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MAGQYSVPGKRHSLRRYVATITAVAATCTVLAPLAMESRTIASTLASYVIGIGGNNDGASANIPRKLGGA YSVDYHPVSYPGAIWPVSGLTAPTFKTSVAQGRTNLNDEIVTAGNQPITIVGYSLGAVVVSKSHSDLLQR YPGGNPNIQFVLMGSANTPNGGIFARFPWLKIPLADIESNGAWEPDQFKTKVINTEYDTYGDFPAYFNPL ALANSIAAIQYAHPDAYYDRIDPAALDDPDNPNVVKTVQGNTTYYLVRAEHLPLLQPLRDLTNPIGASFV LDAIEPTLRVFIDMAYDRDTGPGTTTQFSFFTPSKNIVDAFNKLPTAIAEGAHNVENGLAGATPKQSASP EKPASPPVPQPGPTNPGSATTQIPAPEAPTPSVVSLSTAEPPAPPASAKAADPTAISVSTAGASTARDQD FQPDTKPDPKSTPPPTKDSVGEADKSKNTLKPTLRLPKLPVAQPGTAPKSPKFPSLKNHLKSVPGLSEKK NPAADASSKHSQPANAPAHTSDKTSDHASETGRGAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4141 | - | - | 100% (526) | PE/PPE family protein |
| M. abscessus ATCC 19977 | MAB_0936c | - | 8e-09 | 27.63% (228) | hypothetical protein MAB_0936c |
| M. abscessus ATCC 19977 | MAB_4293 | - | 1e-07 | 27.72% (202) | putative Fe-S oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1465 | PE16 | 7e-30 | 37.19% (242) | PE family protein |
| M. gilvum PYR-GCK | Mflv_1918 | - | 5e-20 | 27.66% (423) | hypothetical protein Mflv_1918 |
| M. tuberculosis H37Rv | Rv1430 | PE16 | 7e-30 | 37.19% (242) | PE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 3e-07 | 26.61% (218) | hypothetical protein MLBr_01232 |
| M. marinum M | MMAR_2235 | - | 2e-34 | 34.49% (316) | PE-PGRS family protein, PE16 |
| M. avium 104 | MAV_1760 | - | 2e-08 | 26.43% (227) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_5455 | - | 2e-28 | 27.13% (527) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 2e-43 | 33.75% (397) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 2e-31 | 31.22% (362) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_4815 | - | 4e-29 | 28.27% (474) | hypothetical protein Mvan_4815 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1465|M.bovis_AF2122/97 --MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVS
Rv1430|M.tuberculosis_H37Rv --MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVS
MMAR_2235|M.marinum_M --MSFVVTAPETVVAAASQLTGIGSAIEAANAAAAALTTRLLPAAADEVS
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVS
Mflv_1918|M.gilvum_PYR-GCK -----------------------MGKGDFGLKASEFTGRSSTRFADSVRR
Mvan_4815|M.vanbaalenii_PYR-1 ---------------------------------------------MRLII
MSMEG_5455|M.smegmatis_MC2_155 ---------------------------------------------MGRLL
MLBr_01232|M.leprae_Br4923 -------------------------------------MKRLLATTLAALT
MAV_1760|M.avium_104 -------------------------------------MKQLLAGVTALLS
TH_3724|M.thermoresistible__bu -----------------------------------------VVAVGALTW
MAB_4141|M.abscessus_ATCC_1997 -------------------------------------------MAGQYSV
Mb1465|M.bovis_AF2122/97 AAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALV
Rv1430|M.tuberculosis_H37Rv AAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALV
MMAR_2235|M.marinum_M AGIAALMSTHAQEYQLLGGQLATYHDQLVQALDRTAGWYADAETGNAALL
MUL_0967|M.ulcerans_Agy99 EAIATLFDNYAQGYQAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKAL
Mflv_1918|M.gilvum_PYR-GCK RPGGATYGLYRHDGLGVGTWAWVFARSSRSFPRSRRCWRYPRGVPTPVAV
Mvan_4815|M.vanbaalenii_PYR-1 RPLAALF---------------LVLASVAALPLS---WTLSG----VVVA
MSMEG_5455|M.smegmatis_MC2_155 HSLSTAF---------------LVFVAVVVLCVS-------TSMPTAAHL
MLBr_01232|M.leprae_Br4923 VGTVSGFGSTVASSEPGEPWLPPSPVPVRENSPAKIVYALGGARPPTFDW
MAV_1760|M.avium_104 VSTAGYFGIGTAAADGGPIGGPPTPGAPGD----QTAYALGGAHVLGIPY
TH_3724|M.thermoresistible__bu GGX--------------------GVASPAGQPERAAALRLTATADAIIMP
MAB_4141|M.abscessus_ATCC_1997 PGKRHSLR-----------RYVATITAVAATCTVLAPLAMESRTIASTLA
Mb1465|M.bovis_AF2122/97 D---------------------TAATGAS--------ELGSGG-----RT
Rv1430|M.tuberculosis_H37Rv D---------------------TAATGAS--------ELGSGG-----RT
MMAR_2235|M.marinum_M RNVQQELLTGLTAPGRAWSGAGAASAGASGVDALMSSALLSGG-----RS
MUL_0967|M.ulcerans_Agy99 AGLTEPVAN---LFAPVLSGPESVAASAT--------ALLSGAPLKPVEA
Mflv_1918|M.gilvum_PYR-GCK L-----------------------VANTT--------ALVMGG-----TF
Mvan_4815|M.vanbaalenii_PYR-1 L-----------------------TSNTT--------ALIMGG-----SF
MSMEG_5455|M.smegmatis_MC2_155 L-----------------------LNHPH--------ALVIGG-----TG
MLBr_01232|M.leprae_Br4923 D--------------------------YYTIRAG----------------
MAV_1760|M.avium_104 D--------------------------QYIRMEG----------------
TH_3724|M.thermoresistible__bu G-------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 S-------------------------------------------------
Mb1465|M.bovis_AF2122/97 ALILGSTGTPRPPFDYMQQVYDRYIAPHY-LGYAFSG----LYTPAQFQP
Rv1430|M.tuberculosis_H37Rv ALILGSTGTPRPPFDYMQQVYDRYIAPHY-LGYAFSG----LYTPAQFQP
MMAR_2235|M.marinum_M VLVVGSTGTPRPSYRFMREVYDLFVAPHY-FGDSLFG----VQTPAQFQP
MUL_0967|M.ulcerans_Agy99 ALILSESGVPTPSASYISDVYTKYVEPNFPSATAPQG----VSTPNGLYP
Mflv_1918|M.gilvum_PYR-GCK HPLTGPRDSPEFVTAYLDNAVDNQISAAYGYA---VTNAVAVYTPEEFFP
Mvan_4815|M.vanbaalenii_PYR-1 HPLAEPADAPPFVTAYLDNAVTGHLDPAFADASGPVTNAVAVYTPEQFFP
MSMEG_5455|M.smegmatis_MC2_155 TPVP----PPEYVNGQTDNYIGAEFPGEYRYA---------VHTPQNFWP
MLBr_01232|M.leprae_Br4923 --DEFFPDVNRKLIDYPARAPFRYVPTFLVPGP-----------------
MAV_1760|M.avium_104 --ADWFPGQQRQIVRYPAGQVQGHVLERLFPGIGKLD---------ESFP
TH_3724|M.thermoresistible__bu -TKIGYIPSQDEFTAYATAVIGATAGAPGAVDYLGVP--------GEFWP
MAB_4141|M.abscessus_ATCC_1997 -YVIGIGGNNDGASANIPRKLGGAYSVDYHPVS----------YPGAIWP
Mb1465|M.bovis_AF2122/97 WTGIPSLTYDQSVAEGAGYLHTAIMQQVAA-------------------G
Rv1430|M.tuberculosis_H37Rv WTGIPSLTYDQSVAEGAGYLHTAIMQQVAA-------------------G
MMAR_2235|M.marinum_M FTGIPNLTFDESAATGASYLHAAITQQLAD-------------------G
MUL_0967|M.ulcerans_Agy99 FTGIKDLSLDISLARGATILNDAILQQLAAL----------------PAG
Mflv_1918|M.gilvum_PYR-GCK LG---GLTFDDSVAEGLANLGRCLRAEPGCVFNADPAVAARVGTVAPRHD
Mvan_4815|M.vanbaalenii_PYR-1 IG---QLTFARSVAEGLVNLHRCLGAETDCVFNDDPAIRP--HAVAPRAG
MSMEG_5455|M.smegmatis_MC2_155 VYG--SMSFDESTVAGLAALQAEMAKEG-------------------HFG
MLBr_01232|M.leprae_Br4923 ---RDEVTIGEAIAVATKNLNQAIHRGT----------------------
MAV_1760|M.avium_104 GLGMDGPSVGESVAEGIDNLDAAIRTTG----------------------
TH_3724|M.thermoresistible__bu ATGLDSLTFDASVAXGQAMLTPMVDGAIES-------------------D
MAB_4141|M.abscessus_ATCC_1997 VSGLTAPTFKTSVAQGRTNLNDEIVTAG---------------------N
: : . . * :
Mb1465|M.bovis_AF2122/97 NDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNPNGG
Rv1430|M.tuberculosis_H37Rv NDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNPNGG
MMAR_2235|M.marinum_M NRVVVAGFSQGASVATLEMRHLQSLPIDSRPSPEDLSFVLLGNPNNPNGG
MUL_0967|M.ulcerans_Agy99 SSVAVLGYSQSAVLSSRVMPKLLAEGVTSS----QVNFVLLGNPMNPNGG
Mflv_1918|M.gilvum_PYR-GCK DTFVVFGYSQSAAVASLLKRQLIDAPGPEPA---ATTFMLAANPMRPNGG
Mvan_4815|M.vanbaalenii_PYR-1 DAMMAFGYSQSAVIASLAKLDLIQRYQPGDP---SVSFMLVANPMRPNGG
MSMEG_5455|M.smegmatis_MC2_155 SPLVILGYSSSTRILTADKNRRIAD-GDYAV---DINYVLVSDVAKGNGG
MLBr_01232|M.leprae_Br4923 EPAAVVGLSQGSLALDTEQEQLATDPTAPPP--DQLTFNTFGDPSGYHGF
MAV_1760|M.avium_104 RPGTAIGLSEGAFVVDGEQARLANDPTAPPP--NTLNFATFGDPIGRHAF
TH_3724|M.thermoresistible__bu TPIVVFGHSQSAVIATKEKQRLLAEYPDPDT-APDVTFVMVANPNRPNGG
MAB_4141|M.abscessus_ATCC_1997 QPITIVGYSLGAVVVSKSHSDLLQRYPGGNP---NIQFVLMGSANTPNGG
* * .: : .. :.
Mb1465|M.bovis_AF2122/97 ----ILARFP-GLYLQSLGLTFNGATPDTD---------YATTIYTTQYD
Rv1430|M.tuberculosis_H37Rv ----ILARFP-GLYLQSLGLTFNGATPDTD---------YATTIYTTQYD
MMAR_2235|M.marinum_M ----ILARFP-GLYIQSVGLTFNGATPVTE---------YPTTVYTTQYD
MUL_0967|M.ulcerans_Agy99 ----VLARFP-DLTLPSLGFTFYGATPDNA---------FPTVSYTLEYD
Mflv_1918|M.gilvum_PYR-GCK ----VLGRFP-ALTIPILGITFHGATPTAG---VDG--AYRTVDVVRQYD
Mvan_4815|M.vanbaalenii_PYR-1 ----ILMRLHGWPTIPILEIPFPGASPTDSAVLPDGRHVYPTVDVARQYD
MSMEG_5455|M.smegmatis_MC2_155 ----VMARFP-GWHIPILGVTFDGATRTDS----DG-YAFDTKSISFVHD
MLBr_01232|M.leprae_Br4923 GKSVLASIFRPGDYIPLIDYTMPQRMDS----------QYDSNRVVAAYD
MAV_1760|M.avium_104 GQSFLTAMFGVGSVVPALDYTMPPPYES----------QYDTNRFVAAYD
TH_3724|M.thermoresistible__bu ----LLARFP-GLYIPILGVTFNGATPAPADG------PFDSYDVAREFD
MAB_4141|M.abscessus_ATCC_1997 ----IFARFP-WLKIPLADIESNGAWEPDQ---------FKTKVINTEYD
: : : : : .*
Mb1465|M.bovis_AF2122/97 GFA-DFPKYPLNILADVNALLGIYYSHSLYYGLTPEQVAS---GIVLPVS
Rv1430|M.tuberculosis_H37Rv GFA-DFPKYPLNILADVNALLGIYYSHSLYYGLTPEQVAS---GIVLPVS
MMAR_2235|M.marinum_M GFA-DFPQYPLNVVADVNALLGISYSHSLYYGLTPDQVAA---GVVLPVS
MUL_0967|M.ulcerans_Agy99 GFA-DFPRYPINLLADINAVMGIPFVHADYQDLTQAQLDS---AVQLPTE
Mflv_1918|M.gilvum_PYR-GCK GLGGDFPVRPLNLLATVNALLGYGIMHGETVDVPFAQAR---------FQ
Mvan_4815|M.vanbaalenii_PYR-1 GLGGDFPVRPLNLVATVNALLGYALLHGSAVDIPLAQAR---------FQ
MSMEG_5455|M.smegmatis_MC2_155 GWS-DFPVYPLNVLALANAVAGIAVLHPTYPELDRPDLV---------PV
MLBr_01232|M.leprae_Br4923 GLS-EFPDRADNLLAQLNCFAGGAISHTPSGFFNPEDVPPQ--NIRTTVN
MAV_1760|M.avium_104 SIA-DFPDRPDNMFALANTLMGLATGHTAVAFTNPSMVPPQ--NIRTTIN
TH_3724|M.thermoresistible__bu GWA-DFPRYPLNLVATANAILGIYYLHGGYYELLTENPDILD-DPERTIV
MAB_4141|M.abscessus_ATCC_1997 TYG-DFPAY-FNPLALANSIAAIQYAHPDAYYDRIDPAALDDPDNPNVVK
. :** * .* * . . *
Mb1465|M.bovis_AF2122/97 SPDTNTTYILLPNEDLPLLQPLRGI----VPEPLLDLIEPDLRAIIELGY
Rv1430|M.tuberculosis_H37Rv SPDTNTTYILLPNEDLPLLQPLRGI----VPEPLLDLIEPDLRAIIELGY
MMAR_2235|M.marinum_M SPDVNTTYILIPNEHLPLLQPLRGI----VPDSVLDGIEPGLRDVVELGY
MUL_0967|M.ulcerans_Agy99 GP-TQSTYYMIPTEHLPLLAPLRFIPY--VGDPLAELLEPNLRVLVNFGY
Mflv_1918|M.gilvum_PYR-GCK GREGDTDYYLIGTDLLPLLQPLLLF----VPRPILSALDAPLRVLVEDAY
Mvan_4815|M.vanbaalenii_PYR-1 GRQGDTGYYLVETDLVPLLQPFAFF----VPRPILKAIDAPLRVVIEDAY
MSMEG_5455|M.smegmatis_MC2_155 GSTGDTEYFVIGTDIMPLLMPLETIG---VPRPILLAVDEPLRVLVEAGY
MLBr_01232|M.leprae_Br4923 SRGAKTTTYLIPVNHLPLTLPLRYLG---WSDALVDQIDAVLQPKIDAAY
MAV_1760|M.avium_104 SRGAKDTTIMIPEKHLPLVMPLKYIG---IDENTLNKLDAILTPRVNAGY
TH_3724|M.thermoresistible__bu QQYGDTTYYLIRTEQLPLLRPLRDLG---VPEEFVDALEPYVRRIVDLGY
MAB_4141|M.abscessus_ATCC_1997 TVQGNTTYYLVRAEHLPLLQPLRDLTNPIGASFVLDAIEPTLRVFIDMAY
. :: . :** *: : :: : :: .*
Mb1465|M.bovis_AF2122/97 DR------TGYADVPTPAALFPVHIDP-----------------------
Rv1430|M.tuberculosis_H37Rv DR------TGYADVPTPAALFPVHIDP-----------------------
MMAR_2235|M.marinum_M DR------TGYADVPTPASLFPANVNPNVVAGAFVEGAVRGIDNGLAGMG
MUL_0967|M.ulcerans_Agy99 GDPAYGYDTGPANVPTPFGLFPP-VSP-----------------------
Mflv_1918|M.gilvum_PYR-GCK DR------DAGPGDPTTARWWPVKDFAGTAAKLIASVPVAVDNLTEGFG-
Mvan_4815|M.vanbaalenii_PYR-1 DR------DVGPGVATRASWRPIKDIVGLAARLVASIPVAVDNLTEGLG-
MSMEG_5455|M.smegmatis_MC2_155 RR------DIAPGAPTPARLIPIVNPITLTRNFIAAIPVGVDDAMEELG-
MLBr_01232|M.leprae_Br4923 AY-------NDNPLNKPISVDP----------------------------
MAV_1760|M.avium_104 SR-------NDDPATAPVQVDP----------------------------
TH_3724|M.thermoresistible__bu DR------NTPYGEPAPVRVLPP---------------------------
MAB_4141|M.abscessus_ATCC_1997 DR------DTGPGTTTQFSFFTPSKNIVDAFNKLPTAIAEGAHNVENGLA
.
Mb1465|M.bovis_AF2122/97 ---------------------------------IAVPPQIGAAIGGPLTA
Rv1430|M.tuberculosis_H37Rv ---------------------------------IAVPPQIGAAIGGPLTA
MMAR_2235|M.marinum_M LPPLPDLPAAPLLPEIWSNAPPIPGWPASVPSAIAVPPQLGGAIAGPLDH
MUL_0967|M.ulcerans_Agy99 ---------------------------------LTVAEHLAAGTQQGIVN
Mflv_1918|M.gilvum_PYR-GCK -----------------------------LGRVLGTPVPGVFGVGGPDLP
Mvan_4815|M.vanbaalenii_PYR-1 -----------------------------LGRVLGTTEPGAFGVGGPDLP
MSMEG_5455|M.smegmatis_MC2_155 -----------------------------HGRPLGTQPSGVFGVGGEDTE
MLBr_01232|M.leprae_Br4923 ---------------------------------VNGMDP----IAGIDAE
MAV_1760|M.avium_104 ---------------------------------VHGFDPAEVTAPANQAT
TH_3724|M.thermoresistible__bu ----------------------------------LTPAPGPATQHNAGQG
MAB_4141|M.abscessus_ATCC_1997 G--------------ATPKQSASPEKPASPPVPQPGPTNPGSATTQIPAP
Mb1465|M.bovis_AF2122/97 LDGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQ
Rv1430|M.tuberculosis_H37Rv LDGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQ
MMAR_2235|M.marinum_M LYRTLDSVINGQINPAITSGIYQYGADLSAEAARHGASSELLNAIYVGRQ
MUL_0967|M.ulcerans_Agy99 SG----AALQAQGPPSIP--LSDIAHTLTANPPWAGTPA-LPPSTSPASS
Mflv_1918|M.gilvum_PYR-GCK DVDEGGAVTSDIDEDAVAQRDSASSTERSAPAEESRSAVGGADSDGRDDV
Mvan_4815|M.vanbaalenii_PYR-1 AEPEP-AVPDESVEPAVPEQDPESVEYDGGRAAGEGSAGEGSAGAESVDR
MSMEG_5455|M.smegmatis_MC2_155 LKGLPAGVIS-LAKPTLPVSSHTTVVEKTERKDLAKPAAEPEPVVEDEPA
MLBr_01232|M.leprae_Br4923 LR---DSILNVFAQLRSILPPPPG--------------------------
MAV_1760|M.avium_104 FGGGADPLSQIMAGAMSVLSHGAGEADH----------------------
TH_3724|M.thermoresistible__bu ITVASATSTPDKRTPVVEAPVEEPPVQTGRSTLKREKPVSARHLVRNSLR
MAB_4141|M.abscessus_ATCC_1997 EAPTPSVVSLSTAEPPAPPASAKAADPTAISVSTAGASTARDQDFQPDTK
Mb1465|M.bovis_AF2122/97 VLP---------ILVEGPGALVTADTHYLVDAIQDLAAGDLSGFNQNLQL
Rv1430|M.tuberculosis_H37Rv VLP---------ILVEGPGALVTADTHYLVDAIQDLAAGDLSGFNQNLQL
MMAR_2235|M.marinum_M VLP---------ILIEGPGVILTADTYYSINAIKDLAAGNLSGFNQNLQL
MUL_0967|M.ulcerans_Agy99 IED---------FIL----AVQAANSSISRGFVKTLSTAYAT-LLPTTDI
Mflv_1918|M.gilvum_PYR-GCK VDPEPAAPEAETS---------EAETVTET------EADDADD-ADDGAD
Mvan_4815|M.vanbaalenii_PYR-1 VEPDAAPVESDPAPVEADPAPVEADPAPEKSDPAPVEADPAPEKSDPGSD
MSMEG_5455|M.smegmatis_MC2_155 VEDETPVADTKKASPKPLRPKVRGPISFDAPKLPTIRKATGDRPLKRLLS
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
TH_3724|M.thermoresistible__bu AVPG-----------------LRRGEPAATPTPDVTPDVTPDAPAGQPEP
MAB_4141|M.abscessus_ATCC_1997 PDPKSTPPPTKDSVGEADKSKNTLKPTLRLPKLPVAQPGTAPKSPKFPSL
Mb1465|M.bovis_AF2122/97 IPATNIALLVFAAGIPAVAAVAILTGQDFPV-------------------
Rv1430|M.tuberculosis_H37Rv IPATNIALLVFAAGIPAVAAVAILTGQDFPV-------------------
MMAR_2235|M.marinum_M IPATNAMLLTFGATIPIAAGVSAYIGRDFP--------------------
MUL_0967|M.ulcerans_Agy99 ASELVFTLPSYNLNLFLDGVIQAINGQPIGD-------------------
Mflv_1918|M.gilvum_PYR-GCK ADDEDIDADGADADGEDTAG------NTAEAA------------------
Mvan_4815|M.vanbaalenii_PYR-1 ASADDGEAGAATTPTETDEADEPPDEDTAEAA------------------
MSMEG_5455|M.smegmatis_MC2_155 ALTPKRPKPASSHDAGPAAGNKDTDNADKPAARADDAA------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
TH_3724|M.thermoresistible__bu AEPNESAAPPAAAEADDASE------------------------------
MAB_4141|M.abscessus_ATCC_1997 KNHLKSVPGLSEKKNPAADASSKHSQPANAPAHTSDKTSDHASETGRGAA