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LLEFDADQRLWQETVRDAVTKQCPATLVREVAEQGVDPAPLWKNYIEQGWTELTEPENAVELAIVLEELG RATDLTPYLATMTQFAPLAGDRFDAASAGAAVYGGVTARRDETGWVLSGTGRHVLDGDRAETLAVVTEAG VFLVDAGTAAIRRSPVFDPVLHVAEVSFDGVAVADTDRVPVDIEKAHHLALTGMAVHTVGACRRVLDLVL EHAKQRQQFGVPIGSLQAVQHKAVDMHVAIERARALAYFAALTIAENDPRRRLASRMAKASAGECQAVVF RHGLQLFGAMGFTWENDVQFALKRAKAGELLLGGAAEHRAVIAAEYRTTYRGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4806 | - | - | 100% (334) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2993 | - | 7e-29 | 28.88% (367) | acyl-CoA dehydrogenase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6585 | - | 3e-28 | 31.74% (334) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1968c | fadE18 | 7e-27 | 29.81% (359) | acyl-CoA dehydrogenase FADE18 |
| M. gilvum PYR-GCK | Mflv_2491 | - | 1e-150 | 78.29% (327) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3061c | fadE22 | 1e-27 | 32.49% (317) | acyl-CoA dehydrogenase FADE22 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-12 | 24.19% (277) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0593c | - | 2e-27 | 31.29% (326) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4719 | - | 1e-137 | 72.26% (328) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_0934 | - | 1e-143 | 74.70% (328) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3599 | - | 1e-152 | 78.12% (329) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_0319 | - | 1e-135 | 71.34% (328) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4163 | - | 1e-143 | 75.60% (332) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1968c|M.bovis_AF2122/97 --------------MDFRYSTEQDDFRASLRGFLGR---GAPVREMAAAD
MAB_0593c|M.abscessus_ATCC_199 --------------MSPSGNTERQMLRDTVRSLVTKRADSAAVRTAFESE
Rv3061c|M.tuberculosis_H37Rv --------------MGIALTDDHRELSGVARAFLTSQKVRWAARASLDAA
MSMEG_4806|M.smegmatis_MC2_155 --------------MLLEFDADQRLWQETVRDAVTKQCPATLVREVAEQG
TH_3599|M.thermoresistible__bu --------------MLLEFDADQRLWQETVRDAVAKQCPASLIRSIVEDG
Mflv_2491|M.gilvum_PYR-GCK --------------MLLEFDADQRLWQETVRDAVSKQCPASLIRGIAENG
Mvan_4163|M.vanbaalenii_PYR-1 --------------MLLEFDADQKLWQETVRDAVSKQCPASLIRDIAENG
MMAR_4719|M.marinum_M --------------MLLEFDADQRLWQATVRDVVTKQCPPSLVRSVAENG
MUL_0319|M.ulcerans_Agy99 MLFSPVSARREAVRMLLEFDADQRLWQATVRDVVTKQCPPSLVRSVAENG
MAV_0934|M.avium_104 --------------MLLEFDADQRLWQSTVRDAVTKQCPPSLVRSVAEEG
MLBr_00737|M.leprae_Br4923 ----MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRAR
:: *
Mb1968c|M.bovis_AF2122/97 -GSDRRLWQRLCTELELPALHVPPEHGGLGATLVETAIAFAELGRALTPI
MAB_0593c|M.abscessus_ATCC_199 RGYDENLWAVLCEQVGAAALLIPEESGGAGGELADAAVVVEELGRGLVPS
Rv3061c|M.tuberculosis_H37Rv GDARPPFWQNLA-ELGWLGLHIDERHGGSGYGLSELVVVIEELGRAVAPG
MSMEG_4806|M.smegmatis_MC2_155 VDPAP--LWKNYIEQGWTELTEPE-------NAVELAIVLEELGRATDLT
TH_3599|M.thermoresistible__bu VDPGP--LWKSFVDQGWTELTDPE-------NAVELAIVVEELGRATDPT
Mflv_2491|M.gilvum_PYR-GCK VDPAP--LWKSYLDAGWTELTDPE-------NAVELAIVLEELGRATDPT
Mvan_4163|M.vanbaalenii_PYR-1 ADATP--LWNSYLDAGWTELTDPE-------NAVELAIVLEELGRATDPT
MMAR_4719|M.marinum_M ADSDP--LWKVYVDLGWTELNDPA-------SAVELAIVLEELGHATDPT
MUL_0319|M.ulcerans_Agy99 ADSDP--LWKVYVDLGWTELNDPA-------SAVELAIVLEELGHATDPT
MAV_0934|M.avium_104 VDPSP--LWKSYVDQGWTELNDPE-------STVELAIVLEELGHATDPT
MLBr_00737|M.leprae_Br4923 FPEEA---LAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASA
: :.. *:.:
Mb1968c|M.bovis_AF2122/97 PFAATVFAI--EAILRMGDDEQRKRLLAGLLTGARIGTIAVSGHDVASAT
MAB_0593c|M.abscessus_ATCC_199 PLMGTLWAE--LALLEAGYEG---ELLEALAAGESIGAVAFDPG------
Rv3061c|M.tuberculosis_H37Rv LFVPTVIAS--AVVAKEGTDDQRARLLPALIDGTLTAGVGLDSQVQVTDG
MSMEG_4806|M.smegmatis_MC2_155 PYLATMTQF--APLAGDRFDA-------ASAGAAVYGGVTARRDETG---
TH_3599|M.thermoresistible__bu PFLATMTQF--APLVGERFDP-------HRAGAAVYGGISAHRDDTG---
Mflv_2491|M.gilvum_PYR-GCK PFLATLTQF--APLVGDRFDS-------GGSGTAVYSGISAIRDAEG---
Mvan_4163|M.vanbaalenii_PYR-1 PFLATLTQF--APLVGDRYDS-------SVAGTAVYSGVTANRDAQG---
MMAR_4719|M.marinum_M PFLATMSQF--APLAAGCFDP-------HQSGTAVYNGITVRRDAQG---
MUL_0319|M.ulcerans_Agy99 PFLATMSQF--APLAAGCFDP-------HQSGTAVYNGITVRRDAQG---
MAV_0934|M.avium_104 PFLATMSQF--APLVGEHFDP-------HQSGTAVYGGVCAYRDADG---
MLBr_00737|M.leprae_Br4923 SLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDA
:: : :
Mb1968c|M.bovis_AF2122/97 TVRAVRRDGR---PALTGECTPVLHGHVADLFVVPAVADGS-----IVLH
MAB_0593c|M.abscessus_ATCC_199 ---------------------YVVNGDIADVVLT-------------VQG
Rv3061c|M.tuberculosis_H37Rv --------------VADGEAGIVLGAGLAELLLVAAG---------DDVL
MSMEG_4806|M.smegmatis_MC2_155 -------------WVLSGTGRHVLDGDRAETLAVVTEAG---------VF
TH_3599|M.thermoresistible__bu -------------WILDGTARHVLDADRAEQLAVVTSAG---------VF
Mflv_2491|M.gilvum_PYR-GCK -------------WVLTGTDRFVLDGDRADRLAVVTPAG---------VF
Mvan_4163|M.vanbaalenii_PYR-1 -------------WVLSGTDRFVLDGDRADRLAVVTPAG---------VF
MMAR_4719|M.marinum_M -------------WLLDGTARHVLEGDRADRLAVVTDAG---------VF
MUL_0319|M.ulcerans_Agy99 -------------WLLDGTARHVLERDRADRLAVVTDAG---------VF
MAV_0934|M.avium_104 -------------WVLDGTARHVLDGDRVDRLAVVTDAG---------VF
MLBr_00737|M.leprae_Br4923 ASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAF
: .
Mb1968c|M.bovis_AF2122/97 VVAADA-------PGVTVTPLPSFDITRPVATLRLAGSPAEPLTAGTPDD
MAB_0593c|M.abscessus_ATCC_199 ETVCRA-------GQVTALALSTLDPTRRLASIAVG--AAEPVGTAP---
Rv3061c|M.tuberculosis_H37Rv VLERGR-------KGVSVDVPENFDPTRRSGRVRLDN-VRVTTDDILLGA
MSMEG_4806|M.smegmatis_MC2_155 LVDAGT---------AAIRRSPVFDPVLHVAEVSFDG-VAVADTDRVPVD
TH_3599|M.thermoresistible__bu LVDAGV---------ATVRRSQAFDPVLHITDVSFTG-VQVPDTRRLATD
Mflv_2491|M.gilvum_PYR-GCK VVEAGA---------VTTRRVDVFDPVLHVAEVSFPG-VHVAESDRLAVD
Mvan_4163|M.vanbaalenii_PYR-1 CVDPRAD-----SANVTTRRVDVFDPVLHVAEVSFAG-TQVSDSDRLLVD
MMAR_4719|M.marinum_M IVAASQ---------VSARRESVFDPVLHVADLSFRE-VRVPENARVGVD
MUL_0319|M.ulcerans_Agy99 IVAASQ---------VSARRESVFDPVLHVADLSFRE-VRVPENARVGVD
MAV_0934|M.avium_104 ITAANQ---------VSARRTAVFDPVLHVADLSFAE-VRVPDSARLSVD
MLBr_00737|M.leprae_Br4923 IVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKT
.
Mb1968c|M.bovis_AF2122/97 MERVLDVARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHA
MAB_0593c|M.abscessus_ATCC_199 --GLIDKAGLLLAAEQVGAAARALDLTVEYTKTRVQFGRAIGSFQALKHR
Rv3061c|M.tuberculosis_H37Rv YESALARARTLLAAEAVGGAADCVDSAVAYAKVRQQFGRTIATFQAVKHH
MSMEG_4806|M.smegmatis_MC2_155 IEKAHHLALTGMAVHTVGACRRVLDLVLEHAKQRQQFGVPIGSLQAVQHK
TH_3599|M.thermoresistible__bu PEKARHVALTGMAMTMVGACQRVLDLALEHVKQRHQFGVPIGSFQAIQHK
Mflv_2491|M.gilvum_PYR-GCK TERAHHVALMGMAITTVGACQRILDLVLEHAKSRQQFGVAIGTFQAVQHK
Mvan_4163|M.vanbaalenii_PYR-1 TERARHVALMGMAVTMVGACQRILDLVLEHAKSRQQFGVAIGTFQAVQHK
MMAR_4719|M.marinum_M AERARHIALTGMAITMVGACQRILDLVLEHVRSRHQFGVPIGSFQAVQHK
MUL_0319|M.ulcerans_Agy99 AERARHIALTGMAITMVGACQRILDLVLEHVRSRHQFGVPIGSFQAVQHK
MAV_0934|M.avium_104 PERAHHVALTGMAITMVGACQRILDLVLEHVKSRQQFGVPIGSFQAVQHK
MLBr_00737|M.leprae_Br4923 ALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFM
: :. :* . :* .: :. * **. .*.::*:::.
Mb1968c|M.bovis_AF2122/97 CADMMIEIDATRATVMFAAMSAANGDE-LQTVAPLAKAQTAETFVLCAGS
MAB_0593c|M.abscessus_ATCC_199 MADLYVLVESARATVYQAIHDLTPEG------ATVARIKASEALSAVSGD
Rv3061c|M.tuberculosis_H37Rv CANMLVAAESAIAAVWDAARAAAEDEEQFRLAAAVAAALAFPAYARNAEL
MSMEG_4806|M.smegmatis_MC2_155 AVDMHVAIERARALAYFAALTIAENDPRRRLASRMAKASAGECQAVVFRH
TH_3599|M.thermoresistible__bu AADMHVAIERARALSYFAALTISVDDPRRRLAAAMAKASAGECQSLVFRH
Mflv_2491|M.gilvum_PYR-GCK ATDMYVAIERARALSYFAALTIAADDPRRRLAAAMAKASAGECQALVFKH
Mvan_4163|M.vanbaalenii_PYR-1 ATDMFVAIERARALSYFAALTIAADDPRRRLAAAMAKASAGECQSLVFRH
MMAR_4719|M.marinum_M AADMHVAVQRARALAYFAALTISADDPRRRLAAAMAKASAGECQSLVFRH
MUL_0319|M.ulcerans_Agy99 AADMHVAVQRARALAYFAALTFSADDPRRRLAAAMAKASAGECQSLVFLH
MAV_0934|M.avium_104 VADMHVAVQRARALAYFAALTIAADDPRRRLAAAMAKASAGECQSLAFRH
MLBr_00737|M.leprae_Br4923 LADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTD
.:: : : : * : : :
Mb1968c|M.bovis_AF2122/97 ALQIHGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGLVKA-
MAB_0593c|M.abscessus_ATCC_199 SIQLHGGIAITWEHDAHLYFKRAHGSALLLGTPRQLLPNLETAAGL----
Rv3061c|M.tuberculosis_H37Rv NIQVHGGIGFTWEHDAHLHLRRALVTVGLFGGDAPVRDVFERTAAGVTRA
MSMEG_4806|M.smegmatis_MC2_155 GLQLFGAMGFTWENDVQFALKRAKAGELLLGGAAEHRAVIAAEYRTTYRG
TH_3599|M.thermoresistible__bu GLQMFGAMGFTWENDLQFALKRAKAGELMLGGAAEHRAVIAEEYRTF---
Mflv_2491|M.gilvum_PYR-GCK GIQLFGAMGFTWENDLQFALKRAKAGELLLGGAAEHRAIIAEEYGRDL--
Mvan_4163|M.vanbaalenii_PYR-1 GVQLFGAMGFTWENDLQFALKRAKAGELMLGGAAEHRAMIAEEYREMV--
MMAR_4719|M.marinum_M GLQLFGAMGFTWENDLQFALKRAKAGELMLGGAAQHRVQIAEEYRAADF-
MUL_0319|M.ulcerans_Agy99 GLQLFGAMGFTWGNDLQFALKRAKAGELMLGGAAQHRAQIAEEYRAADF-
MAV_0934|M.avium_104 GLQLHGAMGFTWENDLQFALKRAKAGELMLGGAAEHRARIAEEYRAADF-
MLBr_00737|M.leprae_Br4923 AVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----
:*:.*. . * . : * * :
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
MAB_0593c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv ISLDLPAQAEELRARIRSDAAEIAALEKDAQRDKLIETGYVMPHWPRPWG
MSMEG_4806|M.smegmatis_MC2_155 L-------------------------------------------------
TH_3599|M.thermoresistible__bu --------------------------------------------------
Mflv_2491|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4163|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4719|M.marinum_M --------------------------------------------------
MUL_0319|M.ulcerans_Agy99 --------------------------------------------------
MAV_0934|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
MAB_0593c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv RAAGAVEQLVIEEEFSAAGIERPDYSITGWVILTLIQHGTPWQIERFVEK
MSMEG_4806|M.smegmatis_MC2_155 --------------------------------------------------
TH_3599|M.thermoresistible__bu --------------------------------------------------
Mflv_2491|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4163|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4719|M.marinum_M --------------------------------------------------
MUL_0319|M.ulcerans_Agy99 --------------------------------------------------
MAV_0934|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
MAB_0593c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv ALRQQEIWCQLFSEPDAGSDAASVKTRATRVEGGWKINGQKVWTSGAQYC
MSMEG_4806|M.smegmatis_MC2_155 --------------------------------------------------
TH_3599|M.thermoresistible__bu --------------------------------------------------
Mflv_2491|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4163|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4719|M.marinum_M --------------------------------------------------
MUL_0319|M.ulcerans_Agy99 --------------------------------------------------
MAV_0934|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
MAB_0593c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv ARGLATVRTDPDAPKHAGITTVIIDMLAPGVEVRPLRQITGDSEFNEVFF
MSMEG_4806|M.smegmatis_MC2_155 --------------------------------------------------
TH_3599|M.thermoresistible__bu --------------------------------------------------
Mflv_2491|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4163|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4719|M.marinum_M --------------------------------------------------
MUL_0319|M.ulcerans_Agy99 --------------------------------------------------
MAV_0934|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
MAB_0593c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv NDVFVPDEDVVGAPNSGWTVARATLGNERVSIGGSGSYYEAMAAKLVQLV
MSMEG_4806|M.smegmatis_MC2_155 --------------------------------------------------
TH_3599|M.thermoresistible__bu --------------------------------------------------
Mflv_2491|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4163|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4719|M.marinum_M --------------------------------------------------
MUL_0319|M.ulcerans_Agy99 --------------------------------------------------
MAV_0934|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
MAB_0593c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv QRRSDAFAGAPIRVGAFLAEDHALRLLNLRRAARSVEGAGPGPEGNITKL
MSMEG_4806|M.smegmatis_MC2_155 --------------------------------------------------
TH_3599|M.thermoresistible__bu --------------------------------------------------
Mflv_2491|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4163|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4719|M.marinum_M --------------------------------------------------
MUL_0319|M.ulcerans_Agy99 --------------------------------------------------
MAV_0934|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
MAB_0593c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv KVAEHMIEGAAIAAALWGPEIALLDGPGRVIGRTVMGARGMAIAGGTSEV
MSMEG_4806|M.smegmatis_MC2_155 --------------------------------------------------
TH_3599|M.thermoresistible__bu --------------------------------------------------
Mflv_2491|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4163|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4719|M.marinum_M --------------------------------------------------
MUL_0319|M.ulcerans_Agy99 --------------------------------------------------
MAV_0934|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 -------------------
MAB_0593c|M.abscessus_ATCC_199 -------------------
Rv3061c|M.tuberculosis_H37Rv TRNQIAERILGMPRDPLIS
MSMEG_4806|M.smegmatis_MC2_155 -------------------
TH_3599|M.thermoresistible__bu -------------------
Mflv_2491|M.gilvum_PYR-GCK -------------------
Mvan_4163|M.vanbaalenii_PYR-1 -------------------
MMAR_4719|M.marinum_M -------------------
MUL_0319|M.ulcerans_Agy99 -------------------
MAV_0934|M.avium_104 -------------------
MLBr_00737|M.leprae_Br4923 -------------------