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MSKTVVIGASSGLGRCIGVGLARRGDHVALLARRRERDEASCRSTLAAAADALGGIDNLVYAPAISPLVR LAETDADTWRRVFDTNVIGASLATAAALPHLRAAAGKAVYLSSDAGSHAPPWPGLGAYGVSKAALERLVE AWRAEHPEIGFTCVVVGECAGGEGDAQTGTNIGWDRELAMKAYLLWLARGCMPGKLMPVEDLVNIVHTIL RTDAATSIPVVIARGASAPAGVLDAGQS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2753 | - | - | 100% (238) | oxidoreductase |
| M. ulcerans Agy99 | MUL_3865 | - | 9e-12 | 31.35% (185) | dehydrogenase/decarboxylase protein |
| M. ulcerans Agy99 | MUL_0057 | - | 1e-11 | 26.16% (172) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0788c | - | 3e-11 | 28.72% (195) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0854 | - | 4e-15 | 33.33% (171) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0765c | - | 3e-11 | 28.72% (195) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 5e-05 | 29.14% (175) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4922 | - | 3e-16 | 33.72% (172) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_3514 | - | 1e-129 | 90.70% (258) | oxidoreductase |
| M. avium 104 | MAV_4099 | - | 1e-103 | 70.98% (255) | NAD dependent epimerase/dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_4742 | - | 8e-28 | 30.83% (240) | clavaldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4232 | - | 4e-58 | 49.37% (237) | PUTATIVE putative NAD dependent epimerase/dehydratase family |
| M. vanbaalenii PYR-1 | Mvan_6051 | - | 3e-15 | 33.33% (171) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0788c|M.bovis_AF2122/97 --------------------------------------------------
Rv0765c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0854|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_6051|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4922|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
TH_4232|M.thermoresistible__bu --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Mb0788c|M.bovis_AF2122/97 --------------------------------------------------
Rv0765c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0854|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_6051|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4922|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
TH_4232|M.thermoresistible__bu --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Mb0788c|M.bovis_AF2122/97 --------------------------------------------------
Rv0765c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0854|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_6051|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4922|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
TH_4232|M.thermoresistible__bu --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Mb0788c|M.bovis_AF2122/97 --------------------------------------------------
Rv0765c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0854|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_6051|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4922|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
TH_4232|M.thermoresistible__bu --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mb0788c|M.bovis_AF2122/97 --------------------------------------------------
Rv0765c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0854|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_6051|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4922|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
TH_4232|M.thermoresistible__bu --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mb0788c|M.bovis_AF2122/97 --------------------------------------------------
Rv0765c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0854|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_6051|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4922|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
TH_4232|M.thermoresistible__bu --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mb0788c|M.bovis_AF2122/97 ------------------MPRFEPHPARRTTVVAGASSGIGAATATELAG
Rv0765c|M.tuberculosis_H37Rv ------------------MPRFEPHPARRTTVVAGASSGIGAATATELAG
Mflv_0854|M.gilvum_PYR-GCK ------------------MP---------TAMITGASGGLGSALADALAP
Mvan_6051|M.vanbaalenii_PYR-1 ------------------MP---------TAMITGASGGVGSALADALAP
MAB_4922|M.abscessus_ATCC_1997 ------------------MP---------HALITGAAGGLGAAIARALAA
MUL_2753|M.ulcerans_Agy99 ---------------------MS------KTVVIGASSGLGRCIGVGLAR
MMAR_3514|M.marinum_M ---------------------MS------KTVVIGASSGLGRCIGVGLAR
MAV_4099|M.avium_104 -------------------------------MVVGASSGLGRCIGVGLAQ
TH_4232|M.thermoresistible__bu ---------------------MSEPDRPLRVAVVGASAGLGRCIGVGLSE
MSMEG_4742|M.smegmatis_MC2_155 ------------------MSSQPPDAAGLRLLVVGASSGIGHAVAESAAK
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
: **..*:* . :
Mb0788c|M.bovis_AF2122/97 RGFPVALGARRMDKLAELVDKIRADGGEAVAFPLDVTDPESVKSFVAQTV
Rv0765c|M.tuberculosis_H37Rv RGFPVALGARRMDKLAELVDKIRADGGEAVAFPLDVTDPESVKSFVAQTV
Mflv_0854|M.gilvum_PYR-GCK T-HTLFLAGRPSPRLDAVAERLGAT-----TWPVDLADPD----AMAAVV
Mvan_6051|M.vanbaalenii_PYR-1 T-HTLFLAGRPSPRLDAVAERLGAT-----TWPVDLADPD----AIPAVV
MAB_4922|M.abscessus_ATCC_1997 T-HSLLLGGRPSLRLDTLADELDAT-----PWPVDLSDQD----AILAAV
MUL_2753|M.ulcerans_Agy99 RGDHVALLARRRER-----------------------DEASCRSTLAAAA
MMAR_3514|M.marinum_M RGDHVALLARRRERTEAAAKEAGPG---TVAVECDVTDEASCRSALAAAA
MAV_4099|M.avium_104 RGDRVALLARRRQRIEAAAKDAGPG---AVAIECDVTDQASCASAIGEAV
TH_4232|M.thermoresistible__bu RGAQVAMLARRRERLADAAREAGNG---AVPVVCDVTDQGSCRRAMSEVV
MSMEG_4742|M.smegmatis_MC2_155 RGIDVAVAARRIKLLKTLADSIG-----GHAFELDVEDPAAITRVVNEAA
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
: : * .
Mb0788c|M.bovis_AF2122/97 EALGEVELLVSSAGDMLPGQLHEVSTEAFAEQVQIHLVGANRLATAVLPA
Rv0765c|M.tuberculosis_H37Rv EALGEVELLVSSAGDMLPGQLHEVSTEAFAEQVQIHLVGANRLATAVLPA
Mflv_0854|M.gilvum_PYR-GCK EPIVELDVLIHNAGVAYPGRVAESHVDEWRSTMAVNVVGAVALTLELLPA
Mvan_6051|M.vanbaalenii_PYR-1 EPIVELDVLIHNAGVAYPGRVAESDVDQWRATMAVNVVGAVALTLELLPA
MAB_4922|M.abscessus_ATCC_1997 AGIDALDVLVHNAGVSYPATIADSTLADWRKTLDVNVLAPVALTQALLPA
MUL_2753|M.ulcerans_Agy99 DALGGIDNLVYAPAISPLVRLAETDADTWRRVFDTNVIGASLATAAALPH
MMAR_3514|M.marinum_M DALGGIDNLVYAPAISPLVRLAETDADTWRRVFDTNVIGASLATAAALPH
MAV_4099|M.avium_104 DALGGIDNIVYTPAVGPLVRMVDTDADTWRRIFDTNVIGASLVTAAAVPH
TH_4232|M.thermoresistible__bu DALGRLDALVYTTGMGILSPLVEMTADQWAQLFATNVTGAALITAAAAPH
MSMEG_4742|M.smegmatis_MC2_155 DALGGLDAVVFTSTVIPFAYIEDTDVASWLHAFNVNTLGANNVLRAAVPR
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQR
: :: . . : : . : .
Mb0788c|M.bovis_AF2122/97 MVARRRGDLIFVGSDVGLR-QRPHMGAYGAAKAGLAAMVTNLQMELEGTG
Rv0765c|M.tuberculosis_H37Rv MVARRRGDLIFVGSDVGLR-QRPHMGAYGAAKAGLAAMVTNLQMELEGTG
Mflv_0854|M.gilvum_PYR-GCK LRAAR-GHVVFINSGAGIN-ASPGLASYTASKFALRGFADSLRADEP--T
Mvan_6051|M.vanbaalenii_PYR-1 LRSAG-GHVVFINSGAGIN-ASPGLASYSASKFALRAFADSLRADEP--G
MAB_4922|M.abscessus_ATCC_1997 LRAAQ-GDVVFINSGAGIN-AHPGIGSYSVSKFALRGFADVLRAEEP--A
MUL_2753|M.ulcerans_Agy99 LRAAAGKAVYLSSDAGSHAPPWPGLGAYGVSKAALERLVEAWRAEHP--E
MMAR_3514|M.marinum_M LRAAAGKAVYLSSDAGSHAPPWPGLGAYGVSKAALERLVEAWRAEHP--E
MAV_4099|M.avium_104 LSASAGKAVYLSSDAGAFGPPWPGLGAYGVSKAALERLVEAWRAEHP--D
TH_4232|M.thermoresistible__bu LSAAGGSAVYLSSLSASYTTPWPRLGSYAVTKAALDKLVEAWRVEHP--E
MSMEG_4742|M.smegmatis_MC2_155 LADNG---VVLIASSHDVGRPRAGVAAYSASKAALDEILHSWRSEHP--E
MLBr_00862|M.leprae_Br4923 LVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVG
: . :.:* .:* . : : :
Mb0788c|M.bovis_AF2122/97 VRASIVHPGPTLTGMGWQLSAEQVGPM------LADWAKWGQARHNYFLR
Rv0765c|M.tuberculosis_H37Rv VRASIVHPGPTLTGMGWQLSAEQVGPM------LADWAKWGQARHNYFLR
Mflv_0854|M.gilvum_PYR-GCK LRVTSVHPGRIATAMQEDLVAYEG----------------RPYEPDRFLS
Mvan_6051|M.vanbaalenii_PYR-1 LRVTSVHPGRIATAMQEDLVAYEG----------------RPYDPAQFLS
MAB_4922|M.abscessus_ATCC_1997 LRVTSVHPGRISTPMQQELTEHEG----------------REYNPDDYMR
MUL_2753|M.ulcerans_Agy99 IGFTCVVVGECAGGEGDAQTGTNIGWDRELAMKAYLLWLARGCMPGKLMP
MMAR_3514|M.marinum_M IGFTCVIVGECAGGEGDAQTGMNIGWDRELAMKAYPLWLARGCMPGKLMP
MAV_4099|M.avium_104 IGFTCLIVGECAGGEGDGQTGMNQGWDMDLAMKAVPLWSSRGCMPGKLMP
TH_4232|M.thermoresistible__bu IGFTRLAVGDSLGGTGDSQTEFNKSWDPAAFDDAVNFWMEHGYMQGGLVE
MSMEG_4742|M.smegmatis_MC2_155 LSVIRVGVGPTED------TEILRGADRDLLDQLLKLWVEQGALPARMSA
MLBr_00862|M.leprae_Br4923 VGLTTICPGVIDTNIIQSTRIDTPTAKQE--RVRDRRGQLDMMFRLRRYG
: : *
Mb0788c|M.bovis_AF2122/97 PSDLARAIAFVAETPRG--CVVVNMEIQPEAPLRDAPAHRQKLVLGEEGM
Rv0765c|M.tuberculosis_H37Rv PSDLARAIAFVAETPRG--CVVVNMEIQPEAPLRDAPAHRQKLVLGEEGM
Mflv_0854|M.gilvum_PYR-GCK PQTVARLTVDAINAPAD--AHVHEVIIRPSPAPR----------------
Mvan_6051|M.vanbaalenii_PYR-1 PQTVAQVTADAINAPAD--AHIHEVIVRPR--------------------
MAB_4922|M.abscessus_ATCC_1997 PESVAQLVADAVNLPRD--ARVHQIVVRQN--------------------
MUL_2753|M.ulcerans_Agy99 VEDLVNIVHTILRTDAA--TSIPVVIARGASAP-AGVLDAGQS-------
MMAR_3514|M.marinum_M VEDLVNIVHTILRTDAA--TSIPVVIARGASAP-AGVLDAGQS-------
MAV_4099|M.avium_104 VEDLIDVVHTILRTNAS--TSMPLVVARGAPASQAAFAEANQS-------
TH_4232|M.thermoresistible__bu ADHLVQTVDAILRCGKS--SFIPHLTLAPRPSS--AVDDLR---------
MSMEG_4742|M.smegmatis_MC2_155 LGDVANTLVSLVVTAFENPTVVPEVVQLSPRIRRRQGREPAE--------
MLBr_00862|M.leprae_Br4923 PDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI--
:
Mb0788c|M.bovis_AF2122/97 PG
Rv0765c|M.tuberculosis_H37Rv PG
Mflv_0854|M.gilvum_PYR-GCK --
Mvan_6051|M.vanbaalenii_PYR-1 --
MAB_4922|M.abscessus_ATCC_1997 --
MUL_2753|M.ulcerans_Agy99 --
MMAR_3514|M.marinum_M --
MAV_4099|M.avium_104 --
TH_4232|M.thermoresistible__bu --
MSMEG_4742|M.smegmatis_MC2_155 --
MLBr_00862|M.leprae_Br4923 --