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VAEELVDQPDKVAEELVDQPDKVAEELVDQPDKVAETTEFRFTDEQGQLRAAVRKFGAEYFDEQTVRRLM ESEPRFDPAVWARLGAELGVLGLAVPEADGGAGGTLVDQAVAVEELGAALACGPLIGTVYLSIPALVAAS AGPVRDELLGALVEGARTAAFAVPDRAGAFDPALVGVTASADATLTGTVERIVDGAAADVFLVAATAPDG VALYAVDASDVQRTPLTTLDLTRPQATIALTDTPGRLVSGPGEAERVIGHALQVGAALLAVEQVGAAQHL LDLSVDYAKSRLQFGRPIGSFQAVKHRLADDLVDLEHARSAAYHAVWALADGSDDPALAASIAQATASAA LTKIATDTIQVHGGIGFTWEHQAHLYFKRATTDAALLGTAEAHRDRIAELILDRAVSDQATIDRAPRVAT GTN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6585 | - | - | 100% (423) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1905 | - | 9e-61 | 40.88% (362) | acyl-CoA dehydrogenase protein |
| M. smegmatis MC2 155 | MSMEG_6016 | - | 2e-48 | 36.93% (352) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1968c | fadE18 | 7e-57 | 38.36% (365) | acyl-CoA dehydrogenase FADE18 |
| M. gilvum PYR-GCK | Mflv_0345 | - | 1e-150 | 72.34% (394) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1933c | fadE18 | 7e-57 | 38.36% (365) | acyl-CoA dehydrogenase FADE18 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-24 | 25.13% (386) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3123 | - | 2e-81 | 45.48% (376) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_1954 | fadE18_1 | 4e-65 | 40.87% (367) | acyl-CoA dehydrogenase FadE18_1 |
| M. avium 104 | MAV_1838 | - | 3e-62 | 39.57% (369) | acyl-CoA dehydrogenase protein |
| M. thermoresistible (build 8) | TH_0804 | - | 1e-166 | 73.86% (417) | acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2176 | fadE18_1 | 3e-65 | 40.87% (367) | acyl-CoA dehydrogenase FadE18_1 |
| M. vanbaalenii PYR-1 | Mvan_0393 | - | 1e-154 | 72.96% (392) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1968c|M.bovis_AF2122/97 --------------------------------------MDFRYSTEQDDF
Rv1933c|M.tuberculosis_H37Rv --------------------------------------MDFRYSTEQDDF
MSMEG_6585|M.smegmatis_MC2_155 MAEELVDQPDKVAEELVDQPDKVAEELVDQPDKVAETT-EFRFTDEQGQL
TH_0804|M.thermoresistible__bu -----------VAEELAEQPDNAAEELAEQPDNAAGLSPTFTFTEEQQQL
Mflv_0345|M.gilvum_PYR-GCK --------------------------------MADTAG-EWVFSDEQNQL
Mvan_0393|M.vanbaalenii_PYR-1 --------------------------------MADSQGAEYVFTEEQGQL
MMAR_1954|M.marinum_M -----------------------------------MSTGDLLYSDTEEAL
MUL_2176|M.ulcerans_Agy99 -----------------------------------MSTGDLLYSDTEEAL
MAV_1838|M.avium_104 -----------------------------------MTG---LSLDESREL
MAB_3123|M.abscessus_ATCC_1997 -------MSASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDL
MLBr_00737|M.leprae_Br4923 ----------------------------MVGWSGNPLFDLFKLPEEHNEL
:
Mb1968c|M.bovis_AF2122/97 RASLRGFLGRGAPVREMAAADGS--------DRRLWQRLCTELELPALHV
Rv1933c|M.tuberculosis_H37Rv RASLRGFLGRGAPVREMAAADGS--------DRRLWQRLCTELELPALHV
MSMEG_6585|M.smegmatis_MC2_155 RAAVRKFGAEYFDEQTVRRLMES----EPRFDPAVWARLGAELGVLGLAV
TH_0804|M.thermoresistible__bu RAAVRRFCTEHFDEQTVRRLMES----EPRFDPKVWARLGAELGVLGMSV
Mflv_0345|M.gilvum_PYR-GCK RAAVRAFCADHVDESSVRAAMES----DPPFDAKVWSRLGSELGVLGMAV
Mvan_0393|M.vanbaalenii_PYR-1 RAAVRRFCADHIDETAVRAQMAS----EPRFDPKVWARLGSELGVLGMSV
MMAR_1954|M.marinum_M RASVGQLFAERCPPESVVAAYDS----PPADFAKLWRTLAAELGVAGLLV
MUL_2176|M.ulcerans_Agy99 RASVGQLFAERCPPESVVAAYDS----PPADFAKLWRTLAAELGVAGLLV
MAV_1838|M.avium_104 ARSVRAACERFAPEERVRAIAYNGGGVDAGFDTELWKVLCAQVGVAAIGM
MAB_3123|M.abscessus_ATCC_1997 RSLVRSWCERVWTPKHVRQIAEAG-----SVDLDAWRALGSELGVVGLSL
MLBr_00737|M.leprae_Br4923 RATIRALAEKEIAPHAADVDQRAR------FPEEALAALNAS-GFNAIHV
: * :. . .: :
Mb1968c|M.bovis_AF2122/97 PPEHGGLGATLVETAIAFAELGRALTPIPFAATVFAIEAILRMGDDEQR-
Rv1933c|M.tuberculosis_H37Rv PPEHGGLGATLVETAIAFAELGRALTPIPFAATVFAIEAILRMGDDEQR-
MSMEG_6585|M.smegmatis_MC2_155 PEADGGAGGTLVDQAVAVEELGAALACGPLIGTVYLSIPALVAASAGPV-
TH_0804|M.thermoresistible__bu PEADGGVGGTLVDQAVAVEEFGAALACGPFFGTVYLAVPALAAASAGPV-
Mflv_0345|M.gilvum_PYR-GCK PESAGGAGGNLVDQAVAVEQLGAALACGPLFGTVYLAIPALVAASGG---
Mvan_0393|M.vanbaalenii_PYR-1 PESHGGAGGTLVDQAVAVEQLGAALACGPLFGTVYLAIPALVASSQP---
MMAR_1954|M.marinum_M PESLGGAGASAREAAVVMEEVGRAVAPVPFLSSAVLATVALLHSGET---
MUL_2176|M.ulcerans_Agy99 PESLGGAGASAREAAVVMEEVGRAVAPVPFLSSAVLATVALLHSGET---
MAV_1838|M.avium_104 PEDLGGAGFDATALGVVAHELGRALAPVPFVASAVLATGLLLATRESDPD
MAB_3123|M.abscessus_ATCC_1997 PEQHGGGGLGVIELSIVAEELGRALACLPWISSAALGATALVSSGDDSA-
MLBr_00737|M.leprae_Br4923 PEEYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEEL
* ** * :. :.. . : . :.
Mb1968c|M.bovis_AF2122/97 -KRLLAGLLTGARIGTIAVSGHDVASATTVRAVR---RDGRPALTGECTP
Rv1933c|M.tuberculosis_H37Rv -KRLLAGLLTGARIGTIAVSGHDVASATTVRAVR---RDGRPALTGECTP
MSMEG_6585|M.smegmatis_MC2_155 RDELLGALVEGARTAAFAVPDRAGAFDPALVGVT---ASADATLTGTVER
TH_0804|M.thermoresistible__bu RDELLGPLLEGARTAAVILADRAGVFDPTAVTVT---TDG-ATLTGTASQ
Mflv_0345|M.gilvum_PYR-GCK -QELLGPLVDGTRTAAFAVRDDAGAFDASSVEVQAVPTEQGWALSGTVER
Mvan_0393|M.vanbaalenii_PYR-1 -GDLLAPLIEGIRTAAFAVPDAGGDFDADAVTVEAIPTDQGWTLTGTVQR
MMAR_1954|M.marinum_M --ETLSELAQGELTAALVVPLATAPGDPVAGVSR-----GSAGLSGRVCG
MUL_2176|M.ulcerans_Agy99 --ETLSELAQGELTAALVVPLATAPGDPVAGASR-----GSAGLSGRVCG
MAV_1838|M.avium_104 SEQRLSGLMEGHRTAAAAVTGDGGLWQRDSVTLVANANIDGWAVNGTVRH
MAB_3123|M.abscessus_ATCC_1997 LAEWVPALAAGEKTITLAG-GRTRLADAITVSAES--DTDGWKLTGDTEH
MLBr_00737|M.leprae_Br4923 KKQVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCW
: * : :.*
Mb1968c|M.bovis_AF2122/97 VLHGHVADLFVVPAVAD-----GSIVLHVVAADAPGVTVTPLPSFDITR-
Rv1933c|M.tuberculosis_H37Rv VLHGHVADLFVVPAVAD-----GSIVLHVVAADAPGVTVTPLPSFDITR-
MSMEG_6585|M.smegmatis_MC2_155 IVDGAAADVFLVAATAP-----DGVALYAVDAS--DVQRTPLTTLDLTR-
TH_0804|M.thermoresistible__bu VVDVDAADDLLVAADGP-----DGVGLYAVDATGPGVTRTPLVTMDLTR-
Mflv_0345|M.gilvum_PYR-GCK VVDAGAADVLLVAATTP-----DGVGLFVVEADSLGVQRIRLTTLDLTR-
Mvan_0393|M.vanbaalenii_PYR-1 VVDAGAADVVLVAAAGP-----DGLGLYAIEADNIGVQRIPLTTLDLTR-
MMAR_1954|M.marinum_M VAGAREADVLVVPVAGA-----DGVELHTVRANAPGVEIVPLLAFDMTR-
MUL_2176|M.ulcerans_Agy99 VAGAREADVLVVPVAGA-----DGVELHTVRANAPGVEIVPLLAFDMTR-
MAV_1838|M.avium_104 VLNGCAANDLVVVAKAD-----DQPALFLIDPMAEGVAVEAERVLDGTR-
MAB_3123|M.abscessus_ATCC_1997 VPDGATADVILVLADTD-----SGPSLFAVDGDAPGVDRHSLATLDMTR-
MLBr_00737|M.leprae_Br4923 ITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGIKG
: : * . . . : .. :
Mb1968c|M.bovis_AF2122/97 -PVATLRLAGS---PAEPLTAGTPDD--MERVLDVARVLLAAEMLGGAEA
Rv1933c|M.tuberculosis_H37Rv -PVATLRLAGS---PAEPLTAGTPDD--MERVLDVARVLLAAEMLGGAEA
MSMEG_6585|M.smegmatis_MC2_155 -PQATIALTDT---PGRLVSGPGEAERVIGHALQVGAALLAVEQVGAAQH
TH_0804|M.thermoresistible__bu -PQAAVRFSGA---PARLVAEPGTAERVITRALQVGAALLAVEQVGAAQH
Mflv_0345|M.gilvum_PYR-GCK -PQATVGLLDA---PAQLIAGPEEAERVITHALQVGAALLAVEQVGAAQH
Mvan_0393|M.vanbaalenii_PYR-1 -PQATVGLFHA---PARLVAGPAEAERVITHALQIGAALLAVEQVGAAQH
MMAR_1954|M.marinum_M -PLADVVFSGA---ASAPVG-LGSAEAALAEALQTGAALLASEQLGIAQW
MUL_2176|M.ulcerans_Agy99 -PLADVVFSGA---ASAPVG-LGSAEAALAEALQTGAALLASEQLGIAQW
MAV_1838|M.avium_104 -PMATITFTGA---TALKLTGREAVDTIIEHNIDVALAVLSAEQVGACER
MAB_3123|M.abscessus_ATCC_1997 -RQANIHFNSA---PARLIGAQGRGAEAVATALDVAATVLAAEQAGIAAH
MLBr_00737|M.leprae_Br4923 SPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQG
: : : : :: :. : * .
Mb1968c|M.bovis_AF2122/97 CLDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRATVMFAAMSA
Rv1933c|M.tuberculosis_H37Rv CLDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRATVMFAAMSA
MSMEG_6585|M.smegmatis_MC2_155 LLDLSVDYAKSRLQFGRPIGSFQAVKHRLADDLVDLEHARSAAYHAVWAL
TH_0804|M.thermoresistible__bu LLDLSVDYAKSRLQFGRPIGSFQAVKHRLADMLVDVEHARSTAYHAVWAL
Mflv_0345|M.gilvum_PYR-GCK LLDLSVDYAKNRLQFGRPIGSFQAVKHRLADDLVAVEHARSTAYHAVWAL
Mvan_0393|M.vanbaalenii_PYR-1 LLDLTVDYAKNRLQFGRPIGSFQAVKHRLADDLVALEHARSTAYHAVWAL
MMAR_1954|M.marinum_M CFDTTLAYTKQRKQFGRAIGSYQAIKHRLADLWLEVGSARAAARYGADTC
MUL_2176|M.ulcerans_Agy99 CFDTTLAYTKQRKQFGRAIGSYQAIKHRLADLWLEVGSARAAARYGADTC
MAV_1838|M.avium_104 VLEIACEYARTREQFGRPIGSFQAIKHKCADMLVDLEWARSASQAALEAV
MAB_3123|M.abscessus_ATCC_1997 MLDVTTEYAKSRIQFGRIIGSFQAVKHRLADMAAATGNVRGAAYHAAWSH
MLBr_00737|M.leprae_Br4923 ALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARA
:: : *: * **.. *.::*:::. ** .* .
Mb1968c|M.bovis_AF2122/97 ANGD----ELQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLY
Rv1933c|M.tuberculosis_H37Rv ANGD----ELQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLY
MSMEG_6585|M.smegmatis_MC2_155 ADGS---DDPALAASIAQATASAALTKIATDTIQVHGGIGFTWEHQAHLY
TH_0804|M.thermoresistible__bu ADPAGELDDPALATGIAQAVCSAAFSRVAADTIQVHGGIGFTWEHSAHLY
Mflv_0345|M.gilvum_PYR-GCK SDGS---DDPALAVSIAQATTSAAFVRVATDTIQVHGGIGFTWEHQAHLY
Mvan_0393|M.vanbaalenii_PYR-1 TDGS---DDPALAVSIAQATCSEALVRVATDTIQVHGGIGFTWEHQAHLY
MMAR_1954|M.marinum_M ARGD---EDAAIAAAIAAAYCGDVAVHAAEECVQLHGGIGMTWEYPAHLY
MUL_2176|M.ulcerans_Agy99 ARGD---EDAAIAAAIAAAYCGDVAVHAAEECVQLHGGIGMTWEYPAHLY
MAV_1838|M.avium_104 VSGE-----RDWRASMAKAVCSESLRNAAHANVQIHGGIGFTWEDSAHLY
MAB_3123|M.abscessus_ATCC_1997 DHPS--LDDPALATSIAQQVASAGAVEVTAKAIQSHGGIGFTWEHPAHLY
MLBr_00737|M.leprae_Br4923 ERGE---PDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERF
: . : :* .*. . * : . :
Mb1968c|M.bovis_AF2122/97 YRRAKTTEALFGSSARNRALLAERAGLVKA------------------
Rv1933c|M.tuberculosis_H37Rv YRRAKTTEALFGSSARNRALLAERAGLVKA------------------
MSMEG_6585|M.smegmatis_MC2_155 FKRATTDAALLGTAEAHRDRIAELILDRAVSDQATIDRAPRVATGTN-
TH_0804|M.thermoresistible__bu YKRAATDAALLGTAEQHRDRVAALALD-----TASPDRVPRVATGSG-
Mflv_0345|M.gilvum_PYR-GCK YKRAYTDAALLGGAEEHRARVADFVLV-----VAPEKDAPRVATGMPS
Mvan_0393|M.vanbaalenii_PYR-1 YKRAYTDAALLGSAEAHRARVAELVLD-----VAPRKDAPRVATGMPS
MMAR_1954|M.marinum_M LKRAKSDQLALGTAYRHRGRLAKLVNLP-------------VS-----
MUL_2176|M.ulcerans_Agy99 LKRAKSDQLALGTAYRHRGRLAKLVNLP-------------VS-----
MAV_1838|M.avium_104 LRRARTDEVLLGGPGQHWDRVGLRVL----------------------
MAB_3123|M.abscessus_ATCC_1997 YKRAVSNSALFGGRAVHAERIAKEVIDA--------------------
MLBr_00737|M.leprae_Br4923 MRDAKITQIYEGTNQIQRVVMSRALLR---------------------
: * * : :.