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SSQPPDAAGLRLLVVGASSGIGHAVAESAAKRGIDVAVAARRIKLLKTLADSIGGHAFELDVEDPAAITR VVNEAADALGGLDAVVFTSTVIPFAYIEDTDVASWLHAFNVNTLGANNVLRAAVPRLADNGVVLIASSHD VGRPRAGVAAYSASKAALDEILHSWRSEHPELSVIRVGVGPTEDTEILRGADRDLLDQLLKLWVEQGALP ARMSALGDVANTLVSLVVTAFENPTVVPEVVQLSPRIRRRQGREPAE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4742 | - | - | 100% (258) | clavaldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6859 | - | 1e-18 | 36.14% (202) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_2279 | - | 1e-18 | 29.32% (249) | 3-hydroxyacyl-CoA dehydrogenase type-2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0494c | - | 4e-16 | 35.22% (159) | putative short-chain type oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4319 | - | 5e-17 | 26.91% (249) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0484c | - | 4e-16 | 35.22% (159) | short-chain type oxidoreductase |
| M. leprae Br4923 | MLBr_00862 | ephD | 9e-10 | 29.74% (195) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2117 | - | 1e-16 | 31.21% (173) | short chain dehydrogenase |
| M. marinum M | MMAR_3514 | - | 8e-32 | 33.06% (242) | oxidoreductase |
| M. avium 104 | MAV_4099 | - | 6e-34 | 35.53% (228) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_1771 | - | 1e-85 | 61.54% (247) | clavaldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2753 | - | 6e-28 | 30.83% (240) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2027 | - | 3e-19 | 28.51% (249) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0494c|M.bovis_AF2122/97 --------------------------------------------------
Rv0484c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4319|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2027|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
TH_1771|M.thermoresistible__bu --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MAB_2117|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0494c|M.bovis_AF2122/97 --------------------------------------------------
Rv0484c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4319|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2027|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
TH_1771|M.thermoresistible__bu --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MAB_2117|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0494c|M.bovis_AF2122/97 --------------------------------------------------
Rv0484c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4319|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2027|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
TH_1771|M.thermoresistible__bu --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MAB_2117|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0494c|M.bovis_AF2122/97 --------------------------------------------------
Rv0484c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4319|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2027|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
TH_1771|M.thermoresistible__bu --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MAB_2117|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0494c|M.bovis_AF2122/97 --------------------------------------------------
Rv0484c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4319|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2027|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
TH_1771|M.thermoresistible__bu --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MAB_2117|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0494c|M.bovis_AF2122/97 --------------------------------------------------
Rv0484c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4319|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2027|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
TH_1771|M.thermoresistible__bu --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MAB_2117|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0494c|M.bovis_AF2122/97 --------------------MTTIGTRKRVAVVTGASSGIGEATARTLAA
Rv0484c|M.tuberculosis_H37Rv --------------------MTTIGTRKRVAVVTGASSGIGEATARTLAA
Mflv_4319|M.gilvum_PYR-GCK -----------------------MEIEGKKAIIVGGASGFGRATAEALAK
Mvan_2027|M.vanbaalenii_PYR-1 -----------------------MEIEGKKAVVVGGASGFGRATAEALAK
MSMEG_4742|M.smegmatis_MC2_155 ------------------MSSQPPDAAGLRLLVVGASSGIGHAVAESAAK
TH_1771|M.thermoresistible__bu ------------------MTDRHSNIDGLRLLVVGASSGIGQALAAAAHT
MMAR_3514|M.marinum_M ---------------------------MSKTVVIGASSGLGRCIGVGLAR
MUL_2753|M.ulcerans_Agy99 ---------------------------MSKTVVIGASSGLGRCIGVGLAR
MAV_4099|M.avium_104 -------------------------------MVVGASSGLGRCIGVGLAQ
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
MAB_2117|M.abscessus_ATCC_1997 ------------------MGSTANGVAGKTVMITGGAGGIGVEVAHRLYA
: *...*:* .
Mb0494c|M.bovis_AF2122/97 QGFHVVAVARRADRITALANQIGG-----TAIVADVTDDAAVEALAR---
Rv0484c|M.tuberculosis_H37Rv QGFHVVAVARRADRITALANQIGG-----TAIVADVTDDAAVEALAR---
Mflv_4319|M.gilvum_PYR-GCK RGATVAVLDRPQSKGKEVADQIGG-----TFYEVDITDFEGTESVLNKVV
Mvan_2027|M.vanbaalenii_PYR-1 RGASVAVLDRPQSKGKEVADQIGG-----SFFEVDITDFEGTESVLNQAV
MSMEG_4742|M.smegmatis_MC2_155 RGIDVAVAARRIKLLKTLADSIGG-----HAFELDVEDPAAITRVVNEAA
TH_1771|M.thermoresistible__bu RGARVALAARRIELLEKLAEQLDG-----SAHELDVADPRAIERVIEATA
MMAR_3514|M.marinum_M RGDHVALLARRRERTEAAAKEAGPG---TVAVECDVTDEASCRSALAAAA
MUL_2753|M.ulcerans_Agy99 RGDHVALLARRRER-----------------------DEASCRSTLAAAA
MAV_4099|M.avium_104 RGDRVALLARRRQRIEAAAKDAGPG---AVAIECDVTDQASCASAIGEAV
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
MAB_2117|M.abscessus_ATCC_1997 KGANVVLTDLDEAKLAAIADELGGDR--VLVAVADVCDLTAMEKVAAQAV
:* *. * .
Mb0494c|M.bovis_AF2122/97 -ALSRVDVLVNNAGG---AKGLQFVADADLEHWRWMWDTNVLGTLRVTRA
Rv0484c|M.tuberculosis_H37Rv -ALSRVDVLVNNAGG---AKGLQFVADADLEHWRWMWDTNVLGTLRVTRA
Mflv_4319|M.gilvum_PYR-GCK EDLGGLHIAVTTAGGGIAERTVKKDGPHSLDSFRKSIDLNLIGTFNISRI
Mvan_2027|M.vanbaalenii_PYR-1 EALGGLHIAVTTAGGGIAERTVKKDGPHSLESFRKSIDLNLIGTFNISRL
MSMEG_4742|M.smegmatis_MC2_155 DALGGLDAVVFTSTVI----PFAYIEDTDVASWLHAFNVNTLGANNVLRA
TH_1771|M.thermoresistible__bu ERFGRLDAIVFTTATV----PFALVDHTDVTTWLHAYAVNAVGATHVLRA
MMAR_3514|M.marinum_M DALGGIDNLVYAPAIS----PLVRLAETDADTWRRVFDTNVIGASLATAA
MUL_2753|M.ulcerans_Agy99 DALGGIDNLVYAPAIS----PLVRLAETDADTWRRVFDTNVIGASLATAA
MAV_4099|M.avium_104 DALGGIDNIVYTPAVG----PLVRMVDTDADTWRRIFDTNVIGASLVTAA
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIG----QAGRFLDTPPEEFDRVLAVNLGGVVNCCRA
MAB_2117|M.abscessus_ATCC_1997 QRFGGIDVVVANAGLL----TFGSVLQIDPATFKKLIDVNVLGVFHTVRA
. . * . : * *.
Mb0494c|M.bovis_AF2122/97 LLPKLIDS--------GDGLIVTVTSIAALEVYDGGAGYTAAKHAQGALH
Rv0484c|M.tuberculosis_H37Rv LLPKLIDS--------GDGLIVTVTSIAAIEVYDGGAGYTAAKHAQGALH
Mflv_4319|M.gilvum_PYR-GCK AAWHMSKNEPVDDEAEERGVIINTASIAAFEGQIGQLAYTASKAAIAGMC
Mvan_2027|M.vanbaalenii_PYR-1 AAWHMSKNDPVDDEAEERGVIINTASIAAFEGQIGQVAYTASKAAIAGMC
MSMEG_4742|M.smegmatis_MC2_155 AVPRLADN-------GVVLIASSHDVG---RPRAGVAAYSASKAALDEIL
TH_1771|M.thermoresistible__bu ALPHLADD-------AVIVVASSHDVG---RPRMGVSAYNASKAALDEMM
MMAR_3514|M.marinum_M ALPHLRAA-------AGKAVYLSSDAGSHAPPWPGLGAYGVSKAALERLV
MUL_2753|M.ulcerans_Agy99 ALPHLRAA-------AGKAVYLSSDAGSHAPPWPGLGAYGVSKAALERLV
MAV_4099|M.avium_104 AVPHLSAS-------AGKAVYLSSDAGAFGPPWPGLGAYGVSKAALERLV
MLBr_00862|M.leprae_Br4923 FGQRLVER-------GTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFS
MAB_2117|M.abscessus_ATCC_1997 ALPSVIER---------RGYVLVVSSLAAYAASPAVTAYNASKAAVEHFA
: . .* .:* * :
Mb0494c|M.bovis_AF2122/97 RTLRGELLGKPVRL-----TEIAPGAV-------ETEFSLVRFDGDQQRA
Rv0484c|M.tuberculosis_H37Rv RTLRGELLGKPVRL-----TEIAPGAV-------ETEFSLVRFDGDQQRA
Mflv_4319|M.gilvum_PYR-GCK LTMARDLGSLGIRA-----LAIAPSLF-------ATGLTEG--IPDEFAT
Mvan_2027|M.vanbaalenii_PYR-1 LTMARDLGSLGIRA-----LAIAPSLF-------ATGLTEG--IPDEFAS
MSMEG_4742|M.smegmatis_MC2_155 HSWRSEHPELSVIR-----VGVGPTED------TEILRGADRDLLDQLLK
TH_1771|M.thermoresistible__bu RSWRTEHPDLPVIR-----VSVGPTQD------TEILRGADRDLLGELYR
MMAR_3514|M.marinum_M EAWRAEHPEIGFTC-----VIVGECAGGEGDAQTGMNIGWDRELAMKAYP
MUL_2753|M.ulcerans_Agy99 EAWRAEHPEIGFTC-----VVVGECAGGEGDAQTGTNIGWDRELAMKAYL
MAV_4099|M.avium_104 EAWRAEHPDIGFTC-----LIVGECAGGEGDGQTGMNQGWDMDLAMKAVP
MLBr_00862|M.leprae_Br4923 DCLRAELDAVGVGL-----TTICPGVIDTNIIQSTRIDTPTAKQERVRDR
MAB_2117|M.abscessus_ATCC_1997 NALRLEVAHRGVDVGSAHMSWIDTSMVNDQKSNLSAFSEMLTRLPPPLRT
: . :
Mb0494c|M.bovis_AF2122/97 DAVYAGMTPLVAADVAE---------------VIGFVATRPSHVNLDQIV
Rv0484c|M.tuberculosis_H37Rv DAVYAGMTPLVAADVAE---------------VIGFVATRPSHVNLDQIV
Mflv_4319|M.gilvum_PYR-GCK VLTKDAAFPKRLGKPEE---------------YAKLAVAIVENPMLNGQC
Mvan_2027|M.vanbaalenii_PYR-1 VLTKDAAFPKRLGKPEE---------------YAKLAVAIVENPMLNGQC
MSMEG_4742|M.smegmatis_MC2_155 LWVEQGALPARMSALGD---------------VANTLVSLVVTAFENPTV
TH_1771|M.thermoresistible__bu SWAQQGQIPATMSAVDD---------------VANTMLSFIAVARANPSV
MMAR_3514|M.marinum_M LWLARGCMPGKLMPVED---------------LVNIVHTILRTDAATS--
MUL_2753|M.ulcerans_Agy99 LWLARGCMPGKLMPVED---------------LVNIVHTILRTDAATS--
MAV_4099|M.avium_104 LWSSRGCMPGKLMPVED---------------LIDVVHTILRTNASTS--
MLBr_00862|M.leprae_Br4923 RGQLDMMFRLRRYGPDK---------------VADTILSAIKKNKPIRPV
MAB_2117|M.abscessus_ATCC_1997 VTSVQACGRAFVKGIERRSRRINCPGWVGITRWLKPVLSTRLGEIPVRGM
:
Mb0494c|M.bovis_AF2122/97 IRPRDQASASRRATHPVR-------------
Rv0484c|M.tuberculosis_H37Rv IRPRDQASASRRATHPVR-------------
Mflv_4319|M.gilvum_PYR-GCK LRLDAGQRFAPK-------------------
Mvan_2027|M.vanbaalenii_PYR-1 LRLDAGQRFAPK-------------------
MSMEG_4742|M.smegmatis_MC2_155 VPEVVQLSPR------IRRRQGRE----PAE
TH_1771|M.thermoresistible__bu VPEIVHLSPRTPHQSQITSNRGGERNINPDT
MMAR_3514|M.marinum_M IPVVIARGASAP-AGVLDAGQS---------
MUL_2753|M.ulcerans_Agy99 IPVVIARGASAP-AGVLDAGQS---------
MAV_4099|M.avium_104 MPLVVARGAPASQAAFAEANQS---------
MLBr_00862|M.leprae_Br4923 APEAYALYGISRVLPQVLRSTARIRVI----
MAB_2117|M.abscessus_ATCC_1997 IPEILPRIDAEVAELQRAARDAIERP-----