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MGFMTATSDVQPPHTFTGTGTIRNPATGAVAGEVRWTDPADVARLAAGLRTAQREWETRGPKGRAKVLAR YAVWLGEHRDEIERLLIAETGKSAADAAQEVPLIIMITSYYVRTMAKALAPETRPASLPFLSIKKITVHY RPRPVVGIIAPWNYPVANALMDAVGALAAGCAVLLKPSERTPLTAELLLRGWLDSGGPDVLALAQGAREV SEAVIDNSDYIQFTGSTATGVKVMERAARRLTPVSLELGGKDPMIVLEDADIDLAAHAAVWGAMFNAGQT CVSVERVYVLEQVYDQFVAAVVRDVESLKMGAGEGNAFGALIDDSQVEITARHVEDALAKGARALTGGKR GSGPGSFYEPTVLVDVDHSMACMTEETFGPTLPIMKVSSVEEAVRLANDSPYGLSAAVFSRDVDRAKAVA LQLDCGGVNVNDVISNLMCTTAPMGGWKSSGIGARFGGPEGLRKYCRIETVVSPRTNVGAGGNYYNNSLR ALKRMNKLMTKLALIRPRRVAK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0771 | - | - | 100% (512) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1572 | - | 3e-64 | 35.22% (477) | gamma-aminobutyraldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | 4e-62 | 33.75% (483) | betaine-aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1760 | gabD2 | 3e-82 | 40.56% (466) | succinic semialdehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0132 | - | 0.0 | 88.80% (509) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv1731 | gabD2 | 3e-82 | 40.56% (466) | succinic semialdehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02639 | - | 2e-48 | 32.89% (447) | aldehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4136c | - | 1e-171 | 59.41% (510) | putative aldehyde dehydrogenase |
| M. marinum M | MMAR_1607 | putA_2 | 1e-119 | 49.80% (488) | succinate-semialdehyde dehydrogenase |
| M. avium 104 | MAV_4946 | - | 3e-65 | 35.79% (461) | aldehyde dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_0889 | - | 0.0 | 83.30% (509) | succinic semialdehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3138 | - | 0.0 | 82.51% (509) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_3430 | putA_2 | 1e-120 | 50.00% (488) | succinate-semialdehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1760|M.bovis_AF2122/97 ---MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKPLTTIPVGTAA
Rv1731|M.tuberculosis_H37Rv ---MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKPLTTIPVGTAA
Mvan_0771|M.vanbaalenii_PYR-1 ----------MGFMTATSDVQPPHTFTGTGTIRNPATGAVAGEVRWTDPA
Mflv_0132|M.gilvum_PYR-GCK -------------MTATSDAHTANPFTGTGTITNPATGAVAGTVHWTDPA
MSMEG_0889|M.smegmatis_MC2_155 -------------MTATPEVDLPNPYTGTGTIHNPATGAVAGEVRWTDPA
TH_3138|M.thermoresistible__bu -------------MTATSGVDA----TETATIRNPATGGVAGEVRWTDPA
MAB_4136c|M.abscessus_ATCC_199 -------------MTTTSENLVSTPSDTSHDVRNPANGQVVGRVNWTDPS
MMAR_1607|M.marinum_M -----------MSSIATEPTTQKDDGQPQIPVENPATGEVIGHVPDMSAA
MUL_3430|M.ulcerans_Agy99 -----------MSSIATEPTMQKDDGQPQIPVENPATGEVIGHVPDMSAA
MAV_4946|M.avium_104 MSDIQTQAKTEYDKLFIGGKWTEPSTSEVIEVHCPATGEYVGKVPLAAAA
MLBr_02639|M.leprae_Br4923 -----------MLSRRAVGSCGKEEALMITESVAQKTAVSKSGVPPHTPP
.. : ..
Mb1760|M.bovis_AF2122/97 DVEAAFAEARAAQT--DWAKRPVIERAAVIRRYRDLVIENREFLMDLLQA
Rv1731|M.tuberculosis_H37Rv DVEAAFAEARAAQT--DWAKRPVIERAAVIRRYRDLVIENREFLMDLLQA
Mvan_0771|M.vanbaalenii_PYR-1 DVARLAAGLRTAQR--EWETRGPKGRAKVLARYAVWLGEHRDEIERLLIA
Mflv_0132|M.gilvum_PYR-GCK DVAQVAAGLRTAQR--EWEARGPKGRAKVLARYALWLGEHRAEIERLLIA
MSMEG_0889|M.smegmatis_MC2_155 DVPRIAAGLREAQK--EWEARGPKGRAKVLARYAVWLGDHRDEIEKLLIA
TH_3138|M.thermoresistible__bu DVPRITAGLREAQR--HWEARGPKGRAKVLARYAVWLGEHRDEIERLLIA
MAB_4136c|M.abscessus_ATCC_199 DIPGIVAQLAKAQP--SWERLGPEGRGQVLARFAQWLIDNTGRIEAQLIA
MMAR_1607|M.marinum_M QIAELARRGRAAQP--GWEALGYEGRAVVLKRMQRWLVDNADQVIATICS
MUL_3430|M.ulcerans_Agy99 QIAELARRGRAAQP--GWEALGYEGRAVVLKRMQRWLVDNADQVIATICS
MAV_4946|M.avium_104 DVDAAVAAARAAFDNGPWPTTPPKERAAVIANALKVMEERKDLFTGLLAA
MLBr_02639|M.leprae_Br4923 GVNSEATVVRLRQTFASGRTRSVDWRTQQLRALQALMVENEGAIAQALAD
: * : : :. . :
Mb1760|M.bovis_AF2122/97 EAGKARWAAQEEIVDL-IANANYYARVCVDLLKP--RKAQPLLPGIGKTT
Rv1731|M.tuberculosis_H37Rv EAGKARWAAQEEIVDL-IANANYYARVCVDLLKP--RKAQPLLPGIGKTT
Mvan_0771|M.vanbaalenii_PYR-1 ETGKSAADAAQEVPLI-IMITSYYVRTMAKALAPETRPASLPFLSIKKIT
Mflv_0132|M.gilvum_PYR-GCK ETGKSAVDAAQEVPLI-LMITSYYVRTMEKALAPESRPAALPFLSIKKIT
MSMEG_0889|M.smegmatis_MC2_155 ETGKSAVDAAQEVPLI-LMILSYYIKTVEKAMAPEKRPAPLPFLSIKKIE
TH_3138|M.thermoresistible__bu ETGKSAVDAAQEVPLI-LMITSYYIKTMEKALAPETRPASMPLLKIKKIT
MAB_4136c|M.abscessus_ATCC_199 ETGKSKIDGGIEIPSI-LAIIAYYAPKAAEFLAPESRPASSIAMNTKKIT
MMAR_1607|M.marinum_M ETGKTYEDAQIAELIYGAAAFGFWADKAPRYLADERIHSSSVFVKGKRLV
MUL_3430|M.ulcerans_Agy99 ETGKTYEDAQIAELIYGAAAFGFWADKAPRYLADERIHSSSVFVKGKRLV
MAV_4946|M.avium_104 ETGQPPTSVETMHWMSSIGALNFFAGPAVDQVKWKEVRTG----GYGQSI
MLBr_02639|M.leprae_Br4923 DLDRNPVEAFIVDIAATVSEAKYAAKKVRKWMRRKYRFLEVS-QLPGRGW
: .: : : :
Mb1760|M.bovis_AF2122/97 VCYQPKGVVGVISPWNYPMTLTVSDSVPALVAGNAVVLKPDSQTPYCALA
Rv1731|M.tuberculosis_H37Rv VCYQPKGVVGVISPWNYPMTLTVSDSVPALVAGNAVVLKPDSQTPYCALA
Mvan_0771|M.vanbaalenii_PYR-1 VHYRPRPVVGIIAPWNYPVANALMDAVGALAAGCAVLLKPSERTPLTAEL
Mflv_0132|M.gilvum_PYR-GCK VHYRPRPVVGIIAPWNYPVANALMDAIGALAAGCAVLLKPSERTPLTAEL
MSMEG_0889|M.smegmatis_MC2_155 VHYRPRAVVGIIAPWNYPVANAMMDAIGALAAGCSVLLKPSERTPLTAEV
TH_3138|M.thermoresistible__bu VHHRPRPVVGVIAPWNYPVANALMDAIGALAAGCAVLLKPSERTPLTAEL
MAB_4136c|M.abscessus_ATCC_199 VHQRPRKVVGVISPWNYPVALGYWDVIPALLAGCSVLLKPSERTPLSDEL
MMAR_1607|M.marinum_M LRYRPMGLIGVIGPWNYPLTNSFGDCIPALAAGNSVILKPSEVTPLTSLL
MUL_3430|M.ulcerans_Agy99 LRYRPMGLIGVIGPWNYPLTNSFGDCIPALAAGNSVILKPSEVTPLTSLL
MAV_4946|M.avium_104 VHREPIGVVGAIVAWNVPLFLAVNKLGPALLAGCTVVLKPAAETPLSANA
MLBr_02639|M.leprae_Br4923 VEYEPYGTVLIIGAWNYPFYLTLVPAVGAIAAGNTMVLKPSEVAAASAHL
: .* : * .** *. *: ** :::*** :.
Mb1760|M.bovis_AF2122/97 CAELLYRAGLPRALYAIVP-GPGSVVGTAITDNCDYLMFTGSSATGSRLA
Rv1731|M.tuberculosis_H37Rv CAELLYRAGLPRALYAIVP-GPGSVVGTAITDNCDYLMFTGSSATGSRLA
Mvan_0771|M.vanbaalenii_PYR-1 LLRGWLDSGGPD-VLALAQ-GAR-EVSEAVIDNSDYIQFTGSTATGVKVM
Mflv_0132|M.gilvum_PYR-GCK LLRGWLEAGGPD-VLALAQ-GAR-AVSEAVIDNSDFIQFTGSSATGAKVM
MSMEG_0889|M.smegmatis_MC2_155 LLRGWLDSGAPE-VFALAQ-GAR-AVSEAVIDNSDYIQFTGSSATGAKVM
TH_3138|M.thermoresistible__bu LLRGWLESGAPE-VFALAQ-GAR-EVSEAVVDNADFIQFTGSTATGIKVM
MAB_4136c|M.abscessus_ATCC_199 IANGWAEIGGPP-VFEVVH-GAR-EVGEALVDNVDFVQFTGSTATGKKIM
MMAR_1607|M.marinum_M LAQGLAESGLPDGVFAVAT-GRG-GTGAAVIDEVDMIMFTGSTATGRKVA
MUL_3430|M.ulcerans_Agy99 LAQGLAESGLPDGVFAVAT-GRG-GTGAAVIDEVDMIMFTGSTATGRKVA
MAV_4946|M.avium_104 LAEAFAEAGLPEGVLSVVPGGIETGQALTSNTDVDIFSFTGSSAVGREIG
MLBr_02639|M.leprae_Br4923 MAELVPR-YLDNDAIAVIE-GGGAVSQELIAQGLDRVMFTGGTEIGRKVY
. : * * . ***.: * .:
Mb1760|M.bovis_AF2122/97 EHAGRRLIGFSAELGGKNPMIVARGANLDKVAKAATRACFSNAGQLCISI
Rv1731|M.tuberculosis_H37Rv EHAGRRLIGFSAELGGKNPMIVARGANLDKVAKAATRACFSNAGQLCISI
Mvan_0771|M.vanbaalenii_PYR-1 ERAARRLTPVSLELGGKDPMIVLEDADIDLAAHAAVWGAMFNAGQTCVSV
Mflv_0132|M.gilvum_PYR-GCK ERAARRLTPVSLELGGKDPMIVLEDADVDLAAHAAVWGAMFNAGQTCVSV
MSMEG_0889|M.smegmatis_MC2_155 ERAARRLTPVSLELGGKDPMIVLEDADIELAANAAVWGAMFNAGQTCVSV
TH_3138|M.thermoresistible__bu ERAARRLTPVSLELGGKDPMIVLEDADIELAANAAVWGAMFNAGQTCVSV
MAB_4136c|M.abscessus_ATCC_199 ERAARRLTPVSLELGGKDPMLVLPDADVKRAAHAAVWGSMFNAGQTCVSV
MMAR_1607|M.marinum_M VRAAERLIPASLELGGKDPMIVLADADIERAANHAAYYSMFNCGQTCISI
MUL_3430|M.ulcerans_Agy99 VRAAERLIPASLELGGKDPMIVLADADIERAANHAAYYSMFNCGQTCISI
MAV_4946|M.avium_104 RRAADMLKPCTLELGGKSAAIVLDDVDLPSALPMLVFSGIMNSGQACVAQ
MLBr_02639|M.leprae_Br4923 EGAASHLTPVTLELGGKSPVIVAVDADIDVAAKRIAWIKILNAGQTCVAP
*. * : *****.. :* ..:: . . : *.** *::
Mb1760|M.bovis_AF2122/97 ERIYVEKDIAEEFTRKFGDAVRNMKLGTAYDFS-VDMGSLISEAQLKTVS
Rv1731|M.tuberculosis_H37Rv ERIYVEKDIAEEFTRKFGDAVRNMKLGTAYDFS-VDMGSLISEAQLKTVS
Mvan_0771|M.vanbaalenii_PYR-1 ERVYVLEQVYDQFVAAVVRDVESLKMGAGEGN---AFGALIDDSQVEITA
Mflv_0132|M.gilvum_PYR-GCK ERVYVLDQVYDQFVDAVVRDVAKLQVGAGEGN---AFGALIDDDQVAVTE
MSMEG_0889|M.smegmatis_MC2_155 ERVYVLESVYDQFVAATVRAVENLKMGAGEGY---DFGSLIDAGQVDITE
TH_3138|M.thermoresistible__bu ERVYVLAPVYEQFVAAVVRAVEKLEVGAGEGR---HFGALIDESQLAVTE
MAB_4136c|M.abscessus_ATCC_199 ERVYVHDSIYEQFVDLVVEEVRGLEIGAGLDH---SVGAMIDENQLEVVD
MMAR_1607|M.marinum_M ERCYVEAPVYDEFVAKVTEKVRAIRQGVPGGPGSVDVGSLTFPPQVETVQ
MUL_3430|M.ulcerans_Agy99 ERCYVEAPVYDEFVAKVTEKVRAIRQGVPAGPGSVDVGSLTFPPQVETVQ
MAV_4946|M.avium_104 TRILAPRSRYDEIVDAVSTFVQSLPVGLPSDP-AAQIGSLISEKQRARVE
MLBr_02639|M.leprae_Br4923 DYVLAAAPIRDELVNKIGFAIAKFRSQDDPSG-----MRIVNQRQFDRLC
. :::. : : . : *
Mb1760|M.bovis_AF2122/97 GHVD--DATAKGAKVIAGGKARPDIGP-LFYEPTVLTNVAPEMECAANET
Rv1731|M.tuberculosis_H37Rv GHVD--DATAKGAKVIAGGKARPDIGP-LFYEPTVLTNVAPEMECAANET
Mvan_0771|M.vanbaalenii_PYR-1 RHVE--DALAKGARALTGGKRGSGPG--SFYEPTVLVDVDHSMACMTEET
Mflv_0132|M.gilvum_PYR-GCK RHVA--DALAKGARALTGGTRGAGSG--SFYEPTVLVDVDHAMLCMTEET
MSMEG_0889|M.smegmatis_MC2_155 RHVN--EALEKGAKALTGGKRPEDGG--SFYPPTVLVDVDHSMSCMNEET
TH_3138|M.thermoresistible__bu RHVA--DAVARGAKVLTGGRRKDGPG--CFYEPTVLVDVDHSMMCMTEET
MAB_4136c|M.abscessus_ATCC_199 RHVR--QAVSSGARALTGGARIPGHG--SFYAPTVLVDVDHSMDCMREET
MMAR_1607|M.marinum_M RHVE--EAVERGAKVLTGGHRGRTKG--YWYEPTVLVDVNHDMACMREET
MUL_3430|M.ulcerans_Agy99 RHVE--EAVERGAKVLTGGHRGRTKG--YWYEPTVLVDVNHDMACMREET
MAV_4946|M.avium_104 GYIA--KGIEEGARLVCGGGRPEGLDSGFFVQPTVFADVDNKMTIAQEEI
MLBr_02639|M.leprae_Br4923 GYLAGVQSAAGGKGVVVVGGKCDAST--LRIQPTVIVDPDPEGPLMTKEI
:: .. * : * ***:.: :*
Mb1760|M.bovis_AF2122/97 FGPVVSIYPVADVDEAVEKANDTDYGLNASVWAGSTAEGQRIAARLRSGT
Rv1731|M.tuberculosis_H37Rv FGPVVSIYPVADVDEAVEKANDTDYGLNASVWAGSTAEGQRIAARLRSGT
Mvan_0771|M.vanbaalenii_PYR-1 FGPTLPIMKVSSVEEAVRLANDSPYGLSAAVFSRDVDRAKAVALQLDCGG
Mflv_0132|M.gilvum_PYR-GCK FGPTLPIMRVSTVDEAVRLANDSPYGLSAAVFSKDLERAEAVAVQLDCGG
MSMEG_0889|M.smegmatis_MC2_155 FGPTLPIMKVSSVEEAVRLANDSPYGLSASVFSKDTERAKKIALQLDCGA
TH_3138|M.thermoresistible__bu FGPTLPIMKVSSVAEAVRLANDTPYGLSGSVFSQDVERAREIALQLDCGA
MAB_4136c|M.abscessus_ATCC_199 FGPTLPIMRYSEESEAIALANDSEYGLSASVWSKDRRRAERVALQLDCGT
MMAR_1607|M.marinum_M FGPTLPIMKVADAEEAIRLANDSEYGLCAAVFSRDLAHAEAVARRVNSGA
MUL_3430|M.ulcerans_Agy99 FGPTLPIMKVADAEEAIRLANDSEYGLCAAVFSRDLAHAEAVARRVNSGA
MAV_4946|M.avium_104 FGPVLSIIPYDTEEDAIKIANDSVYGLAGSVWTADVQRGIAVSEKIRTGT
MLBr_02639|M.leprae_Br4923 FGPILPVLTVQSLDEAIGFINARPKPLAAYLFTKSRKTRDRVIKEVSAGG
*** :.: :*: * * . ::: . : .: *
Mb1760|M.bovis_AF2122/97 VNVDEGYAFAWGSLSAPMGGMG-LSGVGRRHG-PEGLLKYTESQTIATAR
Rv1731|M.tuberculosis_H37Rv VNVDEGYAFAWGSLSAPMGGMG-LSGVGRRHG-PEGLLKYTESQTIATAR
Mvan_0771|M.vanbaalenii_PYR-1 VNVND-VISNLMCTTAPMGGWK-SSGIGARFGGPEGLRKYCRIETVVSPR
Mflv_0132|M.gilvum_PYR-GCK VNIND-VISNLMCTTAPMGGWK-TSGIGARFGGPEGLRKYCRIETVVAPR
MSMEG_0889|M.smegmatis_MC2_155 VNIND-VISNLMCTTAPMGGWK-TSGIGARFGGVDGVRKFCKQETVVAPR
TH_3138|M.thermoresistible__bu VNIND-VISNLMATTAPMGGWK-TSGIGARFGGPEGLRKYCRVETVVEPR
MAB_4136c|M.abscessus_ATCC_199 VNIND-VIMNLSCLTAPHGGWK-GSGLGSRFGGVDGLRKYCRTEAIVDTR
MMAR_1607|M.marinum_M VTVND-ALLNYTALELPMGGAKPGSGVGYRHG-PGGIRKYCRQQALLISR
MUL_3430|M.ulcerans_Agy99 VTVND-ALLNYTALELPMGGAKPGSGVGYRHG-PGGIRKYCRQQALLISR
MAV_4946|M.avium_104 YAINW----YAFDPCCPFGGYK-NSGIGRENG-PEGVEHFTQQKSVLMPM
MLBr_02639|M.leprae_Br4923 MLVNH-LAIQVLTAKLPFGGVG-ESGIGAYHG-KWGFDEFSHRKSVLTKP
:: * ** **:* * *. .: . :::
Mb1760|M.bovis_AF2122/97 VFNLDPPFGIPATVWQKSLLPIVRTVMKLPGRR----
Rv1731|M.tuberculosis_H37Rv VFNLDPPFGIPATVWQKSLLPIVRTVMKLPGRR----
Mvan_0771|M.vanbaalenii_PYR-1 TNVGAGGNYYNNSLRALKRMNKLMTKLALIRPRRVAK
Mflv_0132|M.gilvum_PYR-GCK TNVGAGGNYYNNSPRALKRMNTMMTKLALIRPRRVAK
MSMEG_0889|M.smegmatis_MC2_155 TSVGAGGTYYNNSHKALARMNRLMTKLALARPRRTAK
TH_3138|M.thermoresistible__bu TGIGAGGTYYNNSFKSLGMMNKLLTRMALVRPRRLAK
MAB_4136c|M.abscessus_ATCC_199 VTLPSEPLWYSGPSWLAPVALKSLTKLSNKALRPFRR
MMAR_1607|M.marinum_M FHARRDVHMYPYSARRTRILGRLVGRLYRG-VRGTDS
MUL_3430|M.ulcerans_Agy99 FHARRDVHMYPYSARRTRILGRLVGRLYRG-VRGTDS
MAV_4946|M.avium_104 GYTLEG-------------------------------
MLBr_02639|M.leprae_Br4923 TRPDLSSFIYPPYTERSFRLAHRLF------------