFLVMGA
MUL_0838|M.ulcerans_Agy99 AERMRAVGIWSAVSAVGAAIGPLMGGLLVEYFW-------WGAIFLINVP
MAB_1429|M.abscessus_ATCC_1997 GERAKAVGQTMLGLSVANVVGVPVATWLGNTVG-------WRSAFAVVAV
MAV_4306|M.avium_104 AVRGALLTAYQLAIVSGLIVGYLSGYLLAGTHS-------WRWMLGLACV
TH_0390|M.thermoresistible__bu RQVPLVTQLTGICGQLGQVLSAVLFLALLTARG-------WTPAYLSVVA
. . : *
Rv1672c|M.tuberculosis_H37Rv PALLLAPLLR--------RLLPDNPQRASWLTP--EERAELSARLTEDTP
Mb1699c|M.bovis_AF2122/97 PALLLAPLLR--------RLLPDNPQRASWLTP--EERAELSARLTEDTP
MMAR_0596|M.marinum_M PAIVLGFACW--------YYLVDRPGDAAWLEP--DERQWLVDTLAEEQR
MSMEG_2537|M.smegmatis_MC2_155 PAIILGVAAL--------FWLTDRPSQAAWLTD--AEKEALIADHDEHTP
Mflv_3439|M.gilvum_PYR-GCK ISVLFVPVVL--------AVVGRR--QKPLVES--VAVQQVPVKWWDILR
Mvan_3193|M.vanbaalenii_PYR-1 LSVVFVPVVL--------AVVGRR--QRPVIES--VAAEQVSANWWDILR
MUL_0838|M.ulcerans_Agy99 LALLVLLLVW--------RLVPESRSQARLVLDGLSVSLSIVAVLTSVLA
MAB_1429|M.abscessus_ATCC_1997 IGAITIAALL--------RYLPGLT------------DMRITNPLTELGA
MAV_4306|M.avium_104 PAVLLLPLVFRMPDTARWYLLKGRVDDARRALLRVEPAARVDDELAEIGR
TH_0390|M.thermoresistible__bu LGVLTIALTL---------ALVQNTPDGRAAPATMGTVREIAASLKTVWL
. : : :
Rv1672c|M.tuberculosis_H37Rv APTG----------------------------------------------
Mb1699c|M.bovis_AF2122/97 APTG----------------------------------------------
MMAR_0596|M.marinum_M QVAGDFH-------------------------------------------
MSMEG_2537|M.smegmatis_MC2_155 AEARGHA-------------------------------------------
Mflv_3439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3193|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_0838|M.ulcerans_Agy99 IKQATHHGIDPAAVGYVVIASVGLWWFIRRQISRQRRGIEPLLNVHLFTR
MAB_1429|M.abscessus_ATCC_1997 LR------------------------------------------------
MAV_4306|M.avium_104 AVSEEAASLP------------------------------------AMLA
TH_0390|M.thermoresistible__bu R-------------------------------------------------
Rv1672c|M.tuberculosis_H37Rv ---RSSGAGWDLVLFAVVYGGLYFALYALQFF-----------LPQLVAS
Mb1699c|M.bovis_AF2122/97 ---RSSGAGWDLVLFAVVYGGLYFALYALQFF-----------LPQLVAS
MMAR_0596|M.marinum_M FPLRRALTSPRIWALALVYFGIAYGLYALTFF-----------LPSIISG
MSMEG_2537|M.smegmatis_MC2_155 GGMLSSLRSGRVWIMGFAYLGVVYSLYTIGFF-----------LPSVVSG
Mflv_3439|M.gilvum_PYR-GCK ---KPSYLAIVAGAASISVAGYALTTFAPAFL-----------MRARGMT
Mvan_3193|M.vanbaalenii_PYR-1 ---KPSYLAIVAGAASISVAGYALTTFAPAFL-----------MRARGMS
MUL_0838|M.ulcerans_Agy99 APFTSAVLAVLLAVFSIVGLDLVFAQYLQNFLGFTPIKAALLLTPMAAAT
MAB_1429|M.abscessus_ATCC_1997 -----RVQVWFTLLIGIVGFGGMFAFYTYIST-----------TLTSVSG
MAV_4306|M.avium_104 EMVRSPYRRATVFVVVLGFLIQITGINAIIYY-----------SPRIFEA
TH_0390|M.thermoresistible__bu -------AGTRLGFFTHMGTQFSVTVFALMWG-----------VPYLTVG
Rv1672c|M.tuberculosis_H37Rv LAHGT----ATLTAATLAALPYGVAALAMLAWSHRSIDRSGAQAGHITLP
Mb1699c|M.bovis_AF2122/97 LAHGT----ATLTAATLAALPYGVAALAMLAWSHRSIDRSGAQAGHITLP
MMAR_0596|M.marinum_M FKKSFGIDFSIVQVGLIAAIPYTCAAVAMYLWS-RHADATGEQVWHVAVP
MSMEG_2537|M.smegmatis_MC2_155 FAERFGTDFTVIENGFIIAVPYVFAAAALMLWP-RHATRSGDIGWHVLIS
Mflv_3439|M.gilvum_PYR-GCK LGDVG------LQYGIASGVTGILGLLVVGKVADRLSARDPRWLLWLVAL
Mvan_3193|M.vanbaalenii_PYR-1 LGEVG------LQYGIASGVTGILGLIVVGKVADRLSAADPRWLLWLVAA
MUL_0838|M.ulcerans_Agy99 VVGSLSAHLIVGRCGTRVAISAGLGLTASALLPLLTPGHNGQLLVFVGSL
MAB_1429|M.abscessus_ATCC_1997 LPRALVP---------LALSLYGIGMVTGNVLGGWMADRS--VVRAIAVG
MAV_4306|M.avium_104 MGFTG------NFALLALPALVQVAGLVAVGTALLLVDRVGRRPILLCGT
TH_0390|M.thermoresistible__bu QGLST------QMAGAMLTLSVAVAIVAGVLIGIFTGRHPHRRSRLVLAI
. . :
Rv1672c|M.tuberculosis_H37Rv TTAAGSAALGAALSPMSPIVTL---------------------SWLTIAV
Mb1699c|M.bovis_AF2122/97 TTAAGSAALGAALSPMSPIVTL---------------------SWLTIAV
MMAR_0596|M.marinum_M -MLLGGLAIPVALHLHTPVLVM---------------------VAVAITA
MSMEG_2537|M.smegmatis_MC2_155 -TVVGALGIVIAAFAGDPWIVM---------------------LGVTLCA
Mflv_3439|M.gilvum_PYR-GCK MTAALIPFSTLGLLVASPGLAV---------------------LFISLSY
Mvan_3193|M.vanbaalenii_PYR-1 MTATLIPFSTLGFLVDSSTLAV---------------------CFIALSY
MUL_0838|M.ulcerans_Agy99 AVVGFALDVVLVSANDAIISAVSEDYVGQAAGVEEVAYDLGGGLGIAVLG
MAB_1429|M.abscessus_ATCC_1997 LVLVAAMLLIFAAVSRNPWAAL----------------------ALVFAV
MAV_4306|M.avium_104 AMMIVADVVLVAVFGRGPGGVIAG-----------------FAGVLLFIF
TH_0390|M.thermoresistible__bu IASNAAAWTAVLALPDRAPLWLL--------------------ITLIVVI
: : .
Rv1672c|M.tuberculosis_H37Rv AGILAAMPAFWSRCTAALAGPRVAVAIATVNAVASLASFAGPYATGHLKD
Mb1699c|M.bovis_AF2122/97 AGILAAMPAFWSRCTAALAGPRVAVAIATVNAVASLASFAGPYATGHLKD
MMAR_0596|M.marinum_M MGVFAAIPSFWALPSNFLTGTAAAGAIGLINSVGNLGGFAAPYLTGALEQ
MSMEG_2537|M.smegmatis_MC2_155 VGVISAMPLVYSLPARILSSVAVGAGLALVNTIGNVGGFAGPFVTGWLRD
Mflv_3439|M.gilvum_PYR-GCK VVGTAYMAPSIAAIQRLVPAEQRATASAIFLFFSAILGSAGPFVAGLISD
Mvan_3193|M.vanbaalenii_PYR-1 VVGTAYMAPSIAAIQRLVPAEQRATASAIFLFFSAILGSVGPLVTGLISD
MUL_0838|M.ulcerans_Agy99 SVLTATYTAAFDPISGLIDSQLATAQESIRTANDLADATSAPALASQIRI
MAB_1429|M.abscessus_ATCC_1997 GVSGTSLVPALQTRLMDVADDAQTLAAALNHSALNIANAGGAWLGGLVIT
MAV_4306|M.avium_104 GYTMGFGSLGWVYASESFPSRLRSIGSSTMLTSNLVANAIVAAVFLTLLH
TH_0390|M.thermoresistible__bu SVGGPGSMVGFDFARTFNPSATLGTAQGMVNMGGFLASLLVMQAMGQILD
. :
Rv1672c|M.tuberculosis_H37Rv ATG-----TYHLALLTVAAVLAAAAACSLLLRHAGRTVCANDSEIMLHPS
Mb1699c|M.bovis_AF2122/97 ATG-----TYHLALLTVAAVLAAAAACSLLLRHAGRTVCANDSEIMLHPS
MMAR_0596|M.marinum_M VTG-----TDKAGMWAVGAMMLMSAFVVVLLRAVPGSPTAAERPN-----
MSMEG_2537|M.smegmatis_MC2_155 LFG-----NDQGAFAVVALLLLTSGVISVAVQSRTHSINEALQRNDPASR
Mflv_3439|M.gilvum_PYR-GCK AMK-----AELGSGSLGRALLCVVPVMHLVAIGCYLLASRRYLRELVN--
Mvan_3193|M.vanbaalenii_PYR-1 TLK-----ADLGTMSLGRALLCVVPLMHLVAIGCYLLASRRYVREIVD--
MUL_0838|M.ulcerans_Agy99 EAH-----TAFLAGFHTTIVVAIAILAAAAVAAGALLSTKTLPEPAGQDA
MAB_1429|M.abscessus_ATCC_1997 AGY-----GYRAPSLVGAALAIAGLVVLGLSVLYARSRAVALPSRAG---
MAV_4306|M.avium_104 SLG-----GAGTFAVFAVLAVVAFAFVHRYAPETKGRQLEDIRHFWENGG
TH_0390|M.thermoresistible__bu AAGGYSFDSFRLAWTVQYVVWVVAAVGILITRKKARRQMALEQERMLLES
Rv1672c|M.tuberculosis_H37Rv PATPFV-------------
Mb1699c|M.bovis_AF2122/97 PATPFV-------------
MMAR_0596|M.marinum_M -------------------
MSMEG_2537|M.smegmatis_MC2_155 RHRATIE------------
Mflv_3439|M.gilvum_PYR-GCK -------------------
Mvan_3193|M.vanbaalenii_PYR-1 -------------------
MUL_0838|M.ulcerans_Agy99 PDPSA--------------
MAB_1429|M.abscessus_ATCC_1997 -------------------
MAV_4306|M.avium_104 RWD----------------
TH_0390|M.thermoresistible__bu FEPGPRRHTGPDRTNRPHG