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M. gilvum PYR-GCK Mflv_2491 (-)

annotation: acyl-CoA dehydrogenase domain-containing protein
coordinates: 2590739 - 2591734
length: 331

VLLEFDADQRLWQETVRDAVSKQCPASLIRGIAENGVDPAPLWKSYLDAGWTELTDPENAVELAIVLEEL
GRATDPTPFLATLTQFAPLVGDRFDSGGSGTAVYSGISAIRDAEGWVLTGTDRFVLDGDRADRLAVVTPA
GVFVVEAGAVTTRRVDVFDPVLHVAEVSFPGVHVAESDRLAVDTERAHHVALMGMAITTVGACQRILDLV
LEHAKSRQQFGVAIGTFQAVQHKATDMYVAIERARALSYFAALTIAADDPRRRLAAAMAKASAGECQALV
FKHGIQLFGAMGFTWENDLQFALKRAKAGELLLGGAAEHRAIIAEEYGRDL

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_2491 - - 100% (331) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_0345 - 3e-34 32.51% (366) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_1478 - 7e-30 30.63% (333) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1968c fadE18 2e-29 33.56% (298) acyl-CoA dehydrogenase FADE18
M. tuberculosis H37Rv Rv1933c fadE18 3e-29 33.56% (298) acyl-CoA dehydrogenase FADE18
M. leprae Br4923 MLBr_00737 fadE25 7e-13 30.40% (125) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_0593c - 1e-29 31.25% (320) acyl-CoA dehydrogenase FadE
M. marinum M MMAR_4719 - 1e-142 75.84% (327) acyl-CoA dehydrogenase
M. avium 104 MAV_0934 - 1e-149 78.90% (327) putative acyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_4806 - 1e-149 78.29% (327) putative acyl-CoA dehydrogenase
M. thermoresistible (build 8) TH_3599 - 1e-150 78.29% (327) PUTATIVE acyl-CoA dehydrogenase domain protein
M. ulcerans Agy99 MUL_0319 - 1e-140 75.23% (327) acyl-CoA dehydrogenase
M. vanbaalenii PYR-1 Mvan_4163 - 1e-166 88.52% (331) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb1968c|M.bovis_AF2122/97           --------------MDFRYSTEQDDFRASLRGFLGR---GAPVREMAAAD
Rv1933c|M.tuberculosis_H37Rv        --------------MDFRYSTEQDDFRASLRGFLGR---GAPVREMAAAD
MAB_0593c|M.abscessus_ATCC_199      --------------MSPSGNTERQMLRDTVRSLVTKRADSAAVRTAFESE
Mflv_2491|M.gilvum_PYR-GCK          --------------MLLEFDADQRLWQETVRDAVSKQCPASLIRGIAENG
Mvan_4163|M.vanbaalenii_PYR-1       --------------MLLEFDADQKLWQETVRDAVSKQCPASLIRDIAENG
MSMEG_4806|M.smegmatis_MC2_155      --------------MLLEFDADQRLWQETVRDAVTKQCPATLVREVAEQG
TH_3599|M.thermoresistible__bu      --------------MLLEFDADQRLWQETVRDAVAKQCPASLIRSIVEDG
MMAR_4719|M.marinum_M               --------------MLLEFDADQRLWQATVRDVVTKQCPPSLVRSVAENG
MUL_0319|M.ulcerans_Agy99           MLFSPVSARREAVRMLLEFDADQRLWQATVRDVVTKQCPPSLVRSVAENG
MAV_0934|M.avium_104                --------------MLLEFDADQRLWQSTVRDAVTKQCPPSLVRSVAEEG
MLBr_00737|M.leprae_Br4923          ----MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRAR
                                                         ::   : ::*    :              

Mb1968c|M.bovis_AF2122/97           -GSDRRLWQRLCTELELPALHVPPEHGGLGATLVETAIAFAELGRALTPI
Rv1933c|M.tuberculosis_H37Rv        -GSDRRLWQRLCTELELPALHVPPEHGGLGATLVETAIAFAELGRALTPI
MAB_0593c|M.abscessus_ATCC_199      RGYDENLWAVLCEQVGAAALLIPEESGGAGGELADAAVVVEELGRGLVPS
Mflv_2491|M.gilvum_PYR-GCK          --VDPAPLWKSYLDAGWTELTDPEN-------AVELAIVLEELGRATDPT
Mvan_4163|M.vanbaalenii_PYR-1       --ADATPLWNSYLDAGWTELTDPEN-------AVELAIVLEELGRATDPT
MSMEG_4806|M.smegmatis_MC2_155      --VDPAPLWKNYIEQGWTELTEPEN-------AVELAIVLEELGRATDLT
TH_3599|M.thermoresistible__bu      --VDPGPLWKSFVDQGWTELTDPEN-------AVELAIVVEELGRATDPT
MMAR_4719|M.marinum_M               --ADSDPLWKVYVDLGWTELNDPAS-------AVELAIVLEELGHATDPT
MUL_0319|M.ulcerans_Agy99           --ADSDPLWKVYVDLGWTELNDPAS-------AVELAIVLEELGHATDPT
MAV_0934|M.avium_104                --VDPSPLWKSYVDQGWTELNDPES-------TVELAIVLEELGHATDPT
MLBr_00737|M.leprae_Br4923          ---FPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASA
                                                       :  * .        .  .:.. *:.:     

Mb1968c|M.bovis_AF2122/97           PFAATVFAI--EAILRMGDDEQRKRLLAGLLTGARIGTIAV---SGHDVA
Rv1933c|M.tuberculosis_H37Rv        PFAATVFAI--EAILRMGDDEQRKRLLAGLLTGARIGTIAV---SGHDVA
MAB_0593c|M.abscessus_ATCC_199      PLMGTLWAE--LALLEAGYEG---ELLEALAAGESIGAVAF---DPG---
Mflv_2491|M.gilvum_PYR-GCK          PFLATLTQF--APLVGDRFDS----GGSGTAVYSGISAIRD---AEG---
Mvan_4163|M.vanbaalenii_PYR-1       PFLATLTQF--APLVGDRYDS----SVAGTAVYSGVTANRD---AQG---
MSMEG_4806|M.smegmatis_MC2_155      PYLATMTQF--APLAGDRFDA----ASAGAAVYGGVTARRD---ETG---
TH_3599|M.thermoresistible__bu      PFLATMTQF--APLVGERFDP----HRAGAAVYGGISAHRD---DTG---
MMAR_4719|M.marinum_M               PFLATMSQF--APLAAGCFDP----HQSGTAVYNGITVRRD---AQG---
MUL_0319|M.ulcerans_Agy99           PFLATMSQF--APLAAGCFDP----HQSGTAVYNGITVRRD---AQG---
MAV_0934|M.avium_104                PFLATMSQF--APLVGEHFDP----HQSGTAVYGGVCAYRD---ADG---
MLBr_00737|M.leprae_Br4923          SLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDA
                                    .   ::       :     :        .  .   :              

Mb1968c|M.bovis_AF2122/97           SATTVRAVRRDGRPALTGECTPVLHGHVADLFVVPAVAD---GSIVLHVV
Rv1933c|M.tuberculosis_H37Rv        SATTVRAVRRDGRPALTGECTPVLHGHVADLFVVPAVAD---GSIVLHVV
MAB_0593c|M.abscessus_ATCC_199      ---------------------YVVNGDIADVVLT-----------VQGET
Mflv_2491|M.gilvum_PYR-GCK          -------------WVLTGTDRFVLDGDRADRLAVVT---------PAGVF
Mvan_4163|M.vanbaalenii_PYR-1       -------------WVLSGTDRFVLDGDRADRLAVVT---------PAGVF
MSMEG_4806|M.smegmatis_MC2_155      -------------WVLSGTGRHVLDGDRAETLAVVT---------EAGVF
TH_3599|M.thermoresistible__bu      -------------WILDGTARHVLDADRAEQLAVVT---------SAGVF
MMAR_4719|M.marinum_M               -------------WLLDGTARHVLEGDRADRLAVVT---------DAGVF
MUL_0319|M.ulcerans_Agy99           -------------WLLDGTARHVLERDRADRLAVVT---------DAGVF
MAV_0934|M.avium_104                -------------WVLDGTARHVLDGDRVDRLAVVT---------DAGVF
MLBr_00737|M.leprae_Br4923          ASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAF
                                                          : .        .                

Mb1968c|M.bovis_AF2122/97           AADAPG----VTVTPL-----PSFDITRPVATLRLAGSPAEPLTAGTPDD
Rv1933c|M.tuberculosis_H37Rv        AADAPG----VTVTPL-----PSFDITRPVATLRLAGSPAEPLTAGTPDD
MAB_0593c|M.abscessus_ATCC_199      VCRAGQ----VTALAL-----STLDPTRRLASIAVG--AAEPVGTAP---
Mflv_2491|M.gilvum_PYR-GCK          VVEAGA----VTTRRV-----DVFDPVLHVAEVSFPGVHVAESDRLAVD-
Mvan_4163|M.vanbaalenii_PYR-1       CVDPRADSANVTTRRV-----DVFDPVLHVAEVSFAGTQVSDSDRLLVD-
MSMEG_4806|M.smegmatis_MC2_155      LVDAGT----AAIRRS-----PVFDPVLHVAEVSFDGVAVADTDRVPVD-
TH_3599|M.thermoresistible__bu      LVDAGV----ATVRRS-----QAFDPVLHITDVSFTGVQVPDTRRLATD-
MMAR_4719|M.marinum_M               IVAASQ----VSARRE-----SVFDPVLHVADLSFREVRVPENARVGVD-
MUL_0319|M.ulcerans_Agy99           IVAASQ----VSARRE-----SVFDPVLHVADLSFREVRVPENARVGVD-
MAV_0934|M.avium_104                ITAANQ----VSARRT-----AVFDPVLHVADLSFAEVRVPDSARLSVD-
MLBr_00737|M.leprae_Br4923          IVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKT
                                                                 .    .               

Mb1968c|M.bovis_AF2122/97           MERVLDVARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHA
Rv1933c|M.tuberculosis_H37Rv        MERVLDVARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHA
MAB_0593c|M.abscessus_ATCC_199      --GLIDKAGLLLAAEQVGAAARALDLTVEYTKTRVQFGRAIGSFQALKHR
Mflv_2491|M.gilvum_PYR-GCK          TERAHHVALMGMAITTVGACQRILDLVLEHAKSRQQFGVAIGTFQAVQHK
Mvan_4163|M.vanbaalenii_PYR-1       TERARHVALMGMAVTMVGACQRILDLVLEHAKSRQQFGVAIGTFQAVQHK
MSMEG_4806|M.smegmatis_MC2_155      IEKAHHLALTGMAVHTVGACRRVLDLVLEHAKQRQQFGVPIGSLQAVQHK
TH_3599|M.thermoresistible__bu      PEKARHVALTGMAMTMVGACQRVLDLALEHVKQRHQFGVPIGSFQAIQHK
MMAR_4719|M.marinum_M               AERARHIALTGMAITMVGACQRILDLVLEHVRSRHQFGVPIGSFQAVQHK
MUL_0319|M.ulcerans_Agy99           AERARHIALTGMAITMVGACQRILDLVLEHVRSRHQFGVPIGSFQAVQHK
MAV_0934|M.avium_104                PERAHHVALTGMAITMVGACQRILDLVLEHVKSRQQFGVPIGSFQAVQHK
MLBr_00737|M.leprae_Br4923          ALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFM
                                         . :   :.   :* .   ** .: :.  * **. .*.::*:::. 

Mb1968c|M.bovis_AF2122/97           CADMMIEIDATRATVMFAAMSAANGDELQ-TVAPLAKAQTAETFVLCAGS
Rv1933c|M.tuberculosis_H37Rv        CADMMIEIDATRATVMFAAMSAANGDELQ-TVAPLAKAQTAETFVLCAGS
MAB_0593c|M.abscessus_ATCC_199      MADLYVLVESARATVYQAIHDLTPEG------ATVARIKASEALSAVSGD
Mflv_2491|M.gilvum_PYR-GCK          ATDMYVAIERARALSYFAALTIAADDPRRRLAAAMAKASAGECQALVFKH
Mvan_4163|M.vanbaalenii_PYR-1       ATDMFVAIERARALSYFAALTIAADDPRRRLAAAMAKASAGECQSLVFRH
MSMEG_4806|M.smegmatis_MC2_155      AVDMHVAIERARALAYFAALTIAENDPRRRLASRMAKASAGECQAVVFRH
TH_3599|M.thermoresistible__bu      AADMHVAIERARALSYFAALTISVDDPRRRLAAAMAKASAGECQSLVFRH
MMAR_4719|M.marinum_M               AADMHVAVQRARALAYFAALTISADDPRRRLAAAMAKASAGECQSLVFRH
MUL_0319|M.ulcerans_Agy99           AADMHVAVQRARALAYFAALTFSADDPRRRLAAAMAKASAGECQSLVFLH
MAV_0934|M.avium_104                VADMHVAVQRARALAYFAALTIAADDPRRRLAAAMAKASAGECQSLAFRH
MLBr_00737|M.leprae_Br4923          LADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTD
                                     .*: : :: :*     *              :  ::  :.:        

Mb1968c|M.bovis_AF2122/97           ALQIHGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGLVKA-
Rv1933c|M.tuberculosis_H37Rv        ALQIHGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGLVKA-
MAB_0593c|M.abscessus_ATCC_199      SIQLHGGIAITWEHDAHLYFKRAHGSALLLGTPRQLLPNLETAAGL----
Mflv_2491|M.gilvum_PYR-GCK          GIQLFGAMGFTWENDLQFALKRAKAGELLLGGAAEHRAIIAEEYGRDL--
Mvan_4163|M.vanbaalenii_PYR-1       GVQLFGAMGFTWENDLQFALKRAKAGELMLGGAAEHRAMIAEEYREMV--
MSMEG_4806|M.smegmatis_MC2_155      GLQLFGAMGFTWENDVQFALKRAKAGELLLGGAAEHRAVIAAEYRTTYRG
TH_3599|M.thermoresistible__bu      GLQMFGAMGFTWENDLQFALKRAKAGELMLGGAAEHRAVIAEEYRTF---
MMAR_4719|M.marinum_M               GLQLFGAMGFTWENDLQFALKRAKAGELMLGGAAQHRVQIAEEYRAADF-
MUL_0319|M.ulcerans_Agy99           GLQLFGAMGFTWGNDLQFALKRAKAGELMLGGAAQHRAQIAEEYRAADF-
MAV_0934|M.avium_104                GLQLHGAMGFTWENDLQFALKRAKAGELMLGGAAEHRARIAEEYRAADF-
MLBr_00737|M.leprae_Br4923          AVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----
                                    .:*:.*. . *     .   : *:      *        :          

Mb1968c|M.bovis_AF2122/97           -
Rv1933c|M.tuberculosis_H37Rv        -
MAB_0593c|M.abscessus_ATCC_199      -
Mflv_2491|M.gilvum_PYR-GCK          -
Mvan_4163|M.vanbaalenii_PYR-1       -
MSMEG_4806|M.smegmatis_MC2_155      L
TH_3599|M.thermoresistible__bu      -
MMAR_4719|M.marinum_M               -
MUL_0319|M.ulcerans_Agy99           -
MAV_0934|M.avium_104                -
MLBr_00737|M.leprae_Br4923          -

species	id	gene	e-value	identity (len)	annotation
M. gilvum PYR-GCK	Mflv_2491	-	-	100% (331)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_0345	-	3e-34	32.51% (366)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_1478	-	7e-30	30.63% (333)	acyl-CoA dehydrogenase domain-containing protein