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VADIGRSTLVLDALAEASKPLTLSELATRTGLPRSTVHRIVQSLERSLYLVRGVDRHGYSLGPGLLKFGM NAHLRLLAGNRPLLARLVREVGENVELAIFSGREVVVVDQLASVNRLHGVTKVGKSFSLHASCIGLALLA HLPDDQVAGLLSPPLQRFTEHTVTDLPAIMGRLDEVRRTQIAVDTEEHDVGICAVATAFPGPTGALQAVA VVMPTARFRAKRERAVESLQRINPLLAHRN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2483 | - | - | 100% (240) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_5475 | - | 2e-26 | 33.33% (219) | acetate operon repressor |
| M. smegmatis MC2 155 | MSMEG_2890 | - | 3e-20 | 33.94% (218) | putative transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 7e-30 | 36.12% (227) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_3174 | - | 6e-26 | 31.67% (240) | regulatory protein, IclR |
| M. tuberculosis H37Rv | Rv1719 | - | 7e-30 | 36.12% (227) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4493 | - | 2e-55 | 48.02% (227) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 1e-19 | 28.22% (241) | transcriptional regulatory protein |
| M. avium 104 | MAV_3024 | - | 3e-20 | 33.64% (220) | transcriptional regulator, IclR family protein |
| M. thermoresistible (build 8) | TH_3251 | - | 1e-20 | 31.66% (259) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_1967 | - | 3e-13 | 30.26% (228) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0155 | - | 2e-25 | 34.51% (226) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2483|M.smegmatis_MC2_155 --------------------------MADIGRSTLVLDALAEASKPLTLS
MAB_4493|M.abscessus_ATCC_1997 --------------------------MSVLTRAAQILDALAESNSGLSVR
Mb1748|M.bovis_AF2122/97 -------MSAEEQ-------DTRSGGIQVIARAAELLRVLQAHPGGLSQA
Rv1719|M.tuberculosis_H37Rv -------MSAEEQ-------DTRSGGIQVIARAAELLRVLQAHPGGLSQA
Mvan_0155|M.vanbaalenii_PYR-1 -------MPGADQNGRIDATEGRDDGLQVLRRAAAALDEIATAPGRLRLV
MAV_3024|M.avium_104 ------MPAP------------AETPTAVIDRISLVLDAFD-GPGRLTLA
TH_3251|M.thermoresistible__bu MTATLDQPTPNTTVKRTGTERTGETPSAVLDRISLVLDAFD-GPGRLTLA
MUL_1967|M.ulcerans_Agy99 --------------------MRQDSGIGVIDKAVGLLRATAKSPCG--LA
Mflv_3174|M.gilvum_PYR-GCK --------MESSSVVGSGRMAERSGGVQSVERAFELMELIGRAGGECSLT
MMAR_4423|M.marinum_M MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLELLA-DLGKAGVT
: : :
MSMEG_2483|M.smegmatis_MC2_155 ELATRTGLPRSTVHRIVQSLERSLYLVRGVDRHGYSLGPGLLKFGMNAH-
MAB_4493|M.abscessus_ATCC_1997 ELAEATGLPKSSVHRIVQELTVSQYVMAGGRGGSYQLGPGLLKLGLNNR-
Mb1748|M.bovis_AF2122/97 EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR-
Rv1719|M.tuberculosis_H37Rv EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR-
Mvan_0155|M.vanbaalenii_PYR-1 DVGTNLGLAKSTARRLLVALVDVGFAAVDDS-GRYHLGDRLLGLTSADG-
MAV_3024|M.avium_104 QIVRRTGLPRSSAHRMLERLVQLRWLRRSGRDYELGMRLVELGSLAVHQ-
TH_3251|M.thermoresistible__bu QVVRRTGLPRSSAHRMLERLVQLRWLRRDGRDYELGMRLVELGSLAVHQ-
MUL_1967|M.ulcerans_Agy99 ELCERTGLPRATAYRLAAALEVHRLLG-RDEDGRWGLGPAITELAAHVD-
Mflv_3174|M.gilvum_PYR-GCK ELSAESPLPPPTIHRLLRTLVGLGYVR-QLPNRRYALGPRLIRLGEVAN-
MMAR_4423|M.marinum_M EVADELGVHKSTASRLITALEARGYVEQLSDRGKYQLGIGVSRLARARSG
:: : .: *: * :
MSMEG_2483|M.smegmatis_MC2_155 -LRLLAGNRPLLARLVREVGENVELAIFSGREVVVVDQLASVNRLHGVTK
MAB_4493|M.abscessus_ATCC_1997 -RQFVAPMRKAIATVAREVNENIDLAMLSGGELVIIEQIATVRNLPTVTV
Mb1748|M.bovis_AF2122/97 -LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
Rv1719|M.tuberculosis_H37Rv -LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
Mvan_0155|M.vanbaalenii_PYR-1 -STLAARLRPVIERLALATGETVDLSVLRGRQMWFVDQIESAHRLRAVSA
MAV_3024|M.avium_104 -DRLVRAATPLLVELHRATGLVVHLAVLDGPDVVYLEKVGDRLNSVIPSR
TH_3251|M.thermoresistible__bu -DRLHRAAIPRLHELHAATGLVVHLAVLDGSDVVYLEKVGSRLAAAIPTR
MUL_1967|M.ulcerans_Agy99 -DPLLTAGATVLPRLCETTGESVQLYRREGTSRVCVAALEPPAGLRDTVP
Mflv_3174|M.gilvum_PYR-GCK -RQLGAVAGPVLQSLADDLSETASLAVLDGDMVIYTGQVLSAHMMRTNNE
MMAR_4423|M.marinum_M HSDLVKLSQDACDKLAADLGETANLAILDENRAVNIVEAVSTAEIALQTW
. : . *
MSMEG_2483|M.smegmatis_MC2_155 VGKSFSLHASCIGLALLAHLPDDQVAGLLSPP-LQRFTEHTVTDLPAIMG
MAB_4493|M.abscessus_ATCC_1997 VGRTFALHASSIGKALLSQLPPDQVRNMLPAD-LEVFTTNTITDVTALLR
Mb1748|M.bovis_AF2122/97 VGESFPLYCCANGKALLAALPPERQARALPSR-LAPLTANTITDRAALRD
Rv1719|M.tuberculosis_H37Rv VGESFPLYCCANGKALLAALPPERQARALPSR-LAPLTANTITDRAALRD
Mvan_0155|M.vanbaalenii_PYR-1 VGGRFPLHDTANGKAALALMEDD----AIP---------------DGLLD
MAV_3024|M.avium_104 VGGRQPAHCTAVGKAILAYRDEAT-DLDLG----ARPTKYSISSAPQLAA
TH_3251|M.thermoresistible__bu VGGRRPANCAAVGKAILAYAEDDG-VLSGTGP-LPRNTKYSISDPARLRA
MUL_1967|M.ulcerans_Agy99 VGARLPMTAGSGAKVLLAHSDPATQQAVLP-------------TAKFTDR
Mflv_3174|M.gilvum_PYR-GCK VGKRVGLHTSGVGKAVLAELEDARILKLVTQSGLPAPTENSASTLSAVFA
MMAR_4423|M.marinum_M VGQSCPVHATSSGKVLLAGLDADEVRQRVGAT-LDSFTENTIVTIDALEA
** . . *:
MSMEG_2483|M.smegmatis_MC2_155 RLDEVRRTQIAVDTEEHDVGICAVATAFP-GPTGALQAVAVVMPTARFRA
MAB_4493|M.abscessus_ATCC_1997 ELDDVRSTGVAFDHEEHDVGISSVAVPLP-HPAAIPQAMAIVAPTPRFAQ
Mb1748|M.bovis_AF2122/97 ELNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELVAVSVPVPAQRFYG
Rv1719|M.tuberculosis_H37Rv ELNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELVAVSVPVPAQRFYG
Mvan_0155|M.vanbaalenii_PYR-1 EIAEVRRTGIAYDRDEHTAGISAAGIAVR-LPGGHVVAISVPAPTERFRA
MAV_3024|M.avium_104 ELAKVRAHGVAFEREESLLGFGCVAAPIG-GPGEAAAAVSVCGPLQRMAL
TH_3251|M.thermoresistible__bu ELAKVRAHGVAFDREESLPGIGCVAAPIG-DPGEAVAAISVCGPMNQMAF
MUL_1967|M.ulcerans_Agy99 VLAEVRRRGWAQSVAEREPGVASVSAPVRDGRGVVVAAISVSGPIDRIGR
Mflv_3174|M.gilvum_PYR-GCK NVERVRAEGYAVDDEEFEIGVRSVAMAVP--GAPTPMAIGISGPTARMGK
MMAR_4423|M.marinum_M QLAATRAAGWASAREELEIGLNAVAAPVYDSTGRVAAALSVSGPAYRLPA
: * * * *. ... . *:.: * ::
MSMEG_2483|M.smegmatis_MC2_155 KR-ERAVESLQRINPLLAHRN-----------------------------
MAB_4493|M.abscessus_ATCC_1997 RK-TKYVAALDSLTKRANST------------------------------
Mb1748|M.bovis_AF2122/97 RE-AELAGALLAWVSKVDAWFNGTEDRK----------------------
Rv1719|M.tuberculosis_H37Rv RE-AELAGALLAWVSKVDAWFNGTEDRK----------------------
Mvan_0155|M.vanbaalenii_PYR-1 QE-STIVDALRAAAADP-VWAGGVS-------------------------
MAV_3024|M.avium_104 DQ-RLAAPVRMTAMGVWRNVEGGPQRVAPTLQRLRPLPPMRPQHPVPK--
TH_3251|M.thermoresistible__bu DH-RLVAPVRMAALGIWRAMEGARQRVVPTLQQVRPLRPGPTAQSLSHSA
MUL_1967|M.ulcerans_Agy99 RPGARWAADLLAAADELARRL-----------------------------
Mflv_3174|M.gilvum_PYR-GCK DLIARAVPALKKATGVISEALIGAKEA-----------------------
MMAR_4423|M.marinum_M ADFEEVAQQTIAAADAVSRGLGWTDRIS----------------------
.
MSMEG_2483|M.smegmatis_MC2_155 ---------------------
MAB_4493|M.abscessus_ATCC_1997 ---------------------
Mb1748|M.bovis_AF2122/97 ---------------------
Rv1719|M.tuberculosis_H37Rv ---------------------
Mvan_0155|M.vanbaalenii_PYR-1 ---------------------
MAV_3024|M.avium_104 -PRPALQYA------------
TH_3251|M.thermoresistible__bu LSHPAQSHPARSHRADTRRFA
MUL_1967|M.ulcerans_Agy99 ---------------------
Mflv_3174|M.gilvum_PYR-GCK ---------------------
MMAR_4423|M.marinum_M ---------------------