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VDFRYSTEQDDFRASLRGFLGRGAPVREMAAADGSDRRLWQRLCTELELPALHVPPEHGGLGATLVETAI AFAELGRALTPIPFAATVFAIEAILRMGDDEQRKRLLAGLLTGARIGTIAVSGHDVASATTVRAVRRDGR PALTGECTPVLHGHVADLFVVPAVADGSIVLHVVAADAPGVTVTPLPSFDITRPVATLRLAGSPAEPLTA GTPDDMERVLDVARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRATV MFAAMSAANGDELQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLYYRRAKTTEALFGSSARN RALLAERAGLVKA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1968c | fadE18 | - | 100% (363) | acyl-CoA dehydrogenase FADE18 |
| M. bovis AF2122 / 97 | Mb3594 | fadE33 | 5e-41 | 36.73% (324) | acyl-CoA dehydrogenase FADE33 |
| M. bovis AF2122 / 97 | Mb3604c | fadE34 | 1e-32 | 34.43% (305) | acyl-CoA dehydrogenase FADE34 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0345 | - | 7e-57 | 39.18% (365) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1933c | fadE18 | 0.0 | 100.00% (363) | acyl-CoA dehydrogenase FADE18 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-20 | 26.17% (386) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3123 | - | 3e-47 | 35.71% (364) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_2861 | fadE18 | 1e-153 | 74.66% (363) | acyl-CoA dehydrogenase FadE18 |
| M. avium 104 | MAV_1838 | - | 5e-50 | 36.67% (360) | acyl-CoA dehydrogenase protein |
| M. smegmatis MC2 155 | MSMEG_6585 | - | 8e-57 | 38.36% (365) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4038 | - | 3e-66 | 40.11% (369) | PUTATIVE putative acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_2893 | fadE18 | 1e-153 | 74.66% (363) | acyl-CoA dehydrogenase FadE18 |
| M. vanbaalenii PYR-1 | Mvan_4007 | - | 1e-142 | 70.68% (365) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0345|M.gilvum_PYR-GCK --------------------------MADTAG------EWVFSDEQNQLR
MSMEG_6585|M.smegmatis_MC2_155 MAEELVDQPDKVAEELVDQPDKVAEELVDQPDKVAETTEFRFTDEQGQLR
MAV_1838|M.avium_104 -----------------------------MTG--------LSLDESRELA
Mb1968c|M.bovis_AF2122/97 -------------------------------------MDFRYSTEQDDFR
Rv1933c|M.tuberculosis_H37Rv -------------------------------------MDFRYSTEQDDFR
MMAR_2861|M.marinum_M -------------------------------------MDFRYSTEQDDFR
MUL_2893|M.ulcerans_Agy99 -------------------------------------MDFRYSTEQDDFR
Mvan_4007|M.vanbaalenii_PYR-1 -------------------------------------MDFRYHTEHDDLR
TH_4038|M.thermoresistible__bu ------------------VSTPPAERTKEVDEMTDIPDAFAATDAQDELR
MAB_3123|M.abscessus_ATCC_1997 ------MSASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDLR
MLBr_00737|M.leprae_Br4923 ---------------------------MVGWSGNPLFDLFKLPEEHNELR
::
Mflv_0345|M.gilvum_PYR-GCK AAVRAFCADHVDESSVRAAMES----DPPFDAKVWSRLGSELGVLGMAVP
MSMEG_6585|M.smegmatis_MC2_155 AAVRKFGAEYFDEQTVRRLMES----EPRFDPAVWARLGAELGVLGLAVP
MAV_1838|M.avium_104 RSVRAACERFAPEERVRAIAYNGGGVDAGFDTELWKVLCAQVGVAAIGMP
Mb1968c|M.bovis_AF2122/97 ASLRGFLGRGAP---VREMAAA-----DGSDRRLWQRLCTELELPALHVP
Rv1933c|M.tuberculosis_H37Rv ASLRGFLGRGAP---VREMAAA-----DGSDRRLWQRLCTELELPALHVP
MMAR_2861|M.marinum_M ESLRGFLRDQAPPARVRQVAAV-----GGHDKKLWHRLCAELELPALHAP
MUL_2893|M.ulcerans_Agy99 ESLRGFLRDQAPPARVRQVAAV-----GGHDKKLWHRLCAELELPALHAP
Mvan_4007|M.vanbaalenii_PYR-1 AALRGFLHQTAPAARVREVAAG-----DGCDISLWRRLCTELELPGLHLS
TH_4038|M.thermoresistible__bu RTVRGFFEKKMPEHEVRRIMETP----EGYDRAVWRQMADQLGLQGVAIP
MAB_3123|M.abscessus_ATCC_1997 SLVRSWCERVWTPKHVRQIAEAG-----SVDLDAWRALGSELGVVGLSLP
MLBr_00737|M.leprae_Br4923 ATIRALAEKEIAPHAADVDQRAR------FPEEALAALN-ASGFNAIHVP
:* . : . .: .
Mflv_0345|M.gilvum_PYR-GCK ESAGGAGGNLVDQAVAVEQLGAALACGPLFGTVYLAIPALVAASGG----
MSMEG_6585|M.smegmatis_MC2_155 EADGGAGGTLVDQAVAVEELGAALACGPLIGTVYLSIPALVAASAGPV-R
MAV_1838|M.avium_104 EDLGGAGFDATALGVVAHELGRALAPVPFVASAVLATGLLLATRESDPDS
Mb1968c|M.bovis_AF2122/97 PEHGGLGATLVETAIAFAELGRALTPIP-FAATVFAIEAILRMGDDEQ-R
Rv1933c|M.tuberculosis_H37Rv PEHGGLGATLVETAIAFAELGRALTPIP-FAATVFAIEAILRMGDDEQ-R
MMAR_2861|M.marinum_M PEYGGAGGTLVETAIAFGELGRALTPVP-FAATILAIEAILRMGDSEQ-R
MUL_2893|M.ulcerans_Agy99 PEYGGAGGTLVETAIAFGELGRALTPVP-FAATILAIEAILRMGDSEQ-R
Mvan_4007|M.vanbaalenii_PYR-1 QECGGAGGSLVEAAIVFEELGRALTPVP-MAATVFAIEAVLRLGDDRQ-R
TH_4038|M.thermoresistible__bu EEFGGSGFGYSELGVVVEETGRALLPGPFFGSVVLAGTALLCSADDAA-K
MAB_3123|M.abscessus_ATCC_1997 EQHGGGGLGVIELSIVAEELGRALACLPWISSAALGATALVSSGDDSA-L
MLBr_00737|M.leprae_Br4923 EEYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELK
** * :. : . . . . :. : .
Mflv_0345|M.gilvum_PYR-GCK QELLGPLVDGTRTAAFAVRDDAGAFDASSVEVQAVPTEQGWALSGTVERV
MSMEG_6585|M.smegmatis_MC2_155 DELLGALVEGARTAAFAVPDRAGAFDPALVGVTASADAT---LTGTVERI
MAV_1838|M.avium_104 EQRLSGLMEGHRTAAAAVTGDGGLWQRDSVTLVANANIDGWAVNGTVRHV
Mb1968c|M.bovis_AF2122/97 KRLLAGLLTGARIGTIAVSGHDVAS--ATTVRAVRRDG-RPALTGECTPV
Rv1933c|M.tuberculosis_H37Rv KRLLAGLLTGARIGTIAVSGHDVAS--ATTVRAVRRDG-RPALTGECTPV
MMAR_2861|M.marinum_M KGLLSGLLSGDRIGALAAAGPDLS---VTSVRAGRRDG-RPVLTGECAPV
MUL_2893|M.ulcerans_Agy99 KGLLSGLLSGDRIGALAAAGPDLS---VTSVRAGRRDG-RPVLTGECAPV
Mvan_4007|M.vanbaalenii_PYR-1 SRLLPALLSGERIATLAAARPDALDPARVTVRADRHAG-RTELSGESSPV
TH_4038|M.thermoresistible__bu SRYLPGIATGETIAALALTEQSGRWSADAVQTTARHDGGRWIINGSKTFV
MAB_3123|M.abscessus_ATCC_1997 AEWVPALAAGEKTITLAGGRTRLA---DAITVSAESDTDGWKLTGDTEHV
MLBr_00737|M.leprae_Br4923 KQVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCWI
: : : * :.* :
Mflv_0345|M.gilvum_PYR-GCK VDAGAADVLLVAATTP-----DGVGLFVVEADSLGVQRIRLTTLDLTR--
MSMEG_6585|M.smegmatis_MC2_155 VDGAAADVFLVAATAP-----DGVALYAVDAS--DVQRTPLTTLDLTR--
MAV_1838|M.avium_104 LNGCAANDLVVVAKAD-----DQPALFLIDPMAEGVAVEAERVLDGTR--
Mb1968c|M.bovis_AF2122/97 LHGHVADLFVVPAVAD-----GSIVLHVVAADAPGVTVTPLPSFDITR--
Rv1933c|M.tuberculosis_H37Rv LHGHVADLFVVPAVAD-----GSIVLHVVAADAPGVTVTPLPSFDITR--
MMAR_2861|M.marinum_M LHGHVADLFVVPAESD-----GAVILYVVDAAAPGVAVVGLPSFDITR--
MUL_2893|M.ulcerans_Agy99 LHGHVADLFVVPAESD-----GAVILYVVDAAAPGVAVVGLPSFDITR--
Mvan_4007|M.vanbaalenii_PYR-1 LHGHVADLFVVPAVAD-----GRVALYVVAADAPGVTVDRLPSFDTTR--
TH_4038|M.thermoresistible__bu LDGHAADLLLVAARTD-----SGISLLAVDQTE-GLTRRMLSTLDPTR--
MAB_3123|M.abscessus_ATCC_1997 PDGATADVILVLADTD-----SGPSLFAVDGDAPGVDRHSLATLDMTR--
MLBr_00737|M.leprae_Br4923 TNGGKSTWYTVMAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGIKGS
.. : * * : . : .. :
Mflv_0345|M.gilvum_PYR-GCK PQATVGLLDA---PAQLIAGPEEAERVITHALQVGAALLAVEQVGAAQHL
MSMEG_6585|M.smegmatis_MC2_155 PQATIALTDT---PGRLVSGPGEAERVIGHALQVGAALLAVEQVGAAQHL
MAV_1838|M.avium_104 PMATITFTGA---TALKLTGREAVDTIIEHNIDVALAVLSAEQVGACERV
Mb1968c|M.bovis_AF2122/97 PVATLRLAGS---PAEPLTAG--TPDDMERVLDVARVLLAAEMLGGAEAC
Rv1933c|M.tuberculosis_H37Rv PVATLRLAGS---PAEPLTAG--TPDDMERVLDVARVLLAAEMLGGAEAC
MMAR_2861|M.marinum_M PVAKLRLVRA---PAEALAAS--SADEVARLLDVARVLLAAEMLGGAEAC
MUL_2893|M.ulcerans_Agy99 PVAKLRLVRA---PAEALAAS--SADEVARLLDVARVLLAAEMLGGAEAC
Mvan_4007|M.vanbaalenii_PYR-1 PVARLRLQQA---PAEPLVAG--PHDGIERVLDTARVLLSAEMLGGAEAC
TH_4038|M.thermoresistible__bu RQGRIDFTDT---PAELIGAEGQAWPSLSHALDIAAALLALEQVGGAQRC
MAB_3123|M.abscessus_ATCC_1997 RQANIHFNSA---PARLIGAQGRGAEAVATALDVAATVLAAEQAGIAAHM
MLBr_00737|M.leprae_Br4923 PTTELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGA
: : : :: :. : * .
Mflv_0345|M.gilvum_PYR-GCK LDLSVDYAKNRLQFGRPIGSFQAVKHRLADDLVAVEHARSTAYHAVWALS
MSMEG_6585|M.smegmatis_MC2_155 LDLSVDYAKSRLQFGRPIGSFQAVKHRLADDLVDLEHARSAAYHAVWALA
MAV_1838|M.avium_104 LEIACEYARTREQFGRPIGSFQAIKHKCADMLVDLEWARSASQAALEAVV
Mb1968c|M.bovis_AF2122/97 LDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRATVMFAAMSAA
Rv1933c|M.tuberculosis_H37Rv LDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRATVMFAAMSAA
MMAR_2861|M.marinum_M LDLAIEYACSRKQFDRPIGSFQAVKHRCADMMIEIDATRAAVMFAQLCAA
MUL_2893|M.ulcerans_Agy99 LDLAIEYACSRKQFDRPIGSFQAVKHRCADMMIEIDATRAAVMFAQLCAA
Mvan_4007|M.vanbaalenii_PYR-1 LAMAVEYSCTREQFDRPIGSFQAVKHSCADMMIEIDATRAAVMFAAMSAA
TH_4038|M.thermoresistible__bu LEIAVDYAKTRHQFGKPIGSFQAIRHRFADLMLEIECARGAAQYAVYAAA
MAB_3123|M.abscessus_ATCC_1997 LDVTTEYAKSRIQFGRIIGSFQAVKHRLADMAAATGNVRGAAYHAAWSHD
MLBr_00737|M.leprae_Br4923 LDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAE
* : *: * **.. *.:**:::. ** .* *
Mflv_0345|M.gilvum_PYR-GCK DGS-DDPALAVSIAQATTSAAFVRVATDTIQVHGGIGFTWEHQAHLYYKR
MSMEG_6585|M.smegmatis_MC2_155 DGS-DDPALAASIAQATASAALTKIATDTIQVHGGIGFTWEHQAHLYFKR
MAV_1838|M.avium_104 SGE-RD--WRASMAKAVCSESLRNAAHANVQIHGGIGFTWEDSAHLYLRR
Mb1968c|M.bovis_AF2122/97 NG--DELQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLYYRR
Rv1933c|M.tuberculosis_H37Rv NG--DELQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLYYRR
MMAR_2861|M.marinum_M GG--DELHATAPLAKAQAADTYVLCAGSAIQVHGGIAFTWEHDLHLYFRR
MUL_2893|M.ulcerans_Agy99 GG--DELHATAPLAKAQAAGTYVLCAGSAIQVHGGIAFTWEHDLHLYFRR
Mvan_4007|M.vanbaalenii_PYR-1 DP--DELRITAPLVKAQAADTFTLCAGAAFQVHGGIAFTWEHDMHLYFRR
TH_4038|M.thermoresistible__bu RGL-DELPAAASLAKAYCTDVYTKAAGANIQIHGGIGFTWEHPAHMYFKR
MAB_3123|M.abscessus_ATCC_1997 HPSLDDPALATSIAQQVASAGAVEVTAKAIQSHGGIGFTWEHPAHLYYKR
MLBr_00737|M.leprae_Br4923 RGE-PDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRD
: . : : : .* .*. .:* : . : :
Mflv_0345|M.gilvum_PYR-GCK AYTDAALLGGAEEHRARVADFVLVVAPEKD-----APRVATGMPS
MSMEG_6585|M.smegmatis_MC2_155 ATTDAALLGTAEAHRDRIAELILDRAVSDQATIDRAPRVATGTN-
MAV_1838|M.avium_104 ARTDEVLLGGPGQHWDRVGLRVL----------------------
Mb1968c|M.bovis_AF2122/97 AKTTEALFGSSARNRALLAERAGLVKA------------------
Rv1933c|M.tuberculosis_H37Rv AKTTEALFGSSARNRALLAERAGLVKA------------------
MMAR_2861|M.marinum_M AKTTEALFGSSAHHRSLLADRVGL---------------------
MUL_2893|M.ulcerans_Agy99 AKTTEALFGSSAHHRSLLADRVGL---------------------
Mvan_4007|M.vanbaalenii_PYR-1 AKTTEALFGGSAHHRSLLADRVGL---------------------
TH_4038|M.thermoresistible__bu AKSSEHLLGDAAYHRGLLADRAGI---------------------
MAB_3123|M.abscessus_ATCC_1997 AVSNSALFGGRAVHAERIAKEVIDA--------------------
MLBr_00737|M.leprae_Br4923 AKITQIYEGTNQIQRVVMSRALLR---------------------
* * : :.