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MKTKAAVLWGLHQKWEVEELELDAPRAQEVLVKLTASGLCHSDDHLVTGDMPMNLPVVGGHEGAGVVVDV GPGVTEVEAGDHVVLSFIPACGRCTECARGRSNLCVYGAAIVAGPQLDGTFRFHGSSGGRAYDIGQMCVL GTFSEYTVVPIASVVKVDNDIPLDKAALVGCGVTTGYGAAVRTGEAADGDTVVVMGVGGLGINAIQGAAI AGARNVVALDPVAYKRERSFEFGATHAAADVAEAQALITDLTRGTMADVCVVTTDSAEGAYVAQALSLVG KRGRVVMTAIPHPTDTVVDMSLFDLTLYEKQVRGCLFGSSNPRLDIPRLLDLYGSGRLKLDELITREYTL EEINQGYEDMHNGRNLRGVIRF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0013 | - | - | 100% (372) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5270 | - | e-118 | 54.32% (370) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5164 | - | e-108 | 50.27% (374) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3113 | adhD | 1e-111 | 53.78% (370) | zinc-type alcohol dehydrogenase AdhD |
| M. gilvum PYR-GCK | Mflv_4588 | - | 1e-154 | 69.89% (372) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3086 | adhD | 1e-111 | 53.78% (370) | zinc-type alcohol dehydrogenase AdhD |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 8e-50 | 35.00% (360) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 1e-149 | 66.13% (372) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_3150 | - | 1e-152 | 68.28% (372) | zinc-containing alcohol dehydrogenase NAD- dependent |
| M. avium 104 | MAV_0705 | - | 1e-108 | 50.80% (374) | alcohol dehydrogenase B |
| M. smegmatis MC2 155 | MSMEG_3388 | - | 1e-111 | 54.32% (370) | S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol |
| M. thermoresistible (build 8) | TH_2499 | - | 1e-115 | 53.78% (370) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_0470 | adhB | 1e-104 | 49.47% (374) | zinc-containing alcohol dehydrogenase NAD- dependent AdhB |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3113|M.bovis_AF2122/97 -------------------------------------------MKTTAAV
Rv3086|M.tuberculosis_H37Rv -------------------------------------------MKTTAAV
MSMEG_3388|M.smegmatis_MC2_155 MHSDPSHIDLLGPATFTSRDRRPIGFPPLRCSRHKISWKEPSEMKTKAAV
Mflv_4588|M.gilvum_PYR-GCK -------------------------------------------MKTRAAV
MMAR_3150|M.marinum_M -------------------------------------------MKTRAAV
MAB_2084|M.abscessus_ATCC_1997 -------------------------------------------MKTRAAV
Mvan_0013|M.vanbaalenii_PYR-1 -------------------------------------------MKTKAAV
MAV_0705|M.avium_104 -------------------------------------------MKTKGAL
MUL_0470|M.ulcerans_Agy99 -------------------------------------------MKTKGAL
TH_2499|M.thermoresistible__bu -------------------------------------------MKMNAAV
MLBr_01784|M.leprae_Br4923 -----------------------------------------MSQTVRGVI
. ..:
Mb3113|M.bovis_AF2122/97 LFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGDLPPR-FP
Rv3086|M.tuberculosis_H37Rv LFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGDLPPR-FP
MSMEG_3388|M.smegmatis_MC2_155 SLGVNRPFEIMELELDGPKEGEVLLKNVAAGLCHSDLHLTDGDMPPR-YP
Mflv_4588|M.gilvum_PYR-GCK LWGLGEKWEVDEIELDPPGVDEVLVQLTASGLCHSDEHLVTGDLPFP-LP
MMAR_3150|M.marinum_M LWGLGEKWEVEDIELDPPGPDEVLVQLTATGLCHSDEHLVTGDLPIP-LP
MAB_2084|M.abscessus_ATCC_1997 LWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVTGDLPIP-LP
Mvan_0013|M.vanbaalenii_PYR-1 LWGLHQKWEVEELELDAPRAQEVLVKLTASGLCHSDDHLVTGDMPMN-LP
MAV_0705|M.avium_104 IWEFNQPWSIEEIEIGDPQAHEVKIQMEAAGMCHSDHHLVTGGIPMAGFP
MUL_0470|M.ulcerans_Agy99 IWEFNQPWSVEDIEIGDPVKDEVKIQMEAAGMCRSDNHLVTGGIPMAGFP
TH_2499|M.thermoresistible__bu LWDVNGDWSIEEVELDGPQEGEVLVSFTATGMCHSDHHVRTGDFPAP-LP
MLBr_01784|M.leprae_Br4923 SRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYREGGINDR-YP
.: :: : * *. : * *:*::* *.: *
Mb3113|M.bovis_AF2122/97 IVGGHEGSGVIEEVGAGVTRVKPGDHVVCSFIPNCGTCRYCCTGRQNLCD
Rv3086|M.tuberculosis_H37Rv IVGGHEGSGVIEEVGAGVTRVKPGDHVVCSFIPNCGTCRYCCTGRQNLCD
MSMEG_3388|M.smegmatis_MC2_155 IVGGHEGSAIVEDVGPGVTKVKPGDHVVCSYIPNCGTCRYCATGRSNLCD
Mflv_4588|M.gilvum_PYR-GCK VVGGHEGAGTVVEVGAGVEDLAVGDSVILTFLPSCGHCSYCARGMGNLCD
MMAR_3150|M.marinum_M VVGGHEGAGTVVEVGAGVENVAEGDSVILTFLPSCGHCSYCARGMGNMCD
MAB_2084|M.abscessus_ATCC_1997 VVGGHEGAGTVVECGEGVEDLSEGDSVILTFLPSCGRCSYCARGMGNLCE
Mvan_0013|M.vanbaalenii_PYR-1 VVGGHEGAGVVVDVGPGVTEVEAGDHVVLSFIPACGRCTECARGRSNLCV
MAV_0705|M.avium_104 VLGGHEGAGIVTEVGPGVEDIAPGDHVVLSFIPSCGSCPTCQAGMRNLCD
MUL_0470|M.ulcerans_Agy99 VLGGHEGAGVVTEVGPGVDDIAPGDHVVLSFIPSCGRCPTCQAGLRNLCD
TH_2499|M.thermoresistible__bu IIGGHEGAGVVQEVGPGVRDLKPGDHVVASFLPACGRCRWCATGRSNLCD
MLBr_01784|M.leprae_Br4923 FLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQCRACKRGRPSYCF
.: ***.:. : * ** : ** *: .: . ** * * * . *
Mb3113|M.bovis_AF2122/97 MGATILEGCMP-DGSFRFH----SQGTDFGAMCMLGTFAERATVSQHSVV
Rv3086|M.tuberculosis_H37Rv MGATILEGCMP-DGSFRFH----SQGTDFGAMCMLGTFAERATVSQHSVV
MSMEG_3388|M.smegmatis_MC2_155 MGATILDGRFP-DGTFRFH----KDGVDYGSLCLLGSFAERTTVSQHSVV
Mflv_4588|M.gilvum_PYR-GCK MGAAIMMGPQI-DGTYRFH----ARGEDVGQMCLLGTFSEYTVVPKASLV
MMAR_3150|M.marinum_M LGAALMMGPQI-DGTYRFH----ARGEDVGQMCLLGTFSEYTVVPKASLV
MAB_2084|M.abscessus_ATCC_1997 LGAALMMGPQI-DGTYRFH----ARGEDVGQMCLLGTFSEYTVVPQASVV
Mvan_0013|M.vanbaalenii_PYR-1 YGAAIVAGPQL-DGTFRFHGSSGGRAYDIGQMCVLGTFSEYTVVPIASVV
MAV_0705|M.avium_104 LGAGLLGGEAVSDGTFRIQ----ARGQNVYPMTLLGTFSPYMVVHRSSVV
MUL_0470|M.ulcerans_Agy99 LGAGLLAGAAVSDGTFRIQ----ARGQNVYPMTLLGTFSPYMVVHRSSVV
TH_2499|M.thermoresistible__bu LGAMLLAGTQL-DGTYRRH---LPDGRDVGVALLLGTFAQYGVVSEASLV
MLBr_01784|M.leprae_Br4923 DTFNAQQKMTLIDGTELTP------------ALGIGAFADKTLVHSGQCT
**: :*:*: * . .
Mb3113|M.bovis_AF2122/97 KVDDWLPLETAVLVGCGVPSGWGTAVNAGNLRAGDTAVIYGVGGLGINAV
Rv3086|M.tuberculosis_H37Rv KVDDWLPLETAVLVGCGVPSGWGTAVNAGNLRAGDTAVIYGVGGLGINAV
MSMEG_3388|M.smegmatis_MC2_155 KVDEWIPLETAVLVGCGVPAGWGGPVYNNGIRPGDTAVIYGIGGLGINAI
Mflv_4588|M.gilvum_PYR-GCK KVDHGTPLDKAALIGCGVTTGYGSAVRTGEVRAGDTVVVIGAGGIGMNAI
MMAR_3150|M.marinum_M KIDQGTPLDKAALIGCGVTTGYGSAVRTGEVRAGDTVAVIGAGGIGMNAI
MAB_2084|M.abscessus_ATCC_1997 KIDGGIPLDRAALIGCGVTTGYGSAVRTGEVRAGDTVVVVGAGGIGMNAI
Mvan_0013|M.vanbaalenii_PYR-1 KVDNDIPLDKAALVGCGVTTGYGAAVRTGEAADGDTVVVMGVGGLGINAI
MAV_0705|M.avium_104 KIDPSIPFEVAALVGCGVTTGYGSAVRTADIRPGQDVAIVGVGGVGMAAL
MUL_0470|M.ulcerans_Agy99 KIDPAIPFEVAALVGCGVTTGYGSAVRTADVRPGDDVAIVGLGGVGMAAL
TH_2499|M.thermoresistible__bu KIDDDLPLTRACLIGCGVTTGWGSAVNTAKVQPGDTVVVIGFGGVGSGAV
MLBr_01784|M.leprae_Br4923 KVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIGCGGVGDAAI
*:* * *:**** :* * .: .: ..: * **:* *:
Mb3113|M.bovis_AF2122/97 QGATAAGCKYVVVVDPVAFKRETALKFGATHAF-ADAASAAAKVDELTWG
Rv3086|M.tuberculosis_H37Rv QGATAAGCKYVVVVDPVAFKRETALKFGATHAF-ADAASAAAKVDELTWG
MSMEG_3388|M.smegmatis_MC2_155 QGAVMAGARYVVAVDPVEFKRDMALKFGATHAF-ATAEEAHEAVREITWG
Mflv_4588|M.gilvum_PYR-GCK QGARIAGALTIVAVDPVEFKREQAGGFGATHAV-ATIDEAWSLISDITRG
MMAR_3150|M.marinum_M QGARIAGALNIVAVDPVAFKREQAGGFGATHAV-ATIDEAWSLISDITRG
MAB_2084|M.abscessus_ATCC_1997 QGARIAGALAIVAVDPVNFKREQASGFGATHTA-ASMDEAWSLVSDMTRG
Mvan_0013|M.vanbaalenii_PYR-1 QGAAIAGARNVVALDPVAYKRERSFEFGATHAA-ADVAEAQALITDLTRG
MAV_0705|M.avium_104 QGAVNAGARYIFAIDPVEWKRDQALKFGATHVY-PDIMAAMAGMAEVTYG
MUL_0470|M.ulcerans_Agy99 QGAVTAGARYIFAVEPVEWKRDQALKFGATHVY-PDMEAALMGIAEVTYG
TH_2499|M.thermoresistible__bu QGARLAGAEKIVVVDIVEDKRAKALEFGATHFV-TSMAEATALVGDLTRG
MLBr_01784|M.leprae_Br4923 SGAALVGANRIIAVDIDDTKLEWARTFGATHTVNALELEVVKTIQDLTSG
.** .*. :..:: * : ***** . . : ::* *
Mb3113|M.bovis_AF2122/97 QGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTD
Rv3086|M.tuberculosis_H37Rv QGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTD
MSMEG_3388|M.smegmatis_MC2_155 QMADGALIFVGTPDEKVVSDAFNVIGKGGTVSLASLADPAKLTVHVSGME
Mflv_4588|M.gilvum_PYR-GCK KLADVCVLTTDVAEGAYTAEALSLVGKRGRVVITAIGHPEDTSMSGSLLE
MMAR_3150|M.marinum_M KLADVCVLTTDVAEGSYIGEALSLVGKRGRVVVTAIGHPEDTSMSGSLLE
MAB_2084|M.abscessus_ATCC_1997 KLADVCILTTDVAEGSYTAEALALVGKRGRVVVTAIGHPDESSISGSLLE
Mvan_0013|M.vanbaalenii_PYR-1 TMADVCVVTTDSAEGAYVAQALSLVGKRGRVVMTAIPHPTDTVVDMSLFD
MAV_0705|M.avium_104 LMAHKVVVTVGELQGADVDNYLNITQKGGTCVLTAIGSLLDTNVTLNLAM
MUL_0470|M.ulcerans_Agy99 LMAKKVMITVGELQGSDIDTYLAITSKGGTCVVTAIGSLLDTQVNLNLAM
TH_2499|M.thermoresistible__bu VMADSAILTVGLVEGPMIGECIDIIRKGGAVVLTGIAALADVTPTLPMAM
MLBr_01784|M.leprae_Br4923 FGVDVVIDTVGRPE--TWKQAFYARDLAGTVVLVGVPTP-DMRLDMPLLD
.. : .. : * :..: .
Mb3113|M.bovis_AF2122/97 LTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQLMLDELVTTTYNLEQVN
Rv3086|M.tuberculosis_H37Rv LTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQLMLDELVTTTYNLEQVN
MSMEG_3388|M.smegmatis_MC2_155 MTLMEKTIKGCLFGSSNPQYDIVRLLRLYDEGKLKLDELITTRYRLEDIN
Mflv_4588|M.gilvum_PYR-GCK LTLYEKQIRGALYGSSNAAHDIPRLVELYNSGQLKLDELITREYTLDEIN
MMAR_3150|M.marinum_M LTLYEKQIRGALYGSSNAAHDIPRLVELYNAGHLKLDELITREYTLDQIN
MAB_2084|M.abscessus_ATCC_1997 MTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLLKLDELVTREYSLDQIN
Mvan_0013|M.vanbaalenii_PYR-1 LTLYEKQVRGCLFGSSNPRLDIPRLLDLYGSGRLKLDELITREYTLEEIN
MAV_0705|M.avium_104 LTLMQKNLQGTIFGGGNPQYDIPQLLSMYKAGKLNLDDMITRQYRLEQIN
MUL_0470|M.ulcerans_Agy99 LTLMQKNLQGTIFGGGNPQYDIPHLLSMYKARNLNIDDMITRQYRLEQIN
TH_2499|M.thermoresistible__bu FTLFQKRLLGSLYGEANPRADIPRLLSLYREGKLLLDETVTHEYKLHDIN
MLBr_01784|M.leprae_Br4923 FFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKFVSERIGLGDVE
: : . :* . *: *: :* * :.. :: * :::
Mb3113|M.bovis_AF2122/97 QGYQDLRDGKNIRGVIVH-----
Rv3086|M.tuberculosis_H37Rv QGYQDLRDGKNIRGVIVH-----
MSMEG_3388|M.smegmatis_MC2_155 QGYDDLRAGVNIRGVIIHDPEA-
Mflv_4588|M.gilvum_PYR-GCK EGYDDMRSGRNIRGLIRF-----
MMAR_3150|M.marinum_M EGYADMRSGRNIRGLIRF-----
MAB_2084|M.abscessus_ATCC_1997 EGYQDMRSGRNIRGLVRF-----
Mvan_0013|M.vanbaalenii_PYR-1 QGYEDMHNGRNLRGVIRF-----
MAV_0705|M.avium_104 DGYQDMLDGKNIRGVIRYTDADR
MUL_0470|M.ulcerans_Agy99 EGYQDMIDGKNIRGVIRFTDADR
TH_2499|M.thermoresistible__bu QGYDDMLAGRIIRGVIVHDHS--
MLBr_01784|M.leprae_Br4923 EAFHKIHGGKVLRSVVML-----
:.: .: * :*.::