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VVENQYRFFTTLQANGRRRLLSNTVLITGGAGFIGSALAQRLTHEGYEVAVMDLLHPQVHARGSKVDLPR SVRLFTGDVTHAPDWDAVLRLFQPAQVVHLAAETGTAQSLSEATRHSSVNVVGTTQLLDALSRADLVPDQ IVLASSRAVYGEGEWRTATDSTFYPLPRSHAQLAAGRWDPVGPNGEHAVPLPSCASRTEPRPTNVYAATK LAQEHVLTAWTAAHDTKLSVLRLQNVYGPGQSLTNSYTGIVALFARLAREQQTLEVYEDGNILRDFVFIE DVVEALYAAIRRPADQRRCLDIGSGVGSSIHALAQKVAGICGAPTPKVVGKFRDGDVRAASCDIEPARME LDWRPKWTLDDGLPALLDWIAKSDVSH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0386 | - | - | 100% (377) | NAD dependent epimerase/dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_0991 | - | 2e-44 | 36.15% (343) | NAD-dependent epimerase/dehydratase |
| M. smegmatis MC2 155 | MSMEG_6142 | - | 9e-30 | 29.65% (344) | nucleoside-diphosphate-sugar epimerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0550 | galE3 | 3e-35 | 33.04% (345) | UDP-glucose 4-epimerase |
| M. gilvum PYR-GCK | Mflv_5007 | - | 1e-15 | 25.41% (366) | dTDP-glucose 4,6-dehydratase |
| M. tuberculosis H37Rv | Rv0536 | galE3 | 3e-35 | 33.04% (345) | UDP-glucose 4-epimerase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 8e-27 | 28.78% (344) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_4111c | - | 1e-157 | 77.87% (348) | putative epimerase/dehydratase |
| M. marinum M | MMAR_0882 | galE3 | 1e-37 | 34.03% (335) | UDP-glucose 4-epimerase, GalE3 |
| M. avium 104 | MAV_3269 | - | 1e-153 | 76.59% (346) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_3729 | - | 9e-15 | 24.79% (351) | PUTATIVE UDP-galactose 4-epimerase |
| M. ulcerans Agy99 | MUL_0635 | galE3 | 8e-38 | 34.03% (335) | UDP-glucose 4-epimerase, GalE3 |
| M. vanbaalenii PYR-1 | Mvan_0882 | - | 1e-37 | 32.35% (340) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4111c|M.abscessus_ATCC_199 ------------------------MLISGGAGFIGSALSNRLIQAGYDVA
MAV_3269|M.avium_104 ------------------------MLITGGAGFIGSALSRRLVEAGYDVA
MSMEG_0386|M.smegmatis_MC2_155 MVENQYRFFTTLQANGRRRLLSNTVLITGGAGFIGSALAQRLTHEGYEVA
Mb0550|M.bovis_AF2122/97 ----------------------MRVLLTGAAGFIGSRVDAALRAAGHDVV
Rv0536|M.tuberculosis_H37Rv ----------------------MRVLLTGAAGFIGSRVDAALRAAGHDVV
MMAR_0882|M.marinum_M ----------------------MKVLLTGAAGFIGSRVGAALSAAGHEVV
MUL_0635|M.ulcerans_Agy99 ----------------------MKVLLTGAAGFIGSRVGAALSAAGHEVV
Mvan_0882|M.vanbaalenii_PYR-1 ----------------------MRVLLTGAAGFIGTRIRERLIDGGHDVV
MLBr_00204|M.leprae_Br4923 -----------------MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVV
TH_3729|M.thermoresistible__bu ----------------------MTWLVTGGAGYIGSHVVRALLEADLPVV
Mflv_5007|M.gilvum_PYR-GCK ----------------------MRLLVTGGAGFIGANFVLATVRDRPDVR
*::*.**:**: . *
MAB_4111c|M.abscessus_ATCC_199 VMDVLHPQVHARGRAIDLPASVRLFTGDVTHAPDWDAVLRLFE-PSQVVH
MAV_3269|M.avium_104 LMDVLHPQVHGGDRPVELAPSVRLFTGDVTHAPDFDAVLRLFR-PTQIVH
MSMEG_0386|M.smegmatis_MC2_155 VMDLLHPQVHARGSKVDLPRSVRLFTGDVTHAPDWDAVLRLFQ-PAQVVH
Mb0550|M.bovis_AF2122/97 GVDALLPAAHG-------PNPVLPPGCQRVDVRDASALAPLLAGVDLVCH
Rv0536|M.tuberculosis_H37Rv GVDALLPAAHG-------PNPVLPPGCQRVDVRDASALAPLLAGVDLVCH
MMAR_0882|M.marinum_M GVDVLLPAAHG-------PNPVLPPGCHRVDVRDADAMAPLLAGVDLVCH
MUL_0635|M.ulcerans_Agy99 GVDVLLPAAHG-------PNPVLPPGCHRVDVRDADAMAPLLAGVDLVCH
Mvan_0882|M.vanbaalenii_PYR-1 AVDAMLPAAHG-------EDAAPPDDVARVDVRDAAAVADAVAGVDVVCH
MLBr_00204|M.leprae_Br4923 GLDNFATGHAAN-LEHLASTPALAFVEADIVTADLQTILDEHR-PEVVFH
TH_3729|M.thermoresistible__bu VIDDLSTGLEK------FVPSEVPLVRGTLLDADLVARALREHRVSGVIH
Mflv_5007|M.gilvum_PYR-GCK VTVLDSLTYAGSRESLAGVDTQIRLVQGDITDADLVGRLVGES--DAVVH
. * : *
MAB_4111c|M.abscessus_ATCC_199 LAAETGTAQSLSEATRHGSVNVVGTTQLLDALSRSALVP-DQLVLASSRA
MAV_3269|M.avium_104 LAAETGTAQSLSEATRHGSVNVVGTTQLLDALSRSGLVP-EQLVLASSRA
MSMEG_0386|M.smegmatis_MC2_155 LAAETGTAQSLSEATRHSSVNVVGTTQLLDALSRADLVP-DQIVLASSRA
Mb0550|M.bovis_AF2122/97 QAAMVGAGVNAADAPAYGGHNDFATTVLLAQMFAAGVR---RLVLASSMV
Rv0536|M.tuberculosis_H37Rv QAAMVGAGVNAADAPAYGGHNDFATTVLLAQMFAAGVR---RLVLASSMV
MMAR_0882|M.marinum_M QAAMVGAGVDAADAPAYGGHNDLATTVLLAQMFAAGVR---RLVLASSMV
MUL_0635|M.ulcerans_Agy99 QAAMVGAGVDAADAPAYGGHNDLATTVLLAQMFAAGVR---RLVLASSMV
Mvan_0882|M.vanbaalenii_PYR-1 QAAVVGAGVDAADAPSYAAHNDFATAVLLAQMFGAGCR---RLVLASSMV
MLBr_00204|M.leprae_Br4923 LAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTGVR--KIVHTSSGGS
TH_3729|M.thermoresistible__bu IAGFKYAGVSVQQPLHTYEQNVSAMVTLLKAMQDTGVD---MMVFSSSAA
Mflv_5007|M.gilvum_PYR-GCK FAAETHVDNALADPEPFVRSNIVGTFTILEAVRHAAASRPVRLHHVSTDE
*. . :. * . : : : *
MAB_4111c|M.abscessus_ATCC_199 VYGEGAWQSG-AEVFYPRPRSHAQLLAGEWDPQGPAGASATPLSSCADRT
MAV_3269|M.avium_104 VYGEGAWQSG-AEVFYPQPRSHAQLVAGRWDPQGPAGEQAVPLPSRADRT
MSMEG_0386|M.smegmatis_MC2_155 VYGEGEWRTATDSTFYPLPRSHAQLAAGRWDPVGPNGEHAVPLPSCASRT
Mb0550|M.bovis_AF2122/97 VYGQGRYDCPQHGPVDPLPRRRADLDNGVFEHRCPGCGEPVIWQLVDEDA
Rv0536|M.tuberculosis_H37Rv VYGQGRYDCPQHGPVDPLPRRRADLDNGVFEHRCPGCGEPVIWQLVDEDA
MMAR_0882|M.marinum_M VYGQGRYDCPEHGRIDPLPRRHSDLDAGVFEHRCPLCAEPVRWRLVGEEA
MUL_0635|M.ulcerans_Agy99 VYGQGHYDCPEHGRIDPLPRRHSDLDAGVFEHRCPLCAEPVRWRLVGEEA
Mvan_0882|M.vanbaalenii_PYR-1 VYGQGRYVCPGHGDVDPVPRTRSDLDAGAFDHRCPICGEPVDWALVGEGA
MLBr_00204|M.leprae_Br4923 IYG--------TPSQYPTP----------------------------ETV
TH_3729|M.thermoresistible__bu TFG------------------------------------TPDVDLVTETT
Mflv_5007|M.gilvum_PYR-GCK VYGDLELGDP---------------------------------AKFTEST
:* . .
MAB_4111c|M.abscessus_ATCC_199 EPRPTNIYAGTKLAQEHLLASWAAAHDTNLSVLRLQNVYGPGQS--LTNS
MAV_3269|M.avium_104 EPRPTNVYAATKLAQEHLLAAWTAAHDTNLSVLRLQNVYGPGQS--LTNS
MSMEG_0386|M.smegmatis_MC2_155 EPRPTNVYAATKLAQEHVLTAWTAAHDTKLSVLRLQNVYGPGQS--LTNS
Mb0550|M.bovis_AF2122/97 PLRPRSLYAASKTAQEHYALAWSEASGGSVVALRYHNVYGPGMP--RDTP
Rv0536|M.tuberculosis_H37Rv PLRPRSLYAASKTAQEHYALAWSEASGGSVVALRYHNVYGPGMP--RDTP
MMAR_0882|M.marinum_M ELRPRSLYAASKTAQEHYALAWSESTGGSVVALRYHNVYGPGMP--RDTP
MUL_0635|M.ulcerans_Agy99 ELRPRSLYAASKTAQEHYALAWSESTGGSVVALRYHNVYGPGMP--RDTP
Mvan_0882|M.vanbaalenii_PYR-1 PLRPRSLYAASKVAQEHYALAWSESTGGSVVALRYHNVYGPGMP--RDTP
MLBr_00204|M.leprae_Br4923 PTDPTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYGPRQD--PYG-
TH_3729|M.thermoresistible__bu PTRPESPYGESKLIGEWLLADVGRATGLRHTSLRYFNVVGSGSPELFDVS
Mflv_5007|M.gilvum_PYR-GCK PYNPSSPYSSTKAASDMLVRAWVRSYRLTATLSNCSNNYGPFQH------
* . *. * : * *.
MAB_4111c|M.abscessus_ATCC_199 YTGIVTLFARLAREKQALEVYED------GRIVRDFVFIDDVVDALFAAV
MAV_3269|M.avium_104 YTGIVALFARLARQGQALEVYED------GRIVRDFVYIDDVVDALFAAV
MSMEG_0386|M.smegmatis_MC2_155 YTGIVALFARLAREQQTLEVYED------GNILRDFVFIEDVVEALYAAI
Mb0550|M.bovis_AF2122/97 YSGVAAIFRSAVEKGKPPKVFED------GGQMRDFVHVDDVAAANLAAV
Rv0536|M.tuberculosis_H37Rv YSGVAAIFRSAVEKGKPPKVFED------GGQMRDFVHVDDVAAANLAAV
MMAR_0882|M.marinum_M YSGVAAIFRSSLEKGEPPKVFED------GGQMRDFVHVDDIAAANLAAA
MUL_0635|M.ulcerans_Agy99 YSGVAAIFRSSLEKGEPPKVFED------GGQMRDFVHVDDIAAANLAAA
Mvan_0882|M.vanbaalenii_PYR-1 YSGVAAIFRSALEAGDVPRVFED------GGQMRDFVHVDDVAAANVAAV
MLBr_00204|M.leprae_Br4923 EAGVVAIFVQALLSDRPTKVFGD------GTHTRDYVFVDDVVDAFIKAS
TH_3729|M.thermoresistible__bu PHNLFPLVFDMLYRGETPRINGDDYPTPDGTCVRDYIHVADLALAHVAAA
Mflv_5007|M.gilvum_PYR-GCK VEKFIPRQITNILTGRRPKLYGT------GANVRDWIHVEDHNSAVWKIL
. . .: * **::.: * *
MAB_4111c|M.abscessus_ATCC_199 HTP---ATERRTLDIGSGTATTIHELARKVADICAA-PEPVVVGKFRDGD
MAV_3269|M.avium_104 QRP---ASPQRRLDVGSGRATTIQELANTIAAMCEA-PEPVVVGKFRDGD
MSMEG_0386|M.smegmatis_MC2_155 RRP---ADQRRCLDIGSGVGSSIHALAQKVAGICGA-PTPKVVGKFRDGD
Mb0550|M.bovis_AF2122/97 HLGEADRDGFTAVNVCSGRPISILQVATAICDARGGSMSPAITGHYRSGD
Rv0536|M.tuberculosis_H37Rv HLGEADRDGFTAVNVCSGRPISILQVATAICDARGGSMSPAITGHYRSGD
MMAR_0882|M.marinum_M QLGEVDRHGFVAANVCSGRPISILQVASALCQARGDALSPVITGQYRSGD
MUL_0635|M.ulcerans_Agy99 QLGEVDRHGFVAANVCSGRPISILQVASALCQARGDALSPVITGQYRSGD
Mvan_0882|M.vanbaalenii_PYR-1 EAG---TEGFNAFNVCSGKPVSILDVATALCEARGD-VSPLVTGQYRSGD
MLBr_00204|M.leprae_Br4923 GDAG----GGQRFNIGTGIETSDRQLHTAVSAAVGGPDDPEFH-PPRLGD
TH_3729|M.thermoresistible__bu RRLQAGEPVEPVYNLGSGSGTSVREIMTAIRKVTGVDFVPEIA-PRRPGD
Mflv_5007|M.gilvum_PYR-GCK THG----AVGRTYLIGADGECDNLTVMRTILRLMDRSPDDFDHVTDRAGH
: :. : : * *.
MAB_4111c|M.abscessus_ATCC_199 VRAASCDIAPAVEGLGWSPKWT-LEDGLHALLEWIDKDCPNRF-------
MAV_3269|M.avium_104 VRAASCDIEPATSQLGWHPKWT-LEDGLRALLEWIG----NRP-------
MSMEG_0386|M.smegmatis_MC2_155 VRAASCDIEPARMELDWRPKWT-LDDGLPALLDWIAKSDVSH--------
Mb0550|M.bovis_AF2122/97 VRHIVADPARAARVLGFRAAVD-PGEGLREFAFAPLR-------------
Rv0536|M.tuberculosis_H37Rv VRHIVADPARAARVLGFRAAVD-PGEGLREFAFAPLR-------------
MMAR_0882|M.marinum_M VRHIVADPSRAAEVLGFRAAVE-PLEGLRGFAFAPLR-------------
MUL_0635|M.ulcerans_Agy99 VRHIVADPSRAAEVLGFRAAVE-PLEGLRGFAFAPLR-------------
Mvan_0882|M.vanbaalenii_PYR-1 VRHIVADPARAADVLGFRAVVD-PADGLCEFATAPLRGPALPS-------
MLBr_00204|M.leprae_Br4923 LKRSCLDIGLATTVLGWSPQVQ-LDDGVRRTVEYFRAAQRS---------
TH_3729|M.thermoresistible__bu PARIVASGELAARDLGWRMRHT-LEDMVKSAWEARQRAGDAYPR------
Mflv_5007|M.gilvum_PYR-GCK DLRYAIDATALRDELGWRPAHSDFEAGLRDTIDWYSANESWWGPIKDAVE
. *.: :
MAB_4111c|M.abscessus_ATCC_199 --------
MAV_3269|M.avium_104 --------
MSMEG_0386|M.smegmatis_MC2_155 --------
Mb0550|M.bovis_AF2122/97 --------
Rv0536|M.tuberculosis_H37Rv --------
MMAR_0882|M.marinum_M --------
MUL_0635|M.ulcerans_Agy99 --------
Mvan_0882|M.vanbaalenii_PYR-1 --------
MLBr_00204|M.leprae_Br4923 --------
TH_3729|M.thermoresistible__bu --------
Mflv_5007|M.gilvum_PYR-GCK AGYQSRGQ