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VTETADVVIVGGGLEGAAAAWALSRRGVTDVVVAERNTVGSGMTGKSSGIVRCHYGVSSLAAMAADGLEV FENGEDIFGTDIGFRQTGYVVGVGEQNVESLRKSLAAQRAVGVDTEEIDKDEVAKLWPFADLTPFAAFGW EARGGYGDAYQTAQAFSTAARAAGARVRQGTAVTDLLVDGDRVTGVRTADGSEIFAGTVVVATGVWTRPF LARYGIDVPIRVIREQIVLIDPGVEVGKVPVFSDLVSLQYVRPEVGGEILFGNSDLPGYDAIDPADPDDY LNRATDGFVDLTVDKVGTRFPGFPDAAISGSYAGCYDVTPDWNPIISVAPLDGLVIAAGFSGHGFKIAPA VGRLVADIVVDGHSSDSRIPASDFRFSRFAEDDPLKTPYPYVGAGQMR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5513 | - | - | 100% (398) | FAD dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2290 | - | 5e-28 | 26.87% (387) | FAD dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3930 | - | 3e-10 | 24.19% (372) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_1296 | - | 0.0 | 88.03% (401) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | MLBr_00713 | glpD | 6e-06 | 29.69% (229) | putative glycerol-3-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2651c | - | 3e-12 | 25.33% (383) | oxidoreductase |
| M. marinum M | MMAR_4421 | solA | 4e-18 | 26.58% (380) | dehydrogenase |
| M. avium 104 | MAV_0142 | - | 1e-09 | 27.01% (211) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_6264 | - | 0.0 | 81.52% (395) | putative oxidoreductase |
| M. thermoresistible (build 8) | TH_1303 | - | 1e-08 | 25.08% (307) | iron-sulfur binding oxidoreductase |
| M. ulcerans Agy99 | MUL_2667 | glpD2 | 2e-05 | 44.29% (70) | glycerol-3-phosphate dehydrogenase GlpD2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5513|M.vanbaalenii_PYR-1 -------------------------------MTETADVVIVGGGLEGAAA
Mflv_1296|M.gilvum_PYR-GCK -------------------------------MTETADVVIVGGGLEGAAA
MSMEG_6264|M.smegmatis_MC2_155 -------------------------------MSITADVVIVGGGLEGTAA
MLBr_00713|M.leprae_Br4923 MTDLIQAPESEQTWPASALGPQQRAAAWERFGTEQFDVVVIGGGVVGSGC
MUL_2667|M.ulcerans_Agy99 MSNPTDASQRDQTGPADSLGPEQRALAWERLGAEQFDVVVIGGGVVGSGC
MMAR_4421|M.marinum_M ------------------------------MATTGYDVIVIGLGGMGSAA
MAV_0142|M.avium_104 ------------------------------------MIVVIGAGVCGLAA
MAB_2651c|M.abscessus_ATCC_199 ----------MEYLFDTGWVDRPEVTAAALQGEIRCDVAVIGAGVGGMAA
TH_1303|M.thermoresistible__bu ----------MTSLWLADRTNQPPPPRTLDAGDRRADVVVVGAGITGLIT
: ::* * *
Mvan_5513|M.vanbaalenii_PYR-1 AWALSRRGVTDVVVAERNTVGSG--MTGKSS--GIVRCHYGVSSLAAMAA
Mflv_1296|M.gilvum_PYR-GCK AWALSRRGVTDVVVCERSTVGSG--MTGKSS--GIVRCHYGVSSLAAMAA
MSMEG_6264|M.smegmatis_MC2_155 AWALSQRGVTDVVVAERNTVGSG--MTGKSS--GIVRCHYGVSSLAAMAA
MLBr_00713|M.leprae_Br4923 ALDAATRGLKVALVEAR-DLASG--TSSRSS--KMFHGGLRYLEQLEFGL
MUL_2667|M.ulcerans_Agy99 ALDAATRGLKVALIEAR-DLASG--TSSRSS--KMFHGGLRYLEQLEFGL
MMAR_4421|M.marinum_M AYHLAARGRRVLGLERHQPAHDKGSSHGGSR--IIRQSYFEDPGYVPLLL
MAV_0142|M.avium_104 AHELSRRGHDDVVVLEKGQPFGE--QSAGLA--RIFRIAHQREALCRLAF
MAB_2651c|M.abscessus_ATCC_199 GLRLAERGVDVVVLEAGICGWGASSRNGGYLTDALSGDPRMLSALHRRRL
TH_1303|M.thermoresistible__bu AVLLARGGKDVLVVEAAYVGAGA--TGNTTAKISVLQGSRMSKILAKHGP
. : * : . :
Mvan_5513|M.vanbaalenii_PYR-1 DGLEVFENGEDIFGTDIGFRQTG---YVVGVGEQNVESLRKSLAAQRAVG
Mflv_1296|M.gilvum_PYR-GCK DGLEVFEQAQDIFGTDIGFRQTG---YVVGVGEQNVDALRKSLAAQRSVG
MSMEG_6264|M.smegmatis_MC2_155 VGLDVFEKAEEIFGDDIGFRQTG---YVVGVGEQNVDALRKSLAAQRQVG
MLBr_00713|M.leprae_Br4923 VREALYERELSLTTLAPHLVKPLPFLFPLTKRWWERPYIAAGIFLYDRLG
MUL_2667|M.ulcerans_Agy99 VREALFERELSLTTLAPHLVKPLPFLFPLTKRGWERPYIAAGIFLYDRLG
MMAR_4421|M.marinum_M RSYELWER-LAIDAQSDIYRLTG----GLFIGPPDCATVAGSLRASREWD
MAV_0142|M.avium_104 AARAGWQRWEAEFGVGRLLGSEG----FIAAG----AAADGVAQAMKRAG
MAB_2651c|M.abscessus_ATCC_199 PGVMRFGQSALRFAEDLIERHQIECDYNRVGWVSMASTTRHRAKNAERAA
TH_1303|M.thermoresistible__bu RRARQYVEGNLEGLEWLVRHCAA---HGLSVQREDAYTFAQSLQGVPAAR
: .
Mvan_5513|M.vanbaalenii_PYR-1 ---VDTEEIDKDEVAKLWPFADLTPFAAFG-WEARGGYGDAYQTAQAFST
Mflv_1296|M.gilvum_PYR-GCK ---VETEEIDESEVARLWPFADLTPFAAFG-WEARGGYGDAYQTAQAFST
MSMEG_6264|M.smegmatis_MC2_155 ---VQTEEIDASEVAKLWPWADLEPFAAFG-WEARGGYGDAYQTAQAFAI
MLBr_00713|M.leprae_Br4923 GAKSVPAQKHLTRAGALRLSPGLKRSSLIGGIRYYDTVVDDARHTLTVAR
MUL_2667|M.ulcerans_Agy99 GAKSVPAQKHLTRAGALRLSPGLKRSSLIGGIRYYDTVVDDARHTMTVAR
MMAR_4421|M.marinum_M ---LPHEVLDAPQIAARFPNFTPQP-TDIALYEAKAGLARPELTVRAHLE
MAV_0142|M.avium_104 ---AAFSRLDRDGIAERIPFADVPWETGIF-----DPLGGSLRIRRALTA
MAB_2651c|M.abscessus_ATCC_199 ---EVLRSLGADAEYVDGREFGLPHAFLGGVYEPHGGLCNAGKYALGLRK
TH_1303|M.thermoresistible__bu TEYLAAKIAGLDVEWVDDAEGGVPFPFHGAVRLADQAQFDPMPLLDSLVV
Mvan_5513|M.vanbaalenii_PYR-1 AARAAGARVRQGTAVTDLLVDGDRVTGVRTADG-----SEIFAGTVVVAT
Mflv_1296|M.gilvum_PYR-GCK SARAAGVRVRQGTAVAGLLADADRVTGVRLADG-----SEISAGTTVVAT
MSMEG_6264|M.smegmatis_MC2_155 AARAAGVRIRQGATVTELLMGADRVTGVRLADG-----TEVSAGTVVVAT
MLBr_00713|M.leprae_Br4923 TAAHYGAVVRCSTQVVALLREGDRVIGVRVRDSEDGAVTEIRGHVVVNAT
MUL_2667|M.ulcerans_Agy99 TASHYGAVVRCSTQVVALLREGDRVVGVRVRDSEDGSITEVRGHVVVNAT
MMAR_4421|M.marinum_M LAKRSGATLQFEEPVLNWTTTAS---GVRVTTG----RDTYTAEQLVVCP
MAV_0142|M.avium_104 LARR--VVIRCG-EVVSVADDGR----TVLADG-----TVLRADRVLICA
MAB_2651c|M.abscessus_ATCC_199 VLLASGARVYEQTPVQDLESSGS-AVVITVPGG------KVRADRVLLAT
TH_1303|M.thermoresistible__bu ELEERGGRLVQGLRVHKVSGRGDGLTLHARSGAG--DEFDLRADRCVLAT
: * . . . : ..
Mvan_5513|M.vanbaalenii_PYR-1 -------GVWTRPFLAR------------YGIDVPIR-------------
Mflv_1296|M.gilvum_PYR-GCK -------GVWTRPFLSA------------HGIDMPIR-------------
MSMEG_6264|M.smegmatis_MC2_155 -------GAWTRPFLAP------------YGVDIPIR-------------
MLBr_00713|M.leprae_Br4923 -------GVWTDEIQALSKQRGRFQVRVSKGVHVVVPRDRIVSDVAMILR
MUL_2667|M.ulcerans_Agy99 -------GVWTDEIQALSKQRGRFQVRASKGVHVVVPRDRIVSDVAMILR
MMAR_4421|M.marinum_M -------GAWAPELLSQ------------LGIPITVQR------------
MAV_0142|M.avium_104 -------GVATPKLFGP---------------------------------
MAB_2651c|M.abscessus_ATCC_199 -------NGYSADLPFAPPR------------------------------
TH_1303|M.thermoresistible__bu GIPILDRGGFFARLEPNRSYCLAYEVPGEITRGMYISTDSP---------
. :
Mvan_5513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1296|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6264|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00713|M.leprae_Br4923 TKKSVMFIIPWGNHWIIGTTDTDWNLDLAHPAATKADIDYILQTVNTVLA
MUL_2667|M.ulcerans_Agy99 TEKSVMFIIPWGSHWIIGTTDTDWNLDLAHPAATKADIDYILGTVNAVLA
MMAR_4421|M.marinum_M --------------------------------------------------
MAV_0142|M.avium_104 --------------------------------------------------
MAB_2651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1303|M.thermoresistible__bu --------------------------------------------------
Mvan_5513|M.vanbaalenii_PYR-1 --VIREQIVLIDPGV---EVGKVPVFSDLVSLQYVRPEVGGEILFGNSDL
Mflv_1296|M.gilvum_PYR-GCK --VVREQIVMIDPGIDEAAVGRLPVFSDLVSLQYVRPELGGEILFGNSDL
MSMEG_6264|M.smegmatis_MC2_155 --VIREQIVTISPGL---DIGAVPVFSDLVSLQYVRPELGGEILFGNSDL
MLBr_00713|M.leprae_Br4923 TPLTHADIDGVYAGLRPLLAGESDDTSKLTREHAVAVPVAGLVAIAGGKY
MUL_2667|M.ulcerans_Agy99 TPLTHADIDGVYAGLRPLLAGESDDTSKLSREHAVAVPAAGLVAIAGGKY
MMAR_4421|M.marinum_M --QVMYWLDPVGGTAGFRDHPIFIAENDSGAQIYGFPAIDGPR--GGVKV
MAV_0142|M.avium_104 ----------LGVGFVPHTRFTYRGADATGAACLSAPEGYGLPLGGTGRW
MAB_2651c|M.abscessus_ATCC_199 -LAAPLWVSLLETEPIDPERLDSTGWTNGAGFVSNNNIVSNFRKTPHNTI
TH_1303|M.thermoresistible__bu TRSLRYAPTGAGDLLIVGGAGHPVGHEKNPASSVAELDEWARRHFPGAQQ
Mvan_5513|M.vanbaalenii_PYR-1 PGYDAIDPADPDDYLNRATDGFVDLTVDKVGTR-----------------
Mflv_1296|M.gilvum_PYR-GCK PGYDAIAPADPDAYLNRATDDFVDLTVDKVGTR-----------------
MSMEG_6264|M.smegmatis_MC2_155 G---HGESADPDNYLNRATEEFVDITVEKVGTR-----------------
MLBr_00713|M.leprae_Br4923 TTYRVMAADAIDAAVAFVPARVAPSITEKVGLLGADGYFALINQVEHVAA
MUL_2667|M.ulcerans_Agy99 TTYRVMAADAIDAAVQFVPARVAPSITEKVSLLGADGYFALVNQVEHVGE
MMAR_4421|M.marinum_M AFFRKGIACTPDTIDRVVGPQEIHEMITRVGEL-----------------
MAV_0142|M.avium_104 AFG--QEVADPATVRALFPSLVAVDRVDCVSVR-----------------
MAB_2651c|M.abscessus_ATCC_199 VFGTRNVQAPQGPLGARTTDPAVAKDLLRGFREA----------------
TH_1303|M.thermoresistible__bu RYFWSAQDYSPIDDLPYVGPILPGNESIFVAIGFDKWGMTNG--------
Mvan_5513|M.vanbaalenii_PYR-1 ---------------------------------FPGFPDAAISGSYAGCY
Mflv_1296|M.gilvum_PYR-GCK ---------------------------------FPGFPDASITGSYAGCY
MSMEG_6264|M.smegmatis_MC2_155 ---------------------------------FPGLTDASITGSYAGCY
MLBr_00713|M.leprae_Br4923 LQGLHPYRVRHLLDRYGALIGDVLALAAEAPDLLSPIQEAPGYLKVEARY
MUL_2667|M.ulcerans_Agy99 MVGLHPYRVRHLLDRYGSLINEVLELAADDPDLLTPIKEAPGYLKVEALY
MMAR_4421|M.marinum_M ---------------------------------LPALAGTCLQAATCMYS
MAV_0142|M.avium_104 ----------------------------------------------APWL
MAB_2651c|M.abscessus_ATCC_199 ---------------------------------FPSLRDVATQKTWGGWI
TH_1303|M.thermoresistible__bu -------------------AAAALALSSRILGGRTDWAEAFASWSPHEVS
Mvan_5513|M.vanbaalenii_PYR-1 DVTPDWNPIISVAPLDGLVIAAGFSGHGFK--------IAPAVGRLVADI
Mflv_1296|M.gilvum_PYR-GCK DVTPDWNPVISRGPLDGLVIAAGFSGHGFK--------IAPAVGRLVADL
MSMEG_6264|M.smegmatis_MC2_155 DVTPDWNPVISETDVDGLIVAAGFSGHGFK--------IAPAVGRLVADL
MLBr_00713|M.leprae_Br4923 AVTAEGALHLEDILARRMRVSIEYPHRGVACAREVADVVAPVLGWTAEDI
MUL_2667|M.ulcerans_Agy99 AVTAEGALHLEDILARRMRVSIEYPHRGVDCAREVADVVAPVLGWTVEDI
MMAR_4421|M.marinum_M NTPDQHFVIARHPYCPAVTVACGFSGHGFK--------FVPVVGEILADL
MAV_0142|M.avium_104 DSGGDGWTVARR---GRVLAFVGANLMKFG----------PLLGELLARA
MAB_2651c|M.abscessus_ATCC_199 GMSPTLLPVAGQS-SSRVLYTNGCNGYGMT--------QAPYLATLLADR
TH_1303|M.thermoresistible__bu GIPKAMMLNLQVGMYLARGWLTPVTRTGDRSPDDGCGVVSGPPWHLQARS
Mvan_5513|M.vanbaalenii_PYR-1 VVDGHSSDSRIPASDFRFSR--FAEDDPLKTPYPYVGAGQMR--------
Mflv_1296|M.gilvum_PYR-GCK VVDGHGSDPRIPASDFRFSR--FAENDPLKTPYPYVGAGQMR--------
MSMEG_6264|M.smegmatis_MC2_155 VVDGHSSDPRIPETDFRLSR--FAEDNLLKSPYPYVGAGEMR--------
MLBr_00713|M.leprae_Br4923 DREVATYNARVEAEVLSQAQPDDVSADMLRASAPEARTKIIEPVSLT---
MUL_2667|M.ulcerans_Agy99 EREVANYKARVEAEVLSQAQPDDVSADMLRASAPEARAEILEPVPLN---
MMAR_4421|M.marinum_M VTEGATSQPISLFDPQRLVTV-----------------------------
MAV_0142|M.avium_104 ALSDDIPAELLLD-------------------------------------
MAB_2651c|M.abscessus_ATCC_199 LAGDEMHEDLRAVWYDHNVFPPNPQFSALGARALWTLDRITDQVDRLRS-
TH_1303|M.thermoresistible__bu RVDGVEHRVSPVCPHLGGIVNWNDADQAWECPLHGSRFAPDGALLEGPAT
Mvan_5513|M.vanbaalenii_PYR-1 ------
Mflv_1296|M.gilvum_PYR-GCK ------
MSMEG_6264|M.smegmatis_MC2_155 ------
MLBr_00713|M.leprae_Br4923 ------
MUL_2667|M.ulcerans_Agy99 ------
MMAR_4421|M.marinum_M ------
MAV_0142|M.avium_104 ------
MAB_2651c|M.abscessus_ATCC_199 ------
TH_1303|M.thermoresistible__bu RGLTAS