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MSITADVVIVGGGLEGTAAAWALSQRGVTDVVVAERNTVGSGMTGKSSGIVRCHYGVSSLAAMAAVGLDV FEKAEEIFGDDIGFRQTGYVVGVGEQNVDALRKSLAAQRQVGVQTEEIDASEVAKLWPWADLEPFAAFGW EARGGYGDAYQTAQAFAIAARAAGVRIRQGATVTELLMGADRVTGVRLADGTEVSAGTVVVATGAWTRPF LAPYGVDIPIRVIREQIVTISPGLDIGAVPVFSDLVSLQYVRPELGGEILFGNSDLGHGESADPDNYLNR ATEEFVDITVEKVGTRFPGLTDASITGSYAGCYDVTPDWNPVISETDVDGLIVAAGFSGHGFKIAPAVGR LVADLVVDGHSSDPRIPETDFRLSRFAEDNLLKSPYPYVGAGEMR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6264 | - | - | 100% (395) | putative oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_0665 | - | 4e-33 | 29.32% (399) | sarcosine oxidase subunit beta, putative |
| M. smegmatis MC2 155 | MSMEG_0175 | - | 5e-15 | 27.53% (396) | FAD dependent oxidoreductase, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0423 | thiO | 4e-06 | 22.57% (381) | thiamine biosynthesis oxidoreductase ThiO |
| M. gilvum PYR-GCK | Mflv_1296 | - | 0.0 | 80.80% (401) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv0415 | thiO | 3e-06 | 22.57% (381) | thiamine biosynthesis oxidoreductase ThiO |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2283 | - | 2e-12 | 24.27% (375) | putative oxidoreductase |
| M. marinum M | MMAR_4421 | solA | 4e-20 | 27.51% (378) | dehydrogenase |
| M. avium 104 | MAV_0142 | - | 2e-08 | 27.96% (211) | FAD dependent oxidoreductase, putative |
| M. thermoresistible (build 8) | TH_2138 | - | 2e-11 | 29.70% (266) | D-amino-acid dehydrogenase |
| M. ulcerans Agy99 | MUL_2805 | thiO | 8e-06 | 23.02% (378) | thiamine biosynthesis oxidoreductase ThiO |
| M. vanbaalenii PYR-1 | Mvan_5513 | - | 0.0 | 81.52% (395) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1296|M.gilvum_PYR-GCK -----------------------------MTETADVVIVGGGLEGAAAAW
Mvan_5513|M.vanbaalenii_PYR-1 -----------------------------MTETADVVIVGGGLEGAAAAW
MSMEG_6264|M.smegmatis_MC2_155 -----------------------------MSITADVVIVGGGLEGTAAAW
Mb0423|M.bovis_AF2122/97 --------------------------MASDLHTGSLAVIGGGVIGLSVAR
Rv0415|M.tuberculosis_H37Rv --------------------------MASDLHTGSLAVIGGGVIGLSVAR
MUL_2805|M.ulcerans_Agy99 ---------------------------MSSPSMGSLAVIGGGVIGLSVAR
MMAR_4421|M.marinum_M ----------------------------MATTGYDVIVIGLGGMGSAAAY
TH_2138|M.thermoresistible__bu --------------------MSQRFAERVDGGPRSAIVIGAGIVGLSTAW
MAB_2283|M.abscessus_ATCC_1997 MNGTEIGHLAETAPIWWPGSPESAAPITDGRHDVDVLVIGAGLAGLAAAY
MAV_0142|M.avium_104 ----------------------------------MIVVIGAGVCGLAAAH
::* * * :.*
Mflv_1296|M.gilvum_PYR-GCK ALSRRGVTDVVVCERSTVGS--GMTGKSSGIVRCHYGVSSLAAMAADGLE
Mvan_5513|M.vanbaalenii_PYR-1 ALSRRGVTDVVVAERNTVGS--GMTGKSSGIVRCHYGVSSLAAMAADGLE
MSMEG_6264|M.smegmatis_MC2_155 ALSQRGVTDVVVAERNTVGS--GMTGKSSGIVRCHYGVSSLAAMAAVGLD
Mb0423|M.bovis_AF2122/97 RAAQAGWPVRVHRSDERGAS--WVAG--GMLAPHSEGWPGEERLLRLGLQ
Rv0415|M.tuberculosis_H37Rv RAAQAGWPVRVHRSDERGAS--WVAG--GMLAPHSEGWPGEERLLRLGLQ
MUL_2805|M.ulcerans_Agy99 RAAQAGWAVRVHRRAEPGAS--WAAG--GMLAPHSEGWPGEERLLRLGLE
MMAR_4421|M.marinum_M HLAARGRRVLGLERHQPAHDKGSSHGGSRIIRQSYFEDPGYVPLLLRSYE
TH_2138|M.thermoresistible__bu FLQERGVDVCVVDRTGVAAG--ASWGNAGWISPGLAIPLNEPGVLRYGLR
MAB_2283|M.abscessus_ATCC_1997 FVTELRPELSVAVLEAKHVG-AGATGRSTGIVSPGLSMPMAAFRRKYGDD
MAV_0142|M.avium_104 ELSRRGHDDVVVLEKGQPFG--EQSAGLARIFRIAHQREALCRLAFAARA
. . : .
Mflv_1296|M.gilvum_PYR-GCK VFEQ--AQDIFGTDIGFRQTGYVVGVGEQN--VDALRKSLAAQRSVGVET
Mvan_5513|M.vanbaalenii_PYR-1 VFEN--GEDIFGTDIGFRQTGYVVGVGEQN--VESLRKSLAAQRAVGVDT
MSMEG_6264|M.smegmatis_MC2_155 VFEK--AEEIFGDDIGFRQTGYVVGVGEQN--VDALRKSLAAQRQVGVQT
Mb0423|M.bovis_AF2122/97 SLR------------LWREGSFLDGLG---------PQLVTAHESLVVAV
Rv0415|M.tuberculosis_H37Rv SLR------------LWREGSFLDGLG---------PQLVTAHESLVVAV
MUL_2805|M.ulcerans_Agy99 SLR------------LWHESGFLDGLP---------PQVVTARESLMVAV
MMAR_4421|M.marinum_M LWER--LAIDAQSDIYRLTGGLFIGPPD----CATVAGSLRASREWDLPH
TH_2138|M.thermoresistible__bu NLLSPTAPLHLPLTRDLRQWAFLTRFAANCRRSSWTRALLANKPLNDEAI
MAB_2283|M.abscessus_ATCC_1997 AAIAS-FDATFHGVGLLRDLVAKENIDCDARDEPHTLVALTDRSLARMVT
MAV_0142|M.avium_104 GWQR--WEAEFGVGRLLGSEGFIAAGAAAD-------GVAQAMKRAGAAF
Mflv_1296|M.gilvum_PYR-GCK EEIDESEVARLWPFADLT---PFAAFGWEARGG-----YGDAYQTAQAFS
Mvan_5513|M.vanbaalenii_PYR-1 EEIDKDEVAKLWPFADLT---PFAAFGWEARGG-----YGDAYQTAQAFS
MSMEG_6264|M.smegmatis_MC2_155 EEIDASEVAKLWPWADLE---PFAAFGWEARGG-----YGDAYQTAQAFA
Mb0423|M.bovis_AF2122/97 DRADVADLRTVADWLSAQ---GHPVI-WESAAR-----DVEPLLAQGIRH
Rv0415|M.tuberculosis_H37Rv DRADVADLRTVADWLSAQ---GHPVI-WESAAR-----DVEPLLAQGIRH
MUL_2805|M.ulcerans_Agy99 DRADVADLRTVADWLSEQ---GHPVS-WESAAR-----DVEPLLAQGIRH
MMAR_4421|M.marinum_M EVLDAPQIAARFPNFTPQ---PTDIALYEAKAG-----LARPELTVRAHL
TH_2138|M.thermoresistible__bu EAYDVLTANGVDAPVTDA---PITAVFRDPREAGRLRDELRRVAETGRDV
MAB_2283|M.abscessus_ATCC_1997 HLENLAELGREVPWLSSQEVVQWAGAGYKAGFAYRDAMVVDPYRLVTGMA
MAV_0142|M.avium_104 SRLDRDGIAERIPFADVP----WETGIFDPLGG--------SLRIRRALT
: ..
Mflv_1296|M.gilvum_PYR-GCK TSARAAGVRVRQGTAVAGLLADA---------DRVTG---VRLADGSEIS
Mvan_5513|M.vanbaalenii_PYR-1 TAARAAGARVRQGTAVTDLLVDG---------DRVTG---VRTADGSEIF
MSMEG_6264|M.smegmatis_MC2_155 IAARAAGVRIRQGATVTELLMGA---------DRVTG---VRLADGTEVS
Mb0423|M.bovis_AF2122/97 GFRAPTELAVDNRALLDVLCRDC---------ERLGVRWSSQVSSLSDVD
Rv0415|M.tuberculosis_H37Rv GFRAPTELAVDNRALLDALCRDC---------ERLGVRWSSQVSSLSDVD
MUL_2805|M.ulcerans_Agy99 GFRATTELAVDNRALLDALAVDC---------ERRGVTWAGPVADLSDAT
MMAR_4421|M.marinum_M ELAKRSGATLQFEEPVLNWTTTA---------SGVRV-----TTGRDTYT
TH_2138|M.thermoresistible__bu EVTELSGADLRERVPLASAEITVG--------LEIHGQRYVDPARFVQAL
MAB_2283|M.abscessus_ATCC_1997 DILRRRGAPVYEHSPVISIEADATGVCVFTARAQVRARHAFLATDGYSGT
MAV_0142|M.avium_104 ALARRVVIRCGEVVSVADDGRTV-------------------LADGTVLR
: :
Mflv_1296|M.gilvum_PYR-GCK AGTTVVATGVWTRPFLSAH---GIDMPIRVVREQIVMI--DPGID-----
Mvan_5513|M.vanbaalenii_PYR-1 AGTVVVATGVWTRPFLARY---GIDVPIRVIREQIVLI--DPGV------
MSMEG_6264|M.smegmatis_MC2_155 AGTVVVATGAWTRPFLAPY---GVDIPIRVIREQIVTI--SPGL------
Mb0423|M.bovis_AF2122/97 AHTVVIANGIDAPALWP-------GLPIRPVKGEVLRLRWRP--------
Rv0415|M.tuberculosis_H37Rv AHTVVIANGIDAPALWP-------GLPIRPVKGEVLRLRWRP--------
MUL_2805|M.ulcerans_Agy99 GDAVVIANGIDAPALWP-------GLPVRPVKGEVLRLRWRK--------
MMAR_4421|M.marinum_M AEQLVVCPGAWAPELLS-----QLGIPITVQRQVMYWLDPVGGTA-----
TH_2138|M.thermoresistible__bu ADSVVDRGATIHRMDITGVDSGPGGVTVHSAGGQELSAGAVVIATGAWLH
MAB_2283|M.abscessus_ATCC_1997 LNPLKSSVIPLRTHLLATAPLTEGQLAELGWSGRGAIIDQRTFFN-----
MAV_0142|M.avium_104 ADRVLICAGVATPKLFG-----PLGVGFVPHTR-----------------
:
Mflv_1296|M.gilvum_PYR-GCK --EAAVGRLPVFSDLV---SLQYVRPE-----LGGEILFGNSDLPGYDAI
Mvan_5513|M.vanbaalenii_PYR-1 ----EVGKVPVFSDLV---SLQYVRPE-----VGGEILFGNSDLPGYDAI
MSMEG_6264|M.smegmatis_MC2_155 ----DIGAVPVFSDLV---SLQYVRPE-----LGGEILFGNSDLG---HG
Mb0423|M.bovis_AF2122/97 ------GCMPLP--------QRVIRAR-----VRGRQVYLVPRSDGVVVG
Rv0415|M.tuberculosis_H37Rv ------GCMPLP--------QRVIRAR-----VRGRQVYLVPRSDGVVVG
MUL_2805|M.ulcerans_Agy99 ------GCMPLL--------QRVVRAR-----VHGRQVYLVPRADGVVVG
MMAR_4421|M.marinum_M --G--FRDHPIFIAENDSGAQIYGFPA-----IDGP--RGGVKVAFFRKG
TH_2138|M.thermoresistible__bu QLAQRWVRVPVQAGRGYSFTVPVDRPVPAPVYLPEVRVACTPCAAGLRVA
MAB_2283|M.abscessus_ATCC_1997 -----YYRMSADKRVVFGGGPAFVPSRIPSRDIKRSRVIQQRVRRELTER
MAV_0142|M.avium_104 --------------------FTYRGAD-----ATGAACLSAPEGYGLPLG
.
Mflv_1296|M.gilvum_PYR-GCK APADPDAYLNRATDDFVDLTVDK--VGTRFPGFPDASITGSYAGC--YDV
Mvan_5513|M.vanbaalenii_PYR-1 DPADPDDYLNRATDGFVDLTVDK--VGTRFPGFPDAAISGSYAGC--YDV
MSMEG_6264|M.smegmatis_MC2_155 ESADPDNYLNRATEEFVDITVEK--VGTRFPGLTDASITGSYAGC--YDV
Mb0423|M.bovis_AF2122/97 ATQYEHGRDTAPVVSGVRDLLDD--ACTVLPALGEYELAECEAGL--RPM
Rv0415|M.tuberculosis_H37Rv ATQYEHGRDTAPVVSGVRDLLDD--ACTVLPALGEYELAECEAGL--RPM
MUL_2805|M.ulcerans_Agy99 ATQYEHGRDLAPVVSGVRDLLED--ACAVMPALGEYEFAECTAGL--RPM
MMAR_4421|M.marinum_M IACTPDTIDRVVGPQEIHEMITR--VGELLPALAGTCLQAATCMY--SNT
TH_2138|M.thermoresistible__bu GTMEFRDPDAPLISKRVDAIVAA--ARPLLDGVRWDERGPSWVGP--RPV
MAB_2283|M.abscessus_ATCC_1997 FPVLADVEIDAAWSGITASSFDRNPVVGPVPGMDGLWFAGSWCGHGFSTS
MAV_0142|M.avium_104 GTGRWAFGQEVADPATVRALFPS---LVAVDRVDCVSVRAPWLDS-----
. . . .
Mflv_1296|M.gilvum_PYR-GCK TPDWNPVISRGPLDGLVIAAGFSGHGFKIAP-AVGRLVAD----LVVDGH
Mvan_5513|M.vanbaalenii_PYR-1 TPDWNPIISVAPLDGLVIAAGFSGHGFKIAP-AVGRLVAD----IVVDGH
MSMEG_6264|M.smegmatis_MC2_155 TPDWNPVISETDVDGLIVAAGFSGHGFKIAP-AVGRLVAD----LVVDGH
Mb0423|M.bovis_AF2122/97 TPDNLPLVQRLDSR-TLVAAGHGRSGFLLAPWTAEQIVSE----LVSVGA
Rv0415|M.tuberculosis_H37Rv TPDNLPLVQRLDSR-TLVAAGHGRSGFLLAPWTAEQIVSE----LVSVGA
MUL_2805|M.ulcerans_Agy99 TPDNLPIVGRLDAR-TLVAAGLGRSGFLLAPWTAEQIVSE----LVPIGA
MMAR_4421|M.marinum_M PDQHFVIARHPYCPAVTVACGFSGHGFKFVP-VVGEILAD----LVTEGA
TH_2138|M.thermoresistible__bu TPDGRPLIG-AVAEDVYVAAGHGMWGLTHGP-VTGRLLAE----QITTGK
MAB_2283|M.abscessus_ATCC_1997 VDTGWRFAKTLVGEPLPANIPWFRSGAQRVPTTLLRNVATGAYLKALDAA
MAV_0142|M.avium_104 GGDGWTVARRGRVLAFVGAN-----LMKFGP-LLGELLAR---AALSDDI
. * . ::
Mflv_1296|M.gilvum_PYR-GCK GSDPRIPASDFRFSRFAENDPLKTPYPYVGAGQMR
Mvan_5513|M.vanbaalenii_PYR-1 SSDSRIPASDFRFSRFAEDDPLKTPYPYVGAGQMR
MSMEG_6264|M.smegmatis_MC2_155 SSDPRIPETDFRLSRFAEDNLLKSPYPYVGAGEMR
Mb0423|M.bovis_AF2122/97 AS---------------------------------
Rv0415|M.tuberculosis_H37Rv AS---------------------------------
MUL_2805|M.ulcerans_Agy99 HS---------------------------------
MMAR_4421|M.marinum_M TSQPISLFDPQRLVTV-------------------
TH_2138|M.thermoresistible__bu QPDVLDEFDPLR-----------------------
MAB_2283|M.abscessus_ATCC_1997 DALDAKTSNPPQVARPTAGRQTSRGTTTLAEADK-
MAV_0142|M.avium_104 PAELLLD----------------------------
.