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SQSVARALHLLIQLGNGPATLDELAQSTGVHKTTVLRLLRTLADERFTFRDQSNRYHLGSRVFELAARGT DQREIRAIASPHLVAFNRAYGRTTHLAAMEGNDIVYIDKLESHDQIRMFSRIGLSANLNSTAVAKVILAD LPDAELRPFVATMDFTRRTPNTITTPEAFLAEIDKVRAQGWAQDREENEPSINCIGVPIRGASGRVVAAV SVSVPNVVLPFEEVLDLLGPLQEVGERISRDCGYLPTVKS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3784 | - | - | 100% (251) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_6174 | - | 1e-24 | 28.40% (250) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_4174 | - | 2e-24 | 30.09% (216) | transcriptional regulator, IclR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 2e-17 | 31.80% (217) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_4551 | - | 8e-24 | 34.43% (212) | regulatory protein, IclR |
| M. tuberculosis H37Rv | Rv1719 | - | 2e-17 | 31.80% (217) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0077 | - | 4e-24 | 33.78% (225) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 2e-24 | 32.93% (246) | transcriptional regulatory protein |
| M. avium 104 | MAV_3024 | - | 4e-22 | 34.65% (202) | transcriptional regulator, IclR family protein |
| M. thermoresistible (build 8) | TH_3251 | - | 5e-26 | 35.55% (211) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_1967 | - | 4e-18 | 31.60% (212) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_2889 | - | 4e-24 | 31.42% (226) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4551|M.gilvum_PYR-GCK -----------------------------MTTPVETPSAVIDRVSLVLDA
MAV_3024|M.avium_104 -----------------------------MPAPAETPTAVIDRISLVLDA
Mvan_2889|M.vanbaalenii_PYR-1 MTNRHMPIRSMTFRRIPMTVTIESPAAPAAKVATETPSAVIDRVSLVLDA
TH_3251|M.thermoresistible__bu --------MTATLDQPTPNTTVKR---TGTERTGETPSAVLDRISLVLDA
MAB_0077|M.abscessus_ATCC_1997 ---------------------------MTITADSATPSAVIDRVSLLLDA
Mb1748|M.bovis_AF2122/97 -------------------------MSAEEQDTRSGGIQVIARAAELLRV
Rv1719|M.tuberculosis_H37Rv -------------------------MSAEEQDTRSGGIQVIARAAELLRV
MUL_1967|M.ulcerans_Agy99 -------------------------------MRQDSGIGVIDKAVGLLRA
MSMEG_3784|M.smegmatis_MC2_155 ------------------------------------MSQSVARALHLLIQ
MMAR_4423|M.marinum_M -----------MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLEL
: : :*
Mflv_4551|M.gilvum_PYR-GCK FDG-PGRLTLAQIVRRTGLPRSSAHRMLERLVQLRWLRRTGRD--YELGM
MAV_3024|M.avium_104 FDG-PGRLTLAQIVRRTGLPRSSAHRMLERLVQLRWLRRSGRD--YELGM
Mvan_2889|M.vanbaalenii_PYR-1 FDG-PGRLTLAQIVRRTGLPRSSAHRMLERLVQLRWLRRSGRD--YELGM
TH_3251|M.thermoresistible__bu FDG-PGRLTLAQVVRRTGLPRSSAHRMLERLVQLRWLRRDGRD--YELGM
MAB_0077|M.abscessus_ATCC_1997 FDG-PGRLTLAQLVRRTGLPRSSVHRMLERLVQLRWLRRDGRD--YELGT
Mb1748|M.bovis_AF2122/97 LQAHPGGLSQAEIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGP
Rv1719|M.tuberculosis_H37Rv LQAHPGGLSQAEIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGP
MUL_1967|M.ulcerans_Agy99 TAK--SPCGLAELCERTGLPRATAYRLAAALEVHRLLGRDEDGR-WGLGP
MSMEG_3784|M.smegmatis_MC2_155 LGN--GPATLDELAQSTGVHKTTVLRLLRTLADERFTFRDQSNR-YHLGS
MMAR_4423|M.marinum_M LAD-LGKAGVTEVADELGVHKSTASRLITALEARGYVEQLSDRGKYQLGI
. :: *: :::. *: * : **
Mflv_4551|M.gilvum_PYR-GCK RLVELGSLAVHQDRVHRAATPLLHDLHRATGLVVHLAVLDGSDVVYLDKI
MAV_3024|M.avium_104 RLVELGSLAVHQDRLVRAATPLLVELHRATGLVVHLAVLDGPDVVYLEKV
Mvan_2889|M.vanbaalenii_PYR-1 RLVELGSLAVHQDRLHKAAIPMLHELHAATGLVVHLAVLDGSDVVYMEKV
TH_3251|M.thermoresistible__bu RLVELGSLAVHQDRLHRAAIPRLHELHAATGLVVHLAVLDGSDVVYLEKV
MAB_0077|M.abscessus_ATCC_1997 RLVELGSLAVHQDRLHAAALPMLHELHRATGLVVHLSILDGADVVYLEKI
Mb1748|M.bovis_AF2122/97 EITRMATTVRLG--VVTEMHPFLTELSRELDETVDLSILDGDRADVVDQV
Rv1719|M.tuberculosis_H37Rv EITRMATTVRLG--VVTEMHPFLTELSRELDETVDLSILDGDRADVVDQV
MUL_1967|M.ulcerans_Agy99 AITELAAHVDDP--LLTAGATVLPRLCETTGESVQLYRREGTSRVCVAAL
MSMEG_3784|M.smegmatis_MC2_155 RVFELAARGTDQREIRAIASPHLVAFNRAYGRTTHLAAMEGNDIVYIDKL
MMAR_4423|M.marinum_M GVSRLARARSGHSDLVKLSQDACDKLAADLGETANLAILDENRAVNIVEA
: .:. : : . ..* : :
Mflv_4551|M.gilvum_PYR-GCK GDGMASAIPTRVGGRQPAHCTAVGKAMLAFNDD------VDVDLQSRMTK
MAV_3024|M.avium_104 GDRLNSVIPSRVGGRQPAHCTAVGKAILAYRDEA-----TDLDLGARPTK
Mvan_2889|M.vanbaalenii_PYR-1 GNRMTAAIPTRVGGRQPAHCAAVGKAMLAFAAAEDI-QAYDSAQLPRRTK
TH_3251|M.thermoresistible__bu GSRLAAAIPTRVGGRRPANCAAVGKAILAYAEDDG--VLSGTGPLPRNTK
MAB_0077|M.abscessus_ATCC_1997 GAGIGAAVATRIGGRQPAHCTASGKAILAYRAQIL----DGCTALARKTR
Mb1748|M.bovis_AF2122/97 VPPQRLRAVSAVGESFPLYCCANGKALLAALPPERQ-ARALPSRLAPLTA
Rv1719|M.tuberculosis_H37Rv VPPQRLRAVSAVGESFPLYCCANGKALLAALPPERQ-ARALPSRLAPLTA
MUL_1967|M.ulcerans_Agy99 EPPAGLRDTVPVGARLPMTAGSGAKVLLAHSDPAT-------------QQ
MSMEG_3784|M.smegmatis_MC2_155 ESHDQIRMFSRIGLSANLNSTAVAKVILADLPDAELRPFVATMDFTRRTP
MMAR_4423|M.marinum_M VSTAEIALQTWVGQSCPVHATSSGKVLLAGLDADEV-RQRVGATLDSFTE
:* . : .*.:**
Mflv_4551|M.gilvum_PYR-GCK YSIGTAAQLAAELAKVRAHGVAYEREESLPGFGCVAAAIG-RPGEAVAAV
MAV_3024|M.avium_104 YSISSAPQLAAELAKVRAHGVAFEREESLLGFGCVAAPIG-GPGEAAAAV
Mvan_2889|M.vanbaalenii_PYR-1 YSISTHAQLRTELQKVRSHGIAFDREESVPGFGCVAAPIG-DPGEAAAAV
TH_3251|M.thermoresistible__bu YSISDPARLRAELAKVRAHGVAFDREESLPGIGCVAAPIG-DPGEAVAAI
MAB_0077|M.abscessus_ATCC_1997 YSIGSAAQLRPELDKVRGHGVAFDREELQQGIGCVAAPIG-SIGDAVAAV
Mb1748|M.bovis_AF2122/97 NTITDRAALRDELNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELVAV
Rv1719|M.tuberculosis_H37Rv NTITDRAALRDELNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELVAV
MUL_1967|M.ulcerans_Agy99 AVLPTAKFTDRVLAEVRRRGWAQSVAEREPGVASVSAPVRDGRGVVVAAI
MSMEG_3784|M.smegmatis_MC2_155 NTITTPEAFLAEIDKVRAQGWAQDREENEPSINCIGVPIRGASGRVVAAV
MMAR_4423|M.marinum_M NTIVTIDALEAQLAATRAAGWASAREELEIGLNAVAAPVYDSTGRVAAAL
: : * * * * .. .:.. : . .*:
Mflv_4551|M.gilvum_PYR-GCK SVCGPMNRMAFER-LAAPVRVTAMGIWRNAEDGPARVTPTLQPLRPLRGG
MAV_3024|M.avium_104 SVCGPLQRMALDQRLAAPVRMTAMGVWRNVEGGPQRVAPTLQRLRPLPPM
Mvan_2889|M.vanbaalenii_PYR-1 SVCGPMNAMKFDQRLVAPVRMAAMRIWRAVEGGPMRVAPTLQQVRPLRGG
TH_3251|M.thermoresistible__bu SVCGPMNQMAFDHRLVAPVRMAALGIWRAMEGARQRVVPTLQQVRPLRPG
MAB_0077|M.abscessus_ATCC_1997 SVCGPMTRMTFDQRLAAPVRMTAMGIWRNVENGPSRVAPTLQPIRPLRCG
Mb1748|M.bovis_AF2122/97 SVPVPAQRFYGREAELAGALLAWVSKVDAWFNGTEDRK------------
Rv1719|M.tuberculosis_H37Rv SVPVPAQRFYGREAELAGALLAWVSKVDAWFNGTEDRK------------
MUL_1967|M.ulcerans_Agy99 SVSGPIDRIGRRPGARWAADLLAAADELARRL------------------
MSMEG_3784|M.smegmatis_MC2_155 SVSVPNVVLPFEEVLDLLGPLQEVGERISRDCGYLPTVKS----------
MMAR_4423|M.marinum_M SVSGPAYRLPAADFEEVAQQTIAAADAVSRGLGWTDRIS-----------
** * :
Mflv_4551|M.gilvum_PYR-GCK PAARPVAV---------------RNDALQYA
MAV_3024|M.avium_104 RPQHPVPK---------------PRPALQYA
Mvan_2889|M.vanbaalenii_PYR-1 ---------------------------MQLA
TH_3251|M.thermoresistible__bu PTAQSLSHSALSHPAQSHPARSHRADTRRFA
MAB_0077|M.abscessus_ATCC_1997 PAASSTGR-------------EMNSPALQYA
Mb1748|M.bovis_AF2122/97 -------------------------------
Rv1719|M.tuberculosis_H37Rv -------------------------------
MUL_1967|M.ulcerans_Agy99 -------------------------------
MSMEG_3784|M.smegmatis_MC2_155 -------------------------------
MMAR_4423|M.marinum_M -------------------------------