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MPAPSAADFARLRSLVAIEDLDARQSRPIEEVFTGRELTTIPVGTAEDVAAAFAKARAAQRGWAHRPVAE RAAIMERFRDLVAKNRDFLMDVAQAETGKARSAAQEEIVDMMLNARYYARQAVKLLAPKRVQGLLPGVVK TVVNHHPKGVVGVISPWNYPMALSISDSIPALLAGNAVVVKPDSQTPYCTLANAELLYEAGLPRDLFAVV PGPGSVVGTAIVENCDYLMFTGSTATGRTLAEQCGRRLIGFSAELGGKNPMIVTRGAKLDVAAKAATRAC FSNAGQLCISIERIYVERAVADEFTAKFGEQVRSMRLAATYDFTADMGSLISEDQIKTVSGHVDDAKAKG ATVIAGGNIRPDIGPRFYEPTVLTGVTDEMECARNETFGPVVSIYPVESVAEAIEKANDTEYGLNASVWA GSKTEGEAIAAQLQAGTVNVDEGYALAFGSTAAPMGGMKASGVGRRHGADGILKYTESQTVATSRVLNLD PPLGISGTLWQKAMTPMIRAVQKLPGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5912 | gabD2 | - | 100% (517) | succinic semialdehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0889 | - | 3e-84 | 38.69% (473) | succinic semialdehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0582 | - | 1e-68 | 35.60% (455) | succinic semialdehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1760 | gabD2 | 0.0 | 74.27% (517) | succinic semialdehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0132 | - | 8e-81 | 40.31% (459) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv1731 | gabD2 | 0.0 | 74.27% (517) | succinic semialdehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 5e-59 | 31.18% (449) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4136c | - | 2e-82 | 39.69% (456) | putative aldehyde dehydrogenase |
| M. marinum M | MMAR_2571 | gabD2 | 0.0 | 74.27% (517) | succinate-semialdehyde dehydrogenase |
| M. avium 104 | MAV_2608 | - | 2e-67 | 35.96% (456) | aldehyde dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3138 | - | 1e-83 | 39.11% (496) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_3190 | gabD2 | 0.0 | 73.89% (517) | succinic semialdehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0771 | - | 5e-84 | 41.35% (445) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0132|M.gilvum_PYR-GCK ---MTATSDAHTANPF----------TGTGTITNPATGAVAGTVHWTDPA
Mvan_0771|M.vanbaalenii_PYR-1 MGFMTATSDVQPPHTF----------TGTGTIRNPATGAVAGEVRWTDPA
TH_3138|M.thermoresistible__bu ---MTATSGVDA--------------TETATIRNPATGGVAGEVRWTDPA
MAB_4136c|M.abscessus_ATCC_199 ---MTTTSENLVSTPS----------DTSHDVRNPANGQVVGRVNWTDPS
MMAR_2571|M.marinum_M ---MPVPSSAVFERLLSLAAIKDVDARPTRTIDEVFTGKPLTTIPVGTAE
MUL_3190|M.ulcerans_Agy99 ---MPVPSSAVFECLLSLAAIKDVDARPTRTIDEVFTGKPLTTIPVGTAE
Mb1760|M.bovis_AF2122/97 ---MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKPLTTIPVGTAA
Rv1731|M.tuberculosis_H37Rv ---MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKPLTTIPVGTAA
MSMEG_5912|M.smegmatis_MC2_155 ---MPAPSAADFARLRSLVAIEDLDARQSRPIEEVFTGRELTTIPVGTAE
MLBr_02573|M.leprae_Br4923 ---------------------------MSIATINPATGETVKTFTPTTQD
MAV_2608|M.avium_104 -MTDTATETLVQFDLLIGGESSSAASGLTYDSVDPFTGRPWARVPNAAAA
: : .* .
Mflv_0132|M.gilvum_PYR-GCK DVAQVAAGLRTAQRE-WEARGPKGRAKVLARYALWLGEHRAEIERLLIAE
Mvan_0771|M.vanbaalenii_PYR-1 DVARLAAGLRTAQRE-WETRGPKGRAKVLARYAVWLGEHRDEIERLLIAE
TH_3138|M.thermoresistible__bu DVPRITAGLREAQRH-WEARGPKGRAKVLARYAVWLGEHRDEIERLLIAE
MAB_4136c|M.abscessus_ATCC_199 DIPGIVAQLAKAQPS-WERLGPEGRGQVLARFAQWLIDNTGRIEAQLIAE
MMAR_2571|M.marinum_M DVEAAFAEARAAQAN-WAKRPVSERAEVIRRYRDLVIENREFLMDLLQAE
MUL_3190|M.ulcerans_Agy99 DVEAAFAEAREAQAN-WAKRPVSERAEVIRRYRDLVIENREFLMDLLQAE
Mb1760|M.bovis_AF2122/97 DVEAAFAEARAAQTD-WAKRPVIERAAVIRRYRDLVIENREFLMDLLQAE
Rv1731|M.tuberculosis_H37Rv DVEAAFAEARAAQTD-WAKRPVIERAAVIRRYRDLVIENREFLMDLLQAE
MSMEG_5912|M.smegmatis_MC2_155 DVAAAFAKARAAQRG-WAHRPVAERAAIMERFRDLVAKNRDFLMDVAQAE
MLBr_02573|M.leprae_Br4923 EVEDAIARAYARFDN-YRHTTFTQRAKWANATADLLEAEANQSAALMTLE
MAV_2608|M.avium_104 DVDRAVGAARAALNGPWGALTATARGKLLHRLGEIIAREADQLAELEVRD
:: . : *. : . :
Mflv_0132|M.gilvum_PYR-GCK TGKSAVDAAQEVPLILMITSYYVRTMEKALAPESRPAALPFLSIKKITVH
Mvan_0771|M.vanbaalenii_PYR-1 TGKSAADAAQEVPLIIMITSYYVRTMAKALAPETRPASLPFLSIKKITVH
TH_3138|M.thermoresistible__bu TGKSAVDAAQEVPLILMITSYYIKTMEKALAPETRPASMPLLKIKKITVH
MAB_4136c|M.abscessus_ATCC_199 TGKSKIDGGIEIPSILAIIAYYAPKAAEFLAPESRPASSIAMNTKKITVH
MMAR_2571|M.marinum_M AGKARWAAQEEVVDLVANANYYARVSAGLLKP--RTVQALLPGIGKTTVG
MUL_3190|M.ulcerans_Agy99 AGKARWAAQEEVVDLVANANYYARVSAGLLKP--RTVQALLPGIGKTTVG
Mb1760|M.bovis_AF2122/97 AGKARWAAQEEIVDLIANANYYARVCVDLLKP--RKAQPLLPGIGKTTVC
Rv1731|M.tuberculosis_H37Rv AGKARWAAQEEIVDLIANANYYARVCVDLLKP--RKAQPLLPGIGKTTVC
MSMEG_5912|M.smegmatis_MC2_155 TGKARSAAQEEIVDMMLNARYYARQAVKLLAP--KRVQGLLPGVVKTVVN
MLBr_02573|M.leprae_Br4923 MGKTLQSAKDEAMKCAKGFRYYAEKAETLLAD--EPAEAAAVGASKALAR
MAV_2608|M.avium_104 GGKLVREMVGQMRSLPDYYFYYGGLADKLQGD--VIPVDKPN--YFVYTR
** : ** .
Mflv_0132|M.gilvum_PYR-GCK YRPRPVVGIIAPWNYPVANALMDAIGALAAGCAVLLKPSERTPLTAELLL
Mvan_0771|M.vanbaalenii_PYR-1 YRPRPVVGIIAPWNYPVANALMDAVGALAAGCAVLLKPSERTPLTAELLL
TH_3138|M.thermoresistible__bu HRPRPVVGVIAPWNYPVANALMDAIGALAAGCAVLLKPSERTPLTAELLL
MAB_4136c|M.abscessus_ATCC_199 QRPRKVVGVISPWNYPVALGYWDVIPALLAGCSVLLKPSERTPLSDELIA
MMAR_2571|M.marinum_M YQPKGVVGVISPWNYPMTLTASDSVPALIAGNAVVLKPDSQTPYCALACA
MUL_3190|M.ulcerans_Agy99 YQPKGVVGVISPWNYPMTLTASDSVPALIAGNAVVLKPDSQTPYCALACA
Mb1760|M.bovis_AF2122/97 YQPKGVVGVISPWNYPMTLTVSDSVPALVAGNAVVLKPDSQTPYCALACA
Rv1731|M.tuberculosis_H37Rv YQPKGVVGVISPWNYPMTLTVSDSVPALVAGNAVVLKPDSQTPYCALACA
MSMEG_5912|M.smegmatis_MC2_155 HHPKGVVGVISPWNYPMALSISDSIPALLAGNAVVVKPDSQTPYCTLANA
MLBr_02573|M.leprae_Br4923 YQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALYLA
MAV_2608|M.avium_104 HEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKPSDHTPTSTLAFA
.* ** : *** *: .* ** ::* ...*
Mflv_0132|M.gilvum_PYR-GCK RGWLEAGGP-DVLALAQG-ARAVSEAVI--DNSDFIQFTGSSATGAKVME
Mvan_0771|M.vanbaalenii_PYR-1 RGWLDSGGP-DVLALAQG-AREVSEAVI--DNSDYIQFTGSTATGVKVME
TH_3138|M.thermoresistible__bu RGWLESGAP-EVFALAQG-AREVSEAVV--DNADFIQFTGSTATGIKVME
MAB_4136c|M.abscessus_ATCC_199 NGWAEIGGP-PVFEVVHG-AREVGEALV--DNVDFVQFTGSTATGKKIME
MMAR_2571|M.marinum_M ELLYRAGLPRALYAIVPGPGSVVGTAIA--DNCDYLMFTGSSATGSRLAE
MUL_3190|M.ulcerans_Agy99 ELLYRAGLPRALYAIVPGPGSVVGTAIA--DNCDYLMFTGSSATGSRLAE
Mb1760|M.bovis_AF2122/97 ELLYRAGLPRALYAIVPGPGSVVGTAIT--DNCDYLMFTGSSATGSRLAE
Rv1731|M.tuberculosis_H37Rv ELLYRAGLPRALYAIVPGPGSVVGTAIT--DNCDYLMFTGSSATGSRLAE
MSMEG_5912|M.smegmatis_MC2_155 ELLYEAGLPRDLFAVVPGPGSVVGTAIV--ENCDYLMFTGSTATGRTLAE
MLBr_02573|M.leprae_Br4923 DVIARGGFPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAGQAVGA
MAV_2608|M.avium_104 KLFAEAGFPPGVINVVTGWGPETGAALASHPGVDKVAFTGSTATGIHVGK
* * . . : :*** .:* :
Mflv_0132|M.gilvum_PYR-GCK RAARRLTPVSLELGGKDPMIVLEDADVDLAAHAAVWGAMFNAGQTCVSVE
Mvan_0771|M.vanbaalenii_PYR-1 RAARRLTPVSLELGGKDPMIVLEDADIDLAAHAAVWGAMFNAGQTCVSVE
TH_3138|M.thermoresistible__bu RAARRLTPVSLELGGKDPMIVLEDADIELAANAAVWGAMFNAGQTCVSVE
MAB_4136c|M.abscessus_ATCC_199 RAARRLTPVSLELGGKDPMLVLPDADVKRAAHAAVWGSMFNAGQTCVSVE
MMAR_2571|M.marinum_M HAGRRLIGFSAELGGKNAMIVTRGVNLDKVAKAATRACFSNAGQLCISIE
MUL_3190|M.ulcerans_Agy99 RAGRRLIGFSAELGGKNAMIVTRGVNLDKVAKAATRACFSNAGQLCISIE
Mb1760|M.bovis_AF2122/97 HAGRRLIGFSAELGGKNPMIVARGANLDKVAKAATRACFSNAGQLCISIE
Rv1731|M.tuberculosis_H37Rv HAGRRLIGFSAELGGKNPMIVARGANLDKVAKAATRACFSNAGQLCISIE
MSMEG_5912|M.smegmatis_MC2_155 QCGRRLIGFSAELGGKNPMIVTRGAKLDVAAKAATRACFSNAGQLCISIE
MLBr_02573|M.leprae_Br4923 IAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQSCIAAK
MAV_2608|M.avium_104 AAIENMTRFSLELGGKSAQVVFADADLDAAANGVIAGVFAATGQTCLAGS
. ..: ****... :* ...:. .. . . . ** *:: .
Mflv_0132|M.gilvum_PYR-GCK RVYVLDQVYDQFVDAVVRDVAKLQVGAGEGN--AFGALIDDDQVAVTERH
Mvan_0771|M.vanbaalenii_PYR-1 RVYVLEQVYDQFVAAVVRDVESLKMGAGEGN--AFGALIDDSQVEITARH
TH_3138|M.thermoresistible__bu RVYVLAPVYEQFVAAVVRAVEKLEVGAGEGR--HFGALIDESQLAVTERH
MAB_4136c|M.abscessus_ATCC_199 RVYVHDSIYEQFVDLVVEEVRGLEIGAGLDH--SVGAMIDENQLEVVDRH
MMAR_2571|M.marinum_M RIYVEKDIADEFTRKFGDAVRSMKLGTAYDFSVDMGSLISEGQLKTVSGH
MUL_3190|M.ulcerans_Agy99 RIYVEKDIADEFTRKFGDAVRSMKLGTAYDFSVDMGSLISEGQLKTVSGH
Mb1760|M.bovis_AF2122/97 RIYVEKDIAEEFTRKFGDAVRNMKLGTAYDFSVDMGSLISEAQLKTVSGH
Rv1731|M.tuberculosis_H37Rv RIYVEKDIAEEFTRKFGDAVRNMKLGTAYDFSVDMGSLISEAQLKTVSGH
MSMEG_5912|M.smegmatis_MC2_155 RIYVERAVADEFTAKFGEQVRSMRLAATYDFTADMGSLISEDQIKTVSGH
MLBr_02573|M.leprae_Br4923 RFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVEQQ
MAV_2608|M.avium_104 RLLVDRSVADALVEKIVARAATIKLGDPKDPTTEMGPVSNLPQYEKVLSH
*. . : : :. . :.:. . .*.: . :
Mflv_0132|M.gilvum_PYR-GCK VADALAKGARALTGGTRGAGSG-SFYEPTVLVDVDHAMLCMTEETFGPTL
Mvan_0771|M.vanbaalenii_PYR-1 VEDALAKGARALTGGKRGSGPG-SFYEPTVLVDVDHSMACMTEETFGPTL
TH_3138|M.thermoresistible__bu VADAVARGAKVLTGGRRKDGPG-CFYEPTVLVDVDHSMMCMTEETFGPTL
MAB_4136c|M.abscessus_ATCC_199 VRQAVSSGARALTGGARIPGHG-SFYAPTVLVDVDHSMDCMREETFGPTL
MMAR_2571|M.marinum_M VDDATAKGAKVIAGGKARPDVGPLFYEPTVLTDVTHEMECADNETFGPLV
MUL_3190|M.ulcerans_Agy99 VDDATAKGAKVIAGGKARPDVGPLFYEPTVLTDVTHEMECADNETFGPLV
Mb1760|M.bovis_AF2122/97 VDDATAKGAKVIAGGKARPDIGPLFYEPTVLTNVAPEMECAANETFGPVV
Rv1731|M.tuberculosis_H37Rv VDDATAKGAKVIAGGKARPDIGPLFYEPTVLTNVAPEMECAANETFGPVV
MSMEG_5912|M.smegmatis_MC2_155 VDDAKAKGATVIAGGNIRPDIGPRFYEPTVLTGVTDEMECARNETFGPVV
MLBr_02573|M.leprae_Br4923 VDAAAAAGAVIRCGGK-RPDRPGWFYPPTVITDITKDMALYTDEVFGPVA
MAV_2608|M.avium_104 FASAREQGATVAYGGEPASDLGGFFVKPTVLTGVDPSMRAVAEEIFGPVL
. * ** ** . * ***:..: * :* ***
Mflv_0132|M.gilvum_PYR-GCK PIMRVSTVDEAVRLANDSPYGLSAAVFSKDLERAEAVAVQLDCGGVNIND
Mvan_0771|M.vanbaalenii_PYR-1 PIMKVSSVEEAVRLANDSPYGLSAAVFSRDVDRAKAVALQLDCGGVNVND
TH_3138|M.thermoresistible__bu PIMKVSSVAEAVRLANDTPYGLSGSVFSQDVERAREIALQLDCGAVNIND
MAB_4136c|M.abscessus_ATCC_199 PIMRYSEESEAIALANDSEYGLSASVWSKDRRRAERVALQLDCGTVNIND
MMAR_2571|M.marinum_M SIYPVADVEEAVEKANDTEYGLNASVWAGSTAEGEKIAARLRSGTVNVNE
MUL_3190|M.ulcerans_Agy99 SIYPVADVEEAVEKANDTEYGLNASVWAGSTPEGEKIAARLRSGTVNVNE
Mb1760|M.bovis_AF2122/97 SIYPVADVDEAVEKANDTDYGLNASVWAGSTAEGQRIAARLRSGTVNVDE
Rv1731|M.tuberculosis_H37Rv SIYPVADVDEAVEKANDTDYGLNASVWAGSTAEGQRIAARLRSGTVNVDE
MSMEG_5912|M.smegmatis_MC2_155 SIYPVESVAEAIEKANDTEYGLNASVWAGSKTEGEAIAAQLQAGTVNVDE
MLBr_02573|M.leprae_Br4923 SVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAGQVFING
MAV_2608|M.avium_104 AVMTFEDEDEAVAAANGTEFGLAAAVWTKDVHRAHRVAAKLRAGTVWVNA
.: :*: ** : :** . .:: . . . . .: .* * ::
Mflv_0132|M.gilvum_PYR-GCK -VISNLMCTTAPMGGWKTSGIGARFGGPEGLRKYCRIETVVAPRTNVGAG
Mvan_0771|M.vanbaalenii_PYR-1 -VISNLMCTTAPMGGWKSSGIGARFGGPEGLRKYCRIETVVSPRTNVGAG
TH_3138|M.thermoresistible__bu -VISNLMATTAPMGGWKTSGIGARFGGPEGLRKYCRVETVVEPRTGIGAG
MAB_4136c|M.abscessus_ATCC_199 -VIMNLSCLTAPHGGWKGSGLGSRFGGVDGLRKYCRTEAIVDTRVTLPSE
MMAR_2571|M.marinum_M GYAFAWGSLSAPMGGMGISGVGRRHG-PEGLLKYTESQTIATARVFNLDP
MUL_3190|M.ulcerans_Agy99 GYAFAWGSLSAPMGGMGISGVGRRHG-PEGLLKYTESQTIATARVFNLDP
Mb1760|M.bovis_AF2122/97 GYAFAWGSLSAPMGGMGLSGVGRRHG-PEGLLKYTESQTIATARVFNLDP
Rv1731|M.tuberculosis_H37Rv GYAFAWGSLSAPMGGMGLSGVGRRHG-PEGLLKYTESQTIATARVFNLDP
MSMEG_5912|M.smegmatis_MC2_155 GYALAFGSTAAPMGGMKASGVGRRHG-ADGILKYTESQTVATSRVLNLDP
MLBr_02573|M.leprae_Br4923 ---MTVSYPELPFGGIKRSGYGRELS-THGIREFCNIKTVWIA-------
MAV_2608|M.avium_104 ---YRVVAPHVPFGGIGYSGIGRENG-IDAVKDFTETKAVWVELSGETRD
* ** ** * . . ..: .: . :::
Mflv_0132|M.gilvum_PYR-GCK GNYYNNSPRALKRMNTMMTKLALIRPRRVAK
Mvan_0771|M.vanbaalenii_PYR-1 GNYYNNSLRALKRMNKLMTKLALIRPRRVAK
TH_3138|M.thermoresistible__bu GTYYNNSFKSLGMMNKLLTRMALVRPRRLAK
MAB_4136c|M.abscessus_ATCC_199 PLWYSGPSWLAPVALKSLTKLSNKALRPFRR
MMAR_2571|M.marinum_M PMGVPPTLWQKSLLPIVRTVMKLPGRK----
MUL_3190|M.ulcerans_Agy99 PMGVPPTLWQKSLLPIVRTVMKLPGRK----
Mb1760|M.bovis_AF2122/97 PFGIPATVWQKSLLPIVRTVMKLPGRR----
Rv1731|M.tuberculosis_H37Rv PFGIPATVWQKSLLPIVRTVMKLPGRR----
MSMEG_5912|M.smegmatis_MC2_155 PLGISGTLWQKAMTPMIRAVQKLPGR-----
MLBr_02573|M.leprae_Br4923 -------------------------------
MAV_2608|M.avium_104 PFTLG--------------------------