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MNAHTSVGPLDRAARVYIAGHRGLVGSALLRTFAGAGFTNLLVRSRAELDLTDRAATFDFVLESRPQVVI DAAARVGGILANDTYPADFLSENLQIQVNLLDAAVAARVPRLLFLGSSCIYPKLAPQPIPESALLTGPLE PTNDAYAIAKIAGILAVQAVRRQHGLPWISAMPTNLYGPGDNFSPSGSHLLPALIRRYDEAKASGAPNVT NWGTGTPRRELLHVDDLASACLYLLEHFDGPTHVNVGTGIDHTIGEIAEMVASAVGYSGETRWDPSKPDG TPRKLLDVSVLREAGWRPSIALRDGIEATVAWYREHAGTVRQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1512 | epiA | - | 100% (322) | probable nucleotide-sugar epimerase epiA |
| M. tuberculosis H37Rv | Rv3634c | galE1 | 3e-22 | 29.38% (320) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. tuberculosis H37Rv | Rv3784 | - | 9e-11 | 25.21% (234) | dTDP-glucose 4,6-dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 3e-22 | 29.38% (320) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. gilvum PYR-GCK | Mflv_4753 | - | 1e-127 | 70.83% (312) | NAD-dependent epimerase/dehydratase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 4e-20 | 27.50% (320) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 2e-20 | 28.12% (320) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_5133 | galE1 | 7e-22 | 27.91% (326) | UDP-glucose 4-epimerase GalE1 |
| M. avium 104 | MAV_0524 | - | 2e-21 | 28.44% (320) | nucleoside-diphosphate-sugar epimerase |
| M. smegmatis MC2 155 | MSMEG_5956 | - | 2e-29 | 31.10% (328) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_2143 | - | 6e-06 | 25.37% (272) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_4210 | galE1 | 5e-22 | 27.91% (326) | UDP-glucose 4-epimerase GalE1 |
| M. vanbaalenii PYR-1 | Mvan_1365 | - | 8e-07 | 25.00% (332) | dTDP-glucose 4,6-dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1512|M.tuberculosis_H37Rv -------MNAHTSVGP--LDRAARVYIAGHRGLVGSALLRTFAGAGFTNL
Mflv_4753|M.gilvum_PYR-GCK -------MTASEIVSPRELDRAATFYVAGHRGLVGSAIVRRLRVAGFDNI
MLBr_00204|M.leprae_Br4923 MYGEPVRALVTGAAGFIGSTLVDRLLADGHT-VVGLDNFATGHAANLEHL
MAV_0524|M.avium_104 -----MRALVTGAAGFIGSTLVDRLLADGHT-VVGLDNFASGRASNLEHL
MMAR_5133|M.marinum_M -----MRALVTGAAGFIGSTLVDRLLADGHT-VVGLDNFATGRATNLEHL
MUL_4210|M.ulcerans_Agy99 -----MRALVTGAAGFIGSTLVDRLLADGHT-VVGLDNFATGRATNLEHL
Mb3658c|M.bovis_AF2122/97 -----MRALVTGAAGFIGSTLVDRLLADGHS-VVGLDNFATGRATNLEHL
MAB_0503|M.abscessus_ATCC_1997 -----MRAMVTGAAGFIGSTLVDRLLADGHE-VTGLDNLATGKVANLEAA
MSMEG_5956|M.smegmatis_MC2_155 ----MSRILVTGGVGTIGSAVVRRLLHESAYEIRVCD--QRPAPQWMNEA
Mvan_1365|M.vanbaalenii_PYR-1 -----MRLLVTGGAGFIGANFVRTTVQQRPDVQVTVLDSLTYAGSRESLR
TH_2143|M.thermoresistible__bu ---VAKKKLVIGASGFLGSHVTRQLVREGHDVRVMVRTTSMTRG------
. . .
Rv1512|M.tuberculosis_H37Rv LVRSRAELDLTD--RAATFDFVLESRPQVVIDAAARVGGILANDTYPADF
Mflv_4753|M.gilvum_PYR-GCK VGKTSAELDLKN--RDAVFDFMSEIKPRYVVLAAAKVGGILANSNYPVDF
MLBr_00204|M.leprae_Br4923 ASTPALAFVEADIVTADLQTILDEHRPEVVFHLAAQID-VRHSVVDPQFD
MAV_0524|M.avium_104 VGNPAHVFVEADIVTADLEAILDEHRPEVVFHLAAQID-VRHSVADPQFD
MMAR_5133|M.marinum_M VDNLAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQID-VRHSVADPQFD
MUL_4210|M.ulcerans_Agy99 VDNLAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQID-VRHSVADPQFD
Mb3658c|M.bovis_AF2122/97 ADNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQID-VRRSVADPQFD
MAB_0503|M.abscessus_ATCC_1997 EANAKFTFVKDDIVEADLDAVVAEYSPEVIFHLAAQID-VRHSVADPQFD
MSMEG_5956|M.smegmatis_MC2_155 CEIRTGDLRSADEARAAVDGCTH------VIHLAAIVGGIANFHRLPHTL
Mvan_1365|M.vanbaalenii_PYR-1 GVDSQIRLVEGDITDAELVGKLVADS-DAVVHFAAETH-VDNALADPEPF
TH_2143|M.thermoresistible__bu IDDLDVERCHGDVFDDAALRAAMTGVDDVYYCVVDAR----MWLRDPAPL
: . *
Rv1512|M.tuberculosis_H37Rv LSENLQIQVNLLDAAVAARVPR--LLFLGSS-CIYPKLAPQP--IPESAL
Mflv_4753|M.gilvum_PYR-GCK LSDNIRIQVNVLDAARDCGVER--LLFLGSS-CIYPKFAEQP--IREDSL
MLBr_00204|M.leprae_Br4923 ASVNVIGTVRLAEAARHTGVRK--IVHTSSGGSIYGTPSQYP--TPET-V
MAV_0524|M.avium_104 ASVNVIGTVRLAEAARRTGVRK--IVHTSSGGSIYGTPPTYP--TPET-V
MMAR_5133|M.marinum_M ASVNVIGTLRLAEAARLTGVRK--VVHTSSGGSIYGTPPQYP--TSER-V
MUL_4210|M.ulcerans_Agy99 ASVNVIGTLRLAEAARLTGVRK--VVHTSSGGSIYGTPPQYP--TSER-V
Mb3658c|M.bovis_AF2122/97 AAVNVIGTVRLAEAARQTGVRK--IVHTSSGGSIYGTPPEYP--TPET-A
MAB_0503|M.abscessus_ATCC_1997 SSVNVVGTVRLAEAARKAGVRK--IVHTSSGGSIYGTPKQIP--TSET-V
MSMEG_5956|M.smegmatis_MC2_155 LEMNTGLYNSVFSAALREGVER--LVYVSSS-MVFEQATQFP--TTEEHL
Mvan_1365|M.vanbaalenii_PYR-1 VHSNVLGTFTVLEAVRHASVTKPVRLHHISTDEVYGDLELDDPARFTDAT
TH_2143|M.thermoresistible__bu FRTNVEGLRHVLDAAVEADLNR--FLFTSTT----GTMAINPYRPVTEDD
* : .*. : : :. :
Rv1512|M.tuberculosis_H37Rv LTGPLEPTNDAYAIAKIAGILAVQAVRRQHGLPWISAMPTNLYGPGDNFS
Mflv_4753|M.gilvum_PYR-GCK LTGHLEPTNDAYAIAKIAGILHVQAVRRQYGLPWISAMPTNLYGPNDNYS
MLBr_00204|M.leprae_Br4923 PTDPTSP----YAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYGPRQ--D
MAV_0524|M.avium_104 PTDPASP----YAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQ--D
MMAR_5133|M.marinum_M PTDPASP----YAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQ--D
MUL_4210|M.ulcerans_Agy99 PTDPASP----YAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQ--D
Mb3658c|M.bovis_AF2122/97 PTDPASP----YAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQ--D
MAB_0503|M.abscessus_ATCC_1997 PTDPHSP----YAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQ--D
MSMEG_5956|M.smegmatis_MC2_155 LDCRPPRS--AYGFSKLTGEIYCRAVHEEHGLPFTICRPFNAYGPGE--L
Mvan_1365|M.vanbaalenii_PYR-1 PYNPSSP----YSSTKAAADMLVRAWVRSYRVAATISNCSNNYGPYQH--
TH_2143|M.thermoresistible__bu PHNWTEGG--AYIEARVAAEQLVLRYARERGLPAVALCISTTYGPGD-WQ
* : :. . : . *** :
Rv1512|M.tuberculosis_H37Rv PSGSHLLPALIRRYDEAKASGAPNVTNWGTGTPRRELLHVDD--------
Mflv_4753|M.gilvum_PYR-GCK PTGSHVLPALIRRYDEAVASRAVSVTNWGTGSPRREFLHSDD--------
MLBr_00204|M.leprae_Br4923 PYG---EAGVVAIFVQALLSDRP-TKVFGDGTHTRDYVFVDD--------
MAV_0524|M.avium_104 PHG---EAGVVAIFAQALLSGKP-TKVFGDGTNTRDYVFVDD--------
MMAR_5133|M.marinum_M PHG---EAGVVAIFAQALLSGKP-TKVFGDGTNTRDYVFVDD--------
MUL_4210|M.ulcerans_Agy99 PHG---EAGVVAIFAQALLSGKP-TKVFGDGTNTRDYVFVDD--------
Mb3658c|M.bovis_AF2122/97 PHG---EAGVVAIFAQALLSGKP-TRVFGDGTNTRDYVFVDD--------
MAB_0503|M.abscessus_ATCC_1997 PHG---EAGVVAIFAQALLSGRS-TKVFGDGGNTRDYVFVDD--------
MSMEG_5956|M.smegmatis_MC2_155 PDTEPGIAHAVPDLIRKALSGQHPLQIFGSGTQTRTLTHVDD--------
Mvan_1365|M.vanbaalenii_PYR-1 ------VEKFIPRQITNVLTGRR-PELYGTGANVRDWIHVDD--------
TH_2143|M.thermoresistible__bu PTPHGRLLAMVATGRFPFYLGWS-AEVVGIEDAARAMLLAAEQGRVGERY
: * * :
Rv1512|M.tuberculosis_H37Rv -LASACLYLLEHFDGPTH-VNVGTGIDHTIGEIAEMVASAVGYSGE---T
Mflv_4753|M.gilvum_PYR-GCK -MADACLHLLENYDGPEQ-VNVGSGTDVTIREIAESVAAAVGFSGE---T
MLBr_00204|M.leprae_Br4923 -VVDAFIKASGDAGGGQR-FNIGTGIETSDRQLHTAVSAAVGGPDD---P
MAV_0524|M.avium_104 -VVDAFVKASGDAGGGQR-FNIGTGVETSDRQLHSAVAAAVGGPDD---P
MMAR_5133|M.marinum_M -VVDAFVRAGSDVGGGQR-FNIGTGVETSDRQLHSAVAAAVGGPDD---P
MUL_4210|M.ulcerans_Agy99 -VVDAFVKAGSDVGGGQR-FNIGTGVETSDRQLHSAVAAAVGGPDD---P
Mb3658c|M.bovis_AF2122/97 -VVDAFVRVSADVGGGLR-FNIGTGKETSDRQLHSAVAAAVGGPDD---P
MAB_0503|M.abscessus_ATCC_1997 -VVEAFVRASGPDGGGQR-FNVGTGVETSDRQLHSLVAAAAGAPDD---P
MSMEG_5956|M.smegmatis_MC2_155 -IADGIVTAMFHPAGENQDFNISASEEHTIAEIAQMIWTACGLDPEDFAL
Mvan_1365|M.vanbaalenii_PYR-1 -HNSAVWRILHDGTVGRT-YLIGADGERDNLSVMRTILRLMGRSPED--F
TH_2143|M.thermoresistible__bu IISDRYLHTREVHAIAAEAVGRRAPWFGLPLPVLSVAARGNDLAARLLRR
. : : .
Rv1512|M.tuberculosis_H37Rv RWDPSKP---DGTPRKLLDVSVLR-EAGWRPS-IALRDGIEATVAWYREH
Mflv_4753|M.gilvum_PYR-GCK HWDTTKP---DGTPQKLLDVSKLT-QAGWTSK-ISLQEGIERTVAWYREH
MLBr_00204|M.leprae_Br4923 EFHPPRL---GDLKRSCLDIGLATTVLGWSPQ-VQLDDGVRRTVEYFRAA
MAV_0524|M.avium_104 EFHPPRL---GDLKRSCLDIGLAARVLGWQPK-VGLQQGVARTVEYFRNQ
MMAR_5133|M.marinum_M EFHPPRL---GDLKRSCLDISRAEEVLGWRPQ-VELADGVRRTVDYFRRT
MUL_4210|M.ulcerans_Agy99 EFHPPRL---GDLKRSCLDISRAEEVLGWRPQ-VELADGVRRTVDYFRRT
Mb3658c|M.bovis_AF2122/97 EFHPPRL---GDLKRSCLDIGLAERVLGWRPQ-IELADGVRRTVEYFRHK
MAB_0503|M.abscessus_ATCC_1997 EFHPPRL---GDLRQSCLDVGLAKRVLGWEPR-VPLADGIRRTVDFFRS-
MSMEG_5956|M.smegmatis_MC2_155 ENVPTFE---VDVQRRWPSVEKARMLLGWQAR-VDLRDGIATTVEWLREQ
Mvan_1365|M.vanbaalenii_PYR-1 DHVTDRV---GHDLRYAIDPTPLRDELGWRPEHTDFESGLRDTIDWYRDN
TH_2143|M.thermoresistible__bu DLMFAHVGLKMAELMSPLDHSKAERELGFKPE--PVEDSIAKAARFFLEQ
. *: . . ..: : :
Rv1512|M.tuberculosis_H37Rv AGTVRQ--------------
Mflv_4753|M.gilvum_PYR-GCK VGALRG--------------
MLBr_00204|M.leprae_Br4923 QRS-----------------
MAV_0524|M.avium_104 HN------------------
MMAR_5133|M.marinum_M HGS-----------------
MUL_4210|M.ulcerans_Agy99 HGS-----------------
Mb3658c|M.bovis_AF2122/97 HTD-----------------
MAB_0503|M.abscessus_ATCC_1997 --------------------
MSMEG_5956|M.smegmatis_MC2_155 QCIARNS-------------
Mvan_1365|M.vanbaalenii_PYR-1 ESWWGPLKDAVEATYQRRRR
TH_2143|M.thermoresistible__bu HR------------------