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TETADVVIVGGGLEGAAAAWALSRRGVTDVVVCERSTVGSGMTGKSSGIVRCHYGVSSLAAMAADGLEVF EQAQDIFGTDIGFRQTGYVVGVGEQNVDALRKSLAAQRSVGVETEEIDESEVARLWPFADLTPFAAFGWE ARGGYGDAYQTAQAFSTSARAAGVRVRQGTAVAGLLADADRVTGVRLADGSEISAGTTVVATGVWTRPFL SAHGIDMPIRVVREQIVMIDPGIDEAAVGRLPVFSDLVSLQYVRPELGGEILFGNSDLPGYDAIAPADPD AYLNRATDDFVDLTVDKVGTRFPGFPDASITGSYAGCYDVTPDWNPVISRGPLDGLVIAAGFSGHGFKIA PAVGRLVADLVVDGHGSDPRIPASDFRFSRFAENDPLKTPYPYVGAGQMR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1296 | - | - | 100% (401) | FAD dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3081 | solA | 2e-22 | 28.72% (383) | N-methyltryptophan oxidase |
| M. gilvum PYR-GCK | Mflv_3080 | - | 5e-16 | 30.80% (224) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | MLBr_00713 | glpD | 7e-05 | 30.00% (180) | putative glycerol-3-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2283 | - | 3e-12 | 23.98% (417) | putative oxidoreductase |
| M. marinum M | MMAR_4421 | solA | 1e-20 | 27.88% (373) | dehydrogenase |
| M. avium 104 | MAV_0142 | - | 5e-08 | 26.54% (211) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_6264 | - | 0.0 | 80.80% (401) | putative oxidoreductase |
| M. thermoresistible (build 8) | TH_1303 | - | 3e-07 | 26.15% (218) | iron-sulfur binding oxidoreductase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_5513 | - | 0.0 | 88.03% (401) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1296|M.gilvum_PYR-GCK -------------------------------MTETADVVIVGGGLEGAAA
Mvan_5513|M.vanbaalenii_PYR-1 -------------------------------MTETADVVIVGGGLEGAAA
MSMEG_6264|M.smegmatis_MC2_155 -------------------------------MSITADVVIVGGGLEGTAA
MMAR_4421|M.marinum_M ------------------------------MATTGYDVIVIGLGGMGSAA
MAB_2283|M.abscessus_ATCC_1997 --MNGTEIGHLAETAPIWWPGSPESAAPITDGRHDVDVLVIGAGLAGLAA
MAV_0142|M.avium_104 ------------------------------------MIVVIGAGVCGLAA
MLBr_00713|M.leprae_Br4923 MTDLIQAPESEQTWPASALGPQQRAAAWERFGTEQFDVVVIGGGVVGSGC
TH_1303|M.thermoresistible__bu ----------MTSLWLADRTNQPPPPRTLDAGDRRADVVVVGAGITGLIT
::::* * *
Mflv_1296|M.gilvum_PYR-GCK AWALSRRG--VTDVVVCERSTVGSGMTGKSSGIVRCHYGVSSLAAMAADG
Mvan_5513|M.vanbaalenii_PYR-1 AWALSRRG--VTDVVVAERNTVGSGMTGKSSGIVRCHYGVSSLAAMAADG
MSMEG_6264|M.smegmatis_MC2_155 AWALSQRG--VTDVVVAERNTVGSGMTGKSSGIVRCHYGVSSLAAMAAVG
MMAR_4421|M.marinum_M AYHLAARGRRVLGLERHQPAHDKGSSHGGSRIIRQSYFEDPGYVPLLLRS
MAB_2283|M.abscessus_ATCC_1997 AYFVTELR-PELSVAVLEAKHVGAGATGRSTGIVSPGLSMPMAAFRRKYG
MAV_0142|M.avium_104 AHELSRRG--HDDVVVLEKGQPFGEQSAGLARIFRIAHQREALCRLAFAA
MLBr_00713|M.leprae_Br4923 ALDAATRG---LKVALVEARDLASGTSSRSSKMFHGGLRYLEQLEFGLVR
TH_1303|M.thermoresistible__bu AVLLARGG---KDVLVVEAAYVGAGATGNTTAKISVLQGSRMSKILAKHG
* : : : . .
Mflv_1296|M.gilvum_PYR-GCK LEVFEQAQDIFGTDIGFRQTG---YVVGVGEQNVDALRKSLAAQRSVGVE
Mvan_5513|M.vanbaalenii_PYR-1 LEVFENGEDIFGTDIGFRQTG---YVVGVGEQNVESLRKSLAAQRAVGVD
MSMEG_6264|M.smegmatis_MC2_155 LDVFEKAEEIFGDDIGFRQTG---YVVGVGEQNVDALRKSLAAQRQVGVQ
MMAR_4421|M.marinum_M YELWERLAIDAQSDI-YRLTG---GLF-IGPPDCATVAGSLRASREWDLP
MAB_2283|M.abscessus_ATCC_1997 DDAAIASFDATFHGVGLLRDL---VAKENIDCDARDEPHTLVALTDRSLA
MAV_0142|M.avium_104 RAGWQRWEAEFGVGRLLGSEG---FIAAGAAADG-----VAQAMKRAGAA
MLBr_00713|M.leprae_Br4923 EALYERELSLTTLAPHLVKPLPFLFPLTKRWWERPYIAAGIFLYDRLGGA
TH_1303|M.thermoresistible__bu PRRARQYVEGNLEGLEWLVRHCAAHGLSVQREDAYTFAQSLQGVPAARTE
:
Mflv_1296|M.gilvum_PYR-GCK TEEIDESEVARL------WPFADLTPFAAFGWEARGGYG-----DAYQTA
Mvan_5513|M.vanbaalenii_PYR-1 TEEIDKDEVAKL------WPFADLTPFAAFGWEARGGYG-----DAYQTA
MSMEG_6264|M.smegmatis_MC2_155 TEEIDASEVAKL------WPWADLEPFAAFGWEARGGYG-----DAYQTA
MMAR_4421|M.marinum_M HEVLDAPQIAAR------FPNFTPQPTDIALYEAKAGLA-----RPELTV
MAB_2283|M.abscessus_ATCC_1997 RMVTHLENLAELGREVPWLSSQEVVQWAGAGYKAGFAYRDAMVVDPYRLV
MAV_0142|M.avium_104 FSRLDRDGIAER------------IPFADVPWETGIFDPLG---GSLRIR
MLBr_00713|M.leprae_Br4923 KSVPAQKHLTRAG-------ALRLSPGLKRSSLIGGIRYYDTVVDDARHT
TH_1303|M.thermoresistible__bu YLAAKIAGLDVEW-------VDDAEGGVPFPFHGAVRLADQAQFDPMPLL
:
Mflv_1296|M.gilvum_PYR-GCK QAFSTSARAAGVRVRQGTAVAGLLADADRVTGVRLAD------------G
Mvan_5513|M.vanbaalenii_PYR-1 QAFSTAARAAGARVRQGTAVTDLLVDGDRVTGVRTAD------------G
MSMEG_6264|M.smegmatis_MC2_155 QAFAIAARAAGVRIRQGATVTELLMGADRVTGVRLAD------------G
MMAR_4421|M.marinum_M RAHLELAKRSGATLQFEEPVLNWTTTAS---GVRVTT------------G
MAB_2283|M.abscessus_ATCC_1997 TGMADILRRRGAPVYEHSPVISIEADAT---GVCVFT------------A
MAV_0142|M.avium_104 RALTALARRVVIRCGEVVSVADD--------GRTVLA------------D
MLBr_00713|M.leprae_Br4923 LTVARTAAHYGAVVRCSTQVVALLREGDRVIGVRVRDSEDG--------A
TH_1303|M.thermoresistible__bu DSLVVELEERGGRLVQGLRVHKVSGRGD---GLTLHARSGAGDEFDLRAD
* *
Mflv_1296|M.gilvum_PYR-GCK SE-ISAGTTVVATGVWTRPFLSAHGID--MPIRVVREQIVMIDPGIDEAA
Mvan_5513|M.vanbaalenii_PYR-1 SE-IFAGTVVVATGVWTRPFLARYGID--VPIRVIREQIVLIDPGV---E
MSMEG_6264|M.smegmatis_MC2_155 TE-VSAGTVVVATGAWTRPFLAPYGVD--IPIRVIREQIVTISPGL---D
MMAR_4421|M.marinum_M RDTYTAEQLVVCPGAWAPELLSQLG----IPITVQRQVMYWLDPVGGTAG
MAB_2283|M.abscessus_ATCC_1997 RAQVRARHAFLATDGYSGTLNPLKSSV--IPLRTHLLATAPLTEGQ-LAE
MAV_0142|M.avium_104 GTVLRADRVLICAGVATPKLFGPLG-------------------------
MLBr_00713|M.leprae_Br4923 VTEIRGHVVVNATGVWTDEIQALSKQRGRFQVRVSKGVHVVVPRDRIVSD
TH_1303|M.thermoresistible__bu RCVLATGIPILDRGGFFARLEPNRSYCLAYEVPGEITRGMYISTDSPTRS
. . :
Mflv_1296|M.gilvum_PYR-GCK VGRLPVFS----------DLVSLQYVRPELGGEILFGNSDLPGYDAIAPA
Mvan_5513|M.vanbaalenii_PYR-1 VGKVPVFS----------DLVSLQYVRPEVGGEILFGNSDLPGYDAIDPA
MSMEG_6264|M.smegmatis_MC2_155 IGAVPVFS----------DLVSLQYVRPELGGEILFGNSDLG---HGESA
MMAR_4421|M.marinum_M FRDHPIFIA-------ENDSGAQIYGFPAIDGPR--GGVKVAFFRKGIAC
MAB_2283|M.abscessus_ATCC_1997 LGWSGRGAI-------IDQRTFFNYYRMSADKRVVFGGGPAFVPSRIPSR
MAV_0142|M.avium_104 VGFVPHTR--------------FTYRGADATGAACLSAPEGYGLPLGGTG
MLBr_00713|M.leprae_Br4923 VAMILRTKKSVMFIIPWGNHWIIGTTDTDWNLDLAHPAATKADIDYILQT
TH_1303|M.thermoresistible__bu LRYAPTGAG---------DLLIVGGAGHPVGHEKNPASSVAELDEWARRH
.
Mflv_1296|M.gilvum_PYR-GCK DPDAYLNRATDDFVDLTVDKVGTRFPGFPD-----ASITGSYAGCYDVTP
Mvan_5513|M.vanbaalenii_PYR-1 DPDDYLNRATDGFVDLTVDKVGTRFPGFPD-----AAISGSYAGCYDVTP
MSMEG_6264|M.smegmatis_MC2_155 DPDNYLNRATEEFVDITVEKVGTRFPGLTD-----ASITGSYAGCYDVTP
MMAR_4421|M.marinum_M TPDTIDRVVGPQEIHEMITRVGELLPALAG-----TCLQAATC-MYSNTP
MAB_2283|M.abscessus_ATCC_1997 D-----IKRSRVIQQRVRRELTERFPVLAD-----VEIDAAWSGITASSF
MAV_0142|M.avium_104 R----WAFGQEVADPATVRALFPSLVAVDR-----VDCVSVRAPWLDSGG
MLBr_00713|M.leprae_Br4923 VNTVLATPLTHADIDGVYAGLRPLLAGESD-----DTSKLTREHAVAVPV
TH_1303|M.thermoresistible__bu FPGAQQRYFWSAQDYSPIDDLPYVGPILPGNESIFVAIGFDKWGMTNGAA
:
Mflv_1296|M.gilvum_PYR-GCK DWNPVISRGP------LDGLVIAAGFSGHGFKIAPAVGRLVADLVVDG--
Mvan_5513|M.vanbaalenii_PYR-1 DWNPIISVAP------LDGLVIAAGFSGHGFKIAPAVGRLVADIVVDG--
MSMEG_6264|M.smegmatis_MC2_155 DWNPVISETD------VDGLIVAAGFSGHGFKIAPAVGRLVADLVVDG--
MMAR_4421|M.marinum_M DQHFVIARHPY-----CPAVTVACGFSGHGFKFVPVVGEILADLVTEG--
MAB_2283|M.abscessus_ATCC_1997 DRNPVVGPVPG-----MDGLWFAGSWCGHGFSTSVDTGWRFAKTLVGEPL
MAV_0142|M.avium_104 DGWTVARRGR-----------VLAFVGANLMKFGPLLGELLARAALSD--
MLBr_00713|M.leprae_Br4923 AGLVAIAGGKYTTYRVMAADAIDAAVAFVPARVAPSITEKVGLLGADGYF
TH_1303|M.thermoresistible__bu AALALSSRILGGRTDWAEAFASWSPHEVSGIPKAMMLNLQVGMYLARG--
..
Mflv_1296|M.gilvum_PYR-GCK --------------HGSDPRIPASDFRFSRFAENDPLKTP--------YP
Mvan_5513|M.vanbaalenii_PYR-1 --------------HSSDSRIPASDFRFSRFAEDDPLKTP--------YP
MSMEG_6264|M.smegmatis_MC2_155 --------------HSSDPRIPETDFRLSRFAEDNLLKSP--------YP
MMAR_4421|M.marinum_M --------------ATSQP--------ISLFDPQRLVTV-----------
MAB_2283|M.abscessus_ATCC_1997 PANIPWFRSGAQRVPTTLLRNVATGAYLKALDAADALDAKTSNPPQVARP
MAV_0142|M.avium_104 -----------------------------DIPAELLLD------------
MLBr_00713|M.leprae_Br4923 ALINQVEHVAALQGLHPYRVRHLLDRYGALIGDVLALAAEAPDLLSPIQE
TH_1303|M.thermoresistible__bu ----------WLTPVTRTGDRSPDDGCGVVSGPPWHLQARSRVDGVEHRV
:
Mflv_1296|M.gilvum_PYR-GCK YVGAGQMR------------------------------------------
Mvan_5513|M.vanbaalenii_PYR-1 YVGAGQMR------------------------------------------
MSMEG_6264|M.smegmatis_MC2_155 YVGAGEMR------------------------------------------
MMAR_4421|M.marinum_M --------------------------------------------------
MAB_2283|M.abscessus_ATCC_1997 TAGRQTSRGTTTLAEADK--------------------------------
MAV_0142|M.avium_104 --------------------------------------------------
MLBr_00713|M.leprae_Br4923 APGYLKVEARYAVTAEGALHLEDILARRMRVSIEYPHRGVACAREVADVV
TH_1303|M.thermoresistible__bu SPVCPHLGGIVNWNDADQAWECPLHGSRFAPDGALLEGPATRGLTAS---
Mflv_1296|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5513|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6264|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4421|M.marinum_M --------------------------------------------------
MAB_2283|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_0142|M.avium_104 --------------------------------------------------
MLBr_00713|M.leprae_Br4923 APVLGWTAEDIDREVATYNARVEAEVLSQAQPDDVSADMLRASAPEARTK
TH_1303|M.thermoresistible__bu --------------------------------------------------
Mflv_1296|M.gilvum_PYR-GCK --------
Mvan_5513|M.vanbaalenii_PYR-1 --------
MSMEG_6264|M.smegmatis_MC2_155 --------
MMAR_4421|M.marinum_M --------
MAB_2283|M.abscessus_ATCC_1997 --------
MAV_0142|M.avium_104 --------
MLBr_00713|M.leprae_Br4923 IIEPVSLT
TH_1303|M.thermoresistible__bu --------