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MNGTEIGHLAETAPIWWPGSPESAAPITDGRHDVDVLVIGAGLAGLAAAYFVTELRPELSVAVLEAKHVG AGATGRSTGIVSPGLSMPMAAFRRKYGDDAAIASFDATFHGVGLLRDLVAKENIDCDARDEPHTLVALTD RSLARMVTHLENLAELGREVPWLSSQEVVQWAGAGYKAGFAYRDAMVVDPYRLVTGMADILRRRGAPVYE HSPVISIEADATGVCVFTARAQVRARHAFLATDGYSGTLNPLKSSVIPLRTHLLATAPLTEGQLAELGWS GRGAIIDQRTFFNYYRMSADKRVVFGGGPAFVPSRIPSRDIKRSRVIQQRVRRELTERFPVLADVEIDAA WSGITASSFDRNPVVGPVPGMDGLWFAGSWCGHGFSTSVDTGWRFAKTLVGEPLPANIPWFRSGAQRVPT TLLRNVATGAYLKALDAADALDAKTSNPPQVARPTAGRQTSRGTTTLAEADK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2283 | - | - | 100% (472) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2651c | - | 3e-24 | 26.20% (397) | oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2503c | - | 2e-07 | 27.05% (207) | putative iron-sulfur binding oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0580c | - | 7e-05 | 32.71% (107) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_1109 | - | 5e-39 | 28.79% (455) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv0565c | - | 7e-05 | 32.71% (107) | monooxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_5279 | - | 2e-05 | 22.11% (294) | monooxygenase-like flavoprotein |
| M. avium 104 | MAV_2749 | - | 7e-09 | 25.81% (217) | FAD dependent oxidoreductase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6471 | - | 1e-35 | 27.89% (441) | glycine/D-amino acid oxidase |
| M. thermoresistible (build 8) | TH_2138 | - | 2e-11 | 26.00% (250) | D-amino-acid dehydrogenase |
| M. ulcerans Agy99 | MUL_4352 | - | 2e-05 | 22.11% (294) | monooxygenase-like flavoprotein |
| M. vanbaalenii PYR-1 | Mvan_5703 | - | 1e-37 | 29.89% (455) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1109|M.gilvum_PYR-GCK ---------------------MHTRA-LNGQVSHWFDGLPISRGPLP-GS
Mvan_5703|M.vanbaalenii_PYR-1 ---------MPTSPLGCDNLPVPTRAPVNGYVSHWFDELPFSRGPLP-GS
MSMEG_6471|M.smegmatis_MC2_155 -MAEWQEVLCGHRVISNSWQNLTVLNTVNGQISHWFDTLPTPRAPLP-GD
Mb0580c|M.bovis_AF2122/97 MSVTPNAGCVDVVIVGAGISGLGAAYRIIERNPQLTYTILERRARIG-GT
Rv0565c|M.tuberculosis_H37Rv MSVTPNAGCVDVVIVGAGISGLGAAYRIIERNPQLTYTILERRARIG-GT
MMAR_5279|M.marinum_M MNSSS-IEHVDVLIVGAGISGIGAAYYLQEHQPAKTFAIVEARNDIG-GT
MUL_4352|M.ulcerans_Agy99 MNSSS-IEHVDVLIVGAGISGIGAAYYLQEHQPAKTFAIVEARNDIG-GT
MAB_2283|M.abscessus_ATCC_1997 -------------------MNGTEIGHLAETAPIWWPGSPESAAPITDGR
MAV_2749|M.avium_104 ----------------------MTSLWMSERTERPWAASQLDQGPAS---
TH_2138|M.thermoresistible__bu ---------------------------MSQRFAERVDGGPRS--------
:
Mflv_1109|M.gilvum_PYR-GCK RDADVCIVGAGYTGLWTAYYLKRADPSLRVVVLDARFAGYGASGRNGGWL
Mvan_5703|M.vanbaalenii_PYR-1 RDADVCIVGAGYTGLWTAYYLKRADPSLRIVVLEARFAGFGASGRNGGWL
MSMEG_6471|M.smegmatis_MC2_155 QDADVCIVGAGYTGLWTAYYLKKADPSLRIAILEARFAGFGASGRNGGWL
Mb0580c|M.bovis_AF2122/97 WDLFRYPGVRSDSSIFTLSFPYEPWTREEGIADGAHIREYLTDMAHKYGI
Rv0565c|M.tuberculosis_H37Rv WDLFRYPGVRSDSSIFTLSFPYEPWTREEGIADGAHIREYLTDMAHKYGI
MMAR_5279|M.marinum_M WDLFRYPGIRSDSDLHTFSYEFKAWENEKAIASAGAIMSYLRETVAENSL
MUL_4352|M.ulcerans_Agy99 WDLFRYPGIRSDSDLHTFSYEFKAWENEKAIASAGAIMSYLRETVAENSL
MAB_2283|M.abscessus_ATCC_1997 HDVDVLVIGAGLAGLAAAYFVTELRPELSVAVLEAKHVGAGATGRSTGIV
MAV_2749|M.avium_104 --ADVIVVGAGITGLMTAALLARAG--KDVLVLEARTVGACATANTTAKI
TH_2138|M.thermoresistible__bu ----AIVIGAGIVGLSTAWFLQERG--VDVCVVDRTGVAAGASWGNAGWI
. .: : . :
Mflv_1109|M.gilvum_PYR-GCK SGLVPGDRER-MARQYGRDGVVAWQRALN-DAVDEVIDVAAQEGIDAGIV
Mvan_5703|M.vanbaalenii_PYR-1 SGLVPGDRER-MARRYGRDGVVAWQRALN-DAVDEVIAVAGREGIDAGIV
MSMEG_6471|M.smegmatis_MC2_155 SGLVPGDRHR-MAKLYGRDKVLAWQKALN-EAVDEVIAVADAEGIDAGAV
Mb0580c|M.bovis_AF2122/97 DRHIEFNSYV-RAADWDSS-TDTWTVTFE--QNGVHKHYRSRFVFFGSGY
Rv0565c|M.tuberculosis_H37Rv DRHIEFNSYV-RAADWDSS-TDTWTVTFE--QNGVHKHYRSRFVFFGSGY
MMAR_5279|M.marinum_M ARAIRFGHKV-IEAAWSTR-DARWRVTIERLYSGERVTMSCEWFFCASGY
MUL_4352|M.ulcerans_Agy99 ARAIRFGHKV-IESAWSTR-DARWRVTIERLCSGERVTMSCEWFFCASGY
MAB_2283|M.abscessus_ATCC_1997 SPGLSMPMAA-FRRKYGDDAAIASFDATF-HGVGLLRDLVAKENIDCDAR
MAV_2749|M.avium_104 SLLQGSQLSK-VLPRHGREVTRAYVDGNR---EGQEWVLGHCEAHGVAVQ
TH_2138|M.thermoresistible__bu SPGLAIPLNEPGVLRYGLRNLLSPTAPLHLPLTRDLRQWAFLTRFAANCR
.
Mflv_1109|M.gilvum_PYR-GCK KGGNLEVARNRAQVRRLAAAVDAERRWQVDGVEVLTKSEAAQRIALDGVI
Mvan_5703|M.vanbaalenii_PYR-1 KGGTLEVARNAAQASRLAAAVEAERRWQVDGIEPLTADEATRRIRLDGVV
MSMEG_6471|M.smegmatis_MC2_155 KGGTLEIARNPAQAARLAASIAEERSWGVD-VTELSREQAAERIRFDGLV
Mb0580c|M.bovis_AF2122/97 YNYDEGYTPDFGGIEKFGGAVVHPQHWPED---LDYTGKKIVVIGSGATA
Rv0565c|M.tuberculosis_H37Rv YNYDEGYTPDFGGIEKFGGAVVHPQHWPED---LDYTGKKIVVIGSGATA
MMAR_5279|M.marinum_M YRYDEGYTPEFPGRERFAGQVVHPQQWPEN---LDYRGKRVLIIGSGATA
MUL_4352|M.ulcerans_Agy99 YRYDEGYTPEFPGRERFAGQVVHPQQWPEN---LDYRGKRVLIIGSGATA
MAB_2283|M.abscessus_ATCC_1997 DEPHTLVALTDRSLARMVTHLENLAELGRE--VPWLSSQEVVQWAGAGYK
MAV_2749|M.avium_104 REDAYTYAQSVRGVPSARAEFEACQAVGLP---VVWQDDAEVPFAYHG--
TH_2138|M.thermoresistible__bu RSSWTRALLANKPLN--DEAIEAYDVLTAN----------------GVDA
.
Mflv_1109|M.gilvum_PYR-GCK SAYYSPHCARIQPAQLVRGLADAVERLGVVIYERSPVTEITAGRA----A
Mvan_5703|M.vanbaalenii_PYR-1 AGYHNPHCARIQPAQLVRGLADTVERLGVAVYERSPVIEIGAGRA----V
MSMEG_6471|M.smegmatis_MC2_155 SAYHNPHCARIQPAALARGLADAVERLGVTIYEQSPVTEISQGRA----V
Mb0580c|M.bovis_AF2122/97 VTLIPSLTDRAEKVTMLQRSPTYLISASKYSTFAAVVRKALPPKT----S
Rv0565c|M.tuberculosis_H37Rv VTLIPSLTDRAEKVTMLQRSPTYLISASKYSTFAAVVRKALPPKT----S
MMAR_5279|M.marinum_M VTLVPAMAETAGHVTMLQRSPTYIIPVPSKDRIANTLPKLVGRKR----A
MUL_4352|M.ulcerans_Agy99 VTLVPAMAETAGHVTMLQRSPTYIIPVPSKDRIANTLPKLVGRKR----A
MAB_2283|M.abscessus_ATCC_1997 AGFAYRDAMVVDPYRLVTGMADILRRRGAPVYEHSPVISIEADATGVCVF
MAV_2749|M.avium_104 -GVRLADQAQFDPMPFLDSLAVELLGRGGRLVEHTRVRRVSWRGKGVRVH
TH_2138|M.thermoresistible__bu PVTDAPITAVFRDPREAGRLRDELRRVAETGRDVEVTELSGADLR-----
:
Mflv_1109|M.gilvum_PYR-GCK TPWGA---------------VSAPVVLRATEGFTAGLPGLKRRWLPMNS-
Mvan_5703|M.vanbaalenii_PYR-1 TPWGA---------------VTAPVVLRATEGFTAALPGLKRRWLPMNS-
MSMEG_6471|M.smegmatis_MC2_155 TARGT---------------VRAPIVLRATEGFTAALPGQRRAWLPMNS-
Mb0580c|M.bovis_AF2122/97 HLIVR---------------MYNALLEAVFWFLSRKTPVFVKWLLRRTA-
Rv0565c|M.tuberculosis_H37Rv HLIVR---------------MYNALLEAVFWFLSRKTPVFVKWLLRRTA-
MMAR_5279|M.marinum_M YALTR---------------KKNVAKQRLVWHFCQRYPGAARRVIRHLN-
MUL_4352|M.ulcerans_Agy99 YALTR---------------KKNVAKQRLVWHFCQRYPGAARRVIRHLN-
MAB_2283|M.abscessus_ATCC_1997 TARAQ---------------VRARHAFLATDGYSGTLNPLKSSVIPLRT-
MAV_2749|M.avium_104 ANQGSDAAGHDVELHADQLVLATGIPILDRGGYFARVKPSRSYCLAFKVP
TH_2138|M.thermoresistible__bu -----------------------ERVPLASAEITVGLEIHGQRYVDPAR-
:
Mflv_1109|M.gilvum_PYR-GCK ------SMIATEPVPESVWAEIGWEGRET-LGDTAHGFFYAQRTVDNRIA
Mvan_5703|M.vanbaalenii_PYR-1 ------SMIATDPVPEQVWDTIGWQGRET-LGDTAHGFFYAQRTVDDRIA
MSMEG_6471|M.smegmatis_MC2_155 ------SMIATEPIPAHVWDEIGWQGRET-VGDSAHGFFYAQRTVDDRIA
Mb0580c|M.bovis_AF2122/97 ------IKNLPEGYDIETHFTPRYNPWDQRLCLIPDADLYNAITSGRAEV
Rv0565c|M.tuberculosis_H37Rv ------IKNLPEGYDIETHFTPRYNPWDQRLCLIPDADLYNAITSGRAEV
MMAR_5279|M.marinum_M ------ARLLPTGYPVDEHFRPDYNPWDQRLCAVPDADMFQAIRDGRASV
MUL_4352|M.ulcerans_Agy99 ------ARLLPTGYPVDEHFRPDYNPWDQRLCAVPDADMFQAIRDGRASV
MAB_2283|M.abscessus_ATCC_1997 ------HLLATAPLTEGQLAELGWSGRGA-IIDQRTFFNYYRMSADKRVV
MAV_2749|M.avium_104 GNITRPMMISTDSPTRSVRYAPVPDGERLIVGGAGHTVGREKSPSAALDE
TH_2138|M.thermoresistible__bu ----------FVQALADSVVDRGATIHRMDITGVDSGPGGVTVHSAGGQE
:
Mflv_1109|M.gilvum_PYR-GCK IGGRSVPYRFGSRTDRDGRLPERTIKNLTATLHSILPQVAHVPIAHGWCG
Mvan_5703|M.vanbaalenii_PYR-1 IGGRSVPYRFASRIDRDGRVPERTIAHLTATLHSILPQVADVPIAHGWCG
MSMEG_6471|M.smegmatis_MC2_155 IGGRSVPYRYASRTDVDGQVPPKTIRLLTDVLHAILPQVRDVPIAHGWCG
Mb0580c|M.bovis_AF2122/97 VTDHIDHFDATGIALKSGGHLDADIIVTATGLQ--LQALGGAAISLDGVE
Rv0565c|M.tuberculosis_H37Rv VTDHIDHFDATGIALKSGGHLDADIIVTATGLQ--LQALGGAAISLDGVE
MMAR_5279|M.marinum_M VTDQIETFTERGIRLQSGRELEADIIVTATGLN--LLAFGGIGLSVDGEP
MUL_4352|M.ulcerans_Agy99 VTDQIETFTERGIRLQSGRELEADIIVTATGLN--LLAFGGIGLSVDGEP
MAB_2283|M.abscessus_ATCC_1997 FGGG-PAFVPSRIPSRDIKRSRVIQQRVRRELTERFPVLADVEIDAAWSG
MAV_2749|M.avium_104 LSAWTRKHFPGAVQTHFWSAQDYTPIDHLPYVGPILPNSETIFVATGFNK
TH_2138|M.thermoresistible__bu LSAGAVVIATGAWLHQLAQRWVRVPVQAGRGYSFTVPVDRPVPAPVYLPE
. .
Mflv_1109|M.gilvum_PYR-GCK VLAVPRDWEASV-DFDPATG-LGWAGGYVGHGVTATNLAGRTLTDLVLTR
Mvan_5703|M.vanbaalenii_PYR-1 VLAVPRDWEATV-DFDRETG-LGWAGGYVGHGVTATNLAARTLTDLVLGR
MSMEG_6471|M.smegmatis_MC2_155 VLAVPRDWEASV-VLDRATG-LGWAGGYVGHGVTATNLAGRTLADLVCNR
Mb0580c|M.bovis_AF2122/97 IDPRDRFVYKAH-MLEDVPN-LFWCVGYTNASWTLRADMTARATAKLLAH
Rv0565c|M.tuberculosis_H37Rv IDPRDRFVYKAH-MLEDVPN-LFWCVGYTNASWTLRADMTARATAKLLAH
MMAR_5279|M.marinum_M VDVSQKVAFKGF-LLSDVPN-FAYVFGYTNSSWTLKVGLVCEHFCRLLAH
MUL_4352|M.ulcerans_Agy99 VDVSQKVAFKGF-LLSDVPN-FAYVFGYTNSSWTLKVGLVCEHFCRLLAH
MAB_2283|M.abscessus_ATCC_1997 ITASSFDRNPVVGPVPGMDG-LWFAGSWCGHGFSTSVDTGWRFAKTLVGE
MAV_2749|M.avium_104 WGMTNGAAAALALSSRILGGRMDWARAFASWSPHELSGLATAVQANLEVG
TH_2138|M.thermoresistible__bu VRVACTPCAAGL----RVAGTMEFRDPDAPLISKRVDAIVAAARPLLDGV
. : : :
Mflv_1109|M.gilvum_PYR-GCK ESPLTRLPWVGHECKDWEPEPLRWIGVRGMYLAYKAADWHEARGTKRTSP
Mvan_5703|M.vanbaalenii_PYR-1 QSPLTGLPWVGHRSKSWEPEPLRWLGVRGMYLAYKAADWHEARGARRTSP
MSMEG_6471|M.smegmatis_MC2_155 ATPLTELPWVGHRSRNWEPEPLRWLGVRGLYIAYKLADRHEAGGRPTTSP
Mb0580c|M.bovis_AF2122/97 MAAHGHTRAAPHLGDEPMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVR
Rv0565c|M.tuberculosis_H37Rv MAAHGHTRAAPHLGDEPMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVR
MMAR_5279|M.marinum_M MDANGHNICRPHAP-ASMPTRPLLEITAGYVKRAAAAFPHQGTEGPWRTC
MUL_4352|M.ulcerans_Agy99 MDANGHNICRPHAP-ASMPTRPLLEITAGYVKRAAAAFPHQGTEGPWRTC
MAB_2283|M.abscessus_ATCC_1997 PLP-ANIPWFRSGAQRVPTTLLRNVATGAYLKALDAADALDAKTSNPPQV
MAV_2749|M.avium_104 FNLTKGWITPAVRIGRRSPVDGDGGVVSGPPWHLQARCRVDGTEHRVSPV
TH_2138|M.thermoresistible__bu RWDERGPSWVGPRPVTPDGRPLIGAVAEDVYVAAGHGMWGLTHGPVTGRL
Mflv_1109|M.gilvum_PYR-GCK IAVVANRITGR----------------------------------
Mvan_5703|M.vanbaalenii_PYR-1 IAVVADKIAGRPH--------------------------------
MSMEG_6471|M.smegmatis_MC2_155 IAKVADVITRKPH--------------------------------
Mb0580c|M.bovis_AF2122/97 QNYLADAIDYRFDRIEEAMVFGAA---------------------
Rv0565c|M.tuberculosis_H37Rv QNYLADAIDYRFDRIEEAMVFGAA---------------------
MMAR_5279|M.marinum_M MDYRADRATLREGPVDDDHLQFSASAAADTPPLALTG--------
MUL_4352|M.ulcerans_Agy99 MDYRADRATLREGPVDDDHLQFSASAAADTPPLALTG--------
MAB_2283|M.abscessus_ATCC_1997 ARPTAGRQTSRGTTTLAEADK------------------------
MAV_2749|M.avium_104 CPHLGGIVNWNDADKAWECPLHGSRFAPDGTLLEGPATRDLTASR
TH_2138|M.thermoresistible__bu LAEQITTGKQPDVLDEFDPLR------------------------