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EIEGKKAIIVGGASGFGRATAEALAKRGATVAVLDRPQSKGKEVADQIGGTFYEVDITDFEGTESVLNKV VEDLGGLHIAVTTAGGGIAERTVKKDGPHSLDSFRKSIDLNLIGTFNISRIAAWHMSKNEPVDDEAEERG VIINTASIAAFEGQIGQLAYTASKAAIAGMCLTMARDLGSLGIRALAIAPSLFATGLTEGIPDEFATVLT KDAAFPKRLGKPEEYAKLAVAIVENPMLNGQCLRLDAGQRFAPK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4319 | - | - | 100% (255) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2127 | - | 7e-61 | 50.58% (257) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_3163 | - | 4e-55 | 42.91% (261) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1176 | - | 1e-55 | 45.14% (257) | short-chain type dehydrogenase/reductase |
| M. tuberculosis H37Rv | Rv1144 | - | 1e-55 | 45.14% (257) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 9e-18 | 28.74% (247) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0368 | - | 3e-56 | 46.56% (262) | Short-chain dehydrogenase/reductas |
| M. marinum M | MMAR_1624 | - | 1e-107 | 74.90% (255) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_3936 | - | 1e-110 | 77.65% (255) | 3-hydroxyacyl-CoA dehydrogenase type-2 |
| M. smegmatis MC2 155 | MSMEG_2279 | - | 1e-127 | 87.84% (255) | 3-hydroxyacyl-CoA dehydrogenase type-2 |
| M. thermoresistible (build 8) | TH_3183 | - | 1e-131 | 90.20% (255) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3412 | - | 1e-107 | 74.90% (255) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_2027 | - | 1e-136 | 94.90% (255) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1176|M.bovis_AF2122/97 ----------------MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVV
Rv1144|M.tuberculosis_H37Rv ----------------MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVV
Mflv_4319|M.gilvum_PYR-GCK ----------------MEIEGKKAIIVGGASGFGRATAEALAKRGATVAV
Mvan_2027|M.vanbaalenii_PYR-1 ----------------MEIEGKKAVVVGGASGFGRATAEALAKRGASVAV
TH_3183|M.thermoresistible__bu ----------------MEIEGKKAVVVGGASGFGRATAEALAKRGASVAV
MSMEG_2279|M.smegmatis_MC2_155 ----------------MEIEGKKAVIVGGASGFGRATAEALAKRGATVAV
MMAR_1624|M.marinum_M ----------------MEISGKKAVVIGGASGMGRATAELLAKRGADVAI
MUL_3412|M.ulcerans_Agy99 ----------------MEISGKKAVVIGGASGMGRATAELLAKRGADVAI
MAV_3936|M.avium_104 ----------------MEINGKKAVVVGGASGMGRASAELFAARGADVAI
MAB_0368|M.abscessus_ATCC_1997 ----------------MDINGVSAIVTGGASGLGAATARLLAAQGAKVVI
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
. :: ** *:* * :. : * *.:
Mb1176|M.bovis_AF2122/97 VDLR---GDDVVGGLGDRARFAQADVTDEAAVSNALELA-DSLGPVRVVV
Rv1144|M.tuberculosis_H37Rv VDLR---GDDVVGGLGDRARFAQADVTDEAAVSNALELA-DSLGPVRVVV
Mflv_4319|M.gilvum_PYR-GCK LDRPQSKGKEVADQIG--GTFYEVDITDFEGTESVLNKVVEDLGGLHIAV
Mvan_2027|M.vanbaalenii_PYR-1 LDRPQSKGKEVADQIG--GSFFEVDITDFEGTESVLNQAVEALGGLHIAV
TH_3183|M.thermoresistible__bu LDRPQSKGKEVAEQIG--GSFFDVDVTDFDGTEKVLQQAVDALGGLHIAV
MSMEG_2279|M.smegmatis_MC2_155 LDRPQSKGQEVADSIG--GSFFAVDVTDFDGTEKVLQEAVDALGGLHIAV
MMAR_1624|M.marinum_M LDREGSDGKSVAEAIG--AAFYPVDVTDFAGTEEILQTAVDRLGGLHVIV
MUL_3412|M.ulcerans_Agy99 LDREGSDGKSVAEAIG--AAFYPVDVTDFAGTEEILQTAVDRLGGLHVIV
MAV_3936|M.avium_104 LDRESSDGKAVAEGIG--AAFYPVDVTDFAGTEETLQSAVDKLGGLHVIV
MAB_0368|M.abscessus_ATCC_1997 ADVQDEKGEALAKELG--GAFVHTDVTSEADGIAAVDAA-KELGPVRVLI
MLBr_01807|M.leprae_Br4923 THRAS---VVPDWFFG-----VECDVTDNDAIGAAFKAVEEHQGPVEVLV
. :* *:*. .. . . * :.: :
Mb1176|M.bovis_AF2122/97 NCAGTGNAIRVLSRDG----VFPLAAFRKIVDINLVGTFNVLRLGAERIA
Rv1144|M.tuberculosis_H37Rv NCAGTGNAIRVLSRDG----VFPLAAFRKIVDINLVGTFNVLRLGAERIA
Mflv_4319|M.gilvum_PYR-GCK TTAGGGIAERTVKKDG----PHSLDSFRKSIDLNLIGTFNISRIAAWHMS
Mvan_2027|M.vanbaalenii_PYR-1 TTAGGGIAERTVKKDG----PHSLESFRKSIDLNLIGTFNISRLAAWHMS
TH_3183|M.thermoresistible__bu TTAGGGIAERTVKKDG----PHSLESFRQSVDLNLIGTFNISRLAAWHMS
MSMEG_2279|M.smegmatis_MC2_155 TTAGGGIGERTVKKDG----PHSLDSFRSTIDLNLIGTFNVSRLAAWHMS
MMAR_1624|M.marinum_M TTAGGGIAKRTLTKSG----PHDLESFRSVVDLNLIATFNISRLAAAHMA
MUL_3412|M.ulcerans_Agy99 TTAGGGIAKRTLTKSG----PHDLESFRSVVDLNLIATFNISRLAAAHMA
MAV_3936|M.avium_104 TTAGGGIAKRTLTKNG----PHDLESFQSVIDLNLIATFNISRLAAAHMA
MAB_0368|M.abscessus_ATCC_1997 NCAGVGWPGRTIGKDGQYASAHSLDIFSKVIGINLIGSFNLIRLAATAIS
MLBr_01807|M.leprae_Br4923 ANAGITSDMLIMRMSE--------EQFQKVIDVNLTGVFRVAKLASRNMI
** : . * . :.:** . *.: ::.: :
Mb1176|M.bovis_AF2122/97 KTEPIG---EERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIARD
Rv1144|M.tuberculosis_H37Rv KTEPIG---EERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIARD
Mflv_4319|M.gilvum_PYR-GCK KNEPVDDEAEERGVIINTASIAAFEGQIGQLAYTASKAAIAGMCLTMARD
Mvan_2027|M.vanbaalenii_PYR-1 KNDPVDDEAEERGVIINTASIAAFEGQIGQVAYTASKAAIAGMCLTMARD
TH_3183|M.thermoresistible__bu KNEPVDDEKEERGVIINTASIAAFEGQIGQVAYTASKAAIAGMCLTMARD
MSMEG_2279|M.smegmatis_MC2_155 KNDPVDAEGEERGVIINTASIAAFEGQIGQVAYTASKAAIAGMSLTMARD
MMAR_1624|M.marinum_M NNEPED---DERGVIINTASIAAFEGQIGQVAYTAAKAGIAGMCLTMARD
MUL_3412|M.ulcerans_Agy99 NNEPED---DERGVIINTASIAAFEGQIGQVAYTAAKAGIAGMCLTMARD
MAV_3936|M.avium_104 KNEPED---EERGVIINTASIAAFEGQIGQVAYTAAKAAIAGMCLTMARD
MAB_0368|M.abscessus_ATCC_1997 QEEPVD-EFGERGAIVNTASVAAFDGQIGQAAYSASKGGIVGMTLPIARD
MLBr_01807|M.leprae_Br4923 K--------QRFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARE
: . * : .*:..:.* ** *:*:*..: ** .:**:
Mb1176|M.bovis_AF2122/97 LASKLIRVVTIAPGLFDTPLLAS--LPAEAKASLGQQVPHPSRLGNPDEY
Rv1144|M.tuberculosis_H37Rv LASKLIRVVTIAPGLFDTPLLAS--LPAEAKASLGQQVPHPSRLGNPDEY
Mflv_4319|M.gilvum_PYR-GCK LGSLGIRALAIAPSLFATGLTEG--IPDEFATVLTKDAAFPKRLGKPEEY
Mvan_2027|M.vanbaalenii_PYR-1 LGSLGIRALAIAPSLFATGLTEG--IPDEFASVLTKDAAFPKRLGKPEEY
TH_3183|M.thermoresistible__bu LGSLGIRALAIAPSLFATGLTEG--IPDEFAKQLTKDAAFPKRLGKPEEY
MSMEG_2279|M.smegmatis_MC2_155 LGSLGIRALAIAPSLFATGLTEG--IPDDFAKVLTKDAAFPKRLGKPDEY
MMAR_1624|M.marinum_M LGSMGIRVLAIAPSLFLTGLTAM--VPDEMAAQLVKDAAFPKRMGRPEEY
MUL_3412|M.ulcerans_Agy99 LGSMGIRVLAIAPSLFLTGLTAM--VPDEMAAQLVKDAAFPKRMGRPEEY
MAV_3936|M.avium_104 LGSVGVRVLAIAPSLFATGLTQG--IPDEFATQLTKDAAFPKRLGRPEEY
MAB_0368|M.abscessus_ATCC_1997 LSVVGIRVNTIAPGLIDTPIYGEGESAQQFKDRLAPNVLYPQRLGNPEEF
MLBr_01807|M.leprae_Br4923 LGSRSITANVVAPGFIDTEMTRA--MDSKYQEAALQAIPLG-RIGAVEEI
*. : . .:**.:: * : . *:* :*
Mb1176|M.bovis_AF2122/97 GALVLHIIEN--PMLNGEVIRLDGAIRMAPR
Rv1144|M.tuberculosis_H37Rv GALVLHIIEN--PMLNGEVIRLDGAIRMAPR
Mflv_4319|M.gilvum_PYR-GCK AKLAVAIVEN--PMLNGQCLRLDAGQRFAPK
Mvan_2027|M.vanbaalenii_PYR-1 AKLAVAIVEN--PMLNGQCLRLDAGQRFAPK
TH_3183|M.thermoresistible__bu AKLALAIVEN--PMLNGQCIRLDAGQRFAPK
MSMEG_2279|M.smegmatis_MC2_155 ARLALAIVEN--PMLNGQCIRLDGGQRFAPK
MMAR_1624|M.marinum_M AKLVAAIVDN--PMLNGQCLRLDAGQRFAPK
MUL_3412|M.ulcerans_Agy99 AKLVAAIVDN--PMLNGQCLRLDAGQRFAPK
MAV_3936|M.avium_104 AKLALAIVDN--PMLNGQCLRLDAGQRFAPK
MAB_0368|M.abscessus_ATCC_1997 ASLALELVTN--SYMNAETIRIDGGARLQPK
MLBr_01807|M.leprae_Br4923 AGAVSFLASEDAGYISGAVIPVDGGLGMGH-
. . : : :.. : :*.. :