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MANAPGNNLTPKSDDSARRSALRKVNLRLMPFIFLLYLVNYVDRTALGIAAPNGMSDELQMTATLFGLAS GIFFVGYILLEVPSAMAAQRTGARVWIARIAITWGAVASLTAFVPNYQWLIVARFLLGVAEAGFAPTVLL YLTIWFSNRERPKAFSVYLLGIPISSVVAGPVASWLINAGDGVFGLSGWRFMTLMTGVPAIILGVAALFW LTDRPSQAAWLTDAEKEALIADHDEHTPAEARGHAGGMLSSLRSGRVWIMGFAYLGVVYSLYTIGFFLPS VVSGFAERFGTDFTVIENGFIIAVPYVFAAAALMLWPRHATRSGDIGWHVLISTVVGALGIVIAAFAGDP WIVMLGVTLCAVGVISAMPLVYSLPARILSSVAVGAGLALVNTIGNVGGFAGPFVTGWLRDLFGNDQGAF AVVALLLLTSGVISVAVQSRTHSINEALQRNDPASRRHRATIE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2537 | - | - | 100% (463) | transporter protein |
| M. smegmatis MC2 155 | MSMEG_6375 | - | 7e-67 | 35.11% (413) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_5347 | - | 2e-53 | 32.21% (444) | transporter, major facilitator family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1699c | - | 3e-66 | 34.17% (439) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1840 | - | 2e-08 | 24.02% (383) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1672c | - | 3e-66 | 34.17% (439) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1429 | - | 4e-09 | 22.55% (377) | major facilitator superfamily permease |
| M. marinum M | MMAR_0596 | - | 1e-110 | 44.87% (419) | integral membrane transport protein |
| M. avium 104 | MAV_4306 | - | 2e-06 | 23.65% (406) | transporter, major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_0390 | - | 3e-06 | 21.24% (419) | major facilitator superfamily protein permease |
| M. ulcerans Agy99 | MUL_1444 | sugI | 5e-07 | 21.95% (401) | sugar-transport integral membrane protein SugI |
| M. vanbaalenii PYR-1 | Mvan_4890 | - | 4e-09 | 24.14% (377) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1840|M.gilvum_PYR-GCK ----MSAAVDQQSTPGASVAAPDPVVRRLAVLALALGGFGIGTTEFVAMG
Mvan_4890|M.vanbaalenii_PYR-1 ----MTDTLHRPSGP-VSVAAPDPVVRRLAVVALALGGFGIGTTEFVAMG
MAB_1429|M.abscessus_ATCC_1997 ----MTAVVDSRVQP---AAPVSPRVRRGAILALALGGFGIGTTEFVAMG
MSMEG_2537|M.smegmatis_MC2_155 MANAPGNNLTPKSDDSARRSALRKVNLRLMPFIFLLYLVNYVDRTALGIA
MMAR_0596|M.marinum_M MA------VLDTGERSLEARTIRKLGIRIVPFLMALYFVNYLDRTNLGIA
Mb1699c|M.bovis_AF2122/97 ---------MATIAASPTHNALGKAARRLLPLLFVLYVINFVDRANISVA
Rv1672c|M.tuberculosis_H37Rv ---------MATIAASPTHNALGKAARRLLPLLFVLYVINFVDRANISVA
MAV_4306|M.avium_104 -------------------MARGSRRGLLVGLTAASVGVIYGYDLSIIAG
MUL_1444|M.ulcerans_Agy99 -----------------------MQRGILVALTAASVGLIYGYDLSIIAG
TH_0390|M.thermoresistible__bu ----MNPGRRARTAAGDDDERLAVRPWIVWATGLLAYIVAVLDRTTLGVS
. : .
Mflv_1840|M.gilvum_PYR-GCK LLPDIARSFDVSEPVAGHVISAYALGVVVGAPLIAAITARMARRTLLLAL
Mvan_4890|M.vanbaalenii_PYR-1 LLPDIATGMGVSEPTAGHVISAYALGVVVGAPVIAAVTARMARRKLLLAL
MAB_1429|M.abscessus_ATCC_1997 LLPNIAHGLHVTEPQAGHVISAYALGVVVGAPVIAALTARASRRTLLVAL
MSMEG_2537|M.smegmatis_MC2_155 APNGMSDELQMTATLFGLASGIFFVGYILLEVPSAMAAQRTGARVWIARI
MMAR_0596|M.marinum_M RAD-ISAHLQLTATMFGLASGIFFIGYVLVEVPSNLALDRYGARRWLARI
Mb1699c|M.bovis_AF2122/97 ALA-MNADLRLSATAYGTAAGVFFLGYVLFQVPANAALARFGAGRTLTAV
Rv1672c|M.tuberculosis_H37Rv ALA-MNADLRLSATAYGTAAGVFFLGYVLFQVPANAALARFGAGRTLTAV
MAV_4306|M.avium_104 AQLFVTEDFGLSTRQQELLTTMAVIGQIGGALFAGVLANAIGRRRSVLLI
MUL_1444|M.ulcerans_Agy99 AQLFITEEFGLSTHQQELLTTMVVIGQIVGALGAGVLANAIGRKKSVVML
TH_0390|M.thermoresistible__bu GLA-AADRFNAAPAALSTFVVLQVIVYALAQVPAGLLLDRFGSKALIVAG
: : : . :
Mflv_1840|M.gilvum_PYR-GCK MAVFTLGNLASMLASSYETLVGARFLAGLPHGAYFGVAALVAAHLMGPQH
Mvan_4890|M.vanbaalenii_PYR-1 MALFTIGNLASMLAPTYETLIAARFLAGLPHGAYFGVAALVAAHLMGPQN
MAB_1429|M.abscessus_ATCC_1997 MVAFTIGNAATVFAPGYAALIASRFVAGLPHGAYFGVAALVAAHLAGPGE
MSMEG_2537|M.smegmatis_MC2_155 AITWGAVASLTAFVPNYQWLIVARFLLGVAEAGFAPTVLLYLTIWFSNRE
MMAR_0596|M.marinum_M AVSWGIVVVATGFAPNATTLLVLRFLLGVAEAGLFPGVIYYLSRWFPRDY
Mb1699c|M.bovis_AF2122/97 VLAWGVCSAATALVTSAHTLYLARFALGVAEGGFFPGVIAYLTVWFPCAQ
Rv1672c|M.tuberculosis_H37Rv VLAWGVCSAATALVTSAHTLYLARFALGVAEGGFFPGVIAYLTVWFPCAQ
MAV_4306|M.avium_104 LSGYAVFALLAAFSVGLPMLLTARLLLGLTIGVTVVVVPVYVAESAPTAV
MUL_1444|M.ulcerans_Agy99 LVAYTMFAVLGALSVSLPMLLAARFLLGLAVGVSIVVVPVYVAESAPAAV
TH_0390|M.thermoresistible__bu AAVMATGQLILAFTESLTLAILARAIVGLGDAVTFISVLRLVPHWFRPRQ
: * *: . . .
Mflv_1840|M.gilvum_PYR-GCK RAKAVAHVLTGLTVATVLGVPVASWLG-------QSLGWRAAFGLVVAVG
Mvan_4890|M.vanbaalenii_PYR-1 RAKAVAHVLTGLTVATVLGVPIASWLG-------QSLGWRAAFGLVVGVG
MAB_1429|M.abscessus_ATCC_1997 RAKAVGQTMLGLSVANVVGVPVATWLG-------NTVGWRSAFAVVAVIG
MSMEG_2537|M.smegmatis_MC2_155 RPKAFSVYLLGIPISSVVAGPVASWLINAGDGVFGLSGWRFMTLMTGVPA
MMAR_0596|M.marinum_M RARVVALFMMASPIAAALGTPLAAWLIHLGNGVFGLAGWQFMMIAVGVPA
Mb1699c|M.bovis_AF2122/97 RARAVATFLLAIPVANTVGLPLSGLIVGHVH-MAGLPGWRAMFVIEALPA
Rv1672c|M.tuberculosis_H37Rv RARAVATFLLAIPVANTVGLPLSGLIVGHVH-MAGLPGWRAMFVIEALPA
MAV_4306|M.avium_104 RGALLTAYQLAIVSGLIVGYLSGYLLA-------GTHSWRWMLGLACVPA
MUL_1444|M.ulcerans_Agy99 RGSLLTVYQLTTVSGLIVGYLTGYLLA-------GTHSWRWMLGLATVPA
TH_0390|M.thermoresistible__bu VPLVTQLTGICGQLGQVLSAVLFLALLT-------ARGWTPAYLSVVALG
. :. : .* .
Mflv_1840|M.gilvum_PYR-GCK VLTLTALALWLPVQLRLMRSTSPLTELGALRRPQ----------------
Mvan_4890|M.vanbaalenii_PYR-1 LVTLTALWCWLPFQLKFMRATSPLTELGALRRPQ----------------
MAB_1429|M.abscessus_ATCC_1997 AITIAALLRYLP-GLTDMRITNPLTELGALRRVQ----------------
MSMEG_2537|M.smegmatis_MC2_155 IILGVAALFWLTDRPSQAAWLTDAEKEALIADHDEHTPAEARGHAG----
MMAR_0596|M.marinum_M IVLGFACWYYLVDRPGDAAWLEPDERQWLVDTLAEEQRQVAGDFHF----
Mb1699c|M.bovis_AF2122/97 LLLAPLLRRLLPDNPQRASWLTPEERAELSARLTEDTPAPTG--------
Rv1672c|M.tuberculosis_H37Rv LLLAPLLRRLLPDNPQRASWLTPEERAELSARLTEDTPAPTG--------
MAV_4306|M.avium_104 VLLLPLVFRMPDTARWYLLKGRVDDARRALLRVEPAARVDDELAEIGRAV
MUL_1444|M.ulcerans_Agy99 MLLLPLLIRMPDTPRWYVMKGRIQEARAALLRVDPAADVEEELAEIGTAL
TH_0390|M.thermoresistible__bu VLTIALTLALVQNTPDGRAAPATMGTVREIAASLKTVWLRAG--------
:
Mflv_1840|M.gilvum_PYR-GCK --------------------VWLALAVGMIGFGGMFAVYTYIATTMTDVA
Mvan_4890|M.vanbaalenii_PYR-1 --------------------VWLALLVGMIGFGGMFAVYTYITTTMTDVA
MAB_1429|M.abscessus_ATCC_1997 --------------------VWFTLLIGIVGFGGMFAFYTYISTTLTSVS
MSMEG_2537|M.smegmatis_MC2_155 -------------GMLSSLRSGRVWIMGFAYLGVVYSLYTIGFFLPSVVS
MMAR_0596|M.marinum_M -------------PLRRALTSPRIWALALVYFGIAYGLYALTFFLPSIIS
Mb1699c|M.bovis_AF2122/97 ---------------RSSGAGWDLVLFAVVYGGLYFALYALQFFLPQLVA
Rv1672c|M.tuberculosis_H37Rv ---------------RSSGAGWDLVLFAVVYGGLYFALYALQFFLPQLVA
MAV_4306|M.avium_104 SEEAASLPAMLAEMVRSPYRRATVFVVVLGFLIQITGINAIIYYSPRIFE
MUL_1444|M.ulcerans_Agy99 SEGSG----GVSEMLRPPFLRATIFVITLGFLIQITGINAIIYYSPRIFE
TH_0390|M.thermoresistible__bu ---------------------TRLGFFTHMGTQFSVTVFALMWGVPYLTV
. . :
Mflv_1840|M.gilvum_PYR-GCK GMPRALVP---------VALMVFGLGMFFGNLVGGRLADRSVVRALYLSM
Mvan_4890|M.vanbaalenii_PYR-1 GMPRGLVP---------LALMMFGLGMVLGNLVGGRLADGSVVRALYLSL
MAB_1429|M.abscessus_ATCC_1997 GLPRALVP---------LALSLYGIGMVTGNVLGGWMADRSVVRAIAVGL
MSMEG_2537|M.smegmatis_MC2_155 GFAERFGTDFTVIENGFIIAVPYVFAAAALMLWP-RHATRSGDIGWHVLI
MMAR_0596|M.marinum_M GFKKSFGIDFSIVQVGLIAAIPYTCAAVAMYLWS-RHADATGEQVWHVAV
Mb1699c|M.bovis_AF2122/97 SLAHGT----ATLTAATLAALPYGVAALAMLAWSHRSIDRSGAQAGHITL
Rv1672c|M.tuberculosis_H37Rv SLAHGT----ATLTAATLAALPYGVAALAMLAWSHRSIDRSGAQAGHITL
MAV_4306|M.avium_104 AMGFTGNF------ALLALPALVQVAGLVAVGTALLLVDRVGRRPILLCG
MUL_1444|M.ulcerans_Agy99 AMGFTGDF------ALLGLPALVQIAGVAAVITSLLLVDRVGRRPILLSG
TH_0390|M.thermoresistible__bu GQGLSTQMAG---AMLTLSVAVAIVAGVLIGIFTGRHPHRRSRLVLAIIA
. . :
Mflv_1840|M.gilvum_PYR-GCK G--ALCAMLTLFVAASHNPWTALLALFGIGLTGSAVGPALQTR-----LM
Mvan_4890|M.vanbaalenii_PYR-1 G--ALCGALALFVVASHNPWTALLVLFLIGLTGSAVGPALQTR-----LM
MAB_1429|M.abscessus_ATCC_1997 V--LVAAMLLIFAAVSRNPWAALALVFAVGVSGTSLVPALQTR-----LM
MSMEG_2537|M.smegmatis_MC2_155 S-TVVGALGIVIAAFAGDPWIVMLGVTLCAVGVISAMPLVYSL-----PA
MMAR_0596|M.marinum_M P-MLLGGLAIPVALHLHTPVLVMVAVAITAMGVFAAIPSFWAL-----PS
Mb1699c|M.bovis_AF2122/97 PTTAAGSAALGAALSPMSPIVTLSWLTIAVAGILAAMPAFWSR-----CT
Rv1672c|M.tuberculosis_H37Rv PTTAAGSAALGAALSPMSPIVTLSWLTIAVAGILAAMPAFWSR-----CT
MAV_4306|M.avium_104 TAMMIVADVVLVAVFGRGPGGVIAGFAGVLLFIFGYTMGFGSLGWVYASE
MUL_1444|M.ulcerans_Agy99 IAIMIVADVALMAVFARGQGAAILGFAGILLFIIGYTMGFGSLGWVYASE
TH_0390|M.thermoresistible__bu S-NAAAWTAVLALPDRAPLWLLITLIVVISVGGPGSMVGFDFAR------
: . . .
Mflv_1840|M.gilvum_PYR-GCK DVAH-DAQTLAAALNHSALNIGNATGAWVGG-LVIAAG-----YGYTAPA
Mvan_4890|M.vanbaalenii_PYR-1 DVAH-DAQTLAAALNHSALNIGNATGAWVGG-LVIAAG-----LGYTAPA
MAB_1429|M.abscessus_ATCC_1997 DVAD-DAQTLAAALNHSALNIANAGGAWLGG-LVITAG-----YGYRAPS
MSMEG_2537|M.smegmatis_MC2_155 RILSSVAVGAGLALVNTIGNVGGFAGPFVTGWLRDLFG-----NDQGAFA
MMAR_0596|M.marinum_M NFLTGTAAAGAIGLINSVGNLGGFAAPYLTGALEQVTG-----TDKAGMW
Mb1699c|M.bovis_AF2122/97 AALAGPRVAVAIATVNAVASLASFAGPYATGHLKDATG-----TYHLALL
Rv1672c|M.tuberculosis_H37Rv AALAGPRVAVAIATVNAVASLASFAGPYATGHLKDATG-----TYHLALL
MAV_4306|M.avium_104 SFPSRLRSIGSSTMLTSNLVANAIVAAVFLTLLHSLGG-----AGTFAVF
MUL_1444|M.ulcerans_Agy99 SFPTRLRSIGSSTMLTANLIANAIVAAVFLTMLHSLGG-----SGAFAVF
TH_0390|M.thermoresistible__bu TFNPSATLGTAQGMVNMGGFLASLLVMQAMGQILDAAGGYSFDSFRLAWT
. : * .
Mflv_1840|M.gilvum_PYR-GCK GAGAVLALAGLVVLTVSVVLQKR---------------------------
Mvan_4890|M.vanbaalenii_PYR-1 AAGAVLALAGLAVLTVSVLLQKRG--------------------------
MAB_1429|M.abscessus_ATCC_1997 LVGAALAIAGLVVLGLSVLYARSRAVALPSRAG-----------------
MSMEG_2537|M.smegmatis_MC2_155 VVALLLLTSGVISVAVQSRTHSINEALQRNDPASRRHRATIE--------
MMAR_0596|M.marinum_M AVGAMMLMSAFVVVLLRAVPGSPTAAERPN--------------------
Mb1699c|M.bovis_AF2122/97 TVAAVLAAAAACSLLLRHAGRTVCANDSEIMLHPSPATPFV---------
Rv1672c|M.tuberculosis_H37Rv TVAAVLAAAAACSLLLRHAGRTVCANDSEIMLHPSPATPFV---------
MAV_4306|M.avium_104 AVLAVVAFAFVHRYAPETKGRQLEDIRHFWENGGRWD-------------
MUL_1444|M.ulcerans_Agy99 GVLALVAFGVVYRYAPETKGRQLEEIRHFWENGGRWPEKLTEAP------
TH_0390|M.thermoresistible__bu VQYVVWVVAAVGILITRKKARRQMALEQERMLLESFEPGPRRHTGPDRTN
.
Mflv_1840|M.gilvum_PYR-GCK ----
Mvan_4890|M.vanbaalenii_PYR-1 ----
MAB_1429|M.abscessus_ATCC_1997 ----
MSMEG_2537|M.smegmatis_MC2_155 ----
MMAR_0596|M.marinum_M ----
Mb1699c|M.bovis_AF2122/97 ----
Rv1672c|M.tuberculosis_H37Rv ----
MAV_4306|M.avium_104 ----
MUL_1444|M.ulcerans_Agy99 ----
TH_0390|M.thermoresistible__bu RPHG