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SHTEESAAPRGWALVTGSTSGIGRETALLLARDGYSVIVSGRDEARAGEVVDRITTDGGTALALTADLSD TAAVRTLATDALEVAGGVIDVLVNNAGGGTFAATEDTTDDMFDVAFKVHVKGPFILTAALAPLMAQRGGG AIVNVGSISADLAASGVAIFQASKAALDMLTKSWTAEYGPRGVRVNTVNPGFVITPANEAFRDGYGPFVE TVPARRGAEPEEVAEVIRFLISPAASYIQGAAIAVDGGRTAVLPM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5383 | - | - | 100% (256) | dehydrogenase/reductase SDR family protein member 4 |
| M. smegmatis MC2 155 | MSMEG_5204 | - | 7e-49 | 46.06% (241) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_6753 | - | 3e-43 | 42.74% (241) | oxidoreductase, short chain dehydrogenase/reductase family |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 5e-30 | 35.60% (250) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_0296 | - | 6e-32 | 38.34% (253) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1941 | - | 5e-30 | 35.60% (250) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-26 | 39.51% (205) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0827 | - | 8e-31 | 34.85% (241) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0629 | - | 5e-62 | 50.42% (240) | dehydrogenase |
| M. avium 104 | MAV_5088 | fabG | 1e-32 | 35.71% (238) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. thermoresistible (build 8) | TH_2488 | - | 2e-34 | 37.65% (247) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4442 | - | 2e-30 | 35.51% (245) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0325 | - | 4e-50 | 45.04% (242) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
MMAR_0629|M.marinum_M --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
MSMEG_5383|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0325|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4442|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
MMAR_0629|M.marinum_M --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
MSMEG_5383|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0325|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4442|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
MMAR_0629|M.marinum_M --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
MSMEG_5383|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0325|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4442|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
MMAR_0629|M.marinum_M --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
MSMEG_5383|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0325|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4442|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
MMAR_0629|M.marinum_M --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
MSMEG_5383|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0325|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4442|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
MMAR_0629|M.marinum_M --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
MSMEG_5383|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0325|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4442|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mb1976|M.bovis_AF2122/97 ---------MNHPDLAGKV-----------AIVTGAGAGIGLAVARRLAD
Rv1941|M.tuberculosis_H37Rv ---------MNHPDLAGKV-----------AIVTGAGAGIGLAVARRLAD
MAV_5088|M.avium_104 ---------MAESLLLGKV-----------AVVTGAGQGIGREIARALHR
MMAR_0629|M.marinum_M --------------MAGLT-----------ALITGATSGIGRATAHGLAE
TH_2488|M.thermoresistible__bu ------------MEFQGLH-----------VLVTGGTGGIGLACARAFAE
MSMEG_5383|M.smegmatis_MC2_155 --------MSHTEESAAPRGW---------ALVTGSTSGIGRETALLLAR
Mvan_0325|M.vanbaalenii_PYR-1 -------MNTTAATLSGRT-----------ALVTGSTSGLGAGIAEALAD
Mflv_0296|M.gilvum_PYR-GCK ----------MDMGLSGKR-----------ALVTGSSSGLGRAIAESLAA
MAB_0827|M.abscessus_ATCC_1997 ----------MTSPLKSRR-----------AFVTGGSRGIGAGIVRRLAE
MUL_4442|M.ulcerans_Agy99 -------MILDRFRLDDQV-----------AVITGGGRGFGAAIALAFAE
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
. :**. *:* . :
Mb1976|M.bovis_AF2122/97 EGCHVLCADI-DGDAADAAATKIGCGAAACR---VDVSD--EQQIIAMVD
Rv1941|M.tuberculosis_H37Rv EGCHVLCADI-DGDAADAAATKIGCGAAACR---VDVSD--EQQIIAMVD
MAV_5088|M.avium_104 HGARVVLADL-DGSAARSAAAQIDDSGANCTGLACDVTS--EEQVGALVA
MMAR_0629|M.marinum_M LGATVLVSGR-DEARGREVVDEVTARGGRGIFLAAELRD-VTGVRNLATA
TH_2488|M.thermoresistible__bu AGAEVTVTGR-DAGRG----AAAAGAHPRLRFIRGDLAD-LASVQNLIR-
MSMEG_5383|M.smegmatis_MC2_155 DGYSVIVSGR-DEARAGEVVDRITTDGGTALALTADLSD-TAAVRTLATD
Mvan_0325|M.vanbaalenii_PYR-1 AGAHVVITGR-TRARGEQVVTQIESQGGRAVFVPVDFAAGPGTITDLVVT
Mflv_0296|M.gilvum_PYR-GCK EGASVVVHGR-DEVRTGAVADGIRARGGDAWAAVGDLAT-EGGAG-----
MAB_0827|M.abscessus_ATCC_1997 DGARVVFTYSSSVQQAADVVDDINEDGGWARAVKADVAD--PDQLGAAIG
MUL_4442|M.ulcerans_Agy99 AGADVVIASR-TQSQLDEVADTVRSIGRRAHVVAADLAH--PEATAELAG
MLBr_00862|M.leprae_Br4923 RGAEVVVSDI-DEAAAKNTAAQIVASGGVAYAYALDVSD--AAAVEAFAE
* * :.
Mb1976|M.bovis_AF2122/97 ACVAAFGGVDKLVANAGVVHL-ASLIDTTVEDFDRVIAINLRGAWLCTKH
Rv1941|M.tuberculosis_H37Rv ACVAAFGGVDKLVANAGVVHL-ASLIDTTVEDFDRVIAINLRGAWLCTKH
MAV_5088|M.avium_104 GTVREHGGLDVFVNNAGITRD-ASLKRMTVADFDAVIAVHLRGTWLGVRE
MMAR_0629|M.marinum_M AADAGAGKVDILINSAGAFPF-GPTADTSPDDFDAVFALNVRAPYFLVGA
TH_2488|M.thermoresistible__bu YADA----VDVLVNNAASFPG-ALTVEQDAESFTRTFATNVTGTYFLTAG
MSMEG_5383|M.smegmatis_MC2_155 ALEVAGGVIDVLVNNAGGGTF-AATEDTTDDMFDVAFKVHVKGPFILTAA
Mvan_0325|M.vanbaalenii_PYR-1 ATEALGGRLDILVNNVATLVQPAPTADVTAEEITTAFGVSVATPFLLTGL
Mflv_0296|M.gilvum_PYR-GCK AVAAAAGEVDILVNNAGVYDG-LAWSDLAPRQWQSIYEVNVVSGVRMIEY
MAB_0827|M.abscessus_ATCC_1997 QAAEELGGLDILVNNAGILSI-GDVDTATLADFDEIVAVNVRAVFAGIKA
MUL_4442|M.ulcerans_Agy99 QAVEAFGRLDIVVNNVGGTMP-NTLLTTSTKDLKDAFTFNVATAHALTVA
MLBr_00862|M.leprae_Br4923 QVSAKHGVPDIVVNNAGIGQA-GRFLDTPPEEFDRVLAVNLGGVVNCCRA
* .: ... :
Mb1976|M.bovis_AF2122/97 AAPRMIER-GGGAIVNLSSLAGQVAVGG-TGAYGMSKAGIIQLSRITAAE
Rv1941|M.tuberculosis_H37Rv AAPRMIER-GGGAIVNLSSLAGQVAVGG-TGAYGMSKAGIIQLSRITAAE
MAV_5088|M.avium_104 AAAVMRER-KTGSIVNMSSLSGKAGNPG-QTNYSAAKAGIVGLTKAAAKE
MMAR_0629|M.marinum_M LAPTMAKR-GRGSIVNVTTMVAEFGAAG-TGLYGASKAAIALLTKSWAAE
TH_2488|M.thermoresistible__bu LIPGMLAR-GRGSIVNITSMVATKAVPG-ASVYSSSKAAVESLTRSWAVE
MSMEG_5383|M.smegmatis_MC2_155 LAPLMAQR-GGGAIVNVGSISADLAASG-VAIFQASKAALDMLTKSWTAE
Mvan_0325|M.vanbaalenii_PYR-1 IAPAMVQR-GDGAIVNIGSISGIIGAAG-SALYGATKASVHLLTKAWAAE
Mflv_0296|M.gilvum_PYR-GCK LVPGMRQR-GWGRIIQIGGGLALQPAAD-QPHYNATLAARHNLTVSLARE
MAB_0827|M.abscessus_ATCC_1997 ASPHLTE---GGRIVTIGSINGDSSPTANLSLYSMTKAAVAGLTRGLARE
MUL_4442|M.ulcerans_Agy99 AVPLMLEHSGGGGIINITSTMGRVAGRG-FAAYGTAKVALAHYTRLAALD
MLBr_00862|M.leprae_Br4923 FGQRLVERGTGGHIVNVSSMAAYAPLQS-LSAYCTSKAATYMFSDCLRAE
: * *: : . : : .. : :
Mb1976|M.bovis_AF2122/97 LRSSGIRSNTLLPAFVDTPMQQ---------TAMAMFDGALGAGGARSMI
Rv1941|M.tuberculosis_H37Rv LRSSGIRSNTLLPAFVDTPMQQ---------TAMAMFDGALGAGGARSMI
MAV_5088|M.avium_104 LAHHNVRVNAIQPGLIRTPMT------------AAMPPDVFAEREA----
MMAR_0629|M.marinum_M YGPSGVRVNAVSPGPTRTEG----------TVEMGEALDQLAAAAP----
TH_2488|M.thermoresistible__bu FAAHGIRVNAVAPGPTSTDGV---------ATEWGETNEALGRALP----
MSMEG_5383|M.smegmatis_MC2_155 YGPRGVRVNTVNPGFVITPA----------NEAFRDGYGPFVETVP----
Mvan_0325|M.vanbaalenii_PYR-1 YGPSGVRVNAVAPGPIATER----------TREFGDAIAPVLARVP----
Mflv_0296|M.gilvum_PYR-GCK LAGTGVTSNTVAPGAILTEPVREMTYRVAAQRGWGPTWEDVEKAAATTWF
MAB_0827|M.abscessus_ATCC_1997 FGPRGITINNVQPGPIGT----------DMNPEDGQLADILRPNIA----
MUL_4442|M.ulcerans_Agy99 LCPR-IRVNAIAPGSILTSAL-------EVVAANDELRAPMEQATP----
MLBr_00862|M.leprae_Br4923 LDAVGVGLTTICPGVIDTNIIQS-----TRIDTPTAKQERVRDRRGQLDM
: . : *. * .
Mb1976|M.bovis_AF2122/97 ARLQGRMAAPEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW------
Rv1941|M.tuberculosis_H37Rv ARLQGRMAAPEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW------
MAV_5088|M.avium_104 AVPMKRAGEPEEVAGAVVFLASELSSYITGTVLGVGGGRYM---------
MMAR_0629|M.marinum_M ---AGRPADPTEIASTIVYLASDAASFIHGAVVPVDGGRAAV--------
TH_2488|M.thermoresistible__bu ---IGRTADPDEIAQAVVFLASSRASFITGAVLHVDGGGIAV--------
MSMEG_5383|M.smegmatis_MC2_155 ---ARRGAEPEEVAEVIRFLISPAASYIQGAAIAVDGGRTAVLPM-----
Mvan_0325|M.vanbaalenii_PYR-1 ---SHRMSTVAEVASAVVFLAGPEAANIHGTILSVDGGATAVRDEPAAVT
Mflv_0296|M.gilvum_PYR-GCK PNDIGRFGRPEEVAAAVAFLAGVHAGYISGADLRVDGGAIRSVA------
MAB_0827|M.abscessus_ATCC_1997 ---VGRYGQPRDIASLVSYLVSDEAWYITGTAINIDGGFTA---------
MUL_4442|M.ulcerans_Agy99 ---LRRLGDPVDIAAAAVYLASPAGSFLTGKTLEVDGGLTHPNLDIPVPD
MLBr_00862|M.leprae_Br4923 MFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRST
* . : . *
Mb1976|M.bovis_AF2122/97 ---------
Rv1941|M.tuberculosis_H37Rv ---------
MAV_5088|M.avium_104 ---------
MMAR_0629|M.marinum_M ---------
TH_2488|M.thermoresistible__bu ---------
MSMEG_5383|M.smegmatis_MC2_155 ---------
Mvan_0325|M.vanbaalenii_PYR-1 KLGNHPHPG
Mflv_0296|M.gilvum_PYR-GCK ---------
MAB_0827|M.abscessus_ATCC_1997 ---------
MUL_4442|M.ulcerans_Agy99 L--------
MLBr_00862|M.leprae_Br4923 ARIRVI---