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LLEFDADQKLWQETVRDAVSKQCPASLIRDIAENGADATPLWNSYLDAGWTELTDPENAVELAIVLEELG RATDPTPFLATLTQFAPLVGDRYDSSVAGTAVYSGVTANRDAQGWVLSGTDRFVLDGDRADRLAVVTPAG VFCVDPRADSANVTTRRVDVFDPVLHVAEVSFAGTQVSDSDRLLVDTERARHVALMGMAVTMVGACQRIL DLVLEHAKSRQQFGVAIGTFQAVQHKATDMFVAIERARALSYFAALTIAADDPRRRLAAAMAKASAGECQ SLVFRHGVQLFGAMGFTWENDLQFALKRAKAGELMLGGAAEHRAMIAEEYREMV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4163 | - | - | 100% (335) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4007 | - | 1e-31 | 30.79% (354) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0393 | - | 4e-29 | 32.33% (300) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1968c | fadE18 | 1e-29 | 34.46% (296) | acyl-CoA dehydrogenase FADE18 |
| M. gilvum PYR-GCK | Mflv_2491 | - | 1e-166 | 88.52% (331) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1933c | fadE18 | 2e-29 | 34.46% (296) | acyl-CoA dehydrogenase FADE18 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 9e-13 | 33.04% (115) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3123 | - | 3e-28 | 30.60% (366) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4719 | - | 1e-142 | 74.70% (332) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_0934 | - | 1e-145 | 77.48% (333) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4806 | - | 1e-143 | 75.60% (332) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3599 | - | 1e-147 | 76.81% (332) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_0319 | - | 1e-140 | 73.80% (332) | acyl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1968c|M.bovis_AF2122/97 -------------------------------MDFRYSTEQDDFRASLRGF
Rv1933c|M.tuberculosis_H37Rv -------------------------------MDFRYSTEQDDFRASLRGF
Mvan_4163|M.vanbaalenii_PYR-1 -------------------------------MLLEFDADQKLWQETVRDA
Mflv_2491|M.gilvum_PYR-GCK -------------------------------MLLEFDADQRLWQETVRDA
MSMEG_4806|M.smegmatis_MC2_155 -------------------------------MLLEFDADQRLWQETVRDA
TH_3599|M.thermoresistible__bu -------------------------------MLLEFDADQRLWQETVRDA
MMAR_4719|M.marinum_M -------------------------------MLLEFDADQRLWQATVRDV
MUL_0319|M.ulcerans_Agy99 -----------------MLFSPVSARREAVRMLLEFDADQRLWQATVRDV
MAV_0934|M.avium_104 -------------------------------MLLEFDADQRLWQSTVRDA
MAB_3123|M.abscessus_ATCC_1997 MSASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDLRSLVRSW
MLBr_00737|M.leprae_Br4923 ---------------------MVGWSGNPLFDLFKLPEEHNELRATIRAL
:. :: : :*
Mb1968c|M.bovis_AF2122/97 LGRGAP--VREMAAADG-SDRRLWQRLCTELELPALHVPPEHGGLGATLV
Rv1933c|M.tuberculosis_H37Rv LGRGAP--VREMAAADG-SDRRLWQRLCTELELPALHVPPEHGGLGATLV
Mvan_4163|M.vanbaalenii_PYR-1 VSKQCPASLIRDIAENG-ADATPLWNSYLDAGWTELTDP-------ENAV
Mflv_2491|M.gilvum_PYR-GCK VSKQCPASLIRGIAENG-VDPAPLWKSYLDAGWTELTDP-------ENAV
MSMEG_4806|M.smegmatis_MC2_155 VTKQCPATLVREVAEQG-VDPAPLWKNYIEQGWTELTEP-------ENAV
TH_3599|M.thermoresistible__bu VAKQCPASLIRSIVEDG-VDPGPLWKSFVDQGWTELTDP-------ENAV
MMAR_4719|M.marinum_M VTKQCPPSLVRSVAENG-ADSDPLWKVYVDLGWTELNDP-------ASAV
MUL_0319|M.ulcerans_Agy99 VTKQCPPSLVRSVAENG-ADSDPLWKVYVDLGWTELNDP-------ASAV
MAV_0934|M.avium_104 VTKQCPPSLVRSVAEEG-VDPSPLWKSYVDQGWTELNDP-------ESTV
MAB_3123|M.abscessus_ATCC_1997 CERVWTPKHVRQIAEAGSVDLDAWRALGSELGVVGLSLPEQHGGGGLGVI
MLBr_00737|M.leprae_Br4923 AEKEIAPHAADVDQRAR--FPEEALAALNASGFNAIHVPEEYGGQGADSV
: . : * :
Mb1968c|M.bovis_AF2122/97 ETAIAFAELGRALTPIPFAATVFA--IEAILRMGDDEQRKRLLAGLLTGA
Rv1933c|M.tuberculosis_H37Rv ETAIAFAELGRALTPIPFAATVFA--IEAILRMGDDEQRKRLLAGLLTGA
Mvan_4163|M.vanbaalenii_PYR-1 ELAIVLEELGRATDPTPFLATLTQ--FAPLVGDRYDSSVA----------
Mflv_2491|M.gilvum_PYR-GCK ELAIVLEELGRATDPTPFLATLTQ--FAPLVGDRFDSGGS----------
MSMEG_4806|M.smegmatis_MC2_155 ELAIVLEELGRATDLTPYLATMTQ--FAPLAGDRFDAASA----------
TH_3599|M.thermoresistible__bu ELAIVVEELGRATDPTPFLATMTQ--FAPLVGERFDPHRA----------
MMAR_4719|M.marinum_M ELAIVLEELGHATDPTPFLATMSQ--FAPLAAGCFDPHQS----------
MUL_0319|M.ulcerans_Agy99 ELAIVLEELGHATDPTPFLATMSQ--FAPLAAGCFDPHQS----------
MAV_0934|M.avium_104 ELAIVLEELGHATDPTPFLATMSQ--FAPLVGEHFDPHQS----------
MAB_3123|M.abscessus_ATCC_1997 ELSIVAEELGRALACLPWISSAALG-ATALVSSGDDSALAEWVPALAAGE
MLBr_00737|M.leprae_Br4923 AACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEG
.*. *:.:. . .: : :
Mb1968c|M.bovis_AF2122/97 RIGTIAVSGH---DVASATTVRAVRRDGRPALTGECTPVLHGHVADLFVV
Rv1933c|M.tuberculosis_H37Rv RIGTIAVSGH---DVASATTVRAVRRDGRPALTGECTPVLHGHVADLFVV
Mvan_4163|M.vanbaalenii_PYR-1 -------------GTAVYSGVTANRDAQGWVLSGTDRFVLDGDRADRLAV
Mflv_2491|M.gilvum_PYR-GCK -------------GTAVYSGISAIRDAEGWVLTGTDRFVLDGDRADRLAV
MSMEG_4806|M.smegmatis_MC2_155 -------------GAAVYGGVTARRDETGWVLSGTGRHVLDGDRAETLAV
TH_3599|M.thermoresistible__bu -------------GAAVYGGISAHRDDTGWILDGTARHVLDADRAEQLAV
MMAR_4719|M.marinum_M -------------GTAVYNGITVRRDAQGWLLDGTARHVLEGDRADRLAV
MUL_0319|M.ulcerans_Agy99 -------------GTAVYNGITVRRDAQGWLLDGTARHVLERDRADRLAV
MAV_0934|M.avium_104 -------------GTAVYGGVCAYRDADGWVLDGTARHVLDGDRVDRLAV
MAB_3123|M.abscessus_ATCC_1997 KTITLAGGRT---RLADAITVSAESDTDGWKLTGDTEHVPDGATADVILV
MLBr_00737|M.leprae_Br4923 AMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTV
* . * * : . *
Mb1968c|M.bovis_AF2122/97 PAVADG-----SIVLHVVAADAPG--VTVTPLPSFDITRPVATLRLAGSP
Rv1933c|M.tuberculosis_H37Rv PAVADG-----SIVLHVVAADAPG--VTVTPLPSFDITRPVATLRLAGSP
Mvan_4163|M.vanbaalenii_PYR-1 VTPAG---------VFCVDPRADSANVTTRRVDVFDPVLHVAEVSFAGTQ
Mflv_2491|M.gilvum_PYR-GCK VTPAG---------VFVVEAGA----VTTRRVDVFDPVLHVAEVSFPGVH
MSMEG_4806|M.smegmatis_MC2_155 VTEAG---------VFLVDAGT----AAIRRSPVFDPVLHVAEVSFDGVA
TH_3599|M.thermoresistible__bu VTSAG---------VFLVDAGV----ATVRRSQAFDPVLHITDVSFTGVQ
MMAR_4719|M.marinum_M VTDAG---------VFIVAASQ----VSARRESVFDPVLHVADLSFREVR
MUL_0319|M.ulcerans_Agy99 VTDAG---------VFIVAASQ----VSARRESVFDPVLHVADLSFREVR
MAV_0934|M.avium_104 VTDAG---------VFITAANQ----VSARRTAVFDPVLHVADLSFAEVR
MAB_3123|M.abscessus_ATCC_1997 LADTDS-----GPSLFAVDGDAPG--VDRHSLATLDMTRRQANIHFNSAP
MLBr_00737|M.leprae_Br4923 MAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCR
: :. . . : : :
Mb1968c|M.bovis_AF2122/97 AEP-----LTAGTPDDMERVLDVARVLLAAEMLGGAEACLDLAVQYAGRR
Rv1933c|M.tuberculosis_H37Rv AEP-----LTAGTPDDMERVLDVARVLLAAEMLGGAEACLDLAVQYAGRR
Mvan_4163|M.vanbaalenii_PYR-1 VS------DSDRLLVDTERARHVALMGMAVTMVGACQRILDLVLEHAKSR
Mflv_2491|M.gilvum_PYR-GCK VA------ESDRLAVDTERAHHVALMGMAITTVGACQRILDLVLEHAKSR
MSMEG_4806|M.smegmatis_MC2_155 VA------DTDRVPVDIEKAHHLALTGMAVHTVGACRRVLDLVLEHAKQR
TH_3599|M.thermoresistible__bu VP------DTRRLATDPEKARHVALTGMAMTMVGACQRVLDLALEHVKQR
MMAR_4719|M.marinum_M VP------ENARVGVDAERARHIALTGMAITMVGACQRILDLVLEHVRSR
MUL_0319|M.ulcerans_Agy99 VP------ENARVGVDAERARHIALTGMAITMVGACQRILDLVLEHVRSR
MAV_0934|M.avium_104 VP------DSARLSVDPERAHHVALTGMAITMVGACQRILDLVLEHVKSR
MAB_3123|M.abscessus_ATCC_1997 ARLI---GAQGRGAEAVATALDVAATVLAAEQAGIAAHMLDVTTEYAKSR
MLBr_00737|M.leprae_Br4923 IPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDR
. . : :. * . ** . :. *
Mb1968c|M.bovis_AF2122/97 TQFDRPIGSFQAVKHACADMMIEIDATRATVMFAAMSAANGD--ELQTVA
Rv1933c|M.tuberculosis_H37Rv TQFDRPIGSFQAVKHACADMMIEIDATRATVMFAAMSAANGD--ELQTVA
Mvan_4163|M.vanbaalenii_PYR-1 QQFGVAIGTFQAVQHKATDMFVAIERARALSYFAALTIAADDP-RRRLAA
Mflv_2491|M.gilvum_PYR-GCK QQFGVAIGTFQAVQHKATDMYVAIERARALSYFAALTIAADDP-RRRLAA
MSMEG_4806|M.smegmatis_MC2_155 QQFGVPIGSLQAVQHKAVDMHVAIERARALAYFAALTIAENDP-RRRLAS
TH_3599|M.thermoresistible__bu HQFGVPIGSFQAIQHKAADMHVAIERARALSYFAALTISVDDP-RRRLAA
MMAR_4719|M.marinum_M HQFGVPIGSFQAVQHKAADMHVAVQRARALAYFAALTISADDP-RRRLAA
MUL_0319|M.ulcerans_Agy99 HQFGVPIGSFQAVQHKAADMHVAVQRARALAYFAALTFSADDP-RRRLAA
MAV_0934|M.avium_104 QQFGVPIGSFQAVQHKVADMHVAVQRARALAYFAALTIAADDP-RRRLAA
MAB_3123|M.abscessus_ATCC_1997 IQFGRIIGSFQAVKHRLADMAAATGNVRGAAYHAAWSHDHPSLDDPALAT
MLBr_00737|M.leprae_Br4923 KQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEP-DLGFIS
**. *.::*:::. .** .* ** . :
Mb1968c|M.bovis_AF2122/97 PLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLYYRRAKTTEALFGSS
Rv1933c|M.tuberculosis_H37Rv PLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLYYRRAKTTEALFGSS
Mvan_4163|M.vanbaalenii_PYR-1 AMAKASAGECQSLVFRHGVQLFGAMGFTWENDLQFALKRAKAGELMLGGA
Mflv_2491|M.gilvum_PYR-GCK AMAKASAGECQALVFKHGIQLFGAMGFTWENDLQFALKRAKAGELLLGGA
MSMEG_4806|M.smegmatis_MC2_155 RMAKASAGECQAVVFRHGLQLFGAMGFTWENDVQFALKRAKAGELLLGGA
TH_3599|M.thermoresistible__bu AMAKASAGECQSLVFRHGLQMFGAMGFTWENDLQFALKRAKAGELMLGGA
MMAR_4719|M.marinum_M AMAKASAGECQSLVFRHGLQLFGAMGFTWENDLQFALKRAKAGELMLGGA
MUL_0319|M.ulcerans_Agy99 AMAKASAGECQSLVFLHGLQLFGAMGFTWGNDLQFALKRAKAGELMLGGA
MAV_0934|M.avium_104 AMAKASAGECQSLAFRHGLQLHGAMGFTWENDLQFALKRAKAGELMLGGA
MAB_3123|M.abscessus_ATCC_1997 SIAQQVASAGAVEVTAKAIQSHGGIGFTWEHPAHLYYKRAVSNSALFGGR
MLBr_00737|M.leprae_Br4923 AASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTN
:: :. .:* .*. .:* . : * . *
Mb1968c|M.bovis_AF2122/97 ARNRALLAERAGLVKA--
Rv1933c|M.tuberculosis_H37Rv ARNRALLAERAGLVKA--
Mvan_4163|M.vanbaalenii_PYR-1 AEHRAMIAEEYREMV---
Mflv_2491|M.gilvum_PYR-GCK AEHRAIIAEEYGRDL---
MSMEG_4806|M.smegmatis_MC2_155 AEHRAVIAAEYRTTYRGL
TH_3599|M.thermoresistible__bu AEHRAVIAEEYRTF----
MMAR_4719|M.marinum_M AQHRVQIAEEYRAADF--
MUL_0319|M.ulcerans_Agy99 AQHRAQIAEEYRAADF--
MAV_0934|M.avium_104 AEHRARIAEEYRAADF--
MAB_3123|M.abscessus_ATCC_1997 AVHAERIAKEVIDA----
MLBr_00737|M.leprae_Br4923 QIQRVVMSRALLR-----
: ::