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MDSTTSGMASPRVLVVDDDPDVLASLERGLRLSGFDVSTAVDGAEALRSATETRPDAIVLDINMPVLDGV SVVTALRAMDNDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSSATFSSETI QVGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYL RRKLEAGGAPRLLHTVRGVGFVLRTQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5662 | prrA | - | 100% (236) | DNA-binding response regulator PrrA |
| M. smegmatis MC2 155 | MSMEG_0244 | - | 7e-77 | 65.62% (224) | two component response transcriptional regulatory protein prra |
| M. smegmatis MC2 155 | MSMEG_5488 | - | 2e-59 | 52.02% (223) | DNA-binding response regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0927c | prrA | 1e-119 | 93.22% (236) | two component response transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_1744 | - | 1e-119 | 97.36% (227) | two component transcriptional regulator |
| M. tuberculosis H37Rv | Rv0903c | prrA | 1e-119 | 93.22% (236) | two component response transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_02123 | - | 1e-117 | 93.07% (231) | two-component response regulator |
| M. abscessus ATCC 19977 | MAB_0956c | - | 1e-115 | 91.74% (230) | transcriptional regulatory protein PrrA |
| M. marinum M | MMAR_4633 | prrA | 1e-118 | 93.22% (236) | two-component response transcriptional regulatory protein |
| M. avium 104 | MAV_1022 | - | 1e-118 | 93.64% (236) | two component response transcriptional regulatory protein prra |
| M. thermoresistible (build 8) | TH_4543 | - | 1e-116 | 97.75% (222) | PUTATIVE two component transcriptional regulator, winged helix |
| M. ulcerans Agy99 | MUL_0248 | prrA | 1e-117 | 93.16% (234) | two component response transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_5009 | - | 1e-120 | 96.10% (231) | two component transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5662|M.smegmatis_MC2_155 ---MDSTTSGMASPRVLVVDDDPDVLASLERGLRLSGFDVSTAVDGAEAL
TH_4543|M.thermoresistible__bu -----------------VVDDDPDVLASLERGLRLSGFEVSTAVDGAEAL
Mflv_1744|M.gilvum_PYR-GCK ---MDS-----GSPRVLVVDDDPDVLASLERGLRLSGFDVFTAVDGAEAL
Mvan_5009|M.vanbaalenii_PYR-1 ---MDSGA---GSPKVLVVDDDPDVLASLERGLRLSGFDVYTAVDGAEAL
MMAR_4633|M.marinum_M MGGMDTGAN---SPRVLVVDDDSDVLASLERGLRLSGFEVSTAVDGAEAL
MUL_0248|M.ulcerans_Agy99 MGGMDTGAN---SPRVLVVDDDSDVLASLERGLRLSGFEVSTAVDGAEAL
MAV_1022|M.avium_104 ---MDTAAS---SPRVLVVDDDSDVLASLERGLRLSGFEVSTAVDGAEAL
MLBr_02123|M.leprae_Br4923 ---MDTGVS---SPRVLVVDDDSDVLASLERGLRLSGFEVSTAIDGAEAL
Mb0927c|M.bovis_AF2122/97 MGGMDTGVT---SPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEAL
Rv0903c|M.tuberculosis_H37Rv MGGMDTGVT---SPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEAL
MAB_0956c|M.abscessus_ATCC_199 ---MVDGQG---SPRVLVVDDDADVLASLERGLRLSGFEVNTASDGAEAL
*****.***************:* ** ******
MSMEG_5662|M.smegmatis_MC2_155 RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
TH_4543|M.thermoresistible__bu RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
Mflv_1744|M.gilvum_PYR-GCK RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
Mvan_5009|M.vanbaalenii_PYR-1 RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
MMAR_4633|M.marinum_M RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
MUL_0248|M.ulcerans_Agy99 RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
MAV_1022|M.avium_104 RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
MLBr_02123|M.leprae_Br4923 RNATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
Mb0927c|M.bovis_AF2122/97 RSATENRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
Rv0903c|M.tuberculosis_H37Rv RSATENRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
MAB_0956c|M.abscessus_ATCC_199 RCATEHRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARTSVDDR
* *** **************************************:*****
MSMEG_5662|M.smegmatis_MC2_155 VAGLEAGADDYLVKPFVLAELVARVKALLRRRGSSATFSSETIQVGPLEV
TH_4543|M.thermoresistible__bu VAGLEAGADDYLVKPFVLAELVARVKALLRRRGSSATSSSETIVVGPLEV
Mflv_1744|M.gilvum_PYR-GCK VAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATFSSETITVGPLEV
Mvan_5009|M.vanbaalenii_PYR-1 VAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATFSSETITVGPLEV
MMAR_4633|M.marinum_M VAGLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSETITVGPLEV
MUL_0248|M.ulcerans_Agy99 VAGLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSEIITVGPLEV
MAV_1022|M.avium_104 VAGLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSETITVGPLEV
MLBr_02123|M.leprae_Br4923 VAGLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSETIAVGPLEV
Mb0927c|M.bovis_AF2122/97 VAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEV
Rv0903c|M.tuberculosis_H37Rv VAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEV
MAB_0956c|M.abscessus_ATCC_199 VAGLEAGADDYLTKPFVLAELVARVKALLRRRGAVATSSTETITVGPLEV
************.********************: ** *:* * ******
MSMEG_5662|M.smegmatis_MC2_155 DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
TH_4543|M.thermoresistible__bu DIPGRRARVNGQDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
Mflv_1744|M.gilvum_PYR-GCK DIPGRRARVDGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
Mvan_5009|M.vanbaalenii_PYR-1 DIPGRRARVDGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
MMAR_4633|M.marinum_M DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
MUL_0248|M.ulcerans_Agy99 DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
MAV_1022|M.avium_104 DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
MLBr_02123|M.leprae_Br4923 DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTTVLSRAQLLELVWGYDFA
Mb0927c|M.bovis_AF2122/97 DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
Rv0903c|M.tuberculosis_H37Rv DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
MAB_0956c|M.abscessus_ATCC_199 EIPGRRARINGVEVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
:*******::* :*******************:*****************
MSMEG_5662|M.smegmatis_MC2_155 ADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRTQ
TH_4543|M.thermoresistible__bu ADTNVVDVFIGYLRRKLEATGAPRLLHTVRGVGFVLRTQ
Mflv_1744|M.gilvum_PYR-GCK ADTNVVDVFIGYLRRKLEANGAPRLLHTVRGVGFVLRQQ
Mvan_5009|M.vanbaalenii_PYR-1 ADTNVVDVFIGYLRRKLEANGAPRLLHTVRGVGFVLRQQ
MMAR_4633|M.marinum_M ADTNVVDVFIGYLRRKLEANGGPRLLHTVRGVGFVLRMQ
MUL_0248|M.ulcerans_Agy99 ADTNVVDVFIGYLRRKLEANGGPRLLHTVRGVGFVLRMH
MAV_1022|M.avium_104 ADTNVVDVFIGYLRRKLEANGGPRLLHTVRGVGFVLRMQ
MLBr_02123|M.leprae_Br4923 ADTNVVDVFIGYLRRKLEANSGPRLLHTVRGVGFVLRMQ
Mb0927c|M.bovis_AF2122/97 ADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ
Rv0903c|M.tuberculosis_H37Rv ADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ
MAB_0956c|M.abscessus_ATCC_199 ADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRSQ
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