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LLEFDADQRLWQATVRDVVTKQCPPSLVRSVAENGADSDPLWKVYVDLGWTELNDPASAVELAIVLEELG HATDPTPFLATMSQFAPLAAGCFDPHQSGTAVYNGITVRRDAQGWLLDGTARHVLEGDRADRLAVVTDAG VFIVAASQVSARRESVFDPVLHVADLSFREVRVPENARVGVDAERARHIALTGMAITMVGACQRILDLVL EHVRSRHQFGVPIGSFQAVQHKAADMHVAVQRARALAYFAALTISADDPRRRLAAAMAKASAGECQSLVF RHGLQLFGAMGFTWENDLQFALKRAKAGELMLGGAAQHRVQIAEEYRAADF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4719 | - | - | 100% (332) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_2861 | fadE18 | 1e-32 | 31.23% (365) | acyl-CoA dehydrogenase FadE18 |
| M. marinum M | MMAR_3979 | - | 1e-30 | 30.96% (323) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1968c | fadE18 | 5e-30 | 31.93% (357) | acyl-CoA dehydrogenase FADE18 |
| M. gilvum PYR-GCK | Mflv_2491 | - | 1e-142 | 75.84% (327) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1933c | fadE18 | 5e-30 | 31.93% (357) | acyl-CoA dehydrogenase FADE18 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 5e-12 | 24.24% (231) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0594c | - | 5e-31 | 29.09% (330) | acyl-CoA dehydrogenase FadE |
| M. avium 104 | MAV_0934 | - | 1e-166 | 86.75% (332) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4806 | - | 1e-137 | 72.26% (328) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3599 | - | 1e-149 | 76.22% (328) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_0319 | - | 0.0 | 98.49% (332) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4163 | - | 1e-142 | 74.70% (332) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1968c|M.bovis_AF2122/97 --------------MDFRYSTEQDDFRASLRGFLGRG---APVREMAAAD
Rv1933c|M.tuberculosis_H37Rv --------------MDFRYSTEQDDFRASLRGFLGRG---APVREMAAAD
MAB_0594c|M.abscessus_ATCC_199 --------------MKFDLDTQQRDFAASIDAALSVADVPAAARAWAAGN
MMAR_4719|M.marinum_M --------------MLLEFDADQRLWQATVRDVVTKQCPPSLVRSVAENG
MUL_0319|M.ulcerans_Agy99 MLFSPVSARREAVRMLLEFDADQRLWQATVRDVVTKQCPPSLVRSVAENG
MAV_0934|M.avium_104 --------------MLLEFDADQRLWQSTVRDAVTKQCPPSLVRSVAEEG
MSMEG_4806|M.smegmatis_MC2_155 --------------MLLEFDADQRLWQETVRDAVTKQCPATLVREVAEQG
TH_3599|M.thermoresistible__bu --------------MLLEFDADQRLWQETVRDAVAKQCPASLIRSIVEDG
Mflv_2491|M.gilvum_PYR-GCK --------------MLLEFDADQRLWQETVRDAVSKQCPASLIRGIAENG
Mvan_4163|M.vanbaalenii_PYR-1 --------------MLLEFDADQKLWQETVRDAVSKQCPASLIRDIAENG
MLBr_00737|M.leprae_Br4923 ----MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRAR
: :: ::
Mb1968c|M.bovis_AF2122/97 GSDRRLWQRLCTELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIP
Rv1933c|M.tuberculosis_H37Rv GSDRRLWQRLCTELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIP
MAB_0594c|M.abscessus_ATCC_199 HGPGLAVWSTLAELGVTALAVSEKYDGIGAHPVDLVVALEGLGKWAVPGP
MMAR_4719|M.marinum_M ADSD-PLWKVYVDLGWTELNDP-------ASAVELAIVLEELGHATDPTP
MUL_0319|M.ulcerans_Agy99 ADSD-PLWKVYVDLGWTELNDP-------ASAVELAIVLEELGHATDPTP
MAV_0934|M.avium_104 VDPS-PLWKSYVDQGWTELNDP-------ESTVELAIVLEELGHATDPTP
MSMEG_4806|M.smegmatis_MC2_155 VDPA-PLWKNYIEQGWTELTEP-------ENAVELAIVLEELGRATDLTP
TH_3599|M.thermoresistible__bu VDPG-PLWKSFVDQGWTELTDP-------ENAVELAIVVEELGRATDPTP
Mflv_2491|M.gilvum_PYR-GCK VDPA-PLWKSYLDAGWTELTDP-------ENAVELAIVLEELGRATDPTP
Mvan_4163|M.vanbaalenii_PYR-1 ADAT-PLWNSYLDAGWTELTDP-------ENAVELAIVLEELGRATDPTP
MLBr_00737|M.leprae_Br4923 FPEE--ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASAS
: . * :.. :.: .
Mb1968c|M.bovis_AF2122/97 FAATVFAIEAILRMGDDEQRKRLLAGLLTGARIGTIAVSGHDVASATTVR
Rv1933c|M.tuberculosis_H37Rv FAATVFAIEAILRMGDDEQRKRLLAGLLTGARIGTIAVSGHDVASATTVR
MAB_0594c|M.abscessus_ATCC_199 VVESVAVAPVLLSSHEDG--AEPSTRLASGELIATVAAP-----------
MMAR_4719|M.marinum_M FLATMSQFAPLAAGCFDPHQSGTAVYNGITVRRDAQGWLLDGTAR-----
MUL_0319|M.ulcerans_Agy99 FLATMSQFAPLAAGCFDPHQSGTAVYNGITVRRDAQGWLLDGTAR-----
MAV_0934|M.avium_104 FLATMSQFAPLVGEHFDPHQSGTAVYGGVCAYRDADGWVLDGTAR-----
MSMEG_4806|M.smegmatis_MC2_155 YLATMTQFAPLAGDRFDAASAGAAVYGGVTARRDETGWVLSGTGR-----
TH_3599|M.thermoresistible__bu FLATMTQFAPLVGERFDPHRAGAAVYGGISAHRDDTGWILDGTAR-----
Mflv_2491|M.gilvum_PYR-GCK FLATLTQFAPLVGDRFDSGGSGTAVYSGISAIRDAEGWVLTGTDR-----
Mvan_4163|M.vanbaalenii_PYR-1 FLATLTQFAPLVGDRYDSSVAGTAVYSGVTANRDAQGWVLSGTDR-----
MLBr_00737|M.leprae_Br4923 LIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAA
:: : . . .
Mb1968c|M.bovis_AF2122/97 AVRRDGRPALTGECTPVLHGHVADLFVVPAVADGSIVLHVVAADAPG---
Rv1933c|M.tuberculosis_H37Rv AVRRDGRPALTGECTPVLHGHVADLFVVPAVADGSIVLHVVAADAPG---
MAB_0594c|M.abscessus_ATCC_199 -------------------------PIAPRALDADIAGLVLIADDIG---
MMAR_4719|M.marinum_M --------------------HVLEGDRADRLAVVTDAGVFIVAASQ----
MUL_0319|M.ulcerans_Agy99 --------------------HVLERDRADRLAVVTDAGVFIVAASQ----
MAV_0934|M.avium_104 --------------------HVLDGDRVDRLAVVTDAGVFITAANQ----
MSMEG_4806|M.smegmatis_MC2_155 --------------------HVLDGDRAETLAVVTEAGVFLVDAGT----
TH_3599|M.thermoresistible__bu --------------------HVLDADRAEQLAVVTSAGVFLVDAGV----
Mflv_2491|M.gilvum_PYR-GCK --------------------FVLDGDRADRLAVVTPAGVFVVEAGA----
Mvan_4163|M.vanbaalenii_PYR-1 --------------------FVLDGDRADRLAVVTPAGVFCVDPRADSAN
MLBr_00737|M.leprae_Br4923 SMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGIS-AF
.
Mb1968c|M.bovis_AF2122/97 VTVTPLPSFDITRPVATLRLAGSPAEPL---TAGTPDD------------
Rv1933c|M.tuberculosis_H37Rv VTVTPLPSFDITRPVATLRLAGSPAEPL---TAGTPDD------------
MAB_0594c|M.abscessus_ATCC_199 IREAQAGAQHESIDATRRVFDVQPKE------AGISLD------------
MMAR_4719|M.marinum_M VSARRESVFDPVLHVADLSFREVRVPE----NARVGVD------------
MUL_0319|M.ulcerans_Agy99 VSARRESVFDPVLHVADLSFREVRVPE----NARVGVD------------
MAV_0934|M.avium_104 VSARRTAVFDPVLHVADLSFAEVRVPD----SARLSVD------------
MSMEG_4806|M.smegmatis_MC2_155 AAIRRSPVFDPVLHVAEVSFDGVAVAD----TDRVPVD------------
TH_3599|M.thermoresistible__bu ATVRRSQAFDPVLHITDVSFTGVQVPD----TRRLATD------------
Mflv_2491|M.gilvum_PYR-GCK VTTRRVDVFDPVLHVAEVSFPGVHVAE----SDRLAVD------------
Mvan_4163|M.vanbaalenii_PYR-1 VTTRRVDVFDPVLHVAEVSFAGTQVSD----SDRLLVD------------
MLBr_00737|M.leprae_Br4923 IVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKT
: *
Mb1968c|M.bovis_AF2122/97 MERVLDVARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHA
Rv1933c|M.tuberculosis_H37Rv MERVLDVARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHA
MAB_0594c|M.abscessus_ATCC_199 TSRAIDFGVLAISAQLIGAGQALLDRAVAYAKQRSQFGRPIGSYQAVKHK
MMAR_4719|M.marinum_M AERARHIALTGMAITMVGACQRILDLVLEHVRSRHQFGVPIGSFQAVQHK
MUL_0319|M.ulcerans_Agy99 AERARHIALTGMAITMVGACQRILDLVLEHVRSRHQFGVPIGSFQAVQHK
MAV_0934|M.avium_104 PERAHHVALTGMAITMVGACQRILDLVLEHVKSRQQFGVPIGSFQAVQHK
MSMEG_4806|M.smegmatis_MC2_155 IEKAHHLALTGMAVHTVGACRRVLDLVLEHAKQRQQFGVPIGSLQAVQHK
TH_3599|M.thermoresistible__bu PEKARHVALTGMAMTMVGACQRVLDLALEHVKQRHQFGVPIGSFQAIQHK
Mflv_2491|M.gilvum_PYR-GCK TERAHHVALMGMAITTVGACQRILDLVLEHAKSRQQFGVAIGTFQAVQHK
Mvan_4163|M.vanbaalenii_PYR-1 TERARHVALMGMAVTMVGACQRILDLVLEHAKSRQQFGVAIGTFQAVQHK
MLBr_00737|M.leprae_Br4923 ALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFM
. . :. :* . ** .: :. * **. .*.: *:::.
Mb1968c|M.bovis_AF2122/97 CADMMIEIDATRATVMFAAMSAAN-GDELQTVAPLAKAQTAETFVLCAGS
Rv1933c|M.tuberculosis_H37Rv CADMMIEIDATRATVMFAAMSAAN-GDELQTVAPLAKAQTAETFVLCAGS
MAB_0594c|M.abscessus_ATCC_199 LADVHIALELARPLVYGAALSLADQSPTAARDASAAKVAAAKAAYLAARS
MMAR_4719|M.marinum_M AADMHVAVQRARALAYFAALTISADDPRRRLAAAMAKASAGECQSLVFRH
MUL_0319|M.ulcerans_Agy99 AADMHVAVQRARALAYFAALTFSADDPRRRLAAAMAKASAGECQSLVFLH
MAV_0934|M.avium_104 VADMHVAVQRARALAYFAALTIAADDPRRRLAAAMAKASAGECQSLAFRH
MSMEG_4806|M.smegmatis_MC2_155 AVDMHVAIERARALAYFAALTIAENDPRRRLASRMAKASAGECQAVVFRH
TH_3599|M.thermoresistible__bu AADMHVAIERARALSYFAALTISVDDPRRRLAAAMAKASAGECQSLVFRH
Mflv_2491|M.gilvum_PYR-GCK ATDMYVAIERARALSYFAALTIAADDPRRRLAAAMAKASAGECQALVFKH
Mvan_4163|M.vanbaalenii_PYR-1 ATDMFVAIERARALSYFAALTIAADDPRRRLAAAMAKASAGECQSLVFRH
MLBr_00737|M.leprae_Br4923 LADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTD
.*: : :: :* ** : :* :..
Mb1968c|M.bovis_AF2122/97 ALQIHGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGLVKA-
Rv1933c|M.tuberculosis_H37Rv ALQIHGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGLVKA-
MAB_0594c|M.abscessus_ATCC_199 ALQTHGAIGFTAEYDLSLWILKVRALTSAWGTSEWHRARVLEAL------
MMAR_4719|M.marinum_M GLQLFGAMGFTWENDLQFALKRAKAGELMLGGAAQHRVQIAEEYRAADF-
MUL_0319|M.ulcerans_Agy99 GLQLFGAMGFTWGNDLQFALKRAKAGELMLGGAAQHRAQIAEEYRAADF-
MAV_0934|M.avium_104 GLQLHGAMGFTWENDLQFALKRAKAGELMLGGAAEHRARIAEEYRAADF-
MSMEG_4806|M.smegmatis_MC2_155 GLQLFGAMGFTWENDVQFALKRAKAGELLLGGAAEHRAVIAAEYRTTYRG
TH_3599|M.thermoresistible__bu GLQMFGAMGFTWENDLQFALKRAKAGELMLGGAAEHRAVIAEEYRTF---
Mflv_2491|M.gilvum_PYR-GCK GIQLFGAMGFTWENDLQFALKRAKAGELLLGGAAEHRAIIAEEYGRDL--
Mvan_4163|M.vanbaalenii_PYR-1 GVQLFGAMGFTWENDLQFALKRAKAGELMLGGAAEHRAMIAEEYREMV--
MLBr_00737|M.leprae_Br4923 AVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----
.:* .*. .:* : .: * :*. :
Mb1968c|M.bovis_AF2122/97 -
Rv1933c|M.tuberculosis_H37Rv -
MAB_0594c|M.abscessus_ATCC_199 -
MMAR_4719|M.marinum_M -
MUL_0319|M.ulcerans_Agy99 -
MAV_0934|M.avium_104 -
MSMEG_4806|M.smegmatis_MC2_155 L
TH_3599|M.thermoresistible__bu -
Mflv_2491|M.gilvum_PYR-GCK -
Mvan_4163|M.vanbaalenii_PYR-1 -
MLBr_00737|M.leprae_Br4923 -