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aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_3827 | - | - | 100% (336) | putative dehydrogenase |
| M. thermoresistible (build 8) | TH_1114 | - | 3e-18 | 26.69% (326) | PROBABLE CHOLESTEROL DEHYDROGENASE |
| M. thermoresistible (build 8) | TH_0330 | rfbB | 3e-06 | 33.81% (139) | dTDP-glucose 4,6-dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1136c | - | 3e-18 | 29.15% (247) | cholesterol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2075 | - | 7e-19 | 25.99% (327) | 3-beta hydroxysteroid dehydrogenase/isomerase |
| M. tuberculosis H37Rv | Rv1106c | - | 3e-18 | 29.15% (247) | cholesterol dehydrogenase |
| M. leprae Br4923 | MLBr_01942 | - | 4e-18 | 25.60% (332) | putative cholesterol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4385 | - | 1e-92 | 51.57% (318) | putative oxidoreductase |
| M. marinum M | MMAR_3319 | - | 3e-82 | 49.70% (328) | dehydrogenase |
| M. avium 104 | MAV_1225 | - | 2e-18 | 26.76% (340) | 3-beta hydroxysteroid dehydrogenase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_5956 | - | 1e-17 | 26.71% (337) | NAD dependent epimerase/dehydratase family protein |
| M. ulcerans Agy99 | MUL_0172 | - | 3e-20 | 26.83% (328) | cholesterol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4635 | - | 4e-17 | 26.51% (332) | 3-beta hydroxysteroid dehydrogenase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3827|M.thermoresistible__bu MTDEDRI-PCGAMSRPSVFITGANGFIGRSLGAHFAEN-GYDVRGVD---
MAB_4385|M.abscessus_ATCC_1997 MTD---------MTQR-AFVTGANGFVGRSLSLRLRTL-GWQVSGVD---
MMAR_3319|M.marinum_M MSEHEFDRPAPSLSGRTIFITGANGFIGRAMAARFRAL-GAVVRGVD---
Mb1136c|M.bovis_AF2122/97 MLRRMGDA-SLTTELGRVLVTGGAGFVGANLVTTLLDR-GHWVRSFDRAP
Rv1106c|M.tuberculosis_H37Rv MLRRMGDA-SLTTELGRVLVTGGAGFVGANLVTTLLDR-GHWVRSFDRAP
MAV_1225|M.avium_104 MIGPMGDP-SLTAELGRVLVTGGSGFVGANLVTTLLER-GYQVRSFDRAP
MUL_0172|M.ulcerans_Agy99 MLRPMGDA-SLTTELGRVLVTGGSGFVGSNLVTTLLDR-GHHVRSFDRAP
Mflv_2075|M.gilvum_PYR-GCK ---------MLRTELGRVLVTGGSGFVGANLVTELLDR-GLHVRSFDRVA
Mvan_4635|M.vanbaalenii_PYR-1 ----MGDATTPTTELGRVLVTGGSGFVGANLVTELLDR-GLQVRSFDRVP
MLBr_01942|M.leprae_Br4923 MLRGVGNA-SLTTELGRVLVTGGSGFVGANLVTALLER-GYQVRSFDRAP
MSMEG_5956|M.smegmatis_MC2_155 --------------MSRILVTGGVGTIGSAVVRRLLHESAYEIRVCDQRP
::**. * :* : : . : *
TH_3827|M.thermoresistible__bu --LAADPARNVVAGDVVNPRPWKS---HLQG-CAVVLHTAAVVSNAVAA-
MAB_4385|M.abscessus_ATCC_1997 --LVADPAHNIQGGDINTAGPWMT---EAAA-ADAIFHTAAVVSNIADS-
MMAR_3319|M.marinum_M --LAADPAGDVVAGDITRPETWAAGPTGLEG-ADTVIHTAALLGAAFPL-
Mb1136c|M.bovis_AF2122/97 SLLPAHPQLEVLQGDITDADVCAAAVDG----IDTIFHTAAIIELMGGAS
Rv1106c|M.tuberculosis_H37Rv SLLPAHPQLEVLQGDITDADVCAAAVDG----IDTIFHTAAIIELMGGAS
MAV_1225|M.avium_104 SPLPAHPHLEVLQGDITDAGVCAAAVEG----IDTIFHTAAIIDLMGGAS
MUL_0172|M.ulcerans_Agy99 SPLPPHPQLEVLQGDITDAATCATAVDG----VDTVFHTAAIIELMGGAS
Mflv_2075|M.gilvum_PYR-GCK SALPAHARLEIVEGDITDADDVAAAVEG----VDTVFHTAAIIDLMGGAS
Mvan_4635|M.vanbaalenii_PYR-1 SPLPDHPGLEVVQGDITDVDDVARAVGTGADKADTVFHTAAIIDLMGGAS
MLBr_01942|M.leprae_Br4923 MPLPQHPQLEVLQGDITDATVCTTAMDS----IDTVFHTAAIIELMGGAS
MSMEG_5956|M.smegmatis_MC2_155 APQWMNEACEIRTGDLRSADEARAAVDG----CTHVIHLAAIVGGIANFH
. :: **: ::* **::
TH_3827|M.thermoresistible__bu ------GQQWQANVLGTRRVLEAAARAGVERVVHFSSVRAYGDLGFPDGV
MAB_4385|M.abscessus_ATCC_1997 ------DTAWRVNVLGTKKVIDATAPG--AVFVHLSSVRAFSDLDFPDMV
MMAR_3319|M.marinum_M ------KQAWHVNVLGTSRVLRAAIDAGVRRFVHFSSVAAYG-FEFPDGA
Mb1136c|M.bovis_AF2122/97 VTDEYRQRSFAVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQNIAGG
Rv1106c|M.tuberculosis_H37Rv VTDEYRQRSFAVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQNIAGG
MAV_1225|M.avium_104 VTEEYRQRSFAVNVGGTENLVRAGQAAGVQRFVYTSSNSVVMGGQNIVGG
MUL_0172|M.ulcerans_Agy99 VTDEYRKRSFSVNVGGTENLVRAGQQAGVKRFVYTSSNSVVMGGQIIAGG
Mflv_2075|M.gilvum_PYR-GCK VSEEYRQRSFAVNVTGTQNLVHAAQKAGVTRFVYTASNSVVMGGQRIAGG
Mvan_4635|M.vanbaalenii_PYR-1 VTEEYRQRSFAVNVTGTKNLVHAAQKAGVQRFVYTASNSVVMGGQRIAGG
MLBr_01942|M.leprae_Br4923 VTDEYRQRSYTVNVGGTENLLRAGQKSGVKRFVYTASNSVVMGGTPITGG
MSMEG_5956|M.smegmatis_MC2_155 R---LPHTLLEMNTGLYNSVFSAALREGVERLVYVSSSMVFEQATQFPTT
*. :. * .*: :* .
TH_3827|M.thermoresistible__bu KETWPLRADG-RAYVDTKVAAEATAFAAHASG---EIAVTVVRPGDVYGP
MAB_4385|M.abscessus_ATCC_1997 TEEHPVRTDG-NAYVDTKVASEQVVLQAHGAG---RIDARIARPGDIYGP
MMAR_3319|M.marinum_M DETYPVHVNG-DVYTDTKVNSEAVVLAAHGAG---EIDVTVIRPGDVWGP
Mb1136c|M.bovis_AF2122/97 DETLPYTDRFNDLYTETKVVAERFVLAQNGV---DGMLTCAIRPSGIWGN
Rv1106c|M.tuberculosis_H37Rv DETLPYTDRFNDLYTETKVVAERFVLAQNGV---DGMLTCAIRPSGIWGN
MAV_1225|M.avium_104 DETLPYTDRFNDLYTETKVLAERFVLGQNGV---DGMLTCAIRPSGIWGR
MUL_0172|M.ulcerans_Agy99 DETLPYTNRFNDLYTETKVVAEKFVLSQNGN---NEMLTCAIRPSGIWGT
Mflv_2075|M.gilvum_PYR-GCK DETLPYTERFNDLYTETKVVAEKFVLSQNGV---SGLLTCSIRPSGIWGR
Mvan_4635|M.vanbaalenii_PYR-1 DETLPYTERFNDLYTETKVVAEKFVLSQNGV---SGMLTCSIRPSGIWGR
MLBr_01942|M.leprae_Br4923 DETMPYTKRFNDLYTETKVVAEKFVLSQNGVPDGETMLTCSIRPSGIWGR
MSMEG_5956|M.smegmatis_MC2_155 EEHLLDCRPPRSAYGFSKLTGEIYCRAVHEEH---GLPFTICRPFNAYGP
* * :*: .* : : ** . :*
TH_3827|M.thermoresistible__bu GSRPWTIIPVEEIK---------KGR-LILPAGGQGVFSPVYIDDLIAGI
MAB_4385|M.abscessus_ATCC_1997 GSRPWTILPVEMIR---------SRQ-FVLPAMGRGVFSPIYIDDLVEGV
MMAR_3319|M.marinum_M GS-VWVRSPIAEMR---------KRTGFPLPNGGNGIFSPVYIDNFVDGM
Mb1136c|M.bovis_AF2122/97 GDQTMFRKLFESVL---------KGHVKVLVGRKSARLDNSYVHNLIHGF
Rv1106c|M.tuberculosis_H37Rv GDQTMFRKLFESVL---------KGHVKVLVGRKSARLDNSYVHNLIHGF
MAV_1225|M.avium_104 GDQTMFRKLFESVI---------AGHVKVLIGRKSARLDNSYVHNLIHGF
MUL_0172|M.ulcerans_Agy99 GDQLMFRKLFESVI---------KGHVKVLVGPKSVLLDNSYVDNLIHGF
Mflv_2075|M.gilvum_PYR-GCK GDQTMFRKVFESVL---------AGHVKVLVGNKETKLDNSYVHNLVHGF
Mvan_4635|M.vanbaalenii_PYR-1 GDQTMFRKVFESVL---------AGHVKVLVGNKNVKLDNSYVHNLVHGF
MLBr_01942|M.leprae_Br4923 GDQTMFRKAFESVV---------SGHVKVLIGSKNAKLDNSYVHNLVHGL
MSMEG_5956|M.smegmatis_MC2_155 GELPDTEPGIAHAVPDLIRKALSGQHPLQIFGSGTQTRTLTHVDDIADGI
*. . : ::.:: *.
TH_3827|M.thermoresistible__bu LLAAT----HPDAAGQDFNLPGVEPVTCKTFFGHYTRMLNKPPPRTVPTR
MAB_4385|M.abscessus_ATCC_1997 VALGS----GGAASGQVFTISGGVGVTCAQFFGHYHRMLDRRGPLVLPTA
MMAR_3319|M.marinum_M VLAVS----SDDAVGQIFNITDGKGVRCADFFGRMASMSDG-TIHTLPIR
Mb1136c|M.bovis_AF2122/97 ILAAAHLVPDGTAPGQAYFINDAEPINMFEFARPVLEACGQRWPKMRISG
Rv1106c|M.tuberculosis_H37Rv ILAAAHLVPDGTAPGQAYFINDAEPINMFEFARPVLEACGQRWPKMRISG
MAV_1225|M.avium_104 ILAAQHLTPGGTAPGQAYFINDAEPINMFEFARPVVEACGVNWPRVRVNG
MUL_0172|M.ulcerans_Agy99 MLAAQHLVPGGSAPGQAYFINDAEPINMFDFARPVVEACGEKWPRVRVSG
Mflv_2075|M.gilvum_PYR-GCK ILAAEHLVEGGSAPGQAYFINDGEPINMFEFARPVVQACGEPFPKFRVPG
Mvan_4635|M.vanbaalenii_PYR-1 ILAAQHLVDGGTAPGQAYFINDGEPINMFEFARPVMEACGEPWPTFRVSG
MLBr_01942|M.leprae_Br4923 ILAAEHLVPGGTAPGQAYFINDGEPINFFDFMGPIIKACGENWPRVRISG
MSMEG_5956|M.smegmatis_MC2_155 VTAMFH----PAGENQDFNISASEEHTIAEIAQMIWTACGLDPEDFALEN
: . .* : : : .
TH_3827|M.thermoresistible__bu VAIALATAAGTVERFRG--RSSELNAETVYYLTRAGGYSRAKAERVLGWV
MAB_4385|M.abscessus_ATCC_1997 AAVGLATVKARVLALSG--KATEANAISVRYLARTGSYSIAKAQRILGFE
MMAR_3319|M.marinum_M VAAPAAELLGSLLRRLG--QKTDLSAGTMWLLNRPGTYSIEKAQKMLGYQ
Mb1136c|M.bovis_AF2122/97 PAVRWVMTGWQRLHFRFGFPAPLLEPLAVERLYLDNYFSIAKARRDLGYE
Rv1106c|M.tuberculosis_H37Rv PAVRWVMTGWQRLHFRFGFPAPLLEPLAVERLYLDNYFSIAKARRDLGYE
MAV_1225|M.avium_104 PIVRAAMTGWQRLHFRFGIPAPLLEPLAVERLYLDNFFSIAKASRDLGYQ
MUL_0172|M.ulcerans_Agy99 PMVHRAMTGWQRLHFRFGLPAPLLEPLAVERLYLDNYFSVDKARRDLGYE
Mflv_2075|M.gilvum_PYR-GCK RLVWFAMTIWQFLHFKFGLPKPLLEPLAVERLYLDNYFSIAKAQRDLGYQ
Mvan_4635|M.vanbaalenii_PYR-1 RLVWFAMTIWQFLHFRFGLPKPLLEPLAVERLYLDNYFSIAKAERDLGYR
MLBr_01942|M.leprae_Br4923 RLVRNVMAVWQRLHFGFGLPKPPMEPLAVERVYLDNYFSIEKAHKELGYR
MSMEG_5956|M.smegmatis_MC2_155 VPTFEVDVQRRWP-------------------------SVEKARMLLGWQ
. * ** **:
TH_3827|M.thermoresistible__bu PQVSLDEGMARTEAWLRTEGYLD-------------------
MAB_4385|M.abscessus_ATCC_1997 PRFSLDAGMRATEIWLRDQGYLD-------------------
MMAR_3319|M.marinum_M PRVSIEEGMARVHEWARAERLI--------------------
Mb1136c|M.bovis_AF2122/97 PLFTTQQALTECLPYYVSLFEQMKNEAR--AEKTAATVKP--
Rv1106c|M.tuberculosis_H37Rv PLFTTQQALTECLPYYVSLFEQMKNEAR--AEKTAATVKP--
MAV_1225|M.avium_104 PLFTTEQAMSECLPYYVGMFEQMKRQAL--AGKASA------
MUL_0172|M.ulcerans_Agy99 PKFTTEQALKECLPYYVDLFRQMKSEVK--AGGR--------
Mflv_2075|M.gilvum_PYR-GCK PLFTTEQALAQCIPYYVELFDRMKREAGNPVVQAAAPAPPKG
Mvan_4635|M.vanbaalenii_PYR-1 PLYTTEQALEHCIPYYVDLFGRMKAEAAQPAVQAAAPVPPAG
MLBr_01942|M.leprae_Br4923 PLFTTEQAMAECLPYYTELFEQIKVAAKPHLASIAATPRPE-
MSMEG_5956|M.smegmatis_MC2_155 ARVDLRDGIATTVEWLREQQCIARNS----------------
. .: :