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DPQLDLNLLLALDALLDERSVGGAAERLHTSAPAMSRTLARLRRVLDDPVLVRAGREMVPTPRALALQGR VHDVVQQARAVFTPPEVPDLPNLRRTFSVQLGDGLFSHCGPRLLARVHAEALNVTLKFVGESHEDTHSLR EGSVDIEIGQVRRTEPETIIEPLVEENWVGVARAGHELTGKRVTLKRFADAEHVVFSRRGRLRGPVDDLL AEHGLRRRVVACAPSPAGGLFLIQNSDLVGMLPAGIGAQAIATFALQTFTIPLELPPLVIGMAWHPRFDA DGAHRWLRDCVRSAVRGPQK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5000 | - | - | 100% (301) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_6674 | - | 6e-24 | 29.37% (286) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_0742 | - | 4e-10 | 25.70% (179) | transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0384 | - | 7e-07 | 29.93% (147) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3565 | - | 2e-07 | 26.23% (305) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0377 | - | 7e-07 | 29.93% (147) | LysR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4400c | - | 4e-59 | 43.51% (285) | LysR family transcriptional regulator |
| M. marinum M | MMAR_0653 | - | 2e-06 | 28.47% (144) | LysR family transcriptional regulator |
| M. avium 104 | MAV_2838 | - | 9e-09 | 26.67% (210) | hydrogen peroxide-inducible genes activator |
| M. thermoresistible (build 8) | TH_0172 | - | 9e-10 | 25.00% (204) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY |
| M. ulcerans Agy99 | MUL_0119 | - | 4e-05 | 27.82% (133) | LysR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3362 | - | 2e-11 | 27.97% (286) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0653|M.marinum_M -------MTPAQLRAYSAVVRLGSVRAAATELGLSDAGVSMHVAALRKEL
MUL_0119|M.ulcerans_Agy99 ------------------MVRLGSVRAAATELGLSDAGVSMHVAALRKEL
Mb0384|M.bovis_AF2122/97 -------MTPAQLRAYSAVVRLGSVRAAAAELGLSDAGVSMHVAALRKEL
Rv0377|M.tuberculosis_H37Rv -------MTPAQLRAYSAVVRLGSVRAAAAELGLSDAGVSMHVAALRKEL
TH_0172|M.thermoresistible__bu -------MTPAQLRAFSAVVRLGSVRAAAQELGMSDAGISMHIAQLRKEL
MSMEG_5000|M.smegmatis_MC2_155 ---MDPQLDLNLLLALDALLDERSVGGAAERLHTSAPAMSRTLARLRRVL
MAB_4400c|M.abscessus_ATCC_199 -------MDLNLLRVLDALLQENSVTAAAERLATSPPAVSRSLGRLRRIT
Mflv_3565|M.gilvum_PYR-GCK -------MELRQLEYFVAIVEEGGFTRAASRERVAQPAVSAQIRRLERSV
Mvan_3362|M.vanbaalenii_PYR-1 -------MELRQLEYLVAVVEERSFTKAAQRERVAQPAVSAQIRRLERQV
MAV_2838|M.avium_104 MPDKTYQPTIAGLRAFVAVAEKRQFSGAATALGVSQSTLSQALAALEAGL
: . ** : . :* : *.
MMAR_0653|M.marinum_M DDPLFTRTGAGLAFTPGGLRLASRAVEILGLQQQTA--IEVTEAAHGRRL
MUL_0119|M.ulcerans_Agy99 DDPLFTRTGAGLAFTPGGLRLASGAVEILGLQQQTA--IEVTEAAHGRRL
Mb0384|M.bovis_AF2122/97 DDPLFTRTGAGLAFTPGGLRLASRAVEILGLQQQTA--IEVTEAAHGRRL
Rv0377|M.tuberculosis_H37Rv DDPLFTRTGAGLAFTPGGLRLASRAVEILGLQQQTA--IEVTEAAHGRRL
TH_0172|M.thermoresistible__bu DDPLFHRTKNGLSFTPGGLRLASRAVDILGLQRQTA--IEVTEAAHGRRL
MSMEG_5000|M.smegmatis_MC2_155 DDPVLVRAGREMVPTPRALALQGRVHDVVQQARAVFTPPEVPDLPNLRRT
MAB_4400c|M.abscessus_ATCC_199 GDALLVRAGQGLVPTPRAVQIRDELGGLLRRADQILRPGAEFDPGKLQRT
Mflv_3565|M.gilvum_PYR-GCK GQPLLTRTSREVRLTRAGEALLPHARAALAAVRDGR--AAVDDVAGLLRG
Mvan_3362|M.vanbaalenii_PYR-1 GQPLLTRSHRGVRVTPAGAALLPHARAALAAVRDAQ--AAVDDVANLVRG
MAV_2838|M.avium_104 GTQLVERSTRRVFLTPQGAELLPHAQAVVEAADAFT-AAAAGSADPLRAG
. :. *: : * . : : .
MMAR_0653|M.marinum_M LRIAASSTFAEHAAPGLIELFSSRADDLSVELSVHPTSQFRDLICSRAVD
MUL_0119|M.ulcerans_Agy99 LRIAASSTFAEHAAPGLIELFSSRADDLSVELSVHPTSQFRDLICARAVD
Mb0384|M.bovis_AF2122/97 LRIAASSAFAEHAAPGLIELFSSRADDLSVELSVHPTSRFRELICSRAVD
Rv0377|M.tuberculosis_H37Rv LRIAASSAFAEHAAPGLIELFSSRADDLSVELSVHPTSRFRELICSRAVD
TH_0172|M.thermoresistible__bu LRIAASHAFAEHAAPGLIDLFSSRADDLSVELTVEPVSRFRDLLESRAVD
MSMEG_5000|M.smegmatis_MC2_155 FSVQLGDGLFSHCGPRLLARVHAEALNVTLKFVGESHEDTHS-LREGSVD
MAB_4400c|M.abscessus_ATCC_199 FIVQAAELFLTALAVPLLERLRHDAPGVNVVFAPEAREDTGA-LRRGDID
Mflv_3565|M.gilvum_PYR-GCK SVAIGTVTLHPMNVAHLIAEFHADHPDVEITLGTATSDVLIAELGDGRLD
Mvan_3362|M.vanbaalenii_PYR-1 AVAIGTVTLHPVDVARLMADFHAEHPGVEITLGTDTSDVLLAKLEDGRLD
MAV_2838|M.avium_104 MRLGLIPTVAPYVLPTVLAGIAERRPGLTLRVTEDQTERLLAVLREGALD
. :: . .: : . . : :*
MMAR_0653|M.marinum_M IAIGPASESSIGSDTSLFVRPFLKYQIITVVAPNSPLAVGIPTPSLLRQQ
MUL_0119|M.ulcerans_Agy99 IAIGPASESSIGSDTSLFVRPFLKYQIITVVAPNSPLAVGIPTPSLLRQQ
Mb0384|M.bovis_AF2122/97 IAIGPASESSIGSDGSIFLRPFLKYQIITVVAPNSPLAAGIPMPALLRHQ
Rv0377|M.tuberculosis_H37Rv IAIGPASESSIGSDGSIFLRPFLKYQIITVVAPNSPLAAGIPMPALLRHQ
TH_0172|M.thermoresistible__bu VTLGPAVRE---PGPAIVVRPFLNYQIIAVTSPSNPLAAATPTIAQLRAQ
MSMEG_5000|M.smegmatis_MC2_155 IEIG--QVRRTEP--ETIIEPLVEENWVGVARAGHELTGKR-VTLKRFAD
MAB_4400c|M.abscessus_ATCC_199 IELG--SLDHLDP--ETRHTPVAMLPMVGVAAQDHPLFEGP-IDAGTFAT
Mflv_3565|M.gilvum_PYR-GCK LAIV--SIAVDEDLPGLEVAVITDEAVEAAVADGHPLAHRRSLSLEQLSR
Mvan_3362|M.vanbaalenii_PYR-1 AAIV--SIGADEDPAGLEYEVITDEALEAAVTAQHRLARRKSLSLKQLCE
MAV_2838|M.avium_104 AALI----ALPAETAGVTAIPIYDEDFVLALPPGHPLAGKRRVPATALAD
: . . *
MMAR_0653|M.marinum_M QWMLGPPAGSVAGEIATMLRDLAIPESQQRIFQ-SDAAALEEVMRVGGAT
MUL_0119|M.ulcerans_Agy99 QWMLGPPAGSVAGEIATMLRDLAIPESQQRIFQ-SDAAALEEVMRVGGAT
Mb0384|M.bovis_AF2122/97 QWMLGPSAGSVDGEIATMLRGLAIPESQQRIFQ-SDAAALEEVMRVGGAT
Rv0377|M.tuberculosis_H37Rv QWMLGPSAGSVDGEIATMLRGLAIPESQQRIFQ-SDAAALEEVMRVGGAT
TH_0172|M.thermoresistible__bu SWMLGPSAGGIDGDVAAMLRRLEIPEAAQRIFQ-SDSAAQEEVQRIGGVT
MSMEG_5000|M.smegmatis_MC2_155 AEHVVFSRR---GRLRGPVDDLLAEHGLRRRVV-ACAPSPAGGLFLIQNS
MAB_4400c|M.abscessus_ATCC_199 YGHISVSRR---GKLYGPIDEALARHGLRRRVP-VVVPSHTSAMLLARSS
Mflv_3565|M.gilvum_PYR-GCK HPLISLPAG---TGLRTRLDTACAAAGLRPRIA-FEATSPAELAELARHG
Mvan_3362|M.vanbaalenii_PYR-1 YPVISLPAG---TGLRSRLDDACAAAGLRPRIA-FEATSPLELADLARHG
MAV_2838|M.avium_104 LPLLLLDEG---HCLRDQALDVCHKAGVRAELANTRAASLATAVQCVTGG
: : . : . .:
MMAR_0653|M.marinum_M LTIGFAVAKDLAAGRLVHVTSPGLDKAGEWCVATLPPAARQPAVSELVRF
MUL_0119|M.ulcerans_Agy99 LTIGFAVAKDLAAGRLVHVTSPGLDKAGEWCVATLPPAARQPAVSELVRF
Mb0384|M.bovis_AF2122/97 LAIGFAVAKDLAAGRLVHVTGPGLDRAGEWCVATLAPSARQPAVSELVGF
Rv0377|M.tuberculosis_H37Rv LAIGFAVAKDLAAGRLVHVTGPGLDRAGEWCVATLAPSARQPAVSELVGF
TH_0172|M.thermoresistible__bu LSIGFAVAKDLAAGRLARIK--GVQATAEWCVSTLSSAARQPAASELVRF
MSMEG_5000|M.smegmatis_MC2_155 DLVGMLPAG-IGAQAIATFALQTFTIPLELPPLVIGMAWHPRFDADGAHR
MAB_4400c|M.abscessus_ATCC_199 RLIALTVA---GSVDTAGLGIRMFDIPLELPAVAVGVAWHPRNNDDAAHT
Mflv_3565|M.gilvum_PYR-GCK LGVAILPQ----SMARGGSGLHALRLAPELRGRLV---WAWRADGANPAA
Mvan_3362|M.vanbaalenii_PYR-1 LGVAILPR----SMARGSAGLHPLRLSPELRGRLV---WAWRTDISGPAA
MAV_2838|M.avium_104 LGVTLIPQS-AVPVEASRSRLGLAQFAAPRPGRRIGLVFRSSSGRDDSYR
: : . . :
MMAR_0653|M.marinum_M ITTPRCIQAMIRGSGVGVTRFRPKVHVTLWS
MUL_0119|M.ulcerans_Agy99 ITTPRCIQAMIRGSGVGVTRFRPKMHVTLWS
Mb0384|M.bovis_AF2122/97 ISTPRCIQAMIRGSGVGVTRFRPKVHVTLWS
Rv0377|M.tuberculosis_H37Rv ISTPRCIQAMIPGSGVGVTRFRPKVHVTLWS
TH_0172|M.thermoresistible__bu ITTPRCTQAMIRGTSEGVTRFRPKVHVTLWS
MSMEG_5000|M.smegmatis_MC2_155 WLR-DCVRSAVRGPQK---------------
MAB_4400c|M.abscessus_ATCC_199 WLRGLLIESFARLPV----------------
Mflv_3565|M.gilvum_PYR-GCK RVLGERARAMAVSPGSGAPAVVPGA------
Mvan_3362|M.vanbaalenii_PYR-1 RLLNARARAMIAATG--TPAVIPGA------
MAV_2838|M.avium_104 ELAGLIGELISSQHQVRLVK-----------
.