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aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_2138 | - | - | 100% (420) | D-amino-acid dehydrogenase |
| M. thermoresistible (build 8) | TH_2312 | - | 5e-07 | 23.28% (408) | POSSIBLE THIAMINE BIOSYNTHESIS OXIDOREDUCTASE THIO |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0423 | thiO | 4e-06 | 27.78% (162) | thiamine biosynthesis oxidoreductase ThiO |
| M. gilvum PYR-GCK | Mflv_0955 | - | 1e-103 | 48.57% (420) | D-amino-acid dehydrogenase |
| M. tuberculosis H37Rv | Rv0415 | thiO | 4e-06 | 27.78% (162) | thiamine biosynthesis oxidoreductase ThiO |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4218c | - | 7e-12 | 25.19% (405) | thiamine biosynthesis oxidoreductase ThiO |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_4746 | thiO | 1e-07 | 34.13% (167) | glycine oxidase ThiO |
| M. smegmatis MC2 155 | MSMEG_6291 | - | 1e-169 | 69.49% (413) | D-amino-acid dehydrogenase |
| M. ulcerans Agy99 | MUL_2805 | thiO | 1e-06 | 26.35% (406) | thiamine biosynthesis oxidoreductase ThiO |
| M. vanbaalenii PYR-1 | Mvan_4780 | - | 1e-146 | 61.80% (411) | D-amino-acid dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0423|M.bovis_AF2122/97 ------MASDLHTGSLAVIGGGVIGLSVARRAAQAGWPVRVHRSD--ERG
Rv0415|M.tuberculosis_H37Rv ------MASDLHTGSLAVIGGGVIGLSVARRAAQAGWPVRVHRSD--ERG
MAV_4746|M.avium_104 ------MPSD--CGSLAVVGGGVIGLAVARRAAQAGWSVRVHRSG--ERG
MUL_2805|M.ulcerans_Agy99 ------MSSP-SMGSLAVIGGGVIGLSVARRAAQAGWAVRVHRRA--EPG
MAB_4218c|M.abscessus_ATCC_199 ------MMSS-QKGSVAVIGGGVIGLSVAREAARTGWRVVIHDDG--AKG
TH_2138|M.thermoresistible__bu MSQRFAERVDGGPRSAIVIGAGIVGLSTAWFLQERGVDVCVVDRTGVAAG
MSMEG_6291|M.smegmatis_MC2_155 MVD--GERIDGGPRGAVVVGAGIVGLSTAWFLQERGVDVTVVDRTGVAAG
Mvan_4780|M.vanbaalenii_PYR-1 MSG--GSGMDGGPRSVIVVGAGIVGLSTAWFLQERGVDVTVVDRSGVAAG
Mflv_0955|M.gilvum_PYR-GCK MES-MSERSGGRPQRVVVVGAGMVGLSTAWYLQEHGVEVTVVDSDGVAAG
*:*.*::**:.* . * * : *
Mb0423|M.bovis_AF2122/97 ASWVAGGMLAPHSEGWPGEERLLRLGLQSLR-------------------
Rv0415|M.tuberculosis_H37Rv ASWVAGGMLAPHSEGWPGEERLLRLGLQSLR-------------------
MAV_4746|M.avium_104 ASWVAGGMLAPHSEGWPGEERLLRLGLESLR-------------------
MUL_2805|M.ulcerans_Agy99 ASWAAGGMLAPHSEGWPGEERLLRLGLESLR-------------------
MAB_4218c|M.abscessus_ATCC_199 PSWVAGGMLAPYSEAWPGEDELLELGIESLG-------------------
TH_2138|M.thermoresistible__bu ASWGNAGWISPGLAIPLNEPGVLRYGLRNLLSPTAPLHLPLTRDLRQWAF
MSMEG_6291|M.smegmatis_MC2_155 ASWGNAGWVSPTLTIPLNDPAVLRYGLRSLASPTAPLHIPLTAGVGLWAF
Mvan_4780|M.vanbaalenii_PYR-1 ASWGNAGWVSPALTAPLNSPSVLREGLRALADPAAPLHIPVRADTALARF
Mflv_0955|M.gilvum_PYR-GCK SSWGNAGWLTPSIATPLPEPAVLRYGVRALLSPSSPVYVPLTADPRLIGF
.** .* ::* . :*. *:. *
Mb0423|M.bovis_AF2122/97 ------------LWREGSFLDGLGPQLVTAHESLVVAVDRADVADLRTVA
Rv0415|M.tuberculosis_H37Rv ------------LWREGSFLDGLGPQLVTAHESLVVAVDRADVADLRTVA
MAV_4746|M.avium_104 ------------LWREGGFLDGLPGRLVTARESLVVAVDRADVADLRTVA
MUL_2805|M.ulcerans_Agy99 ------------LWHESGFLDGLPPQVVTARESLMVAVDRADVADLRTVA
MAB_4218c|M.abscessus_ATCC_199 ------------IWRDG-FIDDVENPVITARGSLTVAVDTADVGELRTMT
TH_2138|M.thermoresistible__bu LTRFAANCRRSSWTRALLANKPLNDEAIEAYDVLTANGVDAPVTDAPITA
MSMEG_6291|M.smegmatis_MC2_155 LTRFALNCRLSSWTRAAKANLPLNEECIEAYDVLMANGVDAVTTDAPITA
Mvan_4780|M.vanbaalenii_PYR-1 LLRFAANCRPSAWERAVRANAILNDEAIETFDVLVSNGVDAPVTDTSLAV
Mflv_0955|M.gilvum_PYR-GCK LLRFARNSTASRWQKAMKALIPLNRDALAAFDRMEVQSSEQSSPAEPFIA
: : : : : .
Mb0423|M.bovis_AF2122/97 DWLSAQ-------------------GHPVIWESAARDVEPLLAQGIRHGF
Rv0415|M.tuberculosis_H37Rv DWLSAQ-------------------GHPVIWESAARDVEPLLAQGIRHGF
MAV_4746|M.avium_104 DWLSAQ-------------------GHPVVWESAARDVEPLLAQGIRHGF
MUL_2805|M.ulcerans_Agy99 DWLSEQ-------------------GHPVSWESAARDVEPLLAQGIRHGF
MAB_4218c|M.abscessus_ATCC_199 GWLAAR-------------------GHPVTEIANARDVEPMLAQNVRRGF
TH_2138|M.thermoresistible__bu VFRDPREAGRLRDELRRVAETGRDVEVTELSGADLRERVPLASAEITVGL
MSMEG_6291|M.smegmatis_MC2_155 LFETDRQAGHLLTELQRMADLGQDVKFTQLTSDEVREQVPLASPRITTAV
Mvan_4780|M.vanbaalenii_PYR-1 AFRDAGHAELFLTELNHLRSTGQQLHVETLTGAALHEQVPLASSNVAAVV
Mflv_0955|M.gilvum_PYR-GCK AYRTAADREVLLEEFAQIRAAGQSVNFEVLDGATARAQEPALSPEVDAAI
: : * : : .
Mb0423|M.bovis_AF2122/97 RAPTELAVDNRALLDVLCRDCERLGVRWSS--QVSSLSDVDAHTVVIANG
Rv0415|M.tuberculosis_H37Rv RAPTELAVDNRALLDALCRDCERLGVRWSS--QVSSLSDVDAHTVVIANG
MAV_4746|M.avium_104 TAPTELAVDNRAVLEALDAACERLGVRWAP--PLHDLAEADADAVVIANG
MUL_2805|M.ulcerans_Agy99 RATTELAVDNRALLDALAVDCERRGVTWAG--PVADLSDATGDAVVIANG
MAB_4218c|M.abscessus_ATCC_199 TAPEELSVDNRKVLQALTAECEALGVGRGP--AAVHTRDVDADQVVIANG
TH_2138|M.thermoresistible__bu EIHGQRYVDPARFVQALADSVVDRGATIHR-MDITGVDSGPGGVTVHSAG
MSMEG_6291|M.smegmatis_MC2_155 SVEGQRFVDPGRFVHALADAVVARGATIRT-GEVLDVQPSKPGVRIVLAD
Mvan_4780|M.vanbaalenii_PYR-1 NVSGQRFVDPGRFTHALGFAVAERGATMLS-GEVCRVSGSRDGALLELRD
Mflv_0955|M.gilvum_PYR-GCK AIHDERFVNPSAYVDALAAQVLARGGRIEAGVDVDSVSDTGDGVRVAG--
: *: ..* * :
Mb0423|M.bovis_AF2122/97 -----IDAPALWPGLPIRPVKGEV-LRLRWRPGCMPLPQRVIRARVRG--
Rv0415|M.tuberculosis_H37Rv -----IDAPALWPGLPIRPVKGEV-LRLRWRPGCMPLPQRVIRARVRG--
MAV_4746|M.avium_104 -----IDAPALWPGLPVRPVKGEV-LRLRWRKGCMPVPQRVIRARVHG--
MUL_2805|M.ulcerans_Agy99 -----IDAPALWPGLPVRPVKGEV-LRLRWRKGCMPLLQRVVRARVHG--
MAB_4218c|M.abscessus_ATCC_199 -----VQAAALA-GLPVRPVKGEV-LRLRQRPGAMPPPANVIRARVHG--
TH_2138|M.thermoresistible__bu GQELSAGAVVIATGAWLHQLAQRW-VRVPVQAGRGYSFTVPVDRPVPAPV
MSMEG_6291|M.smegmatis_MC2_155 G-EIQSDAAVIATGAWLSRLVKAW-VPTPVRAGRGYSFTVPVDRPVPTPI
Mvan_4780|M.vanbaalenii_PYR-1 RELLRGDAVVLATGAWLPALTGRR-IRVGLQAGRGYSFTVPVDRALPGPV
Mflv_0955|M.gilvum_PYR-GCK ---QRYDAAVVATGARLNKLLAPFGVRRTVQAGRGYSFTVKVDHLPRGPV
* .: * : : : : * :
Mb0423|M.bovis_AF2122/97 ----RQVYLVPRSDGVVVGATQYEHGRDTAPVVSGVRDLLDDACTVLPAL
Rv0415|M.tuberculosis_H37Rv ----RQVYLVPRSDGVVVGATQYEHGRDTAPVVSGVRDLLDDACTVLPAL
MAV_4746|M.avium_104 ----RQVYLVPRADGVVVGATQYEHGRDTAPVVSGVRDLLDDACAVLPAL
MUL_2805|M.ulcerans_Agy99 ----RQVYLVPRADGVVVGATQYEHGRDLAPVVSGVRDLLEDACAVMPAL
MAB_4218c|M.abscessus_ATCC_199 ----RHVYLVPRADGVVVGATQYEHGHDTAPAVAGVRDLLDDACALLPCL
TH_2138|M.thermoresistible__bu YLPEVRVACTPCAAGLRVAGTMEFRDPDAPLISKRVDAIVAAARPLLDGV
MSMEG_6291|M.smegmatis_MC2_155 YLPDARVACTPYQGGLRVAGTMEFRSPDDPVQPARVDAIIASATPLLDGV
Mvan_4780|M.vanbaalenii_PYR-1 YLPEARVACTPYRGGLRVAGTMEFRRPSEPLAQRRIDAIIASATPLLDGV
Mflv_0955|M.gilvum_PYR-GCK YFPTQRVACTPVGDRLRIAGMMEFRAVDAPLDPRRIEVLKNAAGELLTGA
:* .* : :.. : . . : : * ::
Mb0423|M.bovis_AF2122/97 GEYELAECEAGLRPMTPDNLPLVQ-RLDSRTLVAAGHGRSGFLLAPWTAE
Rv0415|M.tuberculosis_H37Rv GEYELAECEAGLRPMTPDNLPLVQ-RLDSRTLVAAGHGRSGFLLAPWTAE
MAV_4746|M.avium_104 GEYELAECGAGLRPMTPDNLPLVG-RLDARTLVAAGHGRSGFLLAPWTAE
MUL_2805|M.ulcerans_Agy99 GEYEFAECTAGLRPMTPDNLPIVG-RLDARTLVAAGLGRSGFLLAPWTAE
MAB_4218c|M.abscessus_ATCC_199 GEYEFAECAAGLRPMTDDNLPMVG-RIDERVVVAAGHGRSGFLLAPWTAK
TH_2138|M.thermoresistible__bu RWDERGPSWVGPRPVTPDGRPLIG-AVAEDVYVAAGHGMWGLTHGPVTGR
MSMEG_6291|M.smegmatis_MC2_155 RWDERTDVWVGPRPVTPDGRPLVG-EVAPGVYVAGGHGMWGLAHGPITGR
Mvan_4780|M.vanbaalenii_PYR-1 RWTERTDAWVGPRPVTDDGKPLIG-QLASAMYVAGGHGMWGLAHGPATGR
Mflv_0955|M.gilvum_PYR-GCK HLDTREDEWVGARPCTADGLPLIGRTRSSRVFAAGGHGMWGITLGPVTGR
.* ** * *. *:: .*.* * *: .* *..
Mb0423|M.bovis_AF2122/97 QIVSEL------VSVG------AAS------------------
Rv0415|M.tuberculosis_H37Rv QIVSEL------VSVG------AAS------------------
MAV_4746|M.avium_104 QIVSEL------APVG------AHR------------------
MUL_2805|M.ulcerans_Agy99 QIVSEL------VPIG------AHS------------------
MAB_4218c|M.abscessus_ATCC_199 TIGAVLDGGESPAAVDPRRFEKAHSQEAR--------------
TH_2138|M.thermoresistible__bu LLAEQITTGKQPDVLD------EFDPLR---------------
MSMEG_6291|M.smegmatis_MC2_155 LLAEYLTTGKEPDALR------EFNPLR---------------
Mvan_4780|M.vanbaalenii_PYR-1 LLAEQIVTGKQPEAVR------PFDPLRGRGRATPTEVLTLPL
Mflv_0955|M.gilvum_PYR-GCK LLAEQIVTGRTPDALR------AVDPLR---------------
: : :