For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VVGASSGLGRCIGVGLAQRGDRVALLARRRQRIEAAAKDAGPGAVAIECDVTDQASCASAIGEAVDALGG IDNIVYTPAVGPLVRMVDTDADTWRRIFDTNVIGASLVTAAAVPHLSASAGKAVYLSSDAGAFGPPWPGL GAYGVSKAALERLVEAWRAEHPDIGFTCLIVGECAGGEGDGQTGMNQGWDMDLAMKAVPLWSSRGCMPGK LMPVEDLIDVVHTILRTNASTSMPLVVARGAPASQAAFAEANQS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4099 | - | - | 100% (255) | NAD dependent epimerase/dehydratase family protein |
| M. avium 104 | MAV_4982 | - | 3e-19 | 30.50% (259) | short-chain dehydrogenase/reductase SDR |
| M. avium 104 | MAV_5089 | - | 7e-17 | 33.33% (201) | oxidoreductase, short chain dehydrogenase/reductase family |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 1e-16 | 30.17% (232) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_2396 | - | 2e-17 | 31.67% (240) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1941 | - | 1e-16 | 30.17% (232) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-09 | 33.14% (175) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1215c | - | 8e-18 | 33.64% (214) | short chain dehydrogenase |
| M. marinum M | MMAR_3514 | - | 1e-119 | 78.82% (255) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_4742 | - | 8e-34 | 35.53% (228) | clavaldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4232 | - | 4e-72 | 54.10% (244) | PUTATIVE putative NAD dependent epimerase/dehydratase family |
| M. ulcerans Agy99 | MUL_2753 | - | 1e-103 | 70.98% (255) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4252 | - | 2e-18 | 30.29% (241) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
TH_4232|M.thermoresistible__bu --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MAB_1215c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
TH_4232|M.thermoresistible__bu --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MAB_1215c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
TH_4232|M.thermoresistible__bu --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MAB_1215c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
TH_4232|M.thermoresistible__bu --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MAB_1215c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
TH_4232|M.thermoresistible__bu --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MAB_1215c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3514|M.marinum_M --------------------------------------------------
MUL_2753|M.ulcerans_Agy99 --------------------------------------------------
MAV_4099|M.avium_104 --------------------------------------------------
TH_4232|M.thermoresistible__bu --------------------------------------------------
MSMEG_4742|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MAB_1215c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------MNHPDLAGKVAIVTGAGAGIGLAVARRLAD
Rv1941|M.tuberculosis_H37Rv --------------------MNHPDLAGKVAIVTGAGAGIGLAVARRLAD
Mflv_2396|M.gilvum_PYR-GCK -----------------------MTLDGKVAFVAGASRGIGATVAAALAR
Mvan_4252|M.vanbaalenii_PYR-1 -----------------------MTLHGKVAFVAGASRGIGATVAAALAR
MMAR_3514|M.marinum_M ---------------------MS------KTVVIGASSGLGRCIGVGLAR
MUL_2753|M.ulcerans_Agy99 ---------------------MS------KTVVIGASSGLGRCIGVGLAR
MAV_4099|M.avium_104 -------------------------------MVVGASSGLGRCIGVGLAQ
TH_4232|M.thermoresistible__bu ---------------------MSEPDRPLRVAVVGASAGLGRCIGVGLSE
MSMEG_4742|M.smegmatis_MC2_155 ------------------MSSQPPDAAGLRLLVVGASSGIGHAVAESAAK
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
MAB_1215c|M.abscessus_ATCC_199 ------------------MPRFEPHPARRPSIIAGASSGIGAATAIELAG
: **. *:* . :
Mb1976|M.bovis_AF2122/97 EGCHVLCADIDG---------DAADAAATKIGCGAAACRVDVSDEQQIIA
Rv1941|M.tuberculosis_H37Rv EGCHVLCADIDG---------DAADAAATKIGCGAAACRVDVSDEQQIIA
Mflv_2396|M.gilvum_PYR-GCK AGASVAVAARTEQEGRLPGTIGSVAQRITDEGGRALPVVCDVTREESVEA
Mvan_4252|M.vanbaalenii_PYR-1 AGASVAVAARSEQEGKLPGTIGSVAQGISAAGGRALPVACDVTSEESVNA
MMAR_3514|M.marinum_M RGDHVALLARRR---------ERTEAAAKEAGPGTVAVECDVTDEASCRS
MUL_2753|M.ulcerans_Agy99 RGDHVALLARRR---------ER--------------------DEASCRS
MAV_4099|M.avium_104 RGDRVALLARRR---------QRIEAAAKDAGPGAVAIECDVTDQASCAS
TH_4232|M.thermoresistible__bu RGAQVAMLARRR---------ERLADAAREAGNGAVPVVCDVTDQGSCRR
MSMEG_4742|M.smegmatis_MC2_155 RGIDVAVAARRI---------KLLKTLADSIG--GHAFELDVEDPAAITR
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAA------KNTAAQIVASGGVAYAYALDVSDAAAVEA
MAB_1215c|M.abscessus_ATCC_199 RGFPVALGARRVDK------LTELVEKIRSDGGEAVAFPLDVTDADSVKS
* *
Mb1976|M.bovis_AF2122/97 MVDACVAAFGGVDKLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCT
Rv1941|M.tuberculosis_H37Rv MVDACVAAFGGVDKLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCT
Mflv_2396|M.gilvum_PYR-GCK AVAATVAEFGGIDILVANAGVLWLGPIESTPLKRWQLCLDVNTTGVFLVT
Mvan_4252|M.vanbaalenii_PYR-1 AVAETVAEFGGIDILVANAGVLWLGPIETTPLKRWQLCLDVNTTGVFLVT
MMAR_3514|M.marinum_M ALAAAADALGGIDNLVYAPAISPLVRLAETDADTWRRVFDTNVIGASLAT
MUL_2753|M.ulcerans_Agy99 TLAAAADALGGIDNLVYAPAISPLVRLAETDADTWRRVFDTNVIGASLAT
MAV_4099|M.avium_104 AIGEAVDALGGIDNIVYTPAVGPLVRMVDTDADTWRRIFDTNVIGASLVT
TH_4232|M.thermoresistible__bu AMSEVVDALGRLDALVYTTGMGILSPLVEMTADQWAQLFATNVTGAALIT
MSMEG_4742|M.smegmatis_MC2_155 VVNEAADALGGLDAVVFTSTVIPFAYIEDTDVASWLHAFNVNTLGANNVL
MLBr_00862|M.leprae_Br4923 FAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCC
MAB_1215c|M.abscessus_ATCC_199 FVAESIDALGEIDLLVSGAGDMYPGRVHEMSAATFAAQIQVHLLGANQLA
* * :* . . : : : *.
Mb1976|M.bovis_AF2122/97 KHAAPRMIERGGGAIVNLSSLAGQVAVG-GTGAYGMSKAGIIQLSRITAA
Rv1941|M.tuberculosis_H37Rv KHAAPRMIERGGGAIVNLSSLAGQVAVG-GTGAYGMSKAGIIQLSRITAA
Mflv_2396|M.gilvum_PYR-GCK KAVIPHVRARGGGSLIAVTTTGVTMTDH-GANAYWVSKAAAERLYLGLAA
Mvan_4252|M.vanbaalenii_PYR-1 KAVIPHVRARGGGSLIAVTTTGVNMTDH-GANAYWVSKAAVERLYLGLAA
MMAR_3514|M.marinum_M AAALPHLRAAAGKAVYLSSDAGSHAPPWPGLGAYGVSKAALERLVEAWRA
MUL_2753|M.ulcerans_Agy99 AAALPHLRAAAGKAVYLSSDAGSHAPPWPGLGAYGVSKAALERLVEAWRA
MAV_4099|M.avium_104 AAAVPHLSASAGKAVYLSSDAGAFGPPWPGLGAYGVSKAALERLVEAWRA
TH_4232|M.thermoresistible__bu AAAAPHLSAAGGSAVYLSSLSASYTTPWPRLGSYAVTKAALDKLVEAWRV
MSMEG_4742|M.smegmatis_MC2_155 RAAVPRLADNG---VVLIASSHDVGRPRAGVAAYSASKAALDEILHSWRS
MLBr_00862|M.leprae_Br4923 RAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRA
MAB_1215c|M.abscessus_ATCC_199 TEVVPDMVSRRRGDVVFIG-SDVALHQRPHMGAYGAAKAALLAMVNTMRM
: :* :**. :
Mb1976|M.bovis_AF2122/97 ELRSSGIRSNTLLPAFVDTPMQQTAMAMFDGALGAGGAR---SMIARLQG
Rv1941|M.tuberculosis_H37Rv ELRSSGIRSNTLLPAFVDTPMQQTAMAMFDGALGAGGAR---SMIARLQG
Mflv_2396|M.gilvum_PYR-GCK DLKPDNIAVNCLSP----------SRVVLTEGWQAGGAG---MEIP--PE
Mvan_4252|M.vanbaalenii_PYR-1 DLKPDNIAVNCLSP----------SRVVLTEGWQAGGAG---MQIP--PE
MMAR_3514|M.marinum_M EHPEIGFTCVIVGECAGGEGDAQTGMNIGWDRELAMKAYPLWLARGCMPG
MUL_2753|M.ulcerans_Agy99 EHPEIGFTCVVVGECAGGEGDAQTGTNIGWDRELAMKAYLLWLARGCMPG
MAV_4099|M.avium_104 EHPDIGFTCLIVGECAGGEGDGQTGMNQGWDMDLAMKAVPLWSSRGCMPG
TH_4232|M.thermoresistible__bu EHPEIGFTRLAVGDSLGGTGDSQTEFNKSWDPAAFDDAVNFWMEHGYMQG
MSMEG_4742|M.smegmatis_MC2_155 EHPELSVIRVGVGPTED------TEILRGADRDLLDQLLKLWVEQGALPA
MLBr_00862|M.leprae_Br4923 ELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRL
MAB_1215c|M.abscessus_ATCC_199 ELEGTGVRASIVHPGPTLTSMGWQLSAEQVGPMLEDWKSWGQARHSYFLR
: .. :
Mb1976|M.bovis_AF2122/97 RMAAPEEMAGIVVFLLSDDAS---MITGTTQIADGGTIAALW--------
Rv1941|M.tuberculosis_H37Rv RMAAPEEMAGIVVFLLSDDAS---MITGTTQIADGGTIAALW--------
Mflv_2396|M.gilvum_PYR-GCK MVEPPEAMGRATVMLAQQDAS---GVTGTIQRSEALAL------------
Mvan_4252|M.vanbaalenii_PYR-1 MVEPPEAMADAAVFLAGQDAS---GITGTIQRSEALTF------------
MMAR_3514|M.marinum_M KLMPVEDLVNIVHTILRTDAA--TSIPVVIARGASAP-AGVLDAGQS---
MUL_2753|M.ulcerans_Agy99 KLMPVEDLVNIVHTILRTDAA--TSIPVVIARGASAP-AGVLDAGQS---
MAV_4099|M.avium_104 KLMPVEDLIDVVHTILRTNAS--TSMPLVVARGAPASQAAFAEANQS---
TH_4232|M.thermoresistible__bu GLVEADHLVQTVDAILRCGKS--SFIPHLTLAPRPSS--AVDDLR-----
MSMEG_4742|M.smegmatis_MC2_155 RMSALGDVANTLVSLVVTAFENPTVVPEVVQLSPRIRRRQGREPAE----
MLBr_00862|M.leprae_Br4923 RRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIR
MAB_1215c|M.abscessus_ATCC_199 PSDIARAVTFVAETPRGAHIPEMEVQPEAPLKDAPADKQKLELGEEGMPS
: .
Mb1976|M.bovis_AF2122/97 --
Rv1941|M.tuberculosis_H37Rv --
Mflv_2396|M.gilvum_PYR-GCK --
Mvan_4252|M.vanbaalenii_PYR-1 --
MMAR_3514|M.marinum_M --
MUL_2753|M.ulcerans_Agy99 --
MAV_4099|M.avium_104 --
TH_4232|M.thermoresistible__bu --
MSMEG_4742|M.smegmatis_MC2_155 --
MLBr_00862|M.leprae_Br4923 VI
MAB_1215c|M.abscessus_ATCC_199 --