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TANPEQMLFTSTAQAFLEKEAPLSRVRQLHDEDTSFDAQWWGRAAELGWAGLLVPEDLGGGSVSGDGVAD LALIAEQAGRTVAPGPLHPVSAVLAGLVEAPQGHEETIETLIAGETIASWATYEPKRPFAPTAPTVTATR TATGYRIDGVKDRVEAGDQAGLLLVVALLDGQPRQFLVATDATGVTVTAQKSLDLVKRYARVEFDGVAVE ESAVVGAAEQTPAIIERQRQIALVLQCAETVGILDAVLAMTNQWLLDRNSFGRPLASYQALKHRFADMKM WFEAARATTTGAVAAVGARSKRAAFLVSVAKAYVGERAPVMLQDCVQLHGGIGVTWEHDLHLYLRRASLN RAMFGAPEDHHRAVFELSRRSQPEEARA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2993 | - | - | 100% (379) | acyl-CoA dehydrogenase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6585 | - | 3e-39 | 34.29% (347) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1905 | - | 5e-37 | 29.75% (363) | acyl-CoA dehydrogenase protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1968c | fadE18 | 6e-35 | 32.86% (353) | acyl-CoA dehydrogenase FADE18 |
| M. gilvum PYR-GCK | Mflv_3793 | - | 1e-164 | 76.60% (376) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1933c | fadE18 | 6e-35 | 32.86% (353) | acyl-CoA dehydrogenase FADE18 |
| M. leprae Br4923 | MLBr_00661 | fadE24 | 6e-22 | 30.37% (326) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3123 | - | 2e-35 | 31.20% (359) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_3993 | - | 1e-130 | 62.83% (374) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1618 | - | 1e-136 | 64.96% (371) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_2474 | - | 1e-145 | 67.11% (380) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_2176 | fadE18_1 | 1e-42 | 35.75% (372) | acyl-CoA dehydrogenase FadE18_1 |
| M. vanbaalenii PYR-1 | Mvan_2601 | - | 1e-162 | 76.61% (372) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
Rv1933c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3123|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2176|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3793|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2601|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2993|M.smegmatis_MC2_155 --------------------------------------------------
TH_2474|M.thermoresistible__bu --------------------------------------------------
MMAR_3993|M.marinum_M --------------------------------------------------
MAV_1618|M.avium_104 --------------------------------------------------
MLBr_00661|M.leprae_Br4923 MTDTAPSAKPSSVRLKRGGLRSGVGMQPHKRTGFDVAIAMLTPLVGQDFL
Mb1968c|M.bovis_AF2122/97 ------------------------------------------------MD
Rv1933c|M.tuberculosis_H37Rv ------------------------------------------------MD
MAB_3123|M.abscessus_ATCC_1997 -----------------MSASEDHQTRMSASEDNQTRMSASEDNQAQINE
MUL_2176|M.ulcerans_Agy99 ---------------------------------------------MSTGD
Mflv_3793|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_2601|M.vanbaalenii_PYR-1 -------------------------------------------------M
MSMEG_2993|M.smegmatis_MC2_155 --------------------------------------------------
TH_2474|M.thermoresistible__bu ------------------------------------------------MT
MMAR_3993|M.marinum_M ---------------------------------------MAQERPAGVMT
MAV_1618|M.avium_104 ------------------------------------------------MS
MLBr_00661|M.leprae_Br4923 DKYHLRYPLNRALRYGVKATFSTAAATSRQFKRVQNLRGGATRLQPSGRN
Mb1968c|M.bovis_AF2122/97 FRYSTEQDDFRASLRGFLGRGAP---VREMAAADGSDR-RLWQRLCTELE
Rv1933c|M.tuberculosis_H37Rv FRYSTEQDDFRASLRGFLGRGAP---VREMAAADGSDR-RLWQRLCTELE
MAB_3123|M.abscessus_ATCC_1997 FEFTEEHGDLRSLVRSWCERVWTPKHVRQIAEAGSVDL-DAWRALGSELG
MUL_2176|M.ulcerans_Agy99 LLYSDTEEALRASVGQLFAERCPPESVVAAYDSPPADFAKLWRTLAAELG
Mflv_3793|M.gilvum_PYR-GCK TSPNPEQLLFASTTTTFLEKQASLTHVRGLHASE-VSFQPEWWQRAAELG
Mvan_2601|M.vanbaalenii_PYR-1 TTANPEQLLFASTTQTFLEKQASLTHVRGLHASG-VSFQPEWWQRAAELG
MSMEG_2993|M.smegmatis_MC2_155 MTANPEQMLFTSTAQAFLEKEAPLSRVRQLHDED-TSFDAQWWGRAAELG
TH_2474|M.thermoresistible__bu DVASPERLLFASTAQSFLEKEASLTRVRELHDDG-VSFDADWWRRAAELG
MMAR_3993|M.marinum_M AVDSSENILFISTTHAFLQKEASLRHVRELNAAG-MSFDPKWWRRAAELG
MAV_1618|M.avium_104 TVDSPEKILFTSTTQAFLEKEAPLRRVRELHAAG-TAFDPGWWRRAAELG
MLBr_00661|M.leprae_Br4923 YFDLTPDDNQKLIVETIDEFSAEILRPAAHDADEAAAYPPDLIAKAAKLG
::*
Mb1968c|M.bovis_AF2122/97 LPALHVPPEHGGLGATLV------ETAIAFAELGRALTPIPFAA-TVFAI
Rv1933c|M.tuberculosis_H37Rv LPALHVPPEHGGLGATLV------ETAIAFAELGRALTPIPFAA-TVFAI
MAB_3123|M.abscessus_ATCC_1997 VVGLSLPEQHGGGGLGVI------ELSIVAEELGRALACLPWISSAALGA
MUL_2176|M.ulcerans_Agy99 VAGLLVPESLGGAGASAR------EAAVVMEEVGRAVAPVPFLSSAVLAT
Mflv_3793|M.gilvum_PYR-GCK WASLLVPEELGGGSVSGD---GVADLAIVAEQIGHTVAPGPLHP-VSAVL
Mvan_2601|M.vanbaalenii_PYR-1 WASLLVPEELGGGSVSGD---GVADLAMVAEQIGHTVAPGPLHP-VSIVL
MSMEG_2993|M.smegmatis_MC2_155 WAGLLVPEDLGGGSVSGD---GVADLALIAEQAGRTVAPGPLHP-VSAVL
TH_2474|M.thermoresistible__bu WASLLVPEELGGGSVSGGPAGGVADLALIAEQAGRSVAPGPLHP-VSTVL
MMAR_3993|M.marinum_M WTSLLIPEQLGGGSVSGN---AVVDLAMVAEELGKTVAPGPLHP-VSTVL
MAV_1618|M.avium_104 WTGLLVPEELGGGSVSES---GLADLATVAEQLGKTVAPGPLYP-VSIVL
MLBr_00661|M.leprae_Br4923 ITTINIPEYFDGIAERRS----SVTNVLVAEALAYGDMGLTLPILAPGGV
: :* .* . . . .
Mb1968c|M.bovis_AF2122/97 EAILRMGDDEQRKRLLAGLLTGARI--GTIAVSGHD---VASATTVRAVR
Rv1933c|M.tuberculosis_H37Rv EAILRMGDDEQRKRLLAGLLTGARI--GTIAVSGHD---VASATTVRAVR
MAB_3123|M.abscessus_ATCC_1997 TALVSSGDDSALAEWVPALAAGEKT--ITLAGGRTR---LADAITVSAES
MUL_2176|M.ulcerans_Agy99 VALLHSGETETLSELAQGELTAALV--VPLAT--------APGDPVAGAS
Mflv_3793|M.gilvum_PYR-GCK AALVEAP--NGHEQTIEALVSGELV--ASWAVYEPRRPFAPSQAATTATR
Mvan_2601|M.vanbaalenii_PYR-1 AGLVEAP--GGHEQTIEALVSGELV--ASWAVYEPARPFAPLLAATKATR
MSMEG_2993|M.smegmatis_MC2_155 AGLVEAP--QGHEETIETLIAGETI--ASWATYEPKRPFAPTAPTVTATR
TH_2474|M.thermoresistible__bu AGLAEAP--DRHTDAIEALMSGEAV--ASWAIYAPGRSFDPLNPGVTATP
MMAR_3993|M.marinum_M AALVDCAQRDAHVDLIESLMSGEAV--ASWAVSEPGRGWDPVDPTVTATP
MAV_1618|M.avium_104 SALAECSGAETHRDVIEALISGETV--ASWAVYEPGQGWAPLNPSVTATE
MLBr_00661|M.leprae_Br4923 AATLTYWGSADQQATYLKEFTGENVPQACVAIAEPQPLFDPTRLKTIAVR
. :. * . . .
Mb1968c|M.bovis_AF2122/97 RDGRPALTGECTPVLHGHVADLFVVPAVA--DGSIVLHVVAADAPGVTVT
Rv1933c|M.tuberculosis_H37Rv RDGRPALTGECTPVLHGHVADLFVVPAVA--DGSIVLHVVAADAPGVTVT
MAB_3123|M.abscessus_ATCC_1997 DTDGWKLTGDTEHVPDGATADVILVLADT--DSGPSLFAVDGDAPGVDRH
MUL_2176|M.ulcerans_Agy99 R-GSAGLSGRVCGVAGAREADVLVVPVAG--ADGVELHTVRANAPGVEIV
Mflv_3793|M.gilvum_PYR-GCK TDRGYRIDGVKDRVEAGAESGALVVVAEL--DGVVRQFVVPTDADGVTVT
Mvan_2601|M.vanbaalenii_PYR-1 TDGGYRLDGVKDRVEAGADCGAVLVVAEL--DGAVRQFLVPTDIPGVTVT
MSMEG_2993|M.smegmatis_MC2_155 TATGYRIDGVKDRVEAGDQAGLLLVVALL--DGQPRQFLVATDATGVTVT
TH_2474|M.thermoresistible__bu TDSGFRLDGVSDRVEAGDRCDLLLVTAHC--DGAVRQFLVPTDTTGVTLT
MMAR_3993|M.marinum_M IASGYQIQGSKHQVEAGPQSAVLLVVARC--AGQVRQFLVPTDAPGVRIT
MAV_1618|M.avium_104 TDSGYRIDGVKDRVEAGAQSALLLVVARCGADGQIRQFLVPTDAPGVRIE
MLBr_00661|M.leprae_Br4923 TPSGYRLDGVKSLVPAAASAELFIIGAQL--NGKPALFIVESSTKGLTVK
: * * . . .:: . . . * . *:
Mb1968c|M.bovis_AF2122/97 PLPSFDI-TRPVATLRLAG---SPAEPLTAG--TPDDMERVLDVARVLLA
Rv1933c|M.tuberculosis_H37Rv PLPSFDI-TRPVATLRLAG---SPAEPLTAG--TPDDMERVLDVARVLLA
MAB_3123|M.abscessus_ATCC_1997 SLATLDM-TRRQANIHFNS---APARLIGAQGRGAEAVATALDVAATVLA
MUL_2176|M.ulcerans_Agy99 PLLAFDM-TRPLADVVFSG---AASAPVGLG-SAEAALAEALQTGAALLA
Mflv_3793|M.gilvum_PYR-GCK PQSSVDL-VKRYARVQFDAVEVDESAVVGTADQTPAIIERQRQIVLVLQC
Mvan_2601|M.vanbaalenii_PYR-1 AQDSVDL-VKRYARVRFDGVEVGESAAVGTAEQTPDIVERQRQIALVLQC
MSMEG_2993|M.smegmatis_MC2_155 AQKSLDL-VKRYARVEFDGVAVEESAVVGAAEQTPAIIERQRQIALVLQC
TH_2474|M.thermoresistible__bu PQQSIDL-VKRYAAVTFDGVTVDAAAAVGTAEQTPAVIARQTRIAQILQC
MMAR_3993|M.marinum_M AQQSVDL-VKQYARVDFDGVVVPESAVVGTAAETRSLINRQSQIAQVLQC
MAV_1618|M.avium_104 PQQSVDL-VKQYARVHFDGVVVPRSAAVGTAAETATLIERQSQLAQVLQC
MLBr_00661|M.leprae_Br4923 ADPSMGIRAAALGQVELCGVSAPLDARLGEDDATDNDYSEAIALARLGWA
. :..: . . : : . : .
Mb1968c|M.bovis_AF2122/97 AEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRA
Rv1933c|M.tuberculosis_H37Rv AEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRA
MAB_3123|M.abscessus_ATCC_1997 AEQAGIAAHMLDVTTEYAKSRIQFGRIIGSFQAVKHRLADMAAATGNVRG
MUL_2176|M.ulcerans_Agy99 SEQLGIAQWCFDTTLAYTKQRKQFGRAIGSYQAIKHRLADLWLEVGSARA
Mflv_3793|M.gilvum_PYR-GCK AEIVGILDAVLAMTNQWLFDRHSFGRPLASYQALKHRAADMKMWFEAARG
Mvan_2601|M.vanbaalenii_PYR-1 AEIVGVLDAVLAMTNQWLFDRHSFGRPLASYQALKHRAADMKMWFEAARA
MSMEG_2993|M.smegmatis_MC2_155 AETVGILDAVLAMTNQWLLDRNSFGRPLASYQALKHRFADMKMWFEAARA
TH_2474|M.thermoresistible__bu AELVGVLDTVIGFTIQWAFDRYSFGRPLASYQALKHRYADLKIKLEACRA
MMAR_3993|M.marinum_M AEVVGILQTVFDFTAQWALDRHTFGRPLASYQALKHKFADMKMWVEACRA
MAV_1618|M.avium_104 AEVVGVVQTVFDFTTQWALDRHTFGRPLASYQALKHKFADMKLWLEACRA
MLBr_00661|M.leprae_Br4923 ALAVGTSHAVLDYVMPYVKEREAFGEPIARRQAVAFMCANIAIELDGLRL
: * : . : * *.. :. **: . *:: *
Mb1968c|M.bovis_AF2122/97 TVMFAAMSAANG--DELQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTW
Rv1933c|M.tuberculosis_H37Rv TVMFAAMSAANG--DELQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTW
MAB_3123|M.abscessus_ATCC_1997 AAYHAAWSHDHPSLDDPALATSIAQQVASAGAVEVTAKAIQSHGGIGFTW
MUL_2176|M.ulcerans_Agy99 AARYGADTCARGD-EDAAIAAAIAAAYCGDVAVHAAEECVQLHGGIGMTW
Mflv_3793|M.gilvum_PYR-GCK TTAGAVRAVGNRS-PDAELLVSVAKAYVAERAPVMLQDCVQLHGGIGVTW
Mvan_2601|M.vanbaalenii_PYR-1 TTAGAVRAVADRS-PDAPKLVSVAKAYVAERAPVMLQDCVQLHGGIGVTW
MSMEG_2993|M.smegmatis_MC2_155 TTTGAVAAVGARS-KRAAFLVSVAKAYVGERAPVMLQDCVQLHGGIGVTW
TH_2474|M.thermoresistible__bu TAAAAVKAVGTRS-ADADFAVSVAKSYIGENAPAMIQDCVQLHGGIGVTW
MMAR_3993|M.marinum_M TTAAAVAELAAGS-AEAGRCASIAKSYVGEMASQIVQSCVQMHGGIGVTW
MAV_1618|M.avium_104 TTWAAVAEVAARS-PQAGLSASIAKSYVGEMAGQIVQACVQMHGGIGVTW
MLBr_00661|M.leprae_Br4923 ITWRGASRAEQGL--SFAREAALAKRLGSDKAMQIGLDGVQLLGGHGFIK
. .. ..:* . :* *. ..
Mb1968c|M.bovis_AF2122/97 EHDLHLYYRRAKTTEALFGSSARNRALLAERAGLVKA-------
Rv1933c|M.tuberculosis_H37Rv EHDLHLYYRRAKTTEALFGSSARNRALLAERAGLVKA-------
MAB_3123|M.abscessus_ATCC_1997 EHPAHLYYKRAVSNSALFGGRAVHAERIAKEVIDA---------
MUL_2176|M.ulcerans_Agy99 EYPAHLYLKRAKSDQLALGTAYRHRGRLAKLVNLPVS-------
Mflv_3793|M.gilvum_PYR-GCK EHDLHLYLRRVALYRAMFGSPEDHHRAVYARS---SAQEATA--
Mvan_2601|M.vanbaalenii_PYR-1 EHDLHLFLRRVALYRAMFGSPEDHHRAVYALS---SETEANA--
MSMEG_2993|M.smegmatis_MC2_155 EHDLHLYLRRASLNRAMFGAPEDHHRAVFELSRRSQPEEARA--
TH_2474|M.thermoresistible__bu EHDLHLFLRRAMLYRSMFGTPEEHNVRVYTLTKEAGSKEVESAS
MMAR_3993|M.marinum_M EHDLHLYLRRVMLYRSMFGTPEEHNLRVYEAQRAAT--------
MAV_1618|M.avium_104 EHDLHLYLRRVTLYRGMFGTPEEHNLRVYQFEKAGGAAK-----
MLBr_00661|M.leprae_Br4923 EHPVERWYRDLRAIGVAEGVVVI---------------------
*: . : : *